Half-Life Cancer Research Results

Half-Life, Half-Life: Click to Expand ⟱
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For many drugs, the half-life is the time it takes for half of the drug’s active substance to be eliminated from the bloodstream.
In medicine, knowing a drug’s half-life helps in designing treatment regimens that reduce adverse effects.
Scientific Papers found: Click to Expand⟱
5676- BML,    Intestinal absorption of undegraded proteins in men: presence of bromelain in plasma after oral intake
- in-vivo, NA, NA
Half-Life↝, Dose↝, Dose↝,
5654- BNL,    Pharmacokinetics of natural borneol after oral administration in mice brain and its effect on excitation ratio
- in-vivo, Nor, NA
*BioAv↑, *Half-Life↝, other↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5672- Bor,    A comparative review of the pharmacokinetics of boric acid in rodents and humans
- in-vivo, Nor, NA
*Half-Life↝,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3502- Bor,    Plasma boron concentrations in the general population: a cross-sectional analysis of cardio-metabolic and dietary correlates
- Review, NA, NA
*Half-Life↑, *VitD↑, *cardioP↑, *RenoP↓,
3503- Bor,    Chemical disposition of boron in animals and humans
- Review, NA, NA
*Half-Life↑, *other↑,
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
4624- Bor,  VitD3,    Boron as a Medicinal Ingredient in Oral Natural Health Products
- Review, Pca, NA
*Half-Life↝, *eff↑, PSA↓, TumVol↓, IGF-1↓, *memory↓, *motorD↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5855- CAP,    Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain
- in-vivo, Nor, NA
NP/CIPN↓, BioAv↑, Half-Life↑, TRPV1↑, Pain↓, TRPV1↑,
5854- CAP,    Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
- Review, Var, NA - Review, AD, NA
Obesity↓, Half-Life↓, antiOx↑, TRPV1↑, STAT3↓, Ca+2↑, ROS↑, MMP↓, *neuroP↑, *tau↓, *Inflam↓, *ROS?,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
5879- CAR,    Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle
- in-vivo, Nor, NA
*Dose↝, Half-Life↝, Half-Life↝, Half-Life↝,
5928- Catechins,    Bioavailability of Tea Catechins and Its Improvement
- Review, Nor, NA
*BioAv↝, *BioAv↓, *ROS⇅, *NRF2↑, *BioAv↑, *Half-Life↓, *BioAv↑, *BioAv↑, BioAv↑,
5811- CBC,    The Potential of Cannabichromene (CBC) as a Therapeutic Agent
- Review, Var, NA
*eff?, *Half-Life↝, *Inflam↓,
5968- CET,    Cetuximab as a Key Partner in Personalized Targeted Therapy for Metastatic Colorectal Cancer
- in-vitro, CRC, NA
eff↑, Half-Life↑, Half-Life↑, EGFR↓, OS↑, QoL↑, eff↑, KRAS↓,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6024- CGA,    Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up
- Trial, GBM, NA
*toxicity↓, Half-Life↝, BBB↑,
6029- CGA,    Pharmacokinetics of chlorogenic acids absorbed in human plasma and their metabolites following oral ingestion of coffee drink
- Trial, Nor, NA
*Dose↝, *BioAv↑, *Half-Life↝,
6026- CGA,    Chlorogenic Acid: The Conceivable Chemosensitizer Leading to Cancer Growth Suppression
- Review, Var, NA
ChemoSen↑, AMPK↑, EGFR↓, PI3K↓, mTOR↓, Hif1a↓, VEGF↓, MAPK↓, ERK↓, DNAdam↑, TOP1↓, TOP2↓, Apoptosis↑, *BioAv↝, *Half-Life↓,
6001- Chit,    Recent advances in engineering chitosan-based nanoplatforms in biotherapeutic multi-delivery for multi-targeted disease treatments: Promises and outlooks
