NQO1 Cancer Research Results

NQO1, NAD(P)H quinone dehydrogenase 1: Click to Expand ⟱
Source:
Type:
NQO1 has attracted interest due to its roles in cell defense and marked inducibility during cellular stress. Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research.
NQO1 (NAD(P)H:quinone oxidoreductase 1) is an enzyme that plays a significant role in cellular defense against oxidative stress and the metabolism of various compounds, including quinones and other electrophiles. Its function is crucial in protecting cells from damage caused by reactive oxygen species (ROS) and in the detoxification of potentially harmful substances.
Scientific Papers found: Click to Expand⟱
1431- SFN,    Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
- in-vivo, Nor, NA
*NADPH↑, *NQO1↑, *GSTA1↑, *HO-1↑,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, eff↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, eff↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
2216- SK,    Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- in-vivo, Nor, NA
*NRF2↑, *AhR↑, *CYP1A1↑, *CYP1A2↑, *CYP2C6↑, *CYP2D1↑, *CYP3A2↑, *NQO1↑,
2214- SK,    Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *antiOx↑, *neuroP↑, *ROS↓, *MDA↓, *SOD↑, GSH↑,
4538- TQ,    Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, H2O2↓, Catalase↑, SOD↑, GSH↑, PRNP↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, chemoPv↑, ROS↓,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, NA, NA
*COX2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
3405- TQ,  doxoR,    Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism
- vitro+vivo, NA, NA
*cardioP↑, *NRF2↑, *HO-1↑, *ROS↓, *NQO1↑, *COX2↓, *NOX4↓, *GPx4↑, *FTH1↑, *p‑mTOR↓, *TGF-β↓,
3399- TQ,    Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - NA, BC, MDA-MB-468
ROS↓, H2O2↓, Catalase↑, SOD↑, GSH↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, GSSG↑, GPx1⇅, GPx4↓,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
114- VitC,  QC,    Chemoprevention of prostate cancer cells by vitamin C plus quercetin: role of Nrf2 in inducing oxidative stress
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
GPx↓, GSR↓, NQO1↓, NRF2↓, ROS↑,
5015- Xan,  PEITC,    Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo
- in-vitro, HCC, HepG2
NRF2↓, ROS↑, NF-kB↓, COX2↓, Apoptosis↑, NRF2↑, SOD↑, NQO1↑,

Showing Research Papers: 51 to 62 of 62
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 62

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   GCLM↑, 2,   GPx↓, 1,   GPx1⇅, 1,   GPx4↓, 1,   GSH↑, 3,   GSR↓, 1,   GSSG↑, 1,   H2O2↓, 2,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 2,   NRF2↑, 3,   ROS↓, 2,   ROS↑, 2,   SOD↑, 3,  

Cell Death ⓘ

Apoptosis↑, 1,  

Migration ⓘ

PRNP↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL6↓, 1,   NF-kB↓, 1,   PD-L1↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 2,  

Clinical Biomarkers ⓘ

IL6↓, 1,   PD-L1↓, 2,  

Functional Outcomes ⓘ

chemoPv↑, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

4-HNE↓, 1,   antiOx↑, 3,   Catalase↑, 1,   CYP1A1↑, 1,   GCLC↑, 1,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 2,   GSH/GSSG↑, 1,   GSSG↓, 1,   GSTA1↑, 3,   HO-1↑, 6,   MDA↓, 3,   NOX4↓, 1,   NQO1↑, 8,   NRF2↑, 6,   ROS↓, 5,   SOD↑, 3,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,  

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   CYP2C6↑, 1,   CYP3A2↑, 1,   NADPH↑, 2,  

Cell Death ⓘ

AhR↑, 1,   p‑Akt↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   p‑mTOR↓, 1,  

Migration ⓘ

CYP2D1↑, 1,   TGF-β↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IL1β↓, 1,   Inflam↓, 3,   NF-kB↓, 2,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

p‑tau↓, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   CYP1A2↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   Mood↑, 1,   neuroP↑, 3,   OS↑, 1,  
Total Targets: 53

Scientific Paper Hit Count for: NQO1, NAD(P)H quinone dehydrogenase 1
12 Sulforaphane (mainly Broccoli)
5 Thymoquinone
3 Alpha-Lipoic-Acid
3 Quercetin
3 Luteolin
3 Lycopene
3 Resveratrol
2 Ashwagandha(Withaferin A)
2 Carnosic acid
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Ferulic acid
2 Chemotherapy
2 Phenethyl isothiocyanate
2 xanthohumol
2 Piperlongumine
2 Pterostilbene
2 Shikonin
1 Silver-NanoParticles
1 Berberine
1 immunotherapy
1 Brucea javanica
1 brusatol
1 Boron
1 Capsaicin
1 Chlorogenic acid
1 Copper and Cu NanoParticles
1 diet Methionine-Restricted Diet
1 Genistein (soy isoflavone)
1 HydroxyTyrosol
1 Metformin
1 Plumbagin
1 Selenium
1 Gemcitabine (Gemzar)
1 Silymarin (Milk Thistle) silibinin
1 doxorubicin
1 Vitamin B1/Thiamine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:224  State#:%  Dir#:%
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