lipid-P Cancer Research Results

lipid-P, lipid peroxidation: Click to Expand ⟱
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Type:
Lipid peroxidation is a chain reaction process in which free radicals (often reactive oxygen species, or ROS) attack lipids containing carbon-carbon double bonds, especially polyunsaturated fatty acids. This attack results in the formation of lipid radicals, peroxides, and subsequent breakdown products.
Lipid peroxidation can cause damage to cell membranes, leading to increased permeability and disruption of cellular functions. This damage can initiate a cascade of events that may contribute to carcinogenesis.
The byproducts of lipid peroxidation, such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), can form adducts with DNA, leading to mutations. These mutations can disrupt normal cellular processes and contribute to the development of cancer.
Lipid peroxidation damages cell membranes, disrupts cellular functions, and can trigger inflammatory responses. It is a marker of oxidative stress and is implicated in many chronic diseases.

Negative Prognostic Indicator: In many cancers, high levels of lipid phosphates, particularly S1P, are associated with poor prognosis, indicating a more aggressive tumor phenotype and potential resistance to therapy.
Mixed Evidence: The prognostic significance of lipid phosphates can vary by cancer type, with some studies showing that their expression may not always correlate with adverse outcomes.
Scientific Papers found: Click to Expand⟱
3677- BBR,    Berberine: A Potential Multipotent Natural Product to Combat Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *AChE↓, *BChE↓, *MAOA↓, *Aβ↓, *LDL↓, *ROS↓, *RNS↓, *lipid-P↓, *Dose↝, *MAOB↓, *memory↑, *toxicity↓, *BBB↑,
3679- BBR,    Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway
- in-vivo, AD, NA
*Beclin-1/ATG6↑, *LC3B↑, *p62↓, *ROS↓, *lipid-P↓, *MDA↓, *Ferroptosis↓, *TfR1/CD71↓, *FTH1↑, *memory↑, *JNK↓, *p38↓, *Aβ↓, *Inflam↓,
3682- BBR,    Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and β-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer’s Disease
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *Apoptosis↓, *CD31/PECAM-1↑, *VEGF↑, *N-cadherin↑, *angioG↑, *neuroP↑, *p‑tau↓, *antiOx↑, *AChE↓, *MAOB↓, *lipid-P↓,
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5638- BCA,    Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway
- in-vitro, Oral, NA
tumCV↓, ROS↑, MMP↓, TumCMig↓, TAC↓, lipid-P↓, NF-kB↓, Apoptosis↑,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, eff↑,
5561- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer’s Disease
- Review, AD, NA
*ROS↓, *cognitive↑, *BBB↑, *lipid-P↓, *eff↑,
5563- betaCar,    Carotenoid Supplementation for Alleviating the Symptoms of Alzheimer's Disease
- Review, AD, NA
*BBB↑, *lipid-P↓, *eff↑, *cognitive↑,
5481- BM,    Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies
- in-vitro, HCC, HepG2
tumCV↓, Apoptosis↑, TumCP↓, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, lipid-P↓,
5473- BM,    Bacopa monnieri: Preclinical and Clinical Evidence of Neuroactive Effects, Safety of Use and the Search for Improved Bioavailability
- in-vivo, AD, NA - in-vivo, Park, NA
*neuroP↑, *toxicity∅, *AChE↓, *ROS↓, *antiOx↑, *lipid-P↓, *cognitive↑, *memory↑, *Dose↝, *BioAv↓, *TumCCA↑, *BBB↝,
3698- BM,    Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain
- in-vivo, AD, NA
*lipid-P↓, *ROS↓, *neuroP↑,
3690- BM,    Neurocognitive Effect of Nootropic Drug Brahmi (Bacopa monnieri) in Alzheimer's Disease
- Review, AD, NA
*ROS↓, *5LO↓, *lipid-P↓, *GPx↑, *IronCh↑, *neuroP↑, *AChE↓, *memory↑, *toxicity↓, *SOD↑, *Catalase↑, *cognitive↑, *ChAT↑, *Ach↑, *BP↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
3510- Bor,    Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *antiOx↑, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *lipid-P↓, *GPx↓, *Catalase↑, *SOD↑, *ALAT↓, *AST↓, *ALP↓,
760- Bor,    Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer’s Disease
