TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
Type:
Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
6399- ANE,    Anethole attenuates lung cancer progression by regulating the proliferation and apoptosis through AKT and STAT3 signaling
- vitro+vivo, NSCLC, A549
TumCP↓, TumCG↓, Apoptosis↑, DNAdam↑, Casp3↑, PI3K↓, Akt↓, STAT3↓, Ki-67↓, cl‑Casp3↑,
6405- ANE,    Anethole inhibits human U87 Glioma cell proliferation by inducing apoptosis via the PI3K/AKT pathway
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
BAX↑, Bcl-2↓, PI3K↓, Akt↓, TumCP↓, Apoptosis↑,
6406- ANE,    Anethole induces anti-oral cancer activity by triggering apoptosis, autophagy and oxidative stress and by modulation of multiple signaling pathways
- in-vitro, Oral, Ca9-22
TumCP↓, Apoptosis↑, TumAuto↑, ROS↓, GSH↑, cycD1/CCND1↓, P21↑, P53↑, EMT↓, Casp3↑, PARP1↑, TumMeta↓, MMPs↓, TIMP1↑,
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
177- Api,    Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
- in-vitro, BC, MDA-MB-231
Cyc↓, CycB/CCNB1↓, CDK1↓, P21↑, PCNA↝, HDAC↓, TumCP↓, TumCCA↑, ac‑H3↑, TumW↓, TumVol↓,
175- Api,    Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, DLD1 - vitro+vivo, CRC, LS174T
MMP↓, p‑Akt↓, TumCP↓, TumCI↓, NADH↓, HSP90↓, other↑, talin?,
172- Api,    Apigenin suppresses colorectal cancer cell proliferation, migration and invasion via inhibition of the Wnt/β-catenin signaling pathway
- in-vitro, CRC, SW480 - in-vitro, CRC, HTC15
Wnt/(β-catenin)↓, TCF↓, LEF1↓, TumCP↓, TumCMig↓, TumCI↓,
2632- Api,    Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress
- in-vitro, EC, NA
TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP/DDIT3↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,
2633- Api,    Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells
- in-vitro, EC, NA
TumCP↓, TumCCA↑, MMP↓, Ca+2↑, BAX↑, Cyt‑c↑, ROS↑, lipid-P↑, ER Stress↑, UPR↑, p‑ERK↓, ERK↓, JNK↑,
2593- Api,    Apigenin promotes apoptosis of 4T1 cells through PI3K/AKT/Nrf2 pathway and improves tumor immune microenvironment in vivo
- in-vivo, BC, 4T1
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, MMP↑, ROS↑, p‑PI3K↓, PI3K↓, Akt↓, NRF2↓, AntiTum↑, OS↑,
2299- Api,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
TumCP↓, angioG↓, Hif1a↓, VEGF↓, GLUT1↓, PKM2↓, Glycolysis↓,
2316- Api,    The interaction between apigenin and PKM2 restrains progression of colorectal cancer
- in-vitro, CRC, LS174T - in-vitro, CRC, HCT8 - in-vivo, CRC, NA
TumCP↓, PKM2↓, Glycolysis↓, TumCG↑, selectivity↑,
1552- Api,    Apigenin inhibits the growth of colorectal cancer through down-regulation of E2F1/3 by miRNA-215-5p
- in-vitro, CRC, HCT116
Apoptosis↑, TumCP↓, miR-215-5p↑, TumCCA↑, E2Fs↓,
1565- Api,    Apigenin-7-glucoside induces apoptosis and ROS accumulation in lung cancer cells, and inhibits PI3K/Akt/mTOR pathway
- in-vitro, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1975
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, Cyt‑c↑, MDA↑, GSH↓, ROS↑, PI3K↓, Akt↓, mTOR↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1537- Api,    Apigenin as Tumor Suppressor in Cancers: Biotherapeutic Activity, Nanodelivery, and Mechanisms With Emphasis on Pancreatic Cancer
- Review, PC, NA
TumCP↓, TumCCA↑, Apoptosis↑, MMPs↓, Akt↓, *BioAv↑, *BioAv↓, Half-Life∅, Hif1a↓, GLUT1↓, VEGF↓, ChemoSen↑, ROS↑, Bcl-2↓, Bcl-xL↓, BAX↑, BIM↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
5380- ART/DHA,    Artemisinin and Its Derivatives as Potential Anticancer Agents
- Review, Var, NA
TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,
