Fas Cancer Research Results

Fas, Fas Death receptor: Click to Expand ⟱
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Fas (also known as CD95 or APO-1) and Fas ligand (FasL) are proteins that play a crucial role in the regulation of programmed cell death, also known as apoptosis.

The Fas/FasL system is involved in the elimination of damaged or unwanted cells, including cancer cells.
Fas agonists, which mimic the action of FasL, have been shown to induce apoptosis in cancer cells. FasL inhibitors, which block the interaction between Fas and FasL, have been shown to enhance the effectiveness of chemotherapy and immunotherapy

Fas is often expressed ,and may be associated with better responses to chemotherapy, but its role in promoting cell survival in certain contexts can complicate its prognostic implications.
Scientific Papers found: Click to Expand⟱
4486- Se,  Chit,    Selenium-Modified Chitosan Induces HepG2 Cell Apoptosis and Differential Protein Analysis
- in-vitro, Liver, HepG2
Apoptosis↑, TumCCA↑, MMP↓, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Risk↓, *BioAv↑, *toxicity↑, TumCG↓, AntiTum↑, ROS↑, Cyt‑c↑, Fas↑, FasL↑, FADD↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
3330- SIL,    Mechanistic Insights into the Pharmacological Significance of Silymarin
- Review, Var, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *antiOx↓, *NLRP3↓, *NAD↑, ROS↓, NLRP3↓, TumCMig↓, *COX2↓, *iNOS↓, *MPO↓, *AChE↓, *LDH↓, *Telomerase↓, *Fas↓,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1751- WBV,    Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
- in-vitro, BC, MDA-MB-231 - in-vitro, AML, RAW264.7
BMD↑, YAP/TEAD↑, TumCG↓, Strength↑, TumCI↓, Fas↑, Ca+2↑,

Showing Research Papers: 51 to 57 of 57
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 57

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   MPO↓, 1,   ROS↓, 1,   ROS↑, 2,   ROS⇅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC2↓, 1,   CDC25↓, 1,   MMP↓, 2,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Akt↑, 1,   Apoptosis↑, 3,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-2↑, 1,   BID↓, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   pro‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 2,   pro‑Casp8↑, 1,   Casp9↑, 3,   cl‑Casp9↑, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   DR5↑, 2,   FADD↑, 2,   Fas↑, 6,   FasL↑, 3,   iNOS↓, 1,   JNK↑, 1,   MAPK↑, 1,   Mcl-1↓, 2,   Myc↓, 1,   p27↑, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 3,   TRAIL↑, 1,   YAP/TEAD↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   eIF2α↓, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CYP1B1↑, 1,   DNAdam↑, 1,   DNMT1↓, 1,   p16↑, 1,   P53↑, 2,   cl‑PARP↑, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↑, 2,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cMET↓, 1,   CSCs↓, 1,   ERK↓, 1,   FOXM1↓, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   HDAC1↓, 1,   IGF-1↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   NOTCH↓, 1,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 3,   STAT3↓, 2,   TumCG↓, 2,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 2,   Ca+2↑, 1,   DLC1↑, 1,   E-cadherin↑, 1,   ITGA5↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 2,   N-cadherin↓, 2,   Slug↓, 1,   Snail↓, 2,   TumCI↓, 1,   TumCMig↓, 1,   Twist↓, 2,   VCAM-1↓, 1,   Vim↓, 2,   Zeb1↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   VEGF↓, 2,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCL1↓, 1,   CXCR4↓, 2,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 2,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 2,   JAK2↓, 1,   NF-kB↓, 3,   p50↓, 1,   p65↓, 1,   TNF-α↓, 2,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 1,   eff↑, 2,   eff↝, 1,   RadioS↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   FOXM1↓, 1,   IL6↓, 2,   Myc↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   Risk↓, 2,   Strength↑, 1,   toxicity∅, 1,  
Total Targets: 147

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   MPO↓, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↓, 1,   NAD↑, 1,  

Cell Death ⓘ

Fas↓, 1,   iNOS↓, 1,   Telomerase↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   toxicity↑, 1,  
Total Targets: 18

Scientific Paper Hit Count for: Fas, Fas Death receptor
6 Allicin (mainly Garlic)
4 Luteolin
3 Baicalein
3 Fisetin
3 Quercetin
2 Astragalus
2 Propolis -bee glue
2 Chlorogenic acid
2 chitosan
2 Selenium
2 Emodin
2 Silymarin (Milk Thistle) silibinin
1 Artemisinin
1 Berberine
1 Brucea javanica
1 Caffeic acid
1 Capsaicin
1 Carvacrol
1 Cat’s Claw
1 Celastrol
1 Selenate
1 Chrysin
1 Curcumin
1 Date Fruit Extract
1 EGCG (Epigallocatechin Gallate)
1 Electrical Pulses
1 Fucoidan
1 Ferulic acid
1 Gambogic Acid
1 Garcinol
1 HydroxyCitric Acid
1 tamoxifen
1 HydroxyTyrosol
1 Juglone
1 Magnetic Fields
1 Chemotherapy
1 Phenethyl isothiocyanate
1 Propyl gallate
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Vitamin K2
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:112  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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