- in-vivo, AD, NA
*memory↑, *ROS↓, *GSH↑, *Aβ↓, *Inflam↓, *MMP↑, *lipid-P↓, *Ca+2↓, *cognitive↑, *TOS↓,
4272- Bor,    Neuroprotective properties of borax against aluminum hydroxide-induced neurotoxicity: Possible role of Nrf-2/BDNF/AChE pathways in fish brain
*NRF2↑, *ROS↓, *antiOx↑, *lipid-P↑, *Inflam↓, *DNAdam↓, *BDNF↑, *neuroP↑, *GSH↑,
4270- Bos,    Boswellic acids ameliorate neurodegeneration induced by AlCl3: the implication of Wnt/β-catenin pathway
- in-vivo, AD, NA
*memory↑, *AChE↓, *Aβ↓, *TNF-α↓, *IL1β↓, *lipid-P↓, *TAC↑, *BDNF↑, *β-catenin/ZEB1↑, *Dose↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1425- Bos,    Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway
- in-vivo, Nor, NA
*ChemoSen↑, *NRF2↑, *HO-1↑, *ROS↓, *lipid-P↓, *DNAdam↓,
1447- Bos,    Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, BC, 4T1 - in-vitro, Nor, MCF10
tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,
5713- Brut,    Standardized bergamot polyphenolic fraction – a comprehensive dietary supplement with pleiotropic properties compared to other selected natural lipid-lowering substances available on the market
- Review, Nor, NA
*eff↑, *lipid-P↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
6554- BSB,  doxoR,    α-Bisabolol: A Dietary Sesquiterpene that Attenuates Apoptotic and Nonapoptotic Cell Death Pathways by Regulating the Mitochondrial Biogenesis and Endoplasmic Reticulum Stress–Hippo Signaling Axis in Doxorubicin-Induced Acute Cardiotoxicity in Rats
- in-vivo, Nor, NA
*cardioP↑, *chemoP↑, *antiOx↑, *ROS↓, *toxicity↓, *DNAdam↓, *lipid-P↓, *ER Stress↓,
6560- BSB,  doxoR,    Α-Bisabolol, a Component of German Chamomile Tea Attenuates NLRP3 Inflammasome Mediated Pyroptosis, NF-ΚB/MAPK Signaling Activation and Apoptosis by Invoking NRF2 Mediated Antioxidant Defense Systems in Doxorubicin-Induced Liver Injury in Rats
- in-vivo, Nor, NA
*lipid-P↓, *antiOx↑, *Apoptosis↓, *Inflam↓,
7955- BuckWS,    Buckwheat (Fagopyrum esculentum M.) Sprout Treated with Methyl Jasmonate (MeJA) Improved Anti-Adipogenic Activity Associated with the Oxidative Stress System in 3T3-L1 Adipocytes
- in-vitro, Nor, 3T3
*eff↑, *ROS↓, *lipid-P↓,
7957- BuckWS,    Improving the antioxidant activity of buckwheat (Fagopyrum tataricm Gaertn) sprout with trace element water
- Study, Nor, NA
*Dose↑, *eff↑, *eff↝, *ROS↓, *IronCh↑, *SOD↑, *lipid-P↓,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
7516- CA,    Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against Aβ-Induced Neurodegeneration and Memory Impairment
- in-vivo, AD, NA
*neuroP↑, *antiOx↑, *memory↑, *Learn↑, *cognitive↑, *ROS↓, *lipid-P↓, *NRF2↑, *HO-1↑, *Aβ↓, *BACE/β-secretase↓,
7515- CA,    Protective role of caffeic acid in an Aβ25-35-induced Alzheimer's disease model
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *memory↑, *lipid-P↓, eff↑,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5758- CAPE,  PBG,    Caffeic acid phenethyl ester and therapeutic potentials
- Review, Var, NA
*antiOx↑, *Inflam↓, ChemoSen↑, chemoP↑, COX1↓, COX2/PTGS2↓, selectivity↑, NF-kB↓, RadioS↑, *ROS↓, *lipid-P↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5909- CAR,    Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats
*AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *GSR↑, *hepatoP↑, *lipid-P↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5925- CAR,    Neuroprotective effects of carvacrol against Alzheimer’s disease and other neurodegenerative diseases: A review
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2/PTGS2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
3873- Carno,    Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
- in-vivo, AD, NA
*ROS↓, *IronCh↑, *Aβ↓, *AntiAge↑, *lipid-P↓, *cognitive↑, *memory∅,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2/KDR/Flk1↓, NF-kB↓,
6662- Cen,    Assessment report on Centella asiatica (L.) Urban, herba
- Review, Nor, NA
*cognitive↑, *Inflam↓, *AntiBio↑, *Imm↑, *antiOx↑, *Wound Healing↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *MDA↓, *lipid-P↓, *ROS↓, *memory↑, *GABA↑, *antiPs↑, *BioAv↝,
