AntiDiabetic Cancer Research Results

AntiDiabetic, AntiDiabetic: Click to Expand ⟱
Source:
Type:
AntiDiabetic
Scientific Papers found: Click to Expand⟱
6365- DRE,    AN OVERVIEW OF THERAPEUTIC POTENTIALS OF TARAXACUM OFFICINALE (DANDELION): A TRADITIONALLY VALUABLE HERB WITH A REACH HISTORICAL BACKGROUND
- Review, Var, NA
*Inflam↓, *AntiTum↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *diuretic↑, *RenoP↑, *hepatoP↑, *neuroP↑, AntiTum↑, TNF-α↑, IL1β↑, Apoptosis↑, MMP2↓, MMP9↑, eff↑, Diff↑, *ROS↓, *HO-1↑, *NRF2↑, *lipid-P↓,
6362- DRE,    Taraxacum spp. in vitro and in vivo anticancer activity – A review
- Review, Var, NA
tumCV↓, *AntiDiabetic↑, *Imm↑,
6366- DRE,    A comprehensive review of the benefits of Taraxacum officinale on human health
- Review, Var, NA
*diuretic↑, *hepatoP↑, *Imm↑, *Bacteria↓, *AntiArt↑, *AntiDiabetic↑, *Obesity↓, *antiOx↓, *AntiCan↑, Dose?,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6814- EMD,    Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics
- Review, Nor, NA
AntiCan↑, *hepatoP↑, *Inflam↑, *antiOx↑, *AntiBio↑, *BioAv↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, CSCs↓, NOTCH↓, β-catenin/ZEB1↓, STAT3↓, TumCCA↑, *TNF-α↓, IL6↓, IL1β↓, *MMP9↓, *HO-1↑, cMyc↓, Mcl-1↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6379- Eug,    Safety assessment of a standardized polyphenolic extract of clove buds: Subchronic toxicity and mutagenicity studies
- in-vivo, Nor, NA
*toxicity∅, *Dose↑, *Bacteria↓, *Inflam↓, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *AntiCan↑, *AntiThr↑,
6323- Eug,    Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects
- Review, Var, NA - Review, Arthritis, NA
*AntiCan↑, *AntiDiabetic↑, *cardioP↑, *toxicity↝, *GutMicro↑, *neuroP↑, *BioAv⇅, *BioAv↝, *antiOx↑, *Inflam↑, *AntiArt↑, *TNF-α↓, *IL6↓, *IL10↓, *GSH↑, *GPx↑, *Catalase↑, *MDA↓, *TAC↑, TumCMig↓, TumCI↓, Akt↑, FOXO3↑, Casp3↑, Casp9↑, P21↑, angioG↓, TumCI↓, Apoptosis↑, NF-kB↓, eff↑, eff↑, ChemoSen↑, NA↑, Casp3↑, Casp9↑, *AntiDiabetic↑, *glucose↓, *ROS↓, *Inflam↓, *MDA↓, *GSH↑, *BioAv↑,
6873- FA,    Ferulic acid: extraction, estimation, bioactivity and applications for human health and food
- Review, Nor, NA
*Inflam↓, *AntiBio↑, AntiCan↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *ROS↓, *antiOx↑, *AGEs↓, *Catalase↑, *SOD↑,
6430- FEO,    Foeniculum vulgare: A comprehensive review of its traditional use, phytochemistry, pharmacology, and safety
- Review, Nor, NA
*Dose↝, *Bacteria↓, *hepatoP↑, *antiOx↑, *AntiThr↑, *AntiDiabetic↑, *toxicity↝,
6909- FIS,    Modulation of PI3K/ AKT/ mTOR and apoptosis pathway in colon cancer cells by the plant flavonoid fisetin
- in-vitro, Colon, Caco-2
AntiCan↑, tumCV↓, Bcl-2↓, PI3K↓, mTOR↓, NF-kB↓, BAX↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *antiOx↑, *neuroP↑,
6895- FIS,    Enhanced bioavailability and pharmacokinetics of a novel hybrid-hydrogel formulation of fisetin orally administered in healthy individuals: a randomised double-blinded comparative crossover study
- in-vivo, Nor, NA
*neuroP↑, *cardioP↑, *chemoPv↑, *AntiDiabetic↑, *Inflam↓, *ROS↓, *BioAv↓, *BioAv↑, *eff↑, *Half-Life↓,
6925- Flav,    Important Flavonoids and Their Role as a Therapeutic Agent
- Review, Nor, NA
AntiCan↑, *antiOx↑, *Inflam↓, *AntiViral↑, *neuroP↑, *cardioP↑, *AChE↓, *cognitive↑, Risk↓, *Stroke↓, *AntiDiabetic↑, *AntiFungal↑,
6924- Flav,    Plant Flavonoids: Chemical Characteristics and Biological Activity
- Review, Nor, NA
*ROS↓, *antiOx↑, *Inflam↓, *Bacteria↓, *cardioP↑, AntiCan↑, *AntiAge↑, *AntiDiabetic↑, AntiViral↑, *BioAv↓, *AntiFungal↑,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, eff↑, *toxicity↓, *BioAv↑, *BioAv↑, *eff↑,
6988- Form,    Formononetin ameliorates high glucose‑induced endothelial dysfunction by inhibiting the JAK/STAT signaling pathway
- in-vitro, Nor, HUVECs
*JAK2↓, *Casp3↑, *Inflam↓, *IL1β↓, *ICAM-1↓, *AntiDiabetic↑,
7008- Fuc,    Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
- Review, Var, NA
antiOx↑, AntiViral↑, Imm↝, *AntiThr↑, *AntiDiabetic↑, AntiTum↑, TumMeta↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, EMT↓, N-cadherin↓, E-cadherin↑, TIMP1↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, ChemoSen↑, OS↑, fatigue↓, CD31/PECAM-1↓,
7028- GA,    Gallic acid: Pharmacological activities and molecular mechanisms involved in inflammation-related diseases
- Review, Nor, NA
*toxicity↓, *Inflam↓, *NF-kB↓, AntiTum↑, Bacteria↓, *AntiDiabetic↑, *Obesity↓, *AntiBio↑, *Stroke↓, *NO↓, *PGE2↓, *IL6↓, *MAPK↓, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *ICAM-1↓, *TIMP1↓,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *eff↑,
7103- GEN,    A Comprehensive Review of Genistein's Effects in Preclinical Models of Cervical Cancer
- Review, Cerv, NA
TumCP↓, Apoptosis↑, RadioS↑, ChemoSen↑, *antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, TumCG↓, TumCI↓, TumCCA↑, cl‑PARP↑, selectivity↑, CycB/CCNB1↓, CDK1↓, p‑cDC2↓, p‑ERK↓, p‑p38↑, p‑JNK↑, MMP9↓, TIMP1↑, BioAv↓, BioAv↑, Half-Life↑,
7102- GEN,    Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits
- Review, Var, NA
*antiOx↑, *Inflam↓, *Bacteria↓, *AntiViral↑, *Dose↝, *AntiDiabetic↑, angioG↑, Apoptosis↑, tumCV↓, MyD88↑, Beclin-1/ATG6↑, LC3II↑, TLR4↑, TumAuto↑, mTOR↓, p62↓, TumCCA↑, TumCP↓, Akt↑, P53↑, DNMT3B↓, MEK↓, hTERT/TERT↓, VEGF↓, NF-kB↓, IAP1↓, MDR1↓, p‑Akt↓, eff↑, ChemoSen↑,
6571- Ger,    Unlocking the therapeutic potential of Geraniol: an alternative perspective for metabolic disease management
- Review, Obesity, NA
*lipidLev↓, *antiOx↓, Inflam↓, *ROS↓, *BioAv↑, *AntiDiabetic↑, *Obesity↓,
7338- Gra,    Pharmacological Activities of Soursop (Annona muricata Lin.)
