P-gp/ABCB1 Cancer Research Results

P-gp/ABCB1, permeability-glycoprotein: Click to Expand ⟱
Source:
Type:
P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).

ABCB1 - ATP-Binding Cassette Subfamily B Member 1 / P-Glycoprotein

Abbreviation: ABCB1, P-gp, P-glycoprotein, MDR1

Type: ATP-dependent membrane efflux transporter / multidrug resistance protein

Function: ABCB1 encodes P-glycoprotein, an ATP-binding cassette transporter that exports a broad range of drugs, xenobiotics, lipids, and other substrates across cellular membranes. It is highly expressed in barrier tissues including the intestine, liver, kidney, placenta, and blood-brain barrier, where it limits tissue accumulation of potentially harmful compounds.

Cancer: ↑ Frequently overexpressed or functionally activated in drug-resistant tumors. Increased ABCB1 lowers intracellular concentrations of many anticancer agents by actively transporting them out of cancer cells, producing multidrug resistance and reducing chemotherapy effectiveness.

Alzheimer's Disease: ↓ Reduced ABCB1/P-glycoprotein expression or transport activity at the blood-brain barrier is associated with impaired amyloid-β clearance from the brain. Lower P-gp function correlates with increased cerebral Aβ accumulation and may contribute to Alzheimer's disease progression.
Scientific Papers found: Click to Expand⟱
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7992- itraC,    Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs
P-gp/ABCB1↓, BioEnh↑,
7990- itraC,    A Novel Approach to Reducing Chemoresistance in Advanced Ovarian Cancer: The Effect of Itraconazole-A Single-Institution Randomized Placebo-Controlled Trial
- Trial, Ovarian, NA
Dose↝, DCR↑, PFS↑, CA125↓, P-gp/ABCB1↓, VEGFR2/KDR/Flk1↑, toxicity↓, QoL↑, toxicity↝,
8001- itraC,    Repurposing itraconazole as an anticancer agent
- Review, Var, NA
*AntiFungal↑, AntiCan↑, P-gp/ABCB1↓, HH↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, angioG↓, LymphAG↓, ChemoSen↑, OS↑, Gli1↓, Ki-67↓, CSCs↓,
8016- itraC,    Impact of combination chemotherapy with itraconazole on survival for patients with recurrent or persistent ovarian clear cell carcinoma
- Human, Ovarian, NA
P-gp/ABCB1↓, angioG↓, HH↓, OS↑, Dose↝,
2179- itraC,    Repurposing itraconazole for the treatment of cancer
- Review, Var, NA
HH↓, angioG↓, TumCCA↑, MDR1↓, P-gp/ABCB1↓, mTOR↓, VEGF↓, Smo↓, Gli1↓, OS↑, PSA↓,
8031- IVM,    Antiparasitic agents in oncology: Innovative mechanisms, emerging evidence and clinical potential in cancer treatment
*AntiP↑, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, HH↓, Imm↑, CSCs↓, P-gp/ABCB1↓, Chl↓, angioG↓,
8030- IVM,    Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects
- Review, Var, NA
P450↓, P-gp/ABCB1↓, ABCC2↓, ABCG2↓, OATPs↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8047- IVM,    The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- Review, Var, NA
Half-Life↝, MDR1↓, P-gp/ABCB1↓, mtDam↑, ROS↑, OCR↓, compI↓, MMP↓, mt-SOD↑, ATP↓, p‑Akt↓, p‑mTOR↓, eff↓, ICD↑, TumAuto↑, PAK1↓, Wnt↓, TCF↓, Nanog↓, SOX2↓, CSCs↓, CD44↓, CD24↓, Dose↝,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8252- LCA,    Effects of licochalcone A on the bioavailability and pharmacokinetics of nifedipine in rats: possible role of intestinal CYP3A4 and P-gp inhibition by licochalcone A.
- in-vivo, Nor, NA
*CYP3A4↓, *P-gp/ABCB1↓,
8216- LCA,    Effects of licochalcone A on the bioavailability and pharmacokinetics of nifedipine in rats: possible role of intestinal CYP3A4 and P-gp inhibition by licochalcone A
- in-vivo, Nor, NA
*Dose↝, *CYP3A4↓, *P-gp/ABCB1↓,
3464- MF,    Progressive Study on the Non-thermal Effects of Magnetic Field Therapy in Oncology
- Review, Var, NA
AntiTum↑, TumCG↓, TumCCA↑, Apoptosis↑, TumAuto↑, Diff↑, angioG↓, TumMeta↓, EPR↑, ChemoSen↑, ROS↑, DNAdam↑, P53↑, Akt↓, MAPK↑, Casp9↑, VEGFR2/KDR/Flk1↓, P-gp/ABCB1↓,
5241- MF,    A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment
- Review, Var, NA
