CD44 Cancer Research Results

CD44, CD44: Click to Expand ⟱
Source:
Type:
CD44 represents a common biomarker of cancer stem cells, and promotes epithelial-mesenchymal transition. CD44 is a well-known marker of CSCs and plays important roles in tumor initiation and development.
Scientific Papers found: Click to Expand⟱
5122- Sal,    Identification of selective inhibitors of cancer stem cells by high-throughput screening
- in-vivo, BC, SUM159 - NA, NA, 4T1
CSCs↓, TumCG↓, Diff↑, selectivity↑, CD44↓, CD24↓, TumVol↓,
5036- SAS,    Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
xCT↓, GSH↓, OS↑, Myc↓, CDK1↓, CD44↓, eff↑, TumCG↓,
1730- SFN,    Sulforaphane: An emergent anti-cancer stem cell agent
- Review, Var, NA
BioAv↓, BioAv↑, GSTA1↑, P450↓, TumCCA↑, HDAC↓, P21↑, p27↑, DNMT1↓, DNMT3A↓, cycD1/CCND1↑, DNAdam↑, BAX↑, Cyt‑c↑, Apoptosis↑, ROS↑, AIF↑, CDK1↑, Casp3↑, Casp8↑, Casp9↑, NRF2↑, NF-kB↓, TNF-α↓, IL1β↓, CSCs↓, CD133↓, CD44↓, ALDH↓, Nanog↓, OCT4↓, hTERT/TERT↓, MMP2↓, EMT↓, ALDH1A1↓, Wnt↓, NOTCH↓, ChemoSen↑, *Ki-67↓, *HDAC3↓, *HDAC↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
5337- TFdiG,    Theaflavin 3,3'-digallate suppresses metastasis and reduces insulin-like growth factor-1-induced cancer stemness and invasiveness in human melanoma cells
- in-vitro, Melanoma, A375 - in-vitro, Melanoma, A2058
TumCMig↓, TumCI↓, MMPs↓, ALDH↓, CSCs↓, ABCG2↓, CD44↓, CXCR4↓, TumCG↓, angioG↓, TumMeta↓,

Showing Research Papers: 51 to 58 of 58
Prev Page 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 58

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSH↑, 1,   GSTA1↑, 1,   GSTs↑, 1,   HO-1↑, 1,   MPO↓, 1,   NRF2↑, 3,   ROS?, 1,   ROS↓, 1,   ROS↑, 2,   SOD↑, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

cMyc↓, 1,   SIRT1↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 2,   Bcl-2↓, 1,   Casp↑, 1,   Casp12?, 1,   Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 2,   Casp8∅, 1,   Casp9↑, 4,   Cyt‑c↑, 4,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 1,   Myc↓, 1,   p27↑, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 2,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   p70S6↓, 1,  

Transcription & Epigenetics ⓘ

HATs↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   HSP70/HSPA5↓, 1,   HSP90↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,   P53↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 1,   p19↑, 1,   P21↑, 4,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 2,   ALDH1A1↓, 1,   CD133↓, 1,   CD24↓, 1,   CD44↓, 8,   cMYB↓, 1,   CSCs↓, 5,   Diff↑, 1,   EMT↓, 2,   ERK↓, 2,   ERK↑, 1,   HDAC↓, 4,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   Nanog↓, 1,   NOTCH↓, 2,   OCT4↓, 1,   PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 4,   Wnt↓, 3,  

Migration ⓘ

CA↓, 1,   Ca+2↑, 1,   E-cadherin↑, 3,   FAK↓, 1,   miR-203↑, 1,   MMP1↓, 1,   MMP2↓, 5,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 2,   Zeb1↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 2,   Hif1a↓, 3,   VEGF↓, 4,  

Barriers & Transport ⓘ

NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   CXCR4↓, 2,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 3,   IL2↑, 1,   IL6↓, 2,   NF-kB↓, 5,   p50↓, 1,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

ABCG2↓, 1,   BioAv↓, 4,   BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 2,   eff↓, 3,   eff↑, 2,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 2,   GutMicro↝, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 2,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   cardioP↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   OS↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 1,   TumW↓, 2,  
Total Targets: 170

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC3↓, 1,  

Migration ⓘ

Ki-67↓, 1,   TIMP1↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL8↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,  

Clinical Biomarkers ⓘ

Ki-67↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: CD44, CD44
8 EGCG (Epigallocatechin Gallate)
6 Curcumin
6 Resveratrol
6 Sulforaphane (mainly Broccoli)
4 Quercetin
3 Phenethyl isothiocyanate
3 Pterostilbene
3 salinomycin
2 Ashwagandha(Withaferin A)
2 Bromelain
2 Fisetin
2 Genistein (soy isoflavone)
2 HydroxyTyrosol
1 Astragalus
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Apigenin (mainly Parsley)
1 Artemisinin
1 Atorvastatin
1 Berberine
1 Bufalin/Huachansu
1 Carvacrol
1 Chlorogenic acid
1 Electrical Pulses
1 Honokiol
1 Magnetic Fields
1 Phenylbutyrate
1 immunotherapy
1 isoflavones
1 Sulfasalazine
1 Silymarin (Milk Thistle) silibinin
1 Aflavin-3,3′-digallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:48  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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