| Source: |
| Type: enzyme |
| (or ALT) -Used to be called serum glutamic-pyruvic transaminase (SGPT) Most common in the liver. An enzyme your body needs to break down proteins into energy. It plays a crucial role in amino acid metabolism and is often measured in blood tests to assess liver function. The catabolism of alanine by alanine aminotransferase 2 (ALT2) to pyruvate, was critical for the survival of non-small cell lung carcinoma (NSCLC) cells during glucose starvation. After knockdown of ALT2, cells were significantly more sensitive to glucose withdrawal compared to wildtype cells, which were rescued when supplemented with pyruvate. Alanine aminotransferase (ALT) expression is highly elevated in the serum of patients with hepatocellular carcinoma. A common example of dietary cancer therapy is the ketogenic diet, providing a fat-rich, low carbohydrate diet. The rationale is to reduce circulating glucose levels and induce ketosis. Used as a clinical biomarker for Liver function. |
| 6881- | FA, | Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight |
| - | Review, | Var, | NA |
| 6885- | FA, | Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways |
| - | in-vivo, | Nor, | NA |
| 1656- | FA, | Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling |
| - | Review, | Var, | NA |
| 6981- | Form, | Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | PSA, | NA |
| 4022- | FulvicA, | Chemo, | Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats |
| - | in-vivo, | OS, | NA |
| 7049- | GA, | Pharmacological effects of gallic acid in health and diseases: A mechanistic review |
| - | Review, | Var, | NA |
| 7080- | GABA, | The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention |
| - | Review, | AD, | NA |
| 7311- | Gos, | Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials |
| - | Review, | CLL, | NA |
| 6561- | GSL, | Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes |
| - | in-vivo, | Nor, | NA |
| 7482- | H2, | Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application |
| - | Review, | Var, | NA | - | Review, | IBD, | NA | - | Review, | Stroke, | NA | - | Review, | Sepsis, | NA | - | Review, | AD, | NA |
| 7492- | H2, | Chemo, | Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation |
| - | Review, | Var, | NA |
| 2525- | H2, | Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis |
| - | in-vivo, | NA, | NA |
| 2524- | H2, | Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy |
| - | Trial, | NA, | NA |
| 1415- | HCA, | Hydroxycitrate delays early mortality in mice and promotes muscle regeneration while inducing a rich hepatic energetic status |
| - | in-vivo, | Nor, | NA |
| 2868- | HNK, | Honokiol: A review of its pharmacological potential and therapeutic insights |
| - | Review, | Var, | NA | - | Review, | Sepsis, | NA |
| 4238- | HNK, | Neuropharmacological potential of honokiol and its derivatives from Chinese herb Magnolia species: understandings from therapeutic viewpoint |
| - | Review, | AD, | NA | - | NA, | Park, | NA |
| 7567- | HYP, | Hyperoside: A review on its sources, biological activities, and molecular mechanisms |
| - | Review, | Var, | NA |
| 7560- | HYP, | Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7803- | IBC, | Isobavachalcone induces hepatotoxicity in zebrafish embryos and HepG2 cells via the System Xc--GSH-GPX4 signaling pathway in ferroptosis response |
| - | in-vivo, | Nor, | NA | - | in-vitro, | NA, | HepG2 |
| 7636- | Ins, | Myo-Inositol: Pharmacokinetics, Biological Functions, and Therapeutic Potential in Liver Protection: Insights from Preclinical Models |
| 7814- | ISQ, | Isoquercitrin Attenuates Steatohepatitis by Inhibition of the Activated NLRP3 Inflammasome through HSP90 |
| - | in-vivo, | Nor, | NA |
| 7800- | ISQ, | Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study |
| - | vitro+vivo, | Nor, | HepG2 |
| 8086- | KAE, | Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety |
| - | Review, | Nor, | NA |
| 8105- | KAE, | Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review |
| - | Review, | Var, | NA |
| 8080- | KAE, | Hepatoprotective Effect of Kaempferol—A Review |
| - | Review, | Nor, | NA |
| 8242- | LCA, | Nrf2 signaling and autophagy are complementary in protecting lipopolysaccharide/d-galactosamine-induced acute liver injury by licochalcone A |
| - | in-vivo, | LiverDam, | NA |
| 8245- | LCA, | Licochalcone A Upregulates Nrf2 Antioxidant Pathway and Thereby Alleviates Acetaminophen-Induced Hepatotoxicity |
| - | in-vivo, | LiverDam, | NA |
| 8256- | LCA, | Licochalcone A inhibits the growth of colon carcinoma and attenuates cisplatin-induced toxicity without a loss of chemotherapeutic efficacy in mice |
| - | in-vivo, | Colon, | CT26 |
| 8129- | LF, | Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy |
| - | Trial, | CRC, | NA |
| 2921- | LT, | Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies |
| - | Review, | Nor, | NA |
| 2903- | LT, | Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma |
| - | in-vitro, | GBM, | U251 | - | in-vitro, | GBM, | U87MG | - | in-vivo, | NA, | NA |
| 3268- | Lyco, | Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders |
| - | Review, | AD, | NA |
| 5785- | MET, | Metformin improves healthspan and lifespan in mice |
| - | in-vivo, | Nor, | NA |
| 200- | MFrot, | MF, | Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice |
| - | in-vivo, | BC, | MDA-MB-231 | - | in-vivo, | BC, | MCF7 |
| 3842- | Moringa, | Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 3844- | Moringa, | Review of the Safety and Efficacy of Moringa oleifera |
| - | Review, | NA, | NA |
| 1660- | PBG, | Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents |
| - | Review, | Var, | NA |
| 3257- | PBG, | The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review |
| - | Review, | Var, | NA |
| 3587- | PI, | Piperine: A review of its biological effects |
| - | Review, | Park, | NA | - | Review, | AD, | NA |
| 7431- | Poly, | Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression |
| - | vitro+vivo, | BC, | 4T1 |
| 2344- | QC, | Quercetin: A natural solution with the potential to combat liver fibrosis |
| - | Review, | Nor, | NA |
| 5788- | RES, | Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans |
| - | Trial, | Nor, | NA |
| 3014- | RosA, | Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity |
| - | in-vivo, | Nor, | NA |
| 3007- | RosA, | Hepatoprotective effects of rosmarinic acid: Insight into its mechanisms of action |
| - | Review, | NA, | NA |
| 3933- | RT, | The Pharmacological Potential of Rutin |
| - | Review, | AD, | NA | - | Review, | Stroke, | NA | - | Review, | Arthritis, | NA |
| 3639- | Sage, | Pharmacological properties of Salvia officinalis and its components |
| - | Review, | AD, | NA | - | Review, | Var, | NA |
| 4488- | Se, | Chit, | PEG, | Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats |
| - | in-vivo, | Liver, | HepG2 | - | in-vivo, | Nor, | HL7702 |
| 4601- | SeNPs, | AgNPs, | Antioxidant and hepatoprotective role of selenium against silver nanoparticles |
| - | in-vivo, | Nor, | NA |
| 4441- | SeNPs, | The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures |
| - | Review, | Nor, | NA |
| 4443- | SeNPs, | Bioogenic selenium and its hepatoprotective activity |
| - | in-vivo, | LiverDam, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:554 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid