TumCCA Cancer Research Results

TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
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Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
924- RES,    Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells
- in-vitro, OS, U2OS - in-vitro, Lung, A549
TumCCA↑, ROS↑, γH2AX↑, ATM↑, p‑CHK1↑, cellSen↑, CXCR2↑,
884- RES,  PTS,    Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells
- in-vitro, Cerv, HeLa
TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,
883- RES,    Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy
HDAC↓, TumCCA↑, Apoptosis↑, angioG↓, ROS↑,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
7150- RES,    Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity
- Review, Var, NA
AntiTum↑, PI3K↓, Akt↓, *AntiAge↑, *SIRT1↑, *lipid-P↓, *ROS↓, *BioAv↓, *NRF2↑, *HO-1↑, SOD↑, HDAC1↓, PTEN↑, P53↑, TumCCA↑, TumCI↓, TumMeta↓, EMT↓, MMPs↓, MMP9↓, angioG↓, VEGF↓, EGFR↓, FGF21↓, HIF-1↓, *neuroP↑, *cardioP↑, BMPs↑, ROS↑, Vim↓, N-cadherin↓, MMP3↓, MMP13↓, E-cadherin↑, Ki-67↓,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1/ATG6↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3054- RES,    Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line
- in-vitro, Melanoma, A375
TumCG↓, P21↑, p27/CDKN1B↑, CycB/CCNB1↓, ROS↑, ER Stress↑, p‑p38↑, P53↑, p‑eIF2α↑, EP4/PTGER4↑, CHOP/DDIT3↑, Bcl-2↓, BAX↓, TumCCA↑, NRF2↓, ChemoSen↑, GSH↓,
3055- RES,    Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
- Review, Var, NA
BioAv↓, BioAv↓, Dose↑, eff↑, eff↑, Dose↑, BioAv↑, ROS↑, MMP↓, P21↑, p27/CDKN1B↑, TumCCA↑, ChemoSen↑, COX2/PTGS2↓, 5LO↓, VEGF↓, IL1↓, IL6↓, IL8↓, AR↓, PSA↓, MAPK↓, Hif1a↓, Glycolysis↓, miR-21↓, PTEN↑, Half-Life↝, *IGF-1↓, *IGFBP3↑, Half-Life↓,
2981- RES,    Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways
- in-vitro, Colon, HT-29 - in-vitro, Colon, SW48
TumCCA↑, p27/CDKN1B↑, cycD1/CCND1↓, TumCP↓, IGF-1R↓, Akt↓, Wnt↓, P53↑, Apoptosis↑, Sp1/3/4↓, cl‑PARP↑, β-catenin/ZEB1↓, MDM2↓,
7149- Rhe,    Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
- in-vitro, PC, NA
TumCCA↑, Casp↑, mt-Apoptosis↑, PI3K↓, Akt↓, ChemoSen↑, ROS↑, eff↓,
3027- RosA,    Rosmarinic acid inhibits proliferation and invasion of hepatocellular carcinoma cells SMMC 7721 via PI3K/AKT/mTOR signal pathway
- in-vitro, HCC, SMMC-7721 cell
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, TumCMig↓, MMPs↓, Vim↓,
3005- RosA,    Nanoformulated rosemary extract impact on oral cancer: in vitro study
- in-vitro, Laryn, HEp2
TumCCA↑, ROS↑, Bcl-2↓, BAX↑, Casp3↑, P53↑, necrosis↑, eff↑, BioAv↑,
3003- RosA,    Comprehensive Insights into Biological Roles of Rosmarinic Acid: Implications in Diabetes, Cancer and Neurodegenerative Diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*Inflam↓, *antiOx↑, *neuroP↑, *IL6↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMP↑, *memory↑, *ROS↓, *Aβ↓, *HMGB1↓, TumCG↓, MARK4↓, Zeb1↓, MDM2↓, BNIP3↑, ASC↑, NLRP3↓, PI3K↓, Akt↓, Casp1↓, E-cadherin↑, STAT3↓, TLR4↓, MMP↓, ICAM-1↓, AMPK↓, IL6↑, MMP2↓, Warburg↓, Bcl-xL↓, Bcl-2↓, TumCCA↑, EMT↓, TumMeta↓, mTOR↓, HSP27↓, Casp3↑, GlucoseCon↓, lactateProd↓, VEGF↓, p‑p65↓, GIT1↓, FOXM1↓, cycD1/CCND1↓, CDK4↓, MMP9↓, HDAC2↓,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, eff↑,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