- Review, Var, HepG2 - Review, AD, NA
TumVol↓, toxicity↓, Half-Life↑, eff↑, selectivity↑, Dose↝, *BDNF↑, *NRF2↑, *ROS↓, *neuroP↑, *memory↑, *cognitive↑, *Obesity↓,
5982- Chit,    Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges
- Review, Var, NA
DDS↑, antiOx↑, Bacteria↓, AntiTum↑, Half-Life↑, BioAv↑, toxicity↓,
5991- Chit,    Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies
- Review, BC, NA
*other↝, *BioAv↓, eff↑, toxicity↓, eff↑, TumCD↑, Half-Life↑, selectivity↑, EPR↑, ROS↑, Apoptosis↑, eff↑,
5999- Chit,    How chitosan can help against breast cancer
- Review, BC, NA
eff↑, DDS↑, Half-Life↑, eff↑, eff↑,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
5990- Chit,    Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies
- Review, Var, NA
DDS↑, eff↓, *Bacteria↓, *antiOx↑, *Wound Healing↑, *Imm↑, TumCP↓, TumMeta↓, angioG↓, Apoptosis↑, ROS↑, ER Stress↑, BioAv↑, Half-Life↑, eff↑, EPR↑, ChemoSen↑, eff↑,
6093- CHOC,    The relevance of theobromine for the beneficial effects of cocoa consumption
- Review, Nor, NA - NA, asthmatic, NA
*toxicity↓, *eff↑, *Half-Life↑, *eff↑, *Inflam↓, *HDL↑, *Obesity↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
4826- CUR,    The Bright Side of Curcumin: A Narrative Review of Its Therapeutic Potential in Cancer Management
- Review, Var, NA
*antiOx↑, *Inflam↑, *ROS↓, Apoptosis↑, TumCP↓, BioAv↓, Half-Life↓, eff↑, TumCCA↑, BAX↑, Bak↑, PUMA↑, BIM↑, NOXA↑, TRAIL↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, cMyc↓, Casp↑, NF-kB↓, STAT3↓, AP-1↓, angioG↓, TumMeta↑, VEGF↓, MMPs↓, DNMTs↓, HDAC↓, ROS↑,
2809- CUR,    Comparative absorption of curcumin formulations
- in-vivo, Nor, NA
BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↑, BioAv↓, Half-Life↝,
1882- DCA,    Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
- Analysis, NA, NA
PDKs↓, PDH↑, lactateProd↓, Half-Life∅,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
1614- EA,    Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
- Human, Nor, NA
*BioEnh↝, *Half-Life∅,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
2561- EGCG,  ASA,    Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
- ex-vivo, Nor, NA
AntiAg↑, eff↑, Half-Life↝, other∅,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
2824- FIS,    Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics
- Review, Var, NA
*antiOx↑, *Inflam↓, angioG↓, BioAv↓, BioAv↑, TumCP↓, TumCI↓, TumCMig↓, *neuroP↑, EMT↓, ROS↑, selectivity↑, EGFR↓, NF-kB↓, VEGF↓, MMP9↓, MMP↓, cl‑PARP↑, Casp7↑, Casp8↑, Casp9↑, *ROS↓, uPA↓, MMP1↓, Wnt↓, Akt↓, PI3K↓, ERK↓, Half-Life↝,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2827- FIS,    The Potential Role of Fisetin, a Flavonoid in Cancer Prevention and Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, neuroP↑, hepatoP↑, RenoP↑, cycD1/CCND1↓, TumCCA↑, MMPs↓, VEGF↓, MAPK↓, NF-kB↓, angioG↓, Beclin-1↑, LC3s↑, ATG5↑, Bcl-2↓, BAX↑, Casp↑, TNF-α↓, Half-Life↓, MMP↓, mt-ROS↑, cl‑PARP↑, CDK2↓, CDK4↓, Cyt‑c↑, Diablo↑, DR5↑, Fas↑, PCNA↓, Ki-67↓, p‑H3↓, chemoP↑, Ca+2↑, Dose↝, CDC25↓, CDC2↓, CHK1↑, Chk2↑, ATM↑, PCK1↓, RAS↓, p‑p38↓, Rho↓, uPA↓, MMP7↓, MMP13↓, GSK‐3β↑, E-cadherin↑, survivin↓, VEGFR2↓, IAP2↓, STAT3↓, JAK1↓, mTORC1↓, mTORC2↓, NRF2↑,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,