6660- Cen,    Hepatoprotective effect of Centella asiatica 50% ethanol extract against acetaminophen-induced acute liver injury in BALB/c mice
*hepatoP↑, *NO↓, *lipid-P↓, *IL1β↓, *ALAT↓, *AST↓, *LDH↓, GSH↑, MDA↓,

Showing Research Papers: 51 to 100 of 372
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 372

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↑, 1,   Catalase↓, 1,   Ferroptosis↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 3,   GSH↑, 2,   HO-1↓, 1,   HO-1↑, 1,   i-Iron↑, 1,   lipid-P?, 1,   lipid-P↓, 4,   lipid-P↑, 3,   MDA↓, 3,   MDA↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 11,   SOD↑, 1,   TAC↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 5,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   AMPK↑, 1,   Glycolysis↓, 1,   PPARα↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 8,   Bak↓, 1,   BAX↑, 5,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp↑, 1,   Casp1↑, 1,   Casp3↓, 1,   Casp3↑, 6,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 4,   DR4↑, 1,   DR5↑, 1,   FADD↑, 2,   Fas↑, 2,   Ferroptosis↑, 1,   iNOS↓, 1,   JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 2,   Mcl-1↓, 1,   p38↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   tumCV↓, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3I↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 3,   Cyc↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 2,   P21↓, 1,   P21↑, 3,   p‑RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   ERK↓, 2,   p‑ERK↓, 1,   FGF↓, 1,   GSK‐3β↓, 1,   Let-7↑, 1,   mTOR↓, 2,   PI3K↓, 2,   STAT3↓, 1,   TOP1↓, 2,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AXL↓, 1,   CEA↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   F-actin↓, 1,   Ki-67↓, 2,   miR-200b↑, 1,   MMP1↓, 1,   MMP2↓, 5,   MMP9↓, 5,   MMPs↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   TIMP2↑, 2,   TIMP3↑, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 6,   TumMeta↓, 4,   ZEB2↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   EGFR↓, 1,   EGFR↑, 1,   Hif1a↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   CXCR4↓, 1,   IFN-γ↓, 1,   IKKα↓, 1,   IL1α↓, 1,   IL2↓, 1,   IL4↓, 1,   Imm↑, 1,   Inflam↓, 1,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 6,   NF-kB↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 8,   Dose↑, 1,   Dose↝, 2,   eff↑, 11,   Half-Life↓, 1,   RadioS↑, 5,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2,   AR↓, 1,   ascitic↓, 1,   AST↓, 1,   CEA↓, 1,   creat↓, 1,   EGFR↓, 1,   EGFR↑, 1,   HER2/EBBR2↓, 1,   Ki-67↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   AntiTum↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   hepatoP↑, 2,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 1,   Weight↑, 1,  
Total Targets: 172

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 3,   Learn↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 21,   Catalase↑, 13,   Ferroptosis↓, 2,   GPx↓, 1,   GPx↑, 8,   GPx4↑, 1,   GSH↑, 12,   GSR↑, 5,   GSTs↑, 1,   HNE↓, 1,   HO-1↑, 6,   Keap1↑, 1,   lipid-P↓, 40,   lipid-P↑, 2,   MDA↓, 9,   NOX4↓, 1,   NQO1↑, 1,   NRF2↑, 10,   RNS↓, 1,   ROS↓, 28,   ROS↑, 1,   SOD↑, 17,   TAC↑, 2,   TBARS↓, 1,   TOS↓, 2,   UCPs↑, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↑, 1,   IronCh↑, 4,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↑, 2,   mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 6,   AMPK↑, 1,   LDH↓, 4,   LDL↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 5,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 2,   iNOS↓, 4,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 2,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3B↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   GSK‐3β↑, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↓, 1,   TRPM7↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 1,   APP↓, 1,   Ca+2↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   CD31/PECAM-1↑, 1,   COL1↑, 1,   