- Review, Var, NA
AntiCan↑, *AntiDiabetic↑, *Diar↓, *Bacteria↓, *AntiViral↑, *Wound Healing↑, MMP2↓, MMP9↓, MMP↓, ROS↑, TumCCA↑, BAX↑, Bcl-2↓, Casp3↑, *BAX↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *NO↑, *PGE2↑, *HSP70/HSPA5↑,
7490- H2,    Long-term administration of hydrogen-rich water enhances quality of life in diabetic rats and reduces renal neoplasm incidence through modulation of inflammatory and metabolic pathways
- in-vivo, Diabetic, NA
*BG↓, *AntiDiabetic↑, *BMD↑, *hepatoP↑, *RenoP↑, *QoL↑,
7358- HibSad,    Chemopreventive properties and molecular mechanisms of the bioactive compounds in Hibiscus sabdariffa Linne
- Review, Var, NA
chemoPv↑, *ROS↓, *other↝, *hepatoP↑, *lipid-P↓, Apoptosis↑, *LDL↓, RAS↓, Akt↓, NF-kB↓, Rho↝, MMPs↓, *AntiDiabetic↑, *Catalase↑, *GSH↑,
7359- HibSad,    Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review - PubMed
- Review, Var, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, p27/CDKN1B↑, BAD↑, BAX↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, *AntiBio↑, *Inflam↓, *antiOx↑, *BP↓, *AntiDiabetic↑, HDAC1↓, HDAC3↓, tumCV↓, LDL↓, DNAdam↑, MMP↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑, *antiOx↑, *ROS↓, TumCMig↓, TumCI↓, selectivity↑, RAS↓, Akt↓, NF-kB↓, MMP2↓, PI3K↓, Bcl-2↓, Bcl-xL↓, PCNA↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓,
7372- HOO,    Ozone-modified properties of pumpkin seed oil as anti-H. pylori, anticancer, anti-diabetic and anti-obesity agent
- in-vitro, Pca, PC3
Apoptosis↑, AntiDiabetic↑, Obesity↑, TumCCA↑, other↝,
7630- Ins,    Modulation of both Insulin Resistance and Cancer Growth by Inositol
- Review, Var, NA - Review, Diabetic, NA
*IRes↓, *AntiDiabetic↑, *glucose↝, AntiCan↑, PI3K↓, Akt↓, Glycolysis↓, STK11/LKB1↑, *FASN↓, *LDL↓, *FFA/NEFA↓, *ROS↓, ROS↑, IGF-1↓,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, BioAv↑, BioAv↑, BioAv↑,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7778- ISL,    Isoliquiritigenin, a potent human monoamine oxidase inhibitor, modulates dopamine D1, D3, and vasopressin V1A receptors
- Study, Park, NA - Study, AD, NA
*neuroP?, TumCP↓, *Inflam↓, *hepatoP↑, angioG↓, *AntiBio↑, *AntiDiabetic↓, *ROS↓, *antiOx↑, *MAOA↓, *MAOB↓,
7791- ISQ,    Isoquercitrin: pharmacology, toxicology, and metabolism
- Review, Nor, NA
*BioAv↑, *chemoP↑, *ROS↓, *cardioP↑, *AntiDiabetic↑, *Dose↝,
7814- ISQ,    Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90
- in-vivo, Nor, NA
*ROS↓, *AntiCan↑, *cardioP↑, *AntiDiabetic↑, *NLRP3↓, *HSP90↓, *AST↓, *ALAT↓,
7848- ISQ,    Review of anticancer mechanisms of isoquercitin
- Review, Var, NA
BioAv↑, eff↑, *antiOx↓, TumCP↓, *Inflam↓, *AntiDiabetic↑, lipid-P↓, *toxicity↓, *Half-Life↝, *Half-Life↑, *XO↝, *IronCh↝, *VitC↑, *ROS↓, β-catenin/ZEB1↓, Casp3↑, Casp8↑, Casp9↑, MMP↓, p‑ERK↓, p‑cJun↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
7917- IVT,    A review on the pharmacological effects of vitexin and isovitexin
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *AntiCan↑, *Inflam↓, *neuroP↑, *AChE↓, *BChE↓, *BACE/β-secretase↓, *Stroke↓, *AntiAg↓, *AntiDiabetic↑, *AGEs↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *Obesity↓, *BioAv↝, *BioAv↓,
