Radiotherapy/Radiation Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


Scientific Papers found: Click to Expand⟱
6232- CUR,  Rad,  Chemo,    The Effectiveness of Curcumin in Treating Oral Mucositis Related to Radiation and Chemotherapy: A Systematic Review
- Review, Var, NA
*VEGF↑, *Wound Healing↓, *NRF2↑, *Catalase↑, *SOD↑, *GSH↑, *ROS↓,
5195- DCA,  Rad,    Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells
- in-vitro, BC, 4T1 - in-vitro, BC, EMT6
PDKs↑, ROS↑, p‑PDH↓, ECAR↓, lactateProd↓, selectivity↓, RadioS↑,
1870- DCA,  Rad,    Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
- in-vitro, Pca, PC3
TumCCA↑, Apoptosis↑, MMP↓, eff↑, RadioS↑,
5193- dietMet,  Rad,    A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Trial, Var, NA
toxicity↝, other↝,
6351- DRE,  Rad,    Differential effect of Taraxacum officinale L. (dandelion) root extract on hepatic and testicular tissues of rats exposed to ionizing radiation
- in-vivo, Nor, NA
*radioP↑, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *IL1β↓, *TNF-α↓, *Casp3↓, *eff↑,
5010- DSF,  Cu,  Rad,    Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma
- in-vivo, Melanoma, B16-F10
Apoptosis↑, ICD↑, HMGB1↑, ATP↓, TumCG↓,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2/PTGS2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
3213- EGCG,  Rad,    Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy
- in-vitro, CRC, HCT116
RadioS↑, TumCP↓, NRF2↑,
3234- EGCG,  Rad,    EGCG, a tea polyphenol, as a potential mitigator of hematopoietic radiation injury in mice
- in-vivo, Nor, NA
*DNMTs↓, *radioP↑, *HDAC↑,
6333- Eug,  Cisplatin,  Rad,    Eugenol Exerts Apoptotic Effect and Modulates the Sensitivity of HeLa Cells to Cisplatin and Radiation
- in-vitro, Cerv, HeLa
TumCP↓, LDH↝, ChemoSen↑, RadioS↑, Casp3↑, BAX↑, Cyt‑c↑, Casp9↑, Bcl-2↓, COX2/PTGS2↓, IL1β↓, ROS↑, NF-kB↓, COX2/PTGS2↓, TumCCA↓, Thiols↓, GSH↓,
7518- FA,  Rad,    Radiosensitizing effect of ferulic acid on human cervical carcinoma cells in vitro
- in-vitro, Cerv, HeLa - in-vitro, Cerv, ME-180
lipid-P↑, ROS↑, DNAdam↑, RadioS↑,
1914- Fer,  VitC,  TMZ,  Rad,    Pharmacologic Ascorbate and Ferumoxytol Combined with Temozolomide and Radiation Therapy for the Treatment of Newly Diagnosed Glioblastoma
- Trial, GBM, NA
eff↑,
6906- FIS,  Rad,    Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models
- in-vivo, CRC, CT26 - in-vivo, CRC, HCT116
antiOx↑, Inflam↓, angioG↓, TumCI↓, TumCP↓, TumCG↓, RadioS↑,
832- GAR,  Rad,    Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining
- in-vitro, Lung, A549 - in-vitro, NA, HeLa
HATs↓, other↑,
7100- Geld,  Rad,    Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin
- in-vitro, Var, NA
HSP90↓, Akt↓, RadioS↑, selectivity↑,
7279- GGB,  Rad,    Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling
- in-vivo, Nor, NA
*cognitive↑, *radioP↑, *ROS↓, *p‑Akt↑, *Bcl-2↑, *Mst1↓, *p‑p38↓, *JNK↓, *cl‑Casp3↓, *BAX↓,
7287- GGB,  Rad,    Ginsenoside Rg3 enhances the radiosensitivity of lung cancer A549 and H1299 cells via the PI3K/AKT signaling pathway
- in-vitro, Lung, NA
TumCP↓, Apoptosis↑, TumCMig↓, RadioS↑, TumCCA↑, PI3K↓, p‑Akt↓, PDK1 / PDPK1↓,
3526- GoldNP,  Rad,    Advances in nanoparticle-based radiotherapy for cancer treatment
- Review, Var, NA
RadioS↑, EPR↑, ROS↑, TumCCA↑,
7306- GoldNP,  Rad,    Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma
- in-vivo, SCC, NA
eff↑, RadioS↑,
7307- GoldNP,  Rad,    Uptake and excretion dynamics of gold nanoparticles in cancer cells and fibroblasts
- in-vitro, GBM, U87MG - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, PC, Bxpc-3
eff↑,
4420- GoldNP,  Rad,    Computational modeling and experimental synthesis of BSA-coated bimetallic theranostic MnO₂-Au@curcumin nanoplatform for synergistic radiochemotherapy of breast cancer
- in-vitro, BC, 4T1
RadioS↑,
7305- GoldNP,  Rad,    The use of gold nanoparticles to enhance radiotherapy in mice
- in-vivo, Var, NA
Dose↝, selectivity↑, toxicity↝, RadioS↑,
1901- GoldNP,  Rad,    The role of thioredoxin reductase in gold nanoparticle radiosensitization effects
- in-vitro, Lung, A549
MMP↓, ROS↑, RadioS↑, TrxR↓,
941- Gos,  Rad,    The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis
- in-vivo, NA, NA
lactateProd↓, other↓, TGF-β↓,
3152- H2,  VitC,  Rad,    Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection
- in-vitro, Nor, HUVECs - in-vivo, NA, NA