Showing Research Papers: 51 to 100 of 167
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 167

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Ferroptosis↑, 1,   lipid-P?, 1,   lipid-P↑, 2,   NADH↓, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 17,   mt-ROS↑, 1,   SIRT3↑, 1,   SOD↓, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mt-ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   MMP↓, 7,   MPT↑, 2,   c-Raf↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 3,   GlutMet↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   PCK1↓, 1,   PDH↑, 1,   PDK1↓, 2,   PDK3↑, 1,   PDKs↓, 1,   PPARα↓, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 6,   Apoptosis↑, 10,   Bak↑, 3,   BAX↑, 4,   Bcl-2↓, 4,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↑, 6,   Casp3↑, 8,   Casp7↑, 1,   Casp8↑, 4,   Casp9↑, 4,   Chk2↑, 1,   Cyt‑c↑, 6,   Diablo↑, 2,   DR4↑, 1,   DR5↑, 3,   Fas↑, 1,   Ferroptosis↑, 1,   GADD34↑, 1,   HGF/c-Met↓, 1,   IAP2↓, 1,   JNK↑, 3,   MAPK↓, 4,   Mcl-1↑, 1,   Myc↑, 1,   NOXA↑, 1,   p27↑, 1,   p38↑, 1,   p‑p38↓, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 2,   TRAIL↑, 1,   TRPV1↑, 3,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   EF-1α↓, 1,   p70S6↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   cJun↑, 1,   H3↓, 1,   H3↑, 1,   p‑H3↓, 1,   H4↑, 1,   HATs↑, 1,   other↝, 2,   other∅, 1,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   CHOP↓, 1,   cl‑CHOP↑, 1,   eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 3,   GRP94↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   IRE1↑, 1,   IRE1∅, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 2,   Beclin-1↑, 1,   LC3II↑, 1,   LC3s↑, 1,  

DNA Damage & Repair ⓘ

ATM↑, 1,   CHK1↑, 1,   DNAdam↑, 4,   DNMTs↓, 3,   P53↑, 4,   PARP↑, 1,   cl‑PARP↑, 7,   PCNA↓, 3,  

Cell Cycle & Senescence ⓘ

CDK2↓, 5,   CDK4↓, 4,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   P21?, 1,   P21↑, 1,   p‑RB1↓, 2,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   cFos↓, 1,   CSCs↓, 2,   EMT↓, 4,   ERK↓, 3,   p‑ERK↓, 1,   FOXO↑, 1,   GSK‐3β↑, 1,   HDAC↓, 3,   HDAC1↓, 1,   IGF-1↓, 2,   Let-7↑, 1,   mTOR↓, 5,   mTOR⇅, 1,   mTORC1↓, 3,   mTORC2↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH1↑, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 6,   PTEN↑, 4,   RAS↓, 2,   SOX2↓, 1,   STAT3↓, 7,   TOP1↓, 4,   TOP2↓, 2,   TOP2↑, 1,   TumCG↓, 3,   Wnt↓, 2,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↑, 3,   E-cadherin↑, 2,   p‑FAK↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   miR-200b↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 5,   MMP9↑, 1,   MMPs↓, 5,   N-cadherin↓, 1,   PDGF↓, 1,   Rho↓, 2,   ROCK1↓, 1,   SOX4↓, 1,   TIMP1↑, 2,   TRIB3↑, 1,   TSC1↑, 1,   TumCI↓, 6,   TumCMig↓, 4,   TumCP↓, 8,   TumMeta↓, 6,   TumMeta↑, 1,   uPA↓, 5,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 11,   ATF4↑, 2,   EGFR↓, 4,   EPR↑, 4,   Hif1a↓, 5,   NO↑, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 10,   VEGFR2↓, 2,  

Barriers & Transport ⓘ

BBB↑, 4,   GLUT1↓, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CXCR4↓, 1,   IKKα↓, 2,   IL1α↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   JAK1↓, 2,   JAK2↓, 1,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 10,   NK cell↑, 1,   p65↓, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PGE2↓, 3,   PSA↓, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 10,   BioAv↑, 16,   BioAv↝, 1,   BioAv∅, 1,   ChemoSen↑, 12,   DDS↑, 4,   Dose↑, 1,   Dose↝, 6,   Dose∅, 2,   eff↓, 3,   eff↑, 31,   eff↝, 2,   Half-Life↓, 9,   Half-Life↑, 10,   Half-Life↝, 13,   Half-Life∅, 3,   RadioS↑, 4,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AR↓, 2,   ascitic↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 4,   IL6↓, 1,   Ki-67↓, 3,   KRAS↓, 1,   Myc↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,   PSA↓, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↑, 1,   chemoP↑, 6,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   NP/CIPN↓, 1,   Obesity↓, 2,   OS↑, 3,   Pain↓, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 7,   toxicity∅, 1,   TumVol↓, 2,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 270

