BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
Source:
Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
5666- BNL,    Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider
- in-vivo, AD, NA
*BioAv↑, *eff↑, *Dose↝, *P-gp↓, *BBB↑, *NF-kB↓, *IL1β↓, *MMP9↓,
5667- BNL,    Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer
- in-vivo, Nor, NA
*BioEnh↑, *eff↑, *BBB↑,
5668- BNL,    Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies
- Review, Var, NA
AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,
5669- BNL,    Comparison of pharmacological activity and safety of different stereochemical configurations of borneol: L-borneol, D-borneol, and synthetic borneol
- Review, Nor, NA - Review, AD, NA - Review, Stroke, NA
*eff↑, *eff↑, *toxicity↝, *Inflam↓, *Bacteria↓, *neuroP↑, *Half-Life↝, *BBB↑, *BioEnh↑, *P-gp↓, *CYP3A4↓, *ROS↓, *neuroP↑,
5670- BNL,    Advances and perspectives on pharmacological activities and mechanisms of the monoterpene borneol
- Review, Stroke, NA
*TNF-α↓, *NF-kB↓, IL1β↓, MDA↓, BioEnh↑, BBB↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
4263- CA,    Neuroprotective Effects of Carnosic Acid: Insight into Its Mechanisms of Action
- Review, AD, NA
*neuroP↑, *ROS↓, *NO↓, *COX2↓, *MAPK↓, *NRF2↑, *GSH↑, *HO-1↑, *5HT↑, *BDNF↑, *PI3K↑, *Akt↑, *NF-kB↑, *BBB↑, *SIRT1↑, *memory↑, *Aβ↓, *NLRP3↓,
5864- CA,    Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
- vitro+vivo, Stroke, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NQO1↑, *NRF2↑, *ARE↑, *ROS↓, *BBB↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5908- CAR,    Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI
- in-vivo, Nor, NA
*TRPM7↓, *BBB↑, *motorD↑, *cognitive↑, *Dose↝, MMPs↓,
5901- CAR,    Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement
- Review, Stroke, NA
*neuroP↑, *ROS↓, *MDA↓, *4-HNE↓, *SOD↑, *Catalase↑, *GPx↑, *Apoptosis↓, *cl‑Casp3↓, *TRPM7⇅, *BBB↓, *TRPM7↓,
5899- CAR,  TV,    Evaluation of the Interaction between Carvacrol and Thymol, Major Compounds of Ptychotis verticillata Essential Oil: Antioxidant, Anti-Inflammatory and Anticancer Activities against Breast Cancer Lines
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
eff↑, selectivity↑, BioAv↝, BBB↑, *toxicity↝, *antiOx↑, COX2↓, 5LO↓,
5927- CAR,    Neuroprotective Potential and Underlying Pharmacological Mechanism of Carvacrol for Alzheimer’s and Parkinson’s Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
6024- CGA,    Phase I study of chlorogenic acid injection for recurrent high-grade glioma with long-term follow-up
- Trial, GBM, NA
*toxicity↓, Half-Life↝, BBB↑,
6045- CGA,  SeNPs,    A Flower-like Brain Targeted Selenium Nanocluster Lowers the Chlorogenic Acid Dose for Ameliorating Cognitive Impairment in APP/PS1 Mice
- in-vivo, AD, NA
*neuroP↑, *BioAv↑, *GutMicro↑, *BBB↑, *Aβ↓, *glucose↝,
6034- CGA,    Effect and mechanism of chlorogenic acid on cognitive dysfunction in mice by lipopolysaccharide-induced neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *TNF-α↓, *antiOx↑, *Inflam↓, *neuroP↑, *BBB↑, *eff↑, *memory↑, *AKT1↓, *MMP9↓, *MAPK↓,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
6112- Chol,    Trimethylamine N-oxide induced cognitive impairment through disruption of blood-brain barrier by inhibiting TGF-β pathway
- in-vivo, AD, NA
*TMAO↑, *cognitive↓, *BBB↝, *TJ↝,
6107- Chol,    Choline supplements: An update
- Review, AD, NA
*memory↑, *cognitive↑, *Dose↝, *BBB↑, *cardioP↑, *ROS↓, *TMAO↑, *memory∅, *eff↑,
6118- Chol,    Comparison of the effects of choline alphoscerate and citicoline in patients with dementia disorders: a systematic review and meta-analysis
- Review, NA, NA
*eff↑, *cognitive↑, *BBB↑, *Ach↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
3888- Cin,    Cinnamon, a promising prospect towards Alzheimer's disease
- NA, AD, NA
*tau↓, *Aβ↓, *neuroP↑, *ROS↓, *Inflam↓, *cardioP↑, *antiOx↑, *cognitive↑, *BBB↑, *p‑GSK‐3β↑, *AChE↓,
3891- Cin,    Identification of potential targets of cinnamon for treatment against Alzheimer's disease-related GABAergic synaptic dysfunction using network pharmacology
- Analysis, AD, NA
*BBB↑, *GABA↑, *eff↑, *antiOx↑, *Inflam↑, *Mood↑,
3624- Cro,    Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment
- Review, AD, NA
*AChE↓, *memory↑, *cognitive↑, *MDA↑, *Thiols↑, *GPx↑, *antiOx↑, *ROS↓, *Casp3↓, *neuroP↑, *SOD↑, *Ach↑, *ChAT↑, *BBB↑, *Aβ↓, *tau↓, *cognitive↑, *Inflam↓,
3751- CUR,  Gala,    A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders
- in-vivo, AD, NA
*AChE↓, *MDA↑, *GSH↑, *BBB↑,
3857- CUR,    Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
- Review, AD, NA
*Inflam↓, *antiOx↑, *IronCh↑, *BBB↑, *ADAM10↝,
3590- CUR,    The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?
- Review, Var, NA - Review, AD, NA
*BioAv↓, *BioAv↑, Dose↑, *Dose↝, *BBB↑, *cognitive↑, *BioAv↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
3581- CUR,    Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *NRF2↑, *NF-kB↓, *cognitive↑, *ROS↓, *MDA↓, *SOD↑, *Catalase↑, *INF-γ↓, *IL4↓, *memory↑, *TNF-α↓, *IL1β↓,
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
3201- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*AntiCan↑, *cardioP↑, *neuroP↑, *BioAv↝, *BioAv↓, *BioAv↓, *Dose↝, *Half-Life↝, *BioAv↑, *BBB↑, *hepatoP↓, *other↓, *Inflam↓, *NF-kB↓, *AP-1↓, *iNOS↓, *COX2↓, *ROS↓, *RNS↓, *IL8↓, *JAK↓, *PDGFR-BB↓, *IGF-1R↓, *MMP2↓, *P53↓, *NRF2↑, *TNF-α↓, *IL6↓, *E2Fs↑, *SOD1↑, *SOD2↑, Casp3↑, Cyt‑c↑, PARP↑, DNMTs↓, Telomerase↓, Hif1a↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, TumCP↓, MAPK↓, HGF/c-Met↓, TIMP1↑, HDAC↓, MMP9↓, uPA↓, GlutMet↓, ChemoSen↑, chemoP↑,
4291- EGCG,    Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro
- in-vitro, AD, NA
*tau↓, *BBB∅,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3781- FA,    Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *AChE↓, *BChE↓,
3717- FA,    Neuroprotective Properties of Ferulic Acid in Preclinical Models of Alzheimer's Disease: A Systematic Literature Review
- Review, AD, NA
*toxicity↓, *BBB↑, *Aβ↓, *antiOx↑, *Inflam↓, *neuroP↑,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
3721- Gb,    Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice
- Review, AD, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,
6062- GoldNP,  SeNPs,    Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines
- Review, AD, NA
*DDS↑, *BBB↑, *eff↑,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2513- H2,    Hydrogen therapy: from mechanism to cerebral diseases
- Review, Stroke, NA
*BBB?, *antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Dose↝,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3765- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Study, AD, NA
*antiOx↑, *Inflam↓, *cognitive↑, *BBB↑,