7891- IVT,  VT,    Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
- NA, AD, NA
*AntiDiabetic↑, *Inflam↓, *AGEs↓, *AChE↓, *BChE↓, *PTP1B↓,
8095- KAE,    Kaempferol: A Key Emphasis to Its Anticancer Potential
- Review, Var, NA
*AntiBio↑, *Inflam↓, *AntiTum↓, *antiOx↑, *cardioP↑, *neuroP↑, *AntiDiabetic↑, Risk↓, TumCCA↑, EMT↓, PI3K↓, Akt↓, MMP2↓, Casp3↑, Casp7↑, Casp9↑, PARP↑, *ROS↓, angioG↓, *BioAv↑, BioAv↑, selectivity↑, GLUT1↓, MCT1↓, ROS↓, ROS↑, Trx↓, Cyt‑c↑, MMP↓, miR-21↓, SOCS-3↓, STAT3↓, CDK1↓, CycB/CCNB1↑, HIF-1↓, JAK1↑, PTEN↑,
8058- KAE,    A randomized, placebo‐controlled trial evaluating the safety of excessive administration of kaempferol aglycone
- Trial, Nor, NA
*AntiBio↑, *antiOx↑, *Inflam↓, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *neuroP↑, *Dose↝, *toxicity↓,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
8056- KAE,    Kaempferol: advances in biosynthesis, molecular mechanisms, and therapeutic applications
- Review, Var, NA - Review, Diabetic, NA
*antiOx↑, *ROS↓, *NRF2↑, *Inflam↓, *NF-kB↓, *MAPK↓, *STAT↓, *AntiDiabetic↑, *AMPK↑, *IRes↑, Apoptosis↑, TumCCA↑, TumMeta↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, *AntiBio↑, *hepatoP↑, *SIRT1↝, *BioAv↓,
8200- LGE,    Chemical Properties and Therapeutic Potential of Citral, a Monoterpene Isolated from Lemongrass
- Review, Var, NA
*AntiBio↑, *antiOx↑, *AntiCan↑, *AntiDiabetic↑, *Inflam↓, Dose↝, BioAv↝,
8205- LGE,    Citral: Bioactivity, Metabolism, Delivery Systems, and Food Preservation Applications
- Review, Nor, NA
*CompStab↓, *Bacteria↓, *antiOx↑, *Inflam↓, *AntiDiabetic↑, *AntiCan↑,
4788- Lyco,    Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review)
- Review, Var, NA
AntiCan↑, ChemoSen↑, chemoP↑, Dose↝, BioAv↑, BioAv↑, BioAv↓, cardioP↑, AntiDiabetic↑, hepatoP↑, neuroP↑, MAPK↓, MMP2↓, MMP9↓, TIMP1↑, TIMP2↑,
4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑, *glucose↓, *SOD↑, *Catalase↑, *ROS↓, *MDA↓, *GPx↑, *CYP2E1↓, *AGEs↓, *IL10↑, *neuroP↑, *GutMicro↑,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
5800- MET,    Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect
- Review, Var, NA
ChemoSen↑, RadioS↑, Imm↑, *AntiDiabetic↑, *AMPK↑, TumCP↓, hepatoP↑, ATP↓, AMP↑, glucoNG↓, ROS↑, compI↓, DNAdam↑, CSCs↓, NP/CIPN↓, chemoP↑, toxicity↓, Trx↓, eff↑, cycD1/CCND1↓, CDK4↓, CDK6↓, cycE/CCNE↓, CDK2↓,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,

Showing Research Papers: 51 to 100 of 109
Prev Page 2 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 109

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   compI↓, 1,   lipid-P↓, 1,   MDA↑, 1,   mt-OXPHOS↓, 1,   PARK2↑, 1,   ROS↓, 1,   ROS↑, 10,   SOD↑, 1,   Trx↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MEK↓, 1,   MMP↓, 6,   mtDam↑, 1,   PINK1↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMP↑, 1,   cMyc↓, 2,   glucoNG↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 3,   LDH↓, 1,   LDL↓, 1,   PDK1 / PDPK1↓, 1,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   Akt↑, 2,   p‑Akt↓, 2,   Apoptosis↑, 14,   BAD↑, 1,   BAX↓, 1,   BAX↑, 6,   Bax:Bcl2↓, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Bcl-xL↓, 2,   Casp↑, 1,   Casp12↝, 1,   Casp3↑, 9,   cl‑Casp3↑, 2,   proCasp3↓, 1,   Casp7↑, 3,   Casp8↑, 2,   Casp9↑, 8,   cl‑Casp9↑, 2,   Cyt‑c↑, 4,   hTERT/TERT↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 2,   MCT1↓, 1,   MOMP↑, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   p‑p38↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