other↑, BloodF↑, Glycolysis↓, ATP↓, VEGF↓, ROS↑, P-gp/ABCB1↓, Apoptosis↑, selectivity↑, Ca+2↑, Catalase↑,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
1802- NarG,  ATV,    Bioenhancing effects of naringin on atorvastatin
- in-vivo, Nor, NA
BioEnh↑, LDL↓, P450↓, P-gp/ABCB1↓,
4949- PEITC,    Phenethyl Isothiocyanate Exposure Promotes Oxidative Stress and Suppresses Sp1 Transcription Factor in Cancer Stem Cells
- in-vitro, Cerv, HeLa
ROS↑, selectivity↑, CSCs↓, Sp1/3/4↓, P-gp/ABCB1↓, ALDH↓, GSH↓, TumCP↓, Apoptosis↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp/ABCB1↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3374- QC,    Therapeutic effects of quercetin in oral cancer therapy: a systematic review of preclinical evidence focused on oxidative damage, apoptosis and anti-metastasis
- Review, Oral, NA - Review, AD, NA
α-SMA↓, α-SMA↑, TumCP↓, tumCV↓, TumVol↓, TumCI↓, TumMeta↓, TumCMig↓, ROS↑, Apoptosis↑, BioAv↓, *neuroP↑, *antiOx↑, *Inflam↓, *Aβ↓, *cardioP↑, MMP↓, Cyt‑c↑, MMP2↓, MMP9↓, EMT↓, MMPs↓, Twist↓, Slug↓, Ca+2↑, AIF↑, Endon↑, P-gp/ABCB1↓, LDH↑, HK2↓, PKA↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, GRP78/BiP↑, Casp12↑, CHOP/DDIT3↑,
96- QC,  docx,    Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
PI3K/Akt↓, Ki-67↓, BAX↑, Bcl-2↓, EpCAM↓, Twist↓, E-cadherin↑, P-gp/ABCB1↓, TumCP↓, TumCMig↓, TumCI↓,
926- QC,  PacT,  doxoR,  Tam,    Bioenhancers from mother nature and their applicability in modern medicine
- Review, Nor, NA
*BioEnh↑, BioEnh↑, BioEnh↑, BioEnh↑, BioEnh↑, BioEnh↑, BioEnh↑, P-gp/ABCB1↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP/DDIT3↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp/ABCB1↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, eff↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
3037- RosA,    Unraveling rosmarinic acid anticancer mechanisms in oral cancer malignant transformation
- in-vitro, Oral, SCC9 - in-vitro, Oral, HSC3
survivin↓, AntiCan↑, Vim↓, Snail↓, SOX9↓, EMT↓, MMP2↓, MMP9↓, P-gp/ABCB1↓, TumCG↓, ROS↑, MMP↓, GSH↓, P-gp/ABCB1↓, ATP↓,
1744- RosA,    Therapeutic Applications of Rosmarinic Acid in Cancer-Chemotherapy-Associated Resistance and Toxicity
- Review, Var, NA
chemoR↓, ChemoSideEff↓, RadioS↑, ROS↓, ChemoSen↑, BioAv↑, Half-Life↝, antiOx↑, ROS↑, Fenton↑, DNAdam↑, Apoptosis↑, CSCs↓, HH↓, Bax:Bcl2↑, MDR1↓, P-gp/ABCB1↓, eff↑, eff↑, FOXO4↑, *eff↑, *ROS↓, *JNK↓, *ERK↓, *GSH↑, *H2O2↑, *MDA↓, *SOD↑, *HO-1↑, *CardioT↓, selectivity↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
106- RT,    Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells
- in-vivo, BC, MCF7
P-gp/ABCB1↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5003- Sal,    Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review
- Review, Var, NA
CSCs↓, TumAuto↑, selectivity↑, DNAdam↑, TumCCA↑, P-gp/ABCB1↓, Wnt↓, β-catenin/ZEB1↓, RadioS↑, ChemoSen↑, Shh↓, eff↓, ROS↑, AMPK↑, JNK↑, ER Stress↑,
2549- SDT,    Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation
- Review, Var, NA
sonoP↑, tumCV↓, MMP↓, ROS↑, Ca+2↑, eff↝, eff↑, selectivity↑, Half-Life↝, Dose↝, P-gp/ABCB1↓, ER Stress↑, other↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3327- SIL,    Effects of silymarin on HIF‑1α and MDR1 expression in HepG‑2 cells under hypoxia
- in-vitro, Liver, HepG2
MDR1↓, Hif1a↓, P-gp/ABCB1↓,
5328- TFdiG,    Study on mechanism of low bioavailability of black tea theaflavins by using Caco-2 cell monolayer
- in-vitro, NA, Caco-2
BioAv↓, P-gp/ABCB1↑, MRP1/ABCC1↑, ROS↑, *BioAv↓,
6460- TUR,  CUR,    Neuroprotective Effect of Turmeric Extract in Combination with Its Essential Oil and Enhanced Brain Bioavailability in an Animal Model
- in-vivo, AD, NA
*memory↑, *lipid-P↓, *GSH↑, *AChE↑, *Catalase↑, *BioAv↑, *P-gp/ABCB1↓, *BioAv↑, *SOD↑, *BBB↑, *ROS↓,
6457- TUR,    The Role of Turmerones on Curcumin Transportation and P-Glycoprotein Activities in Intestinal Caco-2 Cells
- in-vitro, Colon, Caco-2
P-gp/ABCB1↑, BioAv↑,
1822- VitK2,    Vitamin K: A novel cancer chemosensitizer
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumCCA↑, P-gp/ABCB1↓,