3033- RosA,    Rosemary (Rosmarinus officinalis) Extract Modulates CHOP/GADD153 to Promote Androgen Receptor Degradation and Decreases Xenograft Tumor Growth
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP - vitro+vivo, NA, NA
ER Stress↑, selectivity↑, AR↓, TumCG↓, TumCCA↑, CHOP/DDIT3↑, PERK↓, GRP78/BiP↑, PSA↓,
1748- RosA,    The Role of Rosmarinic Acid in Cancer Prevention and Therapy: Mechanisms of Antioxidant and Anticancer Activity
- Review, Var, NA
AntiCan↑, *BioAv↝, *CardioT↓, *Iron↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, MARK4↓, MMP9↓, TumCCA↑, Bcl-2↓, BAX↑, Apoptosis↑, E-cadherin↑, N-cadherin↓, Vim↓, Gli1↓, HDAC2↓, Warburg↓, Hif1a↓, miR-155↓, p‑PI3K↑, ROS↑, *IronCh↑,
1747- RosA,    Molecular Pathways of Rosmarinic Acid Anticancer Activity in Triple-Negative Breast Cancer Cells: A Literature Review
- Review, BC, MDA-MB-231 - Review, BC, MDA-MB-468
TumCCA↑, TNF-α↑, GADD45A↑, BNIP3↑, survivin↓, Bcl-2↓, BAX↑, HH↓, eff↑, ChemoSen↑, RadioS↑, TumCP↓, TumCMig↓, Apoptosis↑, RenoP↑, CardioT↓,
7375- RS,    Regulation of hippo signaling mediated apoptosis by Rauvolfia tetraphylla in triple-negative breast cancer
- in-vitro, BC, MDA-MB-231
eff↝, TumCCA↑, TumCMig↓, ROS↑, BAX↑, Mst1↑, Bcl-2↓, YAP/TEAD↓, LATS1↓,
7377- RS,    Reserpine Induces Apoptosis and Cell Cycle Arrest in Hormone Independent Prostate Cancer Cells through Mitochondrial Membrane Potential Failure
- in-vitro, Pca, PC3
TumCCA↑, MMP↑, ROS↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
106- RT,    Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
- in-vivo, BC, MCF7
P-gp/ABCB1↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
4899- Sal,    Anticancer activity of salinomycin quaternary phosphonium salts
- in-vitro, Var, NA
eff↑, selectivity↑, CSCs↓, TumCCA↑, MMP↓, ROS↑, mitResp↑,
4902- Sal,  OXA,    Salinomycin and oxaliplatin synergistically enhances cytotoxic effect on human colorectal cancer cells in vitro and in vivo
- vitro+vivo, CRC, NA
RadioS↑, ChemoSen↑, TumCP↓, Apoptosis↑, ROS↑, MMP↓, MAPK↑, eff↓, TumCG↓, TumCCA↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,
6442- SAO,    Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil: review
- Review, RCC, NA
AntiTum↑, Apoptosis↑, TumCCA↑, *Inflam↓, selectivity↑, tumCV↓, Casp8↓, Casp9↓, Casp6↓, Casp3↓, cl‑PARP↑, angioG↓, VEGFR2/KDR/Flk1↓, Akt↑, mTOR↓, TumCG↓, *GSTs↑, *antiOx↑, *ROS↓,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
6448- SAO,    A novel chemopreventive mechanism for a traditional medicine: East Indian sandalwood oil induces autophagy and cell death in proliferating keratinocytes
- in-vitro, Nor, HaCaT
*TumCCA↑, *AP-1↓, chemoPv↑,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,
5038- SAS,  Rad,    Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma
- in-vivo, Melanoma, B16-F10
xCT/SLC7A11↓, ROS↑, RadioS↓, GSH↓, selectivity↑, DNArepair↓, TumCCA↑, H2O2↑, Dose↝,
