SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱
Source:
Type:
SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.
Scientific Papers found: Click to Expand⟱
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
2938- NAD,    NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling
- in-vivo, BC, NA
TumMeta↓, SIRT1↑,
2932- NAD,    Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
- in-vitro, Nor, NA
*SIRT1↑, *HO-1↑, *neuroP↑, *Apoptosis↓, *Inflam↓, *ROS↓, *antiOx↑, *toxicity↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
2936- NAD,    The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update
*ROS↓, *DNAdam↓, *neuroP↑, *Inflam↓, *BioAv↑, *SIRT1↑, BioAv↝,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
2077- PB,    Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells
- in-vitro, Liver, HUH7
miR-22↑, SIRT1↓, ROS↑, Cyt‑c↑, Casp3↑, eff↓, TumCG↓, TumCP↓, HDAC↓, SIRT1↓, CD44↓, proMMP2↓, MMP↓, SOD↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
2963- PL,    Piperlongumine activates Sirtuin1 and improves cognitive function in a murine model of Alzheimer’s disease
- in-vitro, AD, HEK293
*SIRT1↑, *cognitive↑, *Aβ↓, *Inflam↓, *neuroP↑, memory↑, Dose↓, NAD↑,
3919- PTS,    Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
- in-vivo, AD, NA
*cognitive↑, *SIRT1∅, *PPARα↑, *SOD2↑, *JNK↓, *p‑tau↓,
2338- QC,    Quercetin: A Flavonoid with Potential for Treating Acute Lung Injury
- Review, Nor, NA
*SIRT1↑, *NLRP3↓, *Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, *PKM2↓, *HO-1↑, *ROS↓, *NO↓, *MDA↓, *antiOx↑, *COX2↓, *HMGB1↓, *iNOS↓, *NF-kB↓,
2339- QC,    Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation
- in-vivo, Nor, NA
*Inflam↓, *antiOx↑, *NLRP3↓, *Sepsis↓, *PKM2↓, *SIRT1↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
3607- QC,    Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More
- Review, AD, NA - Review, Park, NA
*neuroP↑, *NRF2↑, *PONs↑, *antiOx↑, *Inflam↓, *SIRT1↑, *eff↑, *ROS↓, *cognitive↑, *eff↑, *lipid-P↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑,
3534- QC,  Lyco,    Synergistic protection of quercetin and lycopene against oxidative stress via SIRT1-Nox4-ROS axis in HUVEC cells
- in-vitro, Nor, HUVECs
*ROS↓, *NOX4↓, *Inflam↓, *NF-kB↓, *p65↓, *SIRT1↑, *cardioP↑, *IL6↓, *COX2↓,
3350- QC,    Quercetin and the mitochondria: A mechanistic view
- Review, NA, NA
*antiOx↑, *Inflam↓, *NRF2↑, ROS⇅, *NRF2↑, *HO-1↑, *PPARα↑, *PGC-1α↑, *SIRT1↑, *ATP↑, ATP↓, ERK↓, cl‑PARP↑, Casp9↑, Casp8↑, BAX↑, MMP↓, Cyt‑c↑, Casp3↑, HSP27↓, HSP72↓, RAS↓, Raf↓,
3365- QC,    Quercetin attenuates sepsis-induced acute lung injury via suppressing oxidative stress-mediated ER stress through activation of SIRT1/AMPK pathways
- in-vivo, Sepsis, NA
*ER Stress↓, *PDI↓, *CHOP↓, *GRP78/BiP↓, *ATF6↓, *PERK↓, *IRE1↓, *MMP↑, *SOD↑, *ROS↓, *MDA↓, *SIRT1↑, *AMPK↑, *Sepsis↓,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
3612- RES,    Resveratrol in Alzheimer's disease: a review of pathophysiology and therapeutic potential
- Review, AD, NA
*other↑, *Aβ↓, *Inflam↓, *NF-kB↓, *neuroP↑, *HO-1↑, *lipid-P↓, *COX2↓, *AMPK↑, *Catalase↑, *SOD↑, *GSR↑, *ROS↓, *MMP9↓, *cognitive↑, *SIRT1↑, *IL1β↓, *IL6↓,
3613- RES,    Resveratrol for Alzheimer's disease
- Review, AD, NA
*SIRT1↑, *BioAv↝, *toxicity↓, *ROS↓, *antiOx↑, *Aβ↓, *MMP9↓, *TNF-α↓,
3614- RES,    Resveratrol--a boon for treating Alzheimer's disease?
- Review, AD, NA
*SIRT1↑, *neuroP↑,
3798- RES,    Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure
- in-vivo, NA, NA
*SIRT1↑, *BDNF↑, *PSD95↑, *memory↑,
1506- RES,    Epigenetic targets of bioactive dietary components for cancer prevention and therapy
- Review, NA, NA
DNMTs↓, BRCA1↑, HDAC↓, SIRT1↑, p300↓, survivin↓, HDAC1↓, HDAC3↓, HDAC8↓,
1282- RES,    Resveratrol Inhibits CD4+ T Cell Activation by Enhancing the Expression and Activity of Sirt1
- vitro+vivo, NA, NA
T-Cell↓, SIRT1↑, CD4+↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