Showing Research Papers: 51 to 92 of 92
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 92

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCC2↓, 1,   DCR↑, 1,   MTA1↓, 1,   MYCN↓, 1,   PFS↑, 1,   TFE3↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   compI↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 1,   GSH↓, 6,   GSH↑, 1,   HO-1↓, 1,   HO-1↑, 3,   ICD↑, 2,   lipid-P↓, 1,   NRF2↑, 4,   Prx4↑, 1,   ROS↓, 4,   ROS↑, 20,   i-ROS↓, 1,   SIRT3↑, 1,   SOD↓, 1,   mt-SOD↑, 1,   SOD2↑, 1,   TAC↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 5,   ATP↑, 1,   mitResp↓, 2,   MMP↓, 13,   mtDam↑, 1,   OCR↓, 2,   OCR↑, 1,   e-Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   ATG7↑, 1,   cMyc↓, 4,   ECAR↓, 1,   GLO-I↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 3,   HK2↓, 2,   lactateProd↓, 2,   LDH↑, 1,   LDL↓, 1,   PI3K/Akt↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 10,   p‑Akt↓, 5,   Apoptosis↑, 11,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 8,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   BID↑, 1,   p‑BID↓, 1,   Casp↑, 2,   Casp10↑, 1,   Casp12↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 6,   cFLIP↓, 1,   Cyt‑c↑, 7,   DR5↑, 3,   Endon↑, 1,   Fas↑, 2,   Hippo↓, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 3,   MAPK↑, 2,   Mcl-1↓, 1,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 1,   p27/CDKN1B↑, 2,   p38↓, 2,   p38↑, 1,   survivin↓, 6,   TNFR 1↑, 1,   TRAILR↑, 1,   TumCD↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,   HER2/EBBR2↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   other↓, 1,   other↑, 2,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 2,   HSP27↓, 2,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↑, 2,   LC3II↑, 2,   SESN2↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   DFF45↑, 1,   DNAdam↑, 5,   DNMT1↓, 1,   P53↑, 7,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 5,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 4,   CDK4↓, 5,   p‑CDK4↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 5,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   mitA↓, 1,   P21?, 1,   P21↑, 4,   p‑RB1↓, 2,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 1,   CD24↓, 1,   CD44↓, 1,   cMET↓, 1,   CSCs↓, 10,   Diff↑, 1,   EMT↓, 6,   EpCAM↓, 1,   ERK↓, 2,   FOXM1↓, 1,   FOXO4↑, 1,   Gli1↓, 2,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 1,   HDAC2↓, 1,   HH↓, 5,   mTOR↓, 9,   p‑mTOR↓, 3,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 1,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 2,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 6,   PTEN↑, 1,   RAS↓, 4,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 2,   STAT1↓, 1,   STAT3↓, 5,   STAT3↝, 1,   STAT6↓, 1,   TCF↓, 1,   TCF↝, 1,   TOP2↓, 1,   TumCG↓, 3,   Wnt↓, 7,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 3,   Ca+2↝, 1,   Chl↓, 1,   Chl↑, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   ER-α36↓, 1,   Ki-67↓, 2,   KRAS↓, 1,   LEF1↓, 1,   LRP1↓, 1,   MMP2↓, 6,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 5,   PAK1↓, 2,   PAK1↑, 1,   PKA↓, 1,   PKCδ↓, 1,   RAGE↓, 1,   Rho↑, 1,   ROCK1↑, 1,   Slug↓, 2,   Snail↓, 2,   SOX4↓, 1,   SOX4↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 5,   TumCMig↓, 5,   TumCP↓, 9,   TumMeta↓, 6,   Twist↓, 4,   VCAM-1↓, 1,   Vim↓, 2,   Zeb1↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 7,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 10,   ATF4↝, 1,   EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 4,   LymphAG↓, 1,   VEGF↓, 8,   VEGFR2/KDR/Flk1↓, 2,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   OATPs↓, 1,   P-gp/ABCB1↓, 35,   P-gp/ABCB1↑, 3,   sonoP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 7,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IKKα↓, 2,   IL1β↓, 2,   IL6↓, 4,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 3,   NF-kB↓, 6,   p65↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 2,   TLR4↓, 1,   TNF-α↓, 4,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 4,   BioAv↑, 4,   BioEnh↑, 9,   chemoR↓, 1,   ChemoSen↑, 14,   Dose↝, 6,   eff↓, 4,   eff↑, 16,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 5,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   MRP1/ABCC1↑, 1,   P450↓, 3,   RadioS↑, 3,   selectivity?, 1,   selectivity↑, 9,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BloodF↑, 1,   BMPs↑, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   EGFR↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 4,   Ki-67↓, 2,   KRAS↓, 1,   LDH↑, 1,   PD-L1↓, 1,   PSA↓, 2,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   OS↑, 4,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 2,  
Total Targets: 321