574- ART/DHA,    Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway
TumCP↓, TumCMig↓, TumCI↓, MMP17↓, p‑EGFR↓, p‑Akt↓,
569- ART/DHA,    Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3
- in-vitro, GBM, NA
TumCP↓, Apoptosis↑, TumCCA↑, Casp3↑, p‑Akt↓,
1079- ART/DHA,    Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2
- in-vitro, GC, BGC-823 - in-vitro, GC, HGC27 - in-vitro, GC, MGC803
TumCP↓, Apoptosis↑, COX2/PTGS2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,
957- ART/DHA,    Artemisinin inhibits the development of esophageal cancer by targeting HIF-1α to reduce glycolysis levels
- in-vitro, ESCC, KYSE150 - in-vitro, ESCC, KYSE170
TumCP↓, TumMeta↓, Glycolysis↓, N-cadherin↓, PKM2↓, Hif1a↓,
5137- ART/DHA,    Autophagy-dependent cell cycle arrest in esophageal cancer cells exposed to dihydroartemisinin
- vitro+vivo, ESCC, Eca109
tumCV↓, TumCCA↑, ROS↑, TumAuto↑, eff↓, TRF2↓, TumCP↓,
5136- ART/DHA,    Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis
- in-vitro, Var, NA
angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
5131- ART/DHA,    Dihydroartemisinin (DHA) induces caspase-3-dependent apoptosis in human lung adenocarcinoma ASTC-a-1 cells
- in-vitro, NSCLC, ASTC-a-1
Apoptosis↑, MMP↓, Casp3↑, TumCP↓,
2322- ART/DHA,    Dihydroartemisinin Regulates Self-Renewal of Human Melanoma-Initiating Cells by Targeting PKM2/LDHARelated Glycolysis
- in-vitro, Melanoma, NA
TumCP↓, PKM2↓, LDHA↓, Glycolysis↓,
5414- ASA,    Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
- Review, Var, NA
Risk↓, *toxicity↓, other↑, *COX1↓, TumCP↓, DNArepair↑, ChemoSen↑, other↓,
1304- ASA,    Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells
- in-vitro, CRC, NA - in-vivo, NA, NA
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, IL10↓, LTA/TNF-β↓,
1028- ASA,    Aspirin Suppressed PD-L1 Expression through Suppressing KAT5 and Subsequently Inhibited PD-1 and PD-L1 Signaling to Attenuate OC Development
- vitro+vivo, Ovarian, NA
TumCP↓, TumW↓, PD-L1↓, Ki-67↓, H3K27ac∅, eff↑,
5395- Ash,    Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCP↓, HSP90↓, Akt↓, CDK4↓, TumCG↓, Apoptosis↑, AntiCan↑,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1/CCL2↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
3172- Ash,    Implications of Withaferin A for the metastatic potential and drug resistance in hepatocellular carcinoma cells via Nrf2-mediated EMT and ferroptosis
- in-vitro, HCC, HepG2 - in-vitro, Nor, HL7702
Keap1↑, NRF2↓, EMT↓, TumCP↓, TumCI↓, selectivity↑, *toxicity↓, ROS↑, MDA↑, GSH↓, Ferroptosis↑,
3167- Ash,    Withaferin A Inhibits the Proteasome Activity in Mesothelioma In Vitro and In Vivo
- in-vitro, MM, H226
TumCP↓, cMyc↓, cFos↓, cJun↓, TIMP2↑, Vim↓, ROS↑, BAX↑, IKKα↑, Casp3↑, cl‑PARP↑,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
1358- Ash,    Withaferin A: A Dietary Supplement with Promising Potential as an Anti-Tumor Therapeutic for Cancer Treatment - Pharmacology and Mechanisms
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, CSCs↓, TumMeta↓, EMT↓, angioG↓, Vim↓, HSP90↓, annexin II↓, m-FAM72A↓, BCR-ABL↓, Mortalin↓, NRF2↓, cMYB↓, ROS↑, ChemoSen↑, eff↑, ChemoSen↑, ChemoSen↑, eff↑, *BioAv↓, ROCK1↓, TumCI↓, Sp1/3/4↓, VEGF↓, Hif1a↓, EGFR↓,
1179- Ash,    Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCP↓, TumCMig↓, STAT3↓, TumVol↓, TumW↓,
1173- Ash,    Withaferin A inhibits proliferation of human endometrial cancer cells via transforming growth factor-β (TGF-β) signalling
- in-vitro, EC, K1 - in-vitro, Nor, THESCs