AntiTum↑, OS↑, QoL↑, TumVol↓, radioP↑, Dose↑, Dose↝, eff↑,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
2902- HNK,  Rad,    Honokiol Mitigates Ionizing Radiation-Induced Injury by Maintaining the Redox Balance of the TrxR/Trx System
- in-vitro, Nor, BEAS-2B
*TrxR1↑, *Trx↑, *radioP↑, *ROS↓,
7577- HPT,  Rad,    Randomized trial of hyperthermia and radiation for superficial tumors
- Trial, Var, NA
RadioS↑, eff↑, Dose↝,
5053- HPT,  Rad,  Chemo,    Association of elevated reactive oxygen species and hyperthermia induced radiosensitivity in cancer stem-like cells
- in-vitro, Var, NA
CSCs↓, TumCP↓, ROS↑, RadioS↑,
7651- HPT,  Rad,    Hyperthermia inhibits homologous recombination repair and sensitizes cells to ionizing radiation in a time- and temperature-dependent manner
- in-vitro, Var, NA
RadioS↑, DNArepair↓, Dose↑,
7649- HPT,  Rad,    A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy
- in-vivo, Laryn, FaDu
Dose↝, BloodF↑, Hypoxia↓, RadioS?,
7627- HPT,  Rad,    Local control rate after the combination of re-irradiation and hyperthermia for irresectable recurrent breast cancer: Results in 248 patients
CR↑, OS↑, *toxicity↝, RadioS↑,
7626- HPT,  Rad,    Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia
- in-vitro, NA, NA
BRCA2↓, selectivity↑, RadioS↑, eff↝,
7572- HPT,  Rad,    The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination
- in-vitro, Cerv, HeLa - in-vitro, Laryn, FaDu
RadioS↑, TumCD↑, BRCA2↓, Dose↝, BloodF↑, ROS↑, Imm↑,
7573- HPT,  Rad,    Heat-induced BRCA2 degradation in human tumours provides rationale for hyperthermia-PARP-inhibitor combination therapies
- vitro+vivo, NA, NA
RadioS↑, BRCA2↓,
7623- HPT,  Rad,    Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i
- Review, Var, NA
BRCA2↓, RadioS↑, eff↑,
7621- HPT,  Rad,    Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone in patients with painful bony metastases: A phase III clinical trial study
- Trial, Pca, NA - Trial, BC, NA
Pain↓, Dose↝, CR↑,
7599- HPT,  Rad,    Recent development on hyperthermia: An effective cotreatment improving radiotherapy outcome
- Review, Var, NA
NA↑, RadioS↑, DNArepair↓, Hypoxia↓, EPR↑, LC↑, OS↑, *toxicity↓, Dose↝, BloodF↑, pH↝, Imm↑, HSP70/HSPA5↑,
7598- HPT,  Rad,  Chemo,    The role of capacitive hyperthermia as an adjunct treatment in oncology: a systematic review of randomized phase III trials
- Review, Var, NA
OS↑, TR↑, LC↑, *toxicity?,
7575- HPT,  Rad,  Chemo,  immuno,    From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy
RadioS↑, ChemoSen↑, Imm↑, BloodF↑, Hypoxia↓, Dose↝, DNArepair↓, e-pH↓,
7549- HYP,  Rad,    Study on the mechanism of hyperoside in affecting the biological progression and radiosensitivity of esophageal carcinoma by modulating the STAT3/AKT/ERK pathway
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE150
TumCP↓, TumCI↓, TumCMig↓, EMT↓, Apoptosis↑, RadioS↑, p‑STAT3↓, p‑Akt↓, p‑ERK↓,
7759- ISL,  Rad,    Isoliquiritigenin, a Bioactive Blood Component Derived from Licorice, Activates Nrf2 Enzymes to Confer Protection Against Radiation-Induced Nerve Injury
- vitro+vivo, Nor, PC12
*radioP↑, *LDH↓, *ROS↓, *SOD1↑, *GSH↑, *TAC↑, *NRF2↓, *cognitive↑, *Learn↑, *memory↑,
8066- KAE,  Rad,    Radiosensitization of non-small cell lung cancer by kaempferol
- in-vivo, Lung, A549
TumCG↓, selectivity↑, TumCCA↑, RadioS↑,
2917- LT,  Rad,    Luteolin acts as a radiosensitizer in non‑small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade
- in-vitro, Lung, NA
Bcl-2↓, Casp3↑, Casp8↑, Casp9↑, p‑p38↑, ROS↑, RadioS↑,
1775- MEL,  Chemo,  Rad,    A Systematic Review of the Chemo/Radioprotective Effects of Melatonin against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy
- Review, Var, NA
chemoP↑, radioP↑, antiOx↑, Inflam↑,
3487- MF,  Rad,    High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field
- Review, Var, NA
radioP↑, *Ca+2↑, RAS↑, MAPK↓,
517- MF,  Rad,    Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis
- in-vivo, NA, MDA-MB-231
TumMeta↓, TumCG↓,
2251- MF,  Rad,    BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage
- in-vitro, Lung, A549 - in-vitro, HNSCC, UTSCC15 - in-vitro, CRC, DLD1 - in-vitro, PC, MIA PaCa-2
RadioS↑, DNAdam↑, ROS↑, ChemoSen∅, Pyruv↓, ADP:ATP↓, ROS↑,
5245- MFrot,  Rad,    The hemoprotective effects of a rotary magnetic field in mice exposed to γ irradiation
- in-vivo, Nor, NA
*OS↑, *radioP↑,
2939- NAD,  Rad,    NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7
- in-vitro, Nor, NA
*SIRT6↑, *DNAdam↓, *radioP↑, *ROS↓,