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   AntiArt↑, 1,   antiD↓, 1,   AntiP↑, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 3,   CYP2E1↓, 1,   GSH↑, 6,   GSTs↑, 1,   H2O2↑, 1,   HO-1↑, 3,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 3,   Nrf1↑, 1,   NRF2↑, 4,   ROS↓, 11,   SIRT3↑, 1,   SOD↑, 7,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   BUN↓, 1,   CYP3A4↓, 2,   lipidLev↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 3,   Casp8↓, 1,   Casp9↓, 2,   Cyt‑c↓, 1,   iNOS↓, 1,   JNK↓, 2,   p‑JNK↓, 1,   MAPK↓, 1,   p38↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   GSK‐3β↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   COL1↓, 1,   PAI-1/SERPINE1↓, 1,   Rho↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,   P-gp/ABCB1↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 3,   IFN-γ↓, 1,   IL10↓, 2,   IL17↓, 1,   IL1β↓, 3,   IL4↓, 1,   IL6↓, 2,   Inflam↓, 5,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 4,   BioAv↝, 1,   BioEnh↑, 2,   Dose↝, 3,   eff↑, 2,   Half-Life↓, 1,   Half-Life↑, 1,   P450↑, 1,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   AST↓, 3,   BG↓, 1,   BP↓, 1,   GutMicro↑, 2,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 2,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 1,   hepatoP↑, 5,   memory↑, 2,   motorD↓, 1,   neuroP?, 1,   neuroP↑, 6,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 108

Scientific Paper Hit Count for: P-gp/ABCB1, permeability-glycoprotein
8 borneol
6 Biochanin A
6 Quercetin
5 Capsaicin
5 itraconazole
5 Ivermectin
4 Baicalein
4 Rosmarinic acid
3 Astragalus
3 Silymarin (Milk Thistle) silibinin
3 Kaempferol
3 Gambogic Acid
3 Honokiol
2 Curcumin
2 CUSP9
2 Disulfiram
2 Emodin
2 doxorubicin
2 Licochalcone A
2 Magnetic Fields
2 Naringin
2 Rutin
2 Turmerones
1 Omeprazole
1 Artemisinin
1 Berbamine
1 Genistein (soy isoflavone)
1 Beta-Caryophyllene
1 Bacopa monnieri
1 Boswellia (frankincense)
1 Piperine
1 Chemotherapy
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celecoxib
1 Cisplatin
1 Centella asiatica / Gotu kola → asiaticoside
1 Cucurbitacin
1 immunotherapy
1 Copper and Cu NanoParticles
1 Zinc
1 EGCG (Epigallocatechin Gallate)
1 Fenbendazole
1 Fisetin
1 Formononetin
1 Hyperoside
1 Atorvastatin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Docetaxel
1 Paclitaxel/Taxol
1 tamoxifen
1 buckwheat sprouts
1 salinomycin
1 SonoDynamic Therapy UltraSound
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:232  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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