TumCP↓, *toxicity↓, Apoptosis↑, TumCCA↑, TumCMig↓, TumCI↓, p‑SMAD2↓, TGF-β↓, *toxicity↓,
2002- Ash,    Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology
- Review, Var, NA
antiOx↑, Inflam↓, TumCP↓, OS↑, RadioS↑, radioP↑, chemoP↑,
5172- Ash,    Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells
Akt↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Snail↓, Slug↓, β-catenin/ZEB1↓, Vim↓, angioG↓,
5174- Ash,    Withaferin A is a potent inhibitor of angiogenesis
- in-vitro, Nor, HUVECs
Inflam↓, *TumCP↓, cycD1/CCND1↓, NF-kB↓, angioG↓,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
5387- AsP,  PacT,    Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy
- in-vivo, Melanoma, B16-F10
Dose↝, TumCG↓, TumCP↓, BioAv↓, BioAv↑, other↑, Apoptosis↑, Bax:Bcl2↑, EPR↑, toxicity↝,
4821- ASTX,    Astaxanthin Reduces Stemness Markers in BT20 and T47D Breast Cancer Stem Cells by Inhibiting Expression of Pontin and Mutant p53
- in-vitro, BC, SkBr3 - in-vitro, BC, BT20 - in-vitro, BC, T47D
Apoptosis↑, CSCs↓, OCT4↓, Nanog↓, TumCP↓,
4820- ASTX,    Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
- in-vitro, NPC, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, Bcl-2↓, P21↑, BAX↑, PI3K↓, Akt↓, NF-kB↓, miR-29b↑,
4817- ASTX,    Low Dose Astaxanthin Treatments Trigger the Hormesis of Human Astroglioma Cells by Up-Regulating the Cyclin-Dependent Kinase and Down-Regulated the Tumor Suppressor Protein P53
- in-vitro, GBM, U251
Dose⇅, ROS∅, SOD↑, CDK1↑, P53↓, TumCP⇅, ROS↑,
4804- ASTX,    Astaxanthin in cancer therapy and prevention (Review)
- Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, ChemoSen⇅, chemoP↑, BioAv↑, TumCP↑, ROS⇅, Apoptosis↑, PI3K↑, Akt↑, GSK‐3β↑, NRF2↑, AntiCan↑, *neuroP↑, eff↑, AntiTum↑,
4810- ASTX,    Effects of Astaxanthin on the Proliferation and Migration of Breast Cancer Cells In Vitro
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, selectivity↑, *BDNF↑, *ROS↓, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓, BAX⇅, Bcl-2↓, *antiOx↑, radioP↑, ChemoSen↑,
4809- ASTX,    Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression
- in-vitro, GC, AGS - in-vitro, GC, MKN45
tumCV↓, TumCP↓, TumCCA↑, p‑ERK↓, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓,

Showing Research Papers: 51 to 100 of 1103
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1103

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CCN1/CYR61↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Ferroptosis↑, 4,   GSH↓, 2,   GSH↑, 1,   HO-1↑, 1,   Keap1↑, 1,   lipid-P↑, 2,   MDA↑, 2,   NADH↓, 1,   NRF2↓, 3,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 15,   ROS⇅, 1,   ROS∅, 1,   SIRT3↓, 1,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   BCR-ABL↓, 1,   CDC25↓, 1,   MMP↓, 6,   MMP↑, 1,   Mortalin↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 3,   GlucoseCon↓, 1,   Glycolysis↓, 5,   lactateProd↓, 1,   LDHA↓, 1,   PKM2↓, 5,   PPARγ↑, 1,   p‑S6↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 13,   Akt↑, 1,   p‑Akt↓, 4,   Apoptosis↑, 24,   Bak↑, 1,   BAX↑, 11,   BAX⇅, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 10,   Bcl-xL↓, 3,   BIM↑, 1,   Casp↓, 1,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 7,   cl‑Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 3,   Cyt‑c↑, 4,   DR5↑, 1,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 4,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 1,   Mcl-1↓, 1,   MDM2↓, 1,   p27/CDKN1B↑, 2,   p38↑, 1,   survivin↓, 2,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   p70S6↓, 1,   Sp1/3/4↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   