4483- Se,  Chit,    Anti-cancer potential of chitosan-starch selenium Nanocomposite: Targeting osteoblastoma and insights of molecular docking
- in-vitro, OS, NA
AntiCan↑, TumCP↓, Apoptosis↑, ROS↑, eff↑, other↝, eff↑, TumCCA↑,
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
4603- SeNPs,    Therapeutic applications of selenium nanoparticles
- Review, Var, NA
AntiCan↑, Imm↑, *AntiDiabetic↑, *antiOx↑, *Inflam↓, ROS↑, ER Stress↑, DNAdam↑, *toxicity↓, *eff↑, *BioAv↑, selectivity↑, TumCCA↑, Risk↓, *lipid-P↓, *TNF-α↓, *CRP↓, TumMeta↓, angioG↓, selectivity↑, eff↑, *eff↑,
4448- SeNPs,    Selenium Nanoparticles: A Comprehensive Examination of Synthesis Techniques and Their Diverse Applications in Medical Research and Toxicology Studies
- Review, Nor, NA
*toxicity↓, *toxicity↓, selectivity↑, *antiOx↑, *cognitive↑, *other↝, TumCCA↑,
4451- SeNPs,    Effects of chitosan-stabilized selenium nanoparticles on cell proliferation, apoptosis and cell cycle pattern in HepG2 cells: comparison with other selenospecies
- in-vitro, Liver, HepG2
*antiOx↑, Apoptosis↑, TumCCA↑,
4453- SeNPs,    Selenium Nanoparticles: Green Synthesis and Biomedical Application
- Review, NA, NA
*toxicity↓, *Bacteria↓, ROS↑, MMP↓, ER Stress↑, P53↑, Apoptosis↑, Casp9↑, DNAdam↑, TumCCA↑, eff↑, Catalase↓, SOD↓, GSH↓, selectivity↓, selectivity↑, PCNA↓, eff↑, *ALAT↓, *AST↓, *ALP↓, *creat↓, *Inflam↓, *toxicity↓, selectivity↑,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
2555- SFN,    Chemopreventive functions of sulforaphane: A potent inducer of antioxidant enzymes and apoptosis
- Review, Var, NA
chemoPv↑, HDAC↓, TumCCA↑, Apoptosis↑, Mets↑, *NRF2↑, ROS⇅,
2445- SFN,    Sulforaphane-Induced Cell Cycle Arrest and Senescence are accompanied by DNA Hypomethylation and Changes in microRNA Profile in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, SkBr3
TumCCA↑, P21↑, p27/CDKN1B↑, NO↑, Akt↓, ATP↓, AMPK↑, TumAuto↑, DNMT1↓, HK2↓, PKM2↓, HDAC3↓, HDAC4↓, HDAC8↓,
2448- SFN,    Sulforaphane and bladder cancer: a potential novel antitumor compound
- Review, Bladder, NA
Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, glucoNG↓, ChemoSen↑, TumCCA↑, Casp3↑, Casp7↑, cl‑PARP↑, survivin↓, EGFR↓, HER2/EBBR2↓, ATP↓, Glycolysis↓, mt-OXPHOS↓, AKT1↓, HK2↓, Hif1a↓, ROS↑, NRF2↑, EMT↓, COX2/PTGS2↓, MMP2↓, MMP9↓, Zeb1↓, Snail↓, HDAC↓, HATs↓, MMP↓, Cyt‑c↓, Shh↓, Smo↓, Gli1↓, BioAv↝, BioAv↝, Dose↝,
1498- SFN,    Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells
- in-vitro, CRC, HCT116 - in-vitro, Nor, NCM460
selectivity↑, TumCCA↑, Apoptosis↑, *p‑ERK↑, cMYB↓, selectivity↑, selectivity↑,
1459- SFN,  AF,    Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
1468- SFN,    Cellular responses to dietary cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
ROS↑, DNAdam↑, MMP↓, Cyt‑c↑, TumCCA↑,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1461- SFN,    Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives
- Review, BC, NA
TumCP↓, Apoptosis↑, TumCCA↑, antiOx↑,
1460- SFN,    High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells
- in-vitro, Lung, NA
ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2/PTGS2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,

Showing Research Papers: 901 to 950 of 1049
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1049

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

LATS1↓, 1,   MYCN↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 4,   H2O2↑, 1,   HO-1↑, 3,   Iron↑, 1,   lipid-P↑, 1,   Mets↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 4,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   ROS↓, 1,   ROS↑, 29,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,   TrxR↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 4,   ATP↑, 1,   mitResp↑, 1,   MMP↓, 15,   MMP↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↓, 1,   AMPK↑, 3,   p‑AMPK↑, 1,   ECAR↓, 1,   FGF21↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 2,   PDH↑, 1,   PFK↓, 1,   PKM2↓, 1,   POLD1↓, 1,   PPP↓, 1,   SIRT1↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 9,   Akt↑, 1,   p‑Akt↓, 3,   Apoptosis↑, 21,   mt-Apoptosis↑, 1,   BAX↓, 1,   BAX↑, 9,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-2∅, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 4,   Casp1↓, 1,   Casp3↓, 1,   Casp3↑, 8,   cl‑Casp3↑, 2,   Casp6↓, 1,   Casp6↑, 1,   Casp7↑, 2,   Casp8↓, 1,   Casp8↑, 2,   Casp8∅, 1,   Casp9↓, 1,   Casp9↑, 4,   cl‑Casp9↑, 1,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 7,   Diablo↑, 1,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   IAP1↑, 1,   ICAD↑, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   MDM2↓, 2,   necrosis↑, 1,   p27/CDKN1B↑, 5,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 3,   TRAIL↑, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 3,   p70S6↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑H3↑, 1,   HATs↓, 1,   miR-21↓, 1,   other↝, 2,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 1,   PERK↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   BNIP3↑, 2,   LC3II↑, 1,   p62↓, 1,   SESN2↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑CHK1↑, 1,   DNAdam↑, 7,   DNArepair↓, 1,   DNMT1↓, 2,   DNMTs↓, 1,   GADD45A↑, 1,   P53↑, 7,   PARP↑, 1,   cl‑PARP↑, 7,   PCNA↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 2,   CDK4↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 3,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   cycE/CCNE↑, 1,   p19↑, 1,   P21↑, 8,   TumCCA?, 1,   TumCCA↑, 48,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   cMET↓, 1,   cMYB↓, 1,   CSCs↓, 6,   EMT↓, 7,   EP4/PTGER4↑, 1,   ERK↑, 1,   FOXM1↓, 1,   FOXO4↓, 1,   Gli1↓, 3,   GSK‐3β↑, 1,   HDAC↓, 5,   HDAC1↓, 1,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 1,   HH↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   Mst1↑, 1,   mTOR↓, 4,   p‑mTOR↓, 2,   p‑P70S6K↓, 1,   PI3K↓, 7,   p‑PI3K↑, 1,   PTEN↑, 2,   Shh↓, 2,   Smo↓, 1,   STAT3↓, 3,   TumCG↓, 12,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   Ca+2↝, 1,   E-cadherin↑, 4,   ER-α36↓, 1,   Fibronectin↓, 1,   GIT1↓, 1,   Ki-67↓, 2,   MARK4↓, 2,   miR-155↓, 1,   MMP13↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 