p‑cJun↑, 1,   miR-21↓, 1,   other↝, 1,   pRB↓, 1,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 2,   LC3II↑, 2,   MitoP↑, 1,   p62↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNMT3B↓, 1,   P53↓, 1,   P53↑, 5,   PARP↑, 2,   cl‑PARP↑, 2,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK2↓, 1,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 2,   mitA↑, 1,   P21↑, 2,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑cDC2↓, 1,   CSCs↓, 3,   Diff↑, 1,   EMT↓, 3,   ERK↓, 1,   p‑ERK↓, 2,   FOXO3↑, 1,   GSK‐3β↑, 1,   HDAC1↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   miR-34a↓, 1,   mTOR↓, 4,   p‑mTOR↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 7,   PTEN↑, 2,   RAS↓, 2,   STAT3↓, 3,   TumCG↓, 2,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

BACH1↓, 1,   CD31/PECAM-1↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   LAMs↓, 1,   MMP2↓, 6,   MMP9↓, 3,   MMP9↑, 1,   MMPs↓, 2,   N-cadherin↓, 1,   Rho↝, 1,   Slug↓, 1,   TIMP1↑, 3,   TIMP2↑, 1,   TRIB3↑, 1,   TumCI↓, 5,   TumCMig↓, 2,   TumCP↓, 9,   TumMeta↓, 2,   TumMeta↑, 2,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   angioG↑, 1,   EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 3,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB∅, 1,   GLUT1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL6↓, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 1,   JAK1↑, 1,   MyD88↑, 1,   NF-kB↓, 8,   NF-kB↑, 1,   PD-1↓, 1,   SOCS-3↓, 1,   TLR4↑, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 8,   BioAv↝, 2,   ChemoSen↑, 9,   Dose?, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 9,   Half-Life↑, 1,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 12,   AntiDiabetic↑, 2,   AntiTum↑, 4,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   fatigue↓, 1,   hepatoP↑, 2,   neuroP↑, 1,   NP/CIPN↓, 2,   Obesity↑, 1,   OS↑, 1,   Risk↓, 4,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 1,  
Total Targets: 195

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 2,   AntiBio↑, 12,   AntiP↑, 1,   CompStab↓, 1,   diuretic↑, 3,   FFA/NEFA↓, 1,   IRes↓, 1,   IRes↑, 1,   Stroke↓, 5,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 26,   Catalase↑, 7,   CYP2E1↓, 1,   GPx↑, 5,   GSH↑, 7,   HO-1↓, 1,   HO-1↑, 3,   Keap1↝, 1,   lipid-P↓, 4,   MDA↓, 6,   MPO↓, 1,   NQO1↑, 1,   NQO1↝, 1,   NRF2↑, 6,   ROS↓, 23,   mt-ROS?, 1,   SOD↑, 6,   SOD2↑, 1,   TAC↑, 2,   TrxR1↑, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↓, 1,   ATP↑, 1,   Insulin↓, 1,   Insulin↑, 1,   MMP↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 5,   AMPK↓, 1,   AMPK↑, 6,   CRM↑, 2,   FASN↓, 1,   glucose↓, 5,   glucose↝, 1,   glyC↓, 1,   LDL↓, 3,   lipidLev↓, 1,   NAD↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↝, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp3↓, 2,   