ac‑H3↑, 1,   other↓, 1,   other↑, 3,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↓, 1,   ER Stress↑, 3,   GRP78/BiP↑, 2,   HSF1↓, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   DNArepair↑, 1,   DNMT1↓, 1,   m-FAM72A↓, 1,   P53↓, 1,   P53↑, 4,   cl‑PARP↑, 2,   PARP1↑, 1,   PCNA↓, 2,   PCNA↝, 1,   SIRT6↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 2,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 4,   CDK4↑, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 2,   E2Fs↓, 2,   P21↑, 5,   TumCCA↑, 18,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 2,   CD44↓, 1,   cFos↓, 1,   cMYB↓, 1,   CSCs↓, 3,   CSCs↑, 1,   Diff↑, 1,   EMT↓, 5,   ERK↓, 3,   p‑ERK↓, 3,   GSK‐3β↑, 1,   H3K27ac∅, 1,   HDAC↓, 1,   HH↓, 1,   miR-34a↑, 1,   mTOR↓, 4,   mTOR↑, 1,   Nanog↓, 3,   OCT4↓, 2,   p‑P70S6K↓, 1,   p85S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 8,   PI3K↑, 1,   p‑PI3K↓, 1,   SOX2↓, 1,   STAT3↓, 5,   p‑STAT3↓, 1,   TCF↓, 1,   TOP2↓, 1,   TRF2↓, 1,   TumCG↓, 5,   TumCG↑, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

annexin II↓, 1,   AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 3,   CAFs/TAFs↓, 1,   CCN2/CTGF↓, 1,   Cdc42↑, 1,   E-cadherin↑, 1,   Ki-67↓, 4,   LEF1↓, 1,   miR-215-5p↑, 1,   miR-29b↑, 1,   MMP17↓, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 6,   MMPs↓, 2,   N-cadherin↓, 2,   PDGF↓, 1,   PKCδ↓, 1,   ROCK1↓, 1,   Slug↓, 2,   p‑SMAD2↓, 1,   Snail?, 1,   Snail↓, 1,   talin?, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 15,   TumCMig↓, 14,   TumCP↓, 46,   TumCP↑, 2,   TumCP⇅, 1,   TumMeta↓, 7,   Twist↓, 1,   uPA↓, 3,   Vim↓, 4,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 11,   ATF4↑, 1,   EGFR↓, 1,   p‑EGFR↓, 1,   EPR↑, 1,   Hif1a↓, 6,   VEGF↓, 8,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IKKα↓, 1,   IKKα↑, 1,   IL10↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 4,   LTA/TNF-β↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 6,   PD-L1↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   ChemoSen↑, 9,   ChemoSen⇅, 1,   Dose⇅, 1,   Dose↝, 1,   eff↓, 3,   eff↑, 15,   Half-Life↓, 1,   Half-Life∅, 1,   RadioS↑, 2,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   p‑EGFR↓, 1,   Ferritin↓, 1,   IL6↓, 3,   Ki-67↓, 4,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 2,   OS↑, 2,   radioP↑, 2,   Risk↓, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 3,  
Total Targets: 245

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   GSH↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   IFN-γ↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 2,   neuroP↑, 1,   RenoP↑, 1,   toxicity↓, 4,  
Total Targets: 23

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
44 Curcumin
25 Quercetin
24 Thymoquinone
23 Shikonin
19 Magnetic Fields
19 EGCG (Epigallocatechin Gallate)
18 Berberine
18 Resveratrol
18 Sulforaphane (mainly Broccoli)
17 Kaempferol
17 Licochalcone A
16 Baicalein
14 Silver-NanoParticles
14 Apigenin (mainly Parsley)
14 Capsaicin
14 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
14 Phenethyl isothiocyanate
13 Formononetin
13 Honokiol
12 Artemisinin
12 Fisetin
12 Garcinol
12 Propolis -bee glue
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Radiotherapy/Radiation
11 Boron
11 Crocetin
11 Emodin
11 Juglone
11 Lycopene
11 Nimbolide
10 Cisplatin
10 Chrysin
10 Metformin
10 Magnolol
10 itraconazole
10 Luteolin
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Gallic acid
9 Hyperoside
9 Ivermectin
8 Citric Acid
8 chitosan
8 Beta-Caryophyllene