6,   MMPs↓, 3,   N-cadherin↓, 2,   Slug↓, 2,   Smad1↑, 1,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 14,   TumMeta↓, 5,   Twist↓, 1,   Vim?, 1,   Vim↓, 3,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   EGFR↓, 4,   HIF-1↓, 1,   Hif1a↓, 4,   NO↑, 1,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↑, 1,   cellSen↑, 1,   COX2/PTGS2↓, 4,   CRP↓, 1,   CXCR2↑, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL1β↓, 2,   IL6↓, 1,   IL6↑, 1,   IL8↓, 1,   Imm↑, 1,   NF-kB↓, 2,   p‑p65↓, 1,   PD-1↓, 1,   PSA↓, 3,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 1,   TNF-α↑, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 2,   ChemoSen↑, 12,   Dose↑, 2,   Dose↝, 2,   eff↓, 11,   eff↑, 15,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   RadioS↓, 1,   RadioS↑, 4,   selectivity↓, 1,   selectivity↑, 17,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 4,   BMPs↑, 1,   CRP↓, 1,   E6↓, 1,   EGFR↓, 4,   FOXM1↓, 1,   GutMicro↝, 1,   HER2/EBBR2↓, 3,   IL6↓, 1,   IL6↑, 1,   Ki-67↓, 2,   PSA↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 3,   CardioT↓, 1,   chemoPv↑, 3,   RenoP↑, 2,   Risk↓, 3,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 282

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 1,   GPx↑, 1,   GSTs↑, 1,   HO-1↑, 1,   Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 4,   ROS↓, 6,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ECAR∅, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   IAP1↓, 1,   JNK↓, 1,   MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↑, 1,   IGF-1↓, 1,   IGFBP3↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   CRP↓, 1,   HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 5,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 2,   BioAv↝, 2,   Dose↝, 1,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   creat↓, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   CardioT↓, 1,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   radioP↑, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 71

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
41 Curcumin
31 Quercetin
29 Silver-NanoParticles
26 Sulforaphane (mainly Broccoli)
25 Thymoquinone
23 Apigenin (mainly Parsley)
22 Berberine
21 Fisetin
21 Kaempferol
17 Phenethyl isothiocyanate
16 Baicalein
16 Emodin
15 Artemisinin
15 Radiotherapy/Radiation
15 Capsaicin
15 Piperlongumine
14 Shikonin
13 Magnetic Fields
13 EGCG (Epigallocatechin Gallate)
13 Chrysin
13 Garcinol
13 Resveratrol
12 Ashwagandha(Withaferin A)
12 Betulinic acid
12 Eugenol
12 Cucurbitacin
12 Honokiol
11 Graviola
11 Magnolol
11 Licochalcone A
11 Lycopene
10 Propolis -bee glue
9 Cisplatin
9 Rosmarinic acid
9 Ellagic acid
9 Formononetin
9 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
9 Ivermectin
9 Silymarin (Milk Thistle) silibinin
9 Urolithin
8 5-fluorouracil
8 Allicin (mainly Garlic)
8 doxorubicin
8 Carvacrol
8 Crocetin
8 Ferulic acid
8 Gallic acid
8 Ginkgetin
8 HydroxyTyrosol
8 Luteolin
7 Chemotherapy
7 chitosan
7 Evodiamine
7 Fucoidan
7 Indole-3-carbinol
7 Juglone
7 Phenylbutyrate
7 Pterostilbene