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 11,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 3,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 1,   GSH↑, 3,   HDL↑, 1,   HO-1↑, 5,   lipid-P↓, 4,   MDA↓, 3,   NQO1↑, 1,   NRF2↑, 7,   RNS↓, 1,   ROS?, 1,   ROS↓, 14,   ROS⇅, 1,   SOD↑, 5,   SOD1↑, 1,   SOD2↑, 1,   TOS↓, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑cMyc↑, 1,   CYP3A4↓, 1,   LDH↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Bax:Bcl2↓, 1,   cl‑Casp8↑, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↑, 1,   p‑MAPK↓, 1,   p38↓, 1,   TRPV1↑, 2,  

Transcription & Epigenetics ⓘ

other↓, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   ERK↑, 1,   IGF-1R↓, 1,   STAT3↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↑, 1,   MMP2↓, 1,   TGF-β↑, 1,   VCAM-1↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   PDGFR-BB↓, 1,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 5,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   ICAM-1↓, 1,   IL1β↓, 2,   IL6↓, 5,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 18,   Inflam↑, 1,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 4,   NF-kB↑, 1,   PGE2↓, 2,   TNF-α↓, 6,   TNF-α↑, 1,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   BDNF↑, 2,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 7,   BioAv↑, 11,   BioAv↝, 4,   BioEnh↑, 2,   BioEnh↝, 1,   Dose↝, 6,   Dose∅, 1,   eff?, 1,   eff↑, 6,   Half-Life↓, 5,   Half-Life↑, 3,   Half-Life↝, 11,   Half-Life∅, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

Bil↑, 1,   BMD↑, 2,   GutMicro↑, 2,   IL6↓, 5,   LDH↓, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   cardioP↑, 5,   chemoP↑, 2,   cognitive↑, 4,   hepatoP↓, 1,   hepatoP↑, 4,   memory↓, 1,   memory↑, 3,   motorD↓, 1,   neuroP↑, 11,   Obesity↓, 2,   Pain↓, 1,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 2,   toxicity↓, 3,   toxicity↝, 1,   toxicity∅, 1,   Weight↓, 1,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 128

Scientific Paper Hit Count for: Half-Life, Half-Life
7 Resveratrol
6 Boron
6 chitosan
6 Silymarin (Milk Thistle) silibinin
5 Auranofin
5 Artemisinin
5 Capsaicin
5 Pterostilbene
4 Alpha-Lipoic-Acid
4 Apigenin (mainly Parsley)
4 Aspirin -acetylsalicylic acid
4 Berberine
4 Curcumin
4 Chlorogenic acid
4 Sulforaphane (mainly Broccoli)
4 Shikonin
4 Selenite (Sodium)
3 Allicin (mainly Garlic)
3 Ashwagandha(Withaferin A)
3 Baicalein
3 Betulinic acid
3 Propolis -bee glue
3 EGCG (Epigallocatechin Gallate)
3 Fisetin
3 Piperlongumine
3 Urolithin
2 borneol
2 Boswellia (frankincense)
2 Disulfiram
2 Ellagic acid
2 Honokiol
2 HydroxyTyrosol
2 Luteolin
2 Lycopene
2 Metformin
2 Phenethyl isothiocyanate
2 Quercetin
2 Rosmarinic acid
2 Thymoquinone
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Anthocyanins
1 Astragalus
1 Silver-NanoParticles
1 Acetyl-l-carnitine
1 Astaxanthin
1 Arsenic trioxide
1 Atorvastatin
1 Baicalin
1 Berbamine
1 Biochanin A
1 Bevacizumab (brand Avastin)
1 Chemotherapy
1 Bicalutamide
1 Bromelain
1 Vitamin D3
1 urea
1 Carvacrol
1 Catechins
1 Cannabichromene
1 cetuximab
1 Chocolate
1 Chrysin
1 Dichloroacetate
1 Copper and Cu NanoParticles
1 Ferulic acid
1 Hydrogen Gas
1 Huperzine A/Huperzia serrata
1 itraconazole
1 Methylene blue
1 Methylsulfonylmethane
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 Phenylbutyrate
1 Phosphatidylserine
1 immunotherapy
1 SonoDynamic Therapy UltraSound
1 Radiotherapy/Radiation
1 Thymol-Thymus vulgaris
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1109  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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