Showing Research Papers: 51 to 100 of 175
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 175

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↑, 1,   MDA↓, 1,   NADH↓, 1,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 7,   mt-ROS↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

mt-ATP↓, 1,   MMP↓, 2,   MPT↑, 1,   mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   PDK1↓, 1,   PDK3↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 3,   BAD↓, 1,   Bak↑, 2,   BAX↑, 3,   Bcl-2↓, 3,   Bcl-xL↓, 2,   BID↓, 1,   Casp↑, 2,   Casp3↑, 3,   Casp8↑, 1,   Casp9↑, 1,   cFLIP↓, 1,   Cyt‑c↑, 3,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   MAPK↓, 1,   Myc↓, 1,   p38↑, 1,   survivin↓, 1,   Telomerase↓, 3,  

Kinase & Signal Transduction ⓘ

FOXD3↑, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

DNMTs↓, 2,   P53?, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   Diff↑, 1,   EIF4E↓, 1,   EMT↓, 1,   ERK↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   IGF-1↓, 1,   mTOR↓, 1,   mTORC1↓, 1,   NOTCH1↑, 1,   PI3K↓, 3,   PTEN↑, 2,   STAT3↓, 3,   TOP1↓, 2,   TOP2↓, 1,   TumCG↓, 4,  

Migration ⓘ

5LO↓, 2,   p‑FAK↓, 1,   Ki-67↓, 2,   MMP2↓, 2,   MMP9↓, 3,   MMP9↑, 1,   MMPs↓, 3,   Rho↓, 1,   ROCK1↓, 1,   TIMP1↑, 1,   TRIB3↑, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 2,   TumMeta↓, 2,   uPA↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EPR↑, 1,   Hif1a↓, 5,   VEGF↓, 2,  

Barriers & Transport ⓘ

BBB↑, 10,   GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1β↓, 3,   IL2↑, 1,   Inflam↓, 1,   NF-kB↓, 6,   PD-L1↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 2,   BioAv∅, 1,   BioEnh↑, 2,   ChemoSen↑, 5,   Dose↑, 1,   Dose↝, 1,   eff↓, 2,   eff↑, 6,   Half-Life↓, 1,   Half-Life↝, 1,   Half-Life∅, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 2,   Myc↓, 1,   PD-L1↓, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↓, 1,   neuroP↑, 1,   Obesity↓, 1,   OS↑, 2,   toxicity↝, 1,   toxicity∅, 2,  
Total Targets: 139