6 Astaxanthin
6 Berbamine
6 Boswellia (frankincense)
6 Celastrol
6 chaetocin
6 Paclitaxel/Taxol
6 Gambogic Acid
6 itraconazole
6 Naringin
6 Selenite (Sodium)
5 Coenzyme Q10
5 Beta-Caryophyllene
5 Bufalin/Huachansu
5 Boron
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Centella asiatica / Gotu kola → asiaticoside
5 Chlorogenic acid
5 Carvone
5 Cynaropicrin
5 Dandelion Root
5 Eurycomanone
5 Fenbendazole
5 Genistein (soy isoflavone)
5 isoorientin
5 Laetrile B17 Amygdalin
5 lambertianic acid
5 Nimbolide
5 Plumbagin
5 salinomycin
5 Ursolic acid
5 Vitamin K2
4 1,8-Cineole
4 Vitamin C (Ascorbic Acid)
4 D-limonene
4 Brucea javanica
4 Caffeic acid
4 Thymol-Thymus vulgaris
4 Selenium
4 Cinnamon
4 Hydroxycinnamic-acid
4 Deguelin
4 Hyperoside
4 Licorice
4 Lemongrass Extract/Citral
4 Linalool
4 Magnetic Field Rotating
4 VitK3,menadione
4 α-Santalol/Sandalwood oil
4 Selenium NanoParticles
4 Aflavin-3,3′-digallate
3 Astragalus
3 Copper and Cu NanoParticles
3 Alpha-Lipoic-Acid
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Andrographis
3 Gemcitabine (Gemzar)
3 Anethole/trans-Anethole
3 Fennel Oil/Foeniculum vulgare
3 Isovitexin
3 Biochanin A
3 borneol
3 Bruteridin(bergamot juice)
3 Carnosic acid
3 Celecoxib
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Date Fruit Extract
3 diet Methionine-Restricted Diet
3 Piperine
3 Ginger/6-Shogaol/Gingerol
3 Hibiscus sabdariffa
3 Inositol
3 Isoliquiritigenin
3 Lasiodin
3 Metformin
3 Propyl gallate
3 Parthenolide
2 Glucose
2 Gold NanoParticles
2 Photodynamic Therapy
2 tamoxifen
2 DTS(dibenzyl trisulphide) from Anamu
2 Ascorbyl Palmitate
2 Melatonin
2 Atorvastatin
2 beta-glucans
2 Baicalin
2 Bacopa monnieri
2 α-Bisabolol / Chamomile oil
2 Butyrate
2 Zinc
2 Chlorophyllin
2 Docetaxel
2 Dihydrocaffeic Acid
2 Cyclopamine
2 Dichloroacetate
2 Diclofenac
2 Echinacea
2 Electrical Pulses
2 carboplatin
2 Geraniol
2 Hyperthermia
2 isoflavones
2 isoquercitrin
2 Vitexin
2 Lactoferrin/Talactoferrin
2 Methylene blue
2 Magnesium
2 Oleuropein
2 Rauwolfia serpentina/Indian Snakeroot
2 Rutin
2 Terpinen-4-ol / Tea Tree Oil
1 3-bromopyruvate
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Arctigenin
1 Aloe anthraquinones
1 immunotherapy
1 epirubicin
1 brusatol
1 Bromelain
1 Carnosine
1 Selenate
1 Chocolate
1 Vitamin E
1 Polyphenols
1 Docosahexaenoic Acid
1 diet FMD Fasting Mimicking Diet
1 Dipyridamole
1 Disulfiram
1 Cannabichromene
1 Citric Acid
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Ginkgolic acids
1 Ginkgo biloba
1 Germanium inorganic
1 Ginkgolide B
1 Ginseng
1 HydroxyCitric Acid
1 Rapamycin
1 High-Ozonide Oil
1 Isobavachalcone
1 iodine
1 Inulin Prebiotic
1 Recombinant Methioninase
1 Lactobacillus
1 Lapachol
1 Methylglyoxal
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Myricetin
1 Niclosamide (Niclocide)
1 Proanthocyanidins
1 Sanguinarine
1 Psoralidin
1 Rhein
1 buckwheat sprouts
1 Oxaliplatin
1 Sulfasalazine
1 Auranofin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Turmerones
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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