Showing Research Papers: 51 to 100 of 137
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 137

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0)

CR↑, 2,   LC↑, 2,   NA↑, 1,   NLR↓, 1,   TR↑, 1,  

Redox & Oxidative Stress(tgid=1)

antiOx↑, 2,   GSH↓, 2,   ICD↑, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS↑, 11,   TBARS↑, 1,   Thiols↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

ADP:ATP↓, 1,   ATP↓, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis(tgid=4)

ECAR↓, 1,   lactateProd↓, 2,   LDH↝, 1,   p‑PDH↓, 1,   PDK1 / PDPK1↓, 1,   PDKs↑, 1,   Pyruv↓, 1,  

Cell Death(tgid=5)

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 5,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   MAPK↓, 1,   p‑p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7)

HATs↓, 1,   other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8)

HSP70/HSPA5↑, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10)

BRCA2↓, 4,   DNAdam↑, 2,   DNArepair↓, 3,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11)

TumCCA↓, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12)

CSCs↓, 1,   EMT↓, 1,   p‑ERK↓, 1,   PI3K↓, 1,   RAS↑, 1,   p‑STAT3↓, 2,   TumCG↓, 4,  

Migration(tgid=13)

MMP9↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 2,   EPR↑, 2,   Hypoxia↓, 3,  

Immune & Inflammatory Signaling(tgid=16)

COX2/PTGS2↓, 3,   CRP↓, 1,   HMGB1↑, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 3,   Inflam↓, 2,   Inflam↑, 1,   NF-kB↓, 1,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Cellular Microenvironment(tgid=17)

pH↝, 1,   e-pH↓, 1,  

Drug Metabolism & Resistance(tgid=21)

ChemoSen↑, 2,   ChemoSen∅, 1,   Dose↑, 2,   Dose↝, 9,   eff↑, 7,   eff↝, 1,   RadioS?, 1,   RadioS↑, 28,   selectivity↓, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22)

BloodF↑, 4,   CRP↓, 1,   IL6↓, 2,   LDH↝, 1,  

Functional Outcomes(tgid=23)

AntiTum↑, 1,   AntiTum∅, 1,   chemoP↑, 1,   OS↑, 4,   Pain↓, 1,   QoL↑, 1,   radioP↑, 4,   toxicity↝, 2,   TumVol↓, 1,  
Total Targets: 101

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0)

Learn↑, 1,  

Redox & Oxidative Stress(tgid=1)

Catalase↑, 1,   GSH↑, 3,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 7,   SOD↑, 2,   SOD1↑, 1,   TAC↑, 1,   Trx↑, 1,   TrxR1↑, 1,  

Core Metabolism/Glycolysis(tgid=4)

LDH↓, 1,  

Cell Death(tgid=5)

p‑Akt↑, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   JNK↓, 1,   p‑p38↓, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↓, 1,   DNMTs↓, 1,   SIRT6↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12)

HDAC↑, 1,   Mst1↓, 1,  

Migration(tgid=13)

Ca+2↑, 1,  

Angiogenesis & Vasculature(tgid=14)

VEGF↑, 1,  

Barriers & Transport(tgid=15)

IBI↑, 1,  

Immune & Inflammatory Signaling(tgid=16)

IL1β↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21)

eff↑, 1,  

Clinical Biomarkers(tgid=22)

LDH↓, 1,  

Functional Outcomes(tgid=23)

cognitive↑, 2,   memory↑, 1,   OS↑, 1,   radioP↑, 7,   toxicity?, 1,   toxicity↓, 2,   toxicity↝, 1,   Wound Healing↓, 1,  
Total Targets: 40

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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