8 chaetocin
8 Dandelion Root
8 HydroxyTyrosol
8 Isobavachalcone
7 Astragalus
7 Anethole/trans-Anethole
7 5-fluorouracil
7 Bufalin/Huachansu
7 Centella asiatica / Gotu kola → asiaticoside
7 Eugenol
7 Ferulic acid
7 Gambogic Acid
7 Ginkgetin
7 Isoliquiritigenin
7 isoorientin
7 Piperlongumine
6 Boswellia (frankincense)
6 Chemotherapy
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Carvone
6 Cucurbitacin
6 Diclofenac
6 Ellagic acid
6 Evodiamine
6 isoquercitrin
6 Lemongrass Extract/Citral
6 Phenylbutyrate
6 salinomycin
5 DTS(dibenzyl trisulphide) from Anamu
5 Gemcitabine (Gemzar)
5 Betulinic acid
5 Carvacrol
5 Cinnamon
5 Copper and Cu NanoParticles
5 Deguelin
5 D-limonene
5 Fucoidan
5 Galloflavin
5 Geraniol
5 Hydrogen Gas
5 Helleborus niger extracts – Christmas Rose
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Melatonin
4 Paclitaxel/Taxol
4 Atorvastatin
4 brusatol
4 Celecoxib
4 Chlorogenic acid
4 Chlorophyllin
4 Photodynamic Therapy
4 Date Fruit Extract
4 Disulfiram
4 Genistein (soy isoflavone)
4 Fenbendazole
4 Ginger/6-Shogaol/Gingerol
4 Indole-3-carbinol
4 iodine
4 Inositol
4 Magnetic Field Rotating
4 Piperine
4 Ursolic acid
3 1,8-Cineole
3 Alpha-Lipoic-Acid
3 Andrographis
3 Isovitexin
3 Aspirin
3 immunotherapy
3 Docetaxel
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Cynaropicrin
3 Dichloroacetate
3 diet Methionine-Restricted Diet
3 Ginkgo biloba-EGb 761
3 Ginkgo biloba
3 Ginkgolide B
3 Vitamin C (Ascorbic Acid)
3 Licorice
3 Lactoferrin/Talactoferrin
3 Linalool
3 Methylene blue
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Selenium
3 Terpinen-4-ol / Tea Tree Oil
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Zerumbone
2 Sorafenib (brand name Nexavar)
2 Auranofin
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Ascorbyl Palmitate
2 Arctigenin
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 Bacopa monnieri
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Hydroxycinnamic-acid
2 Coenzyme Q10
2 Carica papaya leaf extract
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Dichloroacetophenone(2,2-)
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Echinacea
2 Eurycomanone
2 Arsenic trioxide
2 Ginkgolic acids
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Grapeseed extract
2 hydrogen sulfide
2 doxorubicin
2 Laetrile B17 Amygdalin
2 lambertianic acid
2 Lapachol
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 EMF
2 Rutin
2 α-Santalol/Sandalwood oil
2 Sulfasalazine
2 Salvia miltiorrhiza
2 Vitamin D3
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Fennel Oil/Foeniculum vulgare
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 Bullatacin
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Camptothecin
1 irinotecan
1 CUSP9
1 Dasatinib/Phyrago
1 Dihydrocaffeic Acid
1 Electrical Pulses
1 Exercise
1 Vitamin E
1 ferumoxytol
1 Vitamin A, Retinoic Acid
1 Shilajit/Fulvic Acid
1 Ginseng
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 HydroxyCitric Acid
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 Hibiscus sabdariffa
1 Hops (Humulus lupulus)
1 Hyperthermia
1 Inoscavin A
1 Recombinant Methioninase
1 Lactobacillus
1 Caffeine
1 Mushroom Chaga
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 xanthohumol
1 Gold NanoParticles
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Oxaliplatin
1 Selenium NanoParticles
1 diet Plant based
1 Spermidine
1 tetrathiomolybdate
1 Tumor Treating Fields
1 Turmerones
1 Usnic acid
1 Vitexin
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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