2331- RES,    Resveratrol improves follicular development of PCOS rats via regulating glycolysis pathway and targeting SIRT1
- in-vivo, Nor, NA
*LDHA↑, *PKM2↑, *SIRT1↑, *Glycolysis↝,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
2472- RES,    Resveratrol Restores Sirtuin 1 (SIRT1) Activity and Pyruvate Dehydrogenase Kinase 1 (PDK1) Expression after Hemorrhagic Injury in a Rat Model
- in-vivo, Nor, NA
*SIRT1↑, *PGC-1α↑, *cMyc↑, *PDK1↓,
3080- RES,    Resveratrol: A miraculous natural compound for diseases treatment
- Review, Var, NA
SIRT1↑, ROCK1↓, AMPK↑, *lipid-P↓, Aβ↓, COX2↓, angioG↓, Hif1a↓, VEGF↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3076- RES,    Resveratrol for targeting the tumor microenvironment and its interactions with cancer cells
- Review, Var, NA
IL6↓, MMPs↓, MMP2↓, MMP9↓, BioAv↓, Half-Life↑, BioAv↑, Dose↝, angioG↓, IL10↓, VEGF↓, NF-kB↓, COX2↓, SIRT1↑, Wnt↓, cMyc↓, STAT3↓, PTEN↑, ROS↑, RadioS↑, Hif1a↓, E-cadherin↓, Vim↓, angioG↓,
3075- RES,  Rad,    The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice
- in-vivo, Nor, NA
*SIRT1↑, *radioP↑, *NLRP3↓, *Weight↑, *IL1β↓,
3074- RES,    Possible therapeutic targets for NLRP3 inflammasome-induced breast cancer
- Review, BC, NA
NLRP3↓, SIRT1↑,
3092- RES,    Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action
- Review, BC, MDA-MB-231 - Review, BC, MCF-7
TumCP↓, tumCV↓, TumCI↓, TumMeta↓, *antiOx↑, *cardioP↑, *Inflam↓, *neuroP↑, *Keap1↓, *NRF2↑, *ROS↓, p62↓, IL1β↓, CRP↓, VEGF↓, Bcl-2↓, MMP2↓, MMP9↓, FOXO4↓, POLD1↓, CK2↓, MMP↓, ROS↑, Apoptosis↑, TumCCA↑, Beclin-1↓, Ki-67↓, ATP↓, GlutMet↓, PFK↓, TGF-β↓, SMAD2↓, SMAD3↓, Vim?, Snail↓, Slug↓, E-cadherin↑, EMT↓, Zeb1↓, Fibronectin↓, IGF-1↓, PI3K↓, Akt↓, HO-1↑, eff↑, PD-1↓, CD8+↑, Th1 response↑, CSCs↓, RadioS↑, SIRT1↑, Hif1a↓, mTOR↓,
3096- RES,    Identification of potential target genes of non-small cell lung cancer in response to resveratrol treatment by bioinformatics analysis
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCP↓, Apoptosis↑, Akt↓, mTOR↓, p38↑, MAPK↑, STAT3↓, ROS↑, SIRT1↑, SOX2↓,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3100- RES,    Neuroprotective effects of resveratrol in Alzheimer disease pathology
- Review, AD, NA
*neuroP↑, *BioAv↓, *Half-Life↓, *BioAv↑, *BBB↑, *NRF2↑, *BioAv↓, *BioAv↑, *SIRT1↑, *cognitive↑, *lipid-P↓, *HO-1↑, *SOD↑, *GSH↑, *GPx↑, *G6PD↑, *PPARγ↑, *AMPK↑, *Aβ↓,
3071- RES,    Resveratrol and Its Anticancer Effects
- Review, Var, NA
chemoPv↑, SIRT1↑, Hif1a↓, VEGF↓, STAT3↓, NF-kB↓, COX2↓, PI3K↓, mTOR↓, NRF2↑, NLRP3↓, H2O2↑, ROS↑, P53↑, PUMA↑, BAX↑,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3059- RES,    Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury
- in-vivo, Nor, HK-2
*RenoP↑, *Inflam↓, *NRF2↑, *HO-1↑, *SIRT1↑, *ROS↓, AntiAge↑,
3068- RES,    Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation
- in-vitro, lymphoma, U937
p65↓, SOD2↓, Prx↓, Catalase↓, Trx↓, TNF-α↓, IL8↓, MCP1↓, SIRT1↑,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
*antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *AMPK↑, *SIRT1↑, *miR-155↓, *NLRP3↓,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
4706- RES,    Resveratrol as a circadian clock modulator: mechanisms of action and therapeutic applications
- Review, Nor, NA
*SIRT1↑, *CLOCK↝,
4670- RES,  CUR,  EGCG,  TQ,    Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *SIRT1↑, *SIRT3↑, *FOXO↑, *ROS↓,
4286- RES,    Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *Inflam↓, *antiOx↑, *GSH↑, *HO-1↑, *iNOS↓, *BDNF↑, *p‑CREB↑, *PKA↑, *Bcl-2↑, *BAX↓, *IL1β↓, *IL6↓, *MMP9↓, *memory↑, *AMPK↑, *PGC-1α↓, *NF-kB↓, *Aβ↓, *SIRT1↑, *p‑tau↓, *PP2A↑, *lipid-P↓, *NLRP3↓, *BACE↓,
4284- RES,    Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
- in-vitro, AD, HEK293 - NA, Stroke, NA - in-vivo, AD, NA
*p‑tau↓, *PP2A↑, *neuroP↑, *antiOx↑, COX2↓, *AntiAg↑, *SIRT1↑, *AMPK↑, *Acetyl-CoA↓, *FAO↑, *ADAM10↑, *BACE↓, *Aβ↓, *memory↑, *Inflam↓, *ROS↓,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,