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TMAO↑, 2,  

Redox & Oxidative Stress ⓘ

4-HNE↓, 2,   antiOx↑, 23,   ARE↑, 1,   Catalase↑, 8,   Ferroptosis↓, 2,   GPx↑, 4,   GPx4↑, 1,   GSH↑, 7,   GSR↑, 1,   HO-1↑, 6,   HO-2↓, 1,   lipid-P↓, 3,   MDA↓, 4,   MDA↑, 3,   NQO1↑, 1,   NRF2↑, 9,   RNS↓, 2,   ROS↓, 24,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 1,   Thiols↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↑, 1,   IronCh↑, 4,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   AKT1↓, 1,   AMPK↑, 1,   CYP3A4↓, 1,   FAO↓, 1,   glucose↝, 1,   LDH↓, 1,   LDL↓, 2,   NADPH↓, 1,   PPARα↑, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↑, 2,   Apoptosis↓, 2,   Bcl-2↑, 1,   Casp3↓, 1,   cl‑Casp3↓, 1,   Ferroptosis↓, 2,   iNOS↓, 2,   MAPK↓, 2,   TRPV1↑, 1,  

Kinase & Signal Transduction ⓘ

TRPV3↑, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 3,   other↓, 2,   other↑, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

E2Fs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   p‑GSK‐3β↑, 1,   IGF-1R↓, 1,   p‑mTOR↓, 1,   PI3K↑, 2,   TRPM7↓, 3,   TRPM7⇅, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 2,   APP↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   MMP2↓, 1,   MMP9↓, 2,   NFAT↓, 1,   PKCδ↑, 1,   TJ↝, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,   NO↑, 1,   PDGFR-BB↓, 1,  

Barriers & Transport ⓘ

BBB?, 1,   BBB↓, 2,   BBB↑, 35,   BBB↝, 1,   BBB∅, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 7,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL4↓, 1,   IL6↓, 4,   IL6↑, 1,   IL8↓, 2,   INF-γ↓, 1,   Inflam↓, 24,   Inflam↑, 1,   JAK↓, 1,   NF-kB↓, 8,   NF-kB↑, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 10,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 9,   ADAM10↝, 1,   BChE↓, 2,   BDNF↑, 3,   ChAT↑, 2,   GABA↑, 1,   tau↓, 5,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 11,   NLRP3↓, 3,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 6,   BioAv↑, 10,   BioAv↝, 4,   BioEnh↑, 2,   DDS↑, 1,   Dose↑, 1,   Dose↝, 9,   Dose∅, 1,   eff↑, 13,   Half-Life↓, 2,   Half-Life↝, 3,  

Clinical Biomarkers ⓘ

Ferritin↑, 1,   GutMicro↑, 2,   IL6↓, 4,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cardioP↑, 5,   cognitive↓, 1,   cognitive↑, 18,   cognitive↝, 1,   hepatoP↓, 1,   hepatoP↑, 1,   memory↑, 12,   memory∅, 1,   Mood↑, 1,   motorD↑, 2,   neuroP↑, 21,   OS↑, 1,   toxicity↓, 3,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 144

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
14 Selenium NanoParticles
13 Alpha-Lipoic-Acid
11 borneol
9 Hydrogen Gas
8 Curcumin
7 Honokiol
5 Carvacrol
5 Pterostilbene
5 Urolithin
4 Silver-NanoParticles
4 Berberine
4 Chlorogenic acid
4 Quercetin
4 Resveratrol
3 5-Hydroxytryptophan
3 Apigenin (mainly Parsley)
3 Choline
3 EGCG (Epigallocatechin Gallate)
3 Ferulic acid
3 Luteolin
3 Lycopene
3 Mushroom Lion’s Mane
3 Rutin
3 Sulforaphane (mainly Broccoli)
2 almonertinib
2 Baicalein
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Carnosic acid
2 Cinnamon
2 Fisetin
2 Methylene blue
2 Vitamin B3,Niacin
2 Rosmarinic acid
2 S-adenosyl-L-methionine
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Vitamin B5,Pantothenic Acid
1 acetaminophen
1 Anthocyanins
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 Bevacizumab (brand Avastin)
1 Aromatherapy
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Baicalin
1 Betulinic acid
1 Brucea javanica
1 Boswellia (frankincense)
1 Capsaicin
1 Thymol-Thymus vulgaris
1 chitosan
1 Chrysin
1 Propolis -bee glue
1 Crocetin
1 Galantamine
1 Gambogic Acid
1 Ginkgo biloba
1 Gold NanoParticles
1 Huperzine A/Huperzia serrata
1 Magnolol
1 MCToil
1 Melatonin
1 Magnetic Fields
1 Moringa oleifera
1 Methylsulfonylmethane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Metformin
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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