MMP13↓, 1,   N-cadherin↑, 1,   Na+↑, 1,   PKCδ↑, 1,   TGF-β↑, 1,   α-SMA↑, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 2,   NO↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 5,   BBB↝, 1,   GastroP↑, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 6,   IL1β↓, 7,   IL6↓, 5,   IL6↑, 1,   Imm↑, 2,   Inflam↓, 22,   Inflam↑, 2,   JAK2↓, 1,   NF-kB↓, 7,   PGE2↓, 1,   TLR4↓, 2,   TNF-α↓, 9,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 12,   BChE↓, 4,   BDNF↓, 1,   BDNF↑, 3,   ChAT↑, 1,   GABA↑, 1,   GABA↝, 1,   MAOA↓, 2,   tau↓, 1,   p‑tau↓, 4,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 9,   BACE/β-secretase↓, 4,   MAOB↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 1,   Dose↑, 2,   Dose↝, 4,   eff↑, 7,   eff↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 5,   AST↓, 6,   BMD↑, 1,   BP↓, 1,   creat↓, 1,   GutMicro↑, 1,   IL6↓, 5,   IL6↑, 1,   LDH↓, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   AntiCan↑, 1,   AntiDiabetic↑, 2,   antiPs↑, 1,   cardioP↑, 8,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 13,   hepatoP↑, 5,   memory↑, 16,   memory∅, 1,   motorD↑, 1,   neuroP↑, 15,   NP/CIPN↓, 1,   Obesity↓, 2,   OS↑, 1,   Pain↓, 3,   RenoP↑, 3,   toxicity↓, 8,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 4,   CD8+↑, 1,   Diar↓, 1,   Sepsis↓, 1,  
Total Targets: 169

Scientific Paper Hit Count for: lipid-P, lipid peroxidation
17 Curcumin
14 Thymoquinone
13 Quercetin
12 Silymarin (Milk Thistle) silibinin
11 Resveratrol
10 Silver-NanoParticles
10 Alpha-Lipoic-Acid
9 Eugenol
7 Artemisinin
7 Chrysin
7 Ferulic acid
7 Rosmarinic acid
7 Urolithin
6 Ashwagandha(Withaferin A)
6 Berberine
6 Carvacrol
6 Crocetin
6 Copper and Cu NanoParticles
6 Lycopene
6 Shikonin
5 Luteolin
5 Cinnamon
5 Piperlongumine
5 Selenium NanoParticles
5 Selenite (Sodium)
4 Vitamin C (Ascorbic Acid)
4 Bacopa monnieri
4 Boron
4 Boswellia (frankincense)
4 Caffeic acid
4 Propolis -bee glue
4 Centella asiatica / Gotu kola → asiaticoside
4 Chemotherapy
4 Cisplatin
4 isoquercitrin
4 Licochalcone A
3 Allicin (mainly Garlic)
3 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
3 Beta-Caryophyllene
3 α-Bisabolol / Chamomile oil
3 doxorubicin
3 chitosan
3 Coenzyme Q10
3 Selenium
3 Docosahexaenoic Acid
3 Dandelion Root
3 EGCG (Epigallocatechin Gallate)
3 erastin
3 Radiotherapy/Radiation
3 Fisetin
3 Shilajit/Fulvic Acid
3 γ-linolenic acid (Borage Oil)
3 Hydrogen Gas
3 Juglone
3 Moringa oleifera
3 Phenethyl isothiocyanate
3 Pterostilbene
3 salinomycin
2 1,8-Cineole
2 alpha Linolenic acid
2 Astaxanthin
2 Baicalein
2 Biochanin A
2 beta-carotene(VitA)
2 buckwheat sprouts
2 Capsaicin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Carnosine
2 Citric Acid
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Disulfiram
2 Emodin
2 Ginkgo biloba
2 Ginkgetin
2 Graviola
2 Hyperoside
2 Inositol
2 Isoliquiritigenin
2 Kaempferol
2 Nimbolide
2 Piperine
2 Rutin
2 Vitexin
1 Astragalus
1 Glucose
1 Apigenin (mainly Parsley)
1 Atorvastatin
1 Aloe anthraquinones
1 Betulinic acid
1 Bromelain
1 Bruteridin(bergamot juice)
1 Chlorogenic acid
1 Chlorophyllin
1 Chocolate
1 Cichoric acid / Chicoric acid
1 methotrexate
1 immunotherapy
1 Carica papaya leaf extract
1 Cynaropicrin
1 Diclofenac
1 diet Fermented Foods
1 diet Ketogenic
1 Oxygen, Hyperbaric
1 D-limonene
1 eicosapentaenoic acid
1 ferumoxytol
1 Formononetin
1 Fucoidan
1 Gallic acid
1 Gambogic Acid
1 Ginkgolide B
1 Hydroxycinnamic-acid
1 Hibiscus sabdariffa
1 Honokiol
1 HydroxyTyrosol
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Inulin Prebiotic
1 isoflavones
1 Lactobacillus
1 Lapachol
1 Licorice
1 Linalool
1 Melatonin
1 nicotinamide adenine dinucleotide
1 Naringin
1 Phosphatidylserine
1 Sulfasalazine
1 Sulforaphane (mainly Broccoli)
1 Shankhpushpi
1 Spermidine
1 Taurine
1 5-fluorouracil
1 Turmerones
1 Vitamin B5,Pantothenic Acid
1 VitK3,menadione
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:453  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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