Casp3↑, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GADD34↓, 1,   iNOS↓, 1,   MAPK↓, 2,   Pyro↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 3,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3II↓, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GH↑, 1,   GSK‐3β↓, 2,   p‑GSK‐3β↑, 1,   mTOR↓, 1,   PI3K↓, 2,   STAT↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↝, 1,   AntiAg↓, 1,   MMP9↓, 1,   PTP1B↓, 1,   TIMP1↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   Hif1a↓, 1,   NO↓, 2,   NO↑, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   COX2/PTGS2↑, 1,   ICAM-1↓, 2,   IFN-γ↓, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 4,   IL6↓, 6,   IL8↓, 2,   Imm↓, 1,   Imm↑, 5,   Inflam↓, 31,   Inflam↑, 2,   JAK↓, 1,   JAK2↓, 1,   pol-M2 MC↑, 1,   MCP1/CCL2↓, 1,   MyD88↓, 1,   NF-kB↓, 7,   PGE2↓, 2,   PGE2↑, 1,   TLR4↓, 1,   TNF-α↓, 6,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 4,   BChE↓, 2,   BDNF↓, 1,   BDNF↑, 1,   MAOA↓, 1,   NGF↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 5,   BACE/β-secretase↓, 1,   MAOB↓, 1,   NLRP3↓, 3,   XO↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 10,   BioAv⇅, 1,   BioAv↝, 3,   Dose↑, 1,   Dose↝, 4,   eff↑, 3,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   AST↓, 4,   BG↓, 1,   BMD↑, 1,   BP↓, 2,   GutMicro↑, 4,   IL6↓, 6,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 11,   AntiDiabetic↓, 1,   AntiDiabetic↑, 48,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 4,   cardioP↑, 13,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 16,   memory↑, 1,   neuroP?, 1,   neuroP↑, 19,   Obesity↓, 6,   QoL↑, 1,   RenoP↑, 5,   Sleep↑, 1,   Strength↑, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity⇅, 1,   toxicity↝, 5,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 3,   AntiViral↑, 8,   Bacteria↓, 11,   Bacteria↑, 1,   Diar↓, 1,  
Total Targets: 185

Scientific Paper Hit Count for: AntiDiabetic, AntiDiabetic
8 Chlorogenic acid
4 Dandelion Root
4 Emodin
4 Kaempferol
3 Astaxanthin
3 Carvacrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Cinnamon
3 diet Fermented Foods
3 Isoliquiritigenin
3 isoquercitrin
3 Isovitexin
3 Metformin
2 Silver-NanoParticles
2 Allicin (mainly Garlic)
2 Biochanin A
2 Rutin
2 Carica papaya leaf extract
2 D-limonene
2 Eugenol
2 Fisetin
2 flavonoids
2 Formononetin
2 Genistein (soy isoflavone)
2 Hibiscus sabdariffa
2 Vitexin
2 Lemongrass Extract/Citral
2 Nimbolide
2 Ursolic acid
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Anethole/trans-Anethole
1 Aloe anthraquinones
1 Bacopa monnieri
1 buckwheat sprouts
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chocolate
1 Chrysin
1 Hydroxycinnamic-acid
1 Crocetin
1 Carvone
1 Cucurbitacin
1 Date Fruit Extract
1 diet Short Term Fasting
1 Ferulic acid
1 Fennel Oil/Foeniculum vulgare
1 Fucoidan
1 Gallic acid
1 Gamma-aminobutyric acid
1 Geraniol
1 Graviola
1 Hydrogen Gas
1 High-Ozonide Oil
1 Inositol
1 Ivermectin
1 Lycopene
1 Magnolol
1 Neem
1 Psoralidin
1 Quercetin
1 Curcumin
1 Selenium NanoParticles
1 Thymol-Thymus vulgaris
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1385  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page