Showing Research Papers: 51 to 100 of 117
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 117

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   Catalase↓, 2,   Catalase↑, 1,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 2,   GSH↓, 2,   GSH↑, 1,   GSR↓, 1,   GSR↑, 1,   GSTA1↑, 1,   GSTs↓, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 1,   lipid-P↑, 1,   NQO1↓, 1,   NRF2↓, 1,   NRF2↑, 2,   Prx↓, 1,   ROS↓, 3,   ROS↑, 8,   ROS⇅, 1,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 2,   TKT↝, 1,   Trx↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   MMP↓, 4,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AMPK↑, 4,   cMyc↓, 4,   G6PD↓, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 1,   HK2↓, 2,   LDH↓, 1,   NAD↑, 1,   NADPH↑, 1,   PDH↑, 1,   PFK↓, 2,   PFK1↓, 1,   PKM2↓, 1,   POLD1↓, 1,   PPARγ↑, 1,   R5P↝, 1,   SIRT1↓, 5,   SIRT1↑, 15,   SIRT2↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

AhR↓, 1,   Akt↓, 4,   p‑Akt↓, 2,   Apoptosis↑, 3,   BAX↓, 1,   BAX↑, 3,   Bcl-2↓, 3,   Bcl-2↑, 1,   Bcl-xL↓, 1,   BIM↑, 1,   Casp1↓, 1,   Casp3↑, 4,   Casp8↑, 2,   Casp9↑, 1,   Chk2↓, 1,   CK2↓, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 2,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↑, 1,   HGF/c-Met↓, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p‑MDM2↓, 1,   p27↑, 1,   p38↑, 1,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 2,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,   H4↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP72↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   CHK1↓, 1,   DNAdam↓, 1,   DNAdam↑, 1,   DNMTs↓, 1,   P53↓, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 2,   TP53↑, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD34↓, 1,   CD44↓, 2,   cFos↑, 1,   CSCs↓, 2,   EMT↓, 4,   ERK↓, 2,   FOXO↑, 1,   FOXO1↓, 1,   FOXO4↓, 1,   Gli1↓, 1,   HDAC↓, 3,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   mTOR↓, 5,   Nanog↓, 1,   Nestin↓, 1,   NOTCH1↓, 1,   p300↓, 1,   PI3K↓, 4,   p‑PI3K↓, 2,   PTEN↓, 2,   PTEN↑, 2,   RAS↓, 1,   Shh↓, 1,   SOX2↓, 1,   p‑Src↓, 1,   STAT3↓, 6,   p‑STAT6↓, 1,   TCF↓, 1,   TOP2↓, 1,   TumCG↓, 4,   Wnt↓, 3,  

Migration ⓘ

AXL↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 3,   E-cadherin↑, 2,   FAK↓, 1,   Fibronectin↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MALAT1↓, 1,   MET↓, 1,   p‑MET↓, 1,   miR-22↑, 1,   MMP2↓, 5,   proMMP2↓, 1,   MMP7↓, 1,   MMP9↓, 5,   MMPs↓, 1,   N-cadherin↓, 1,   Rac1↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 2,   SMAD2↓, 1,   SMAD3↓, 1,   Snail↓, 2,   talin↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TumCI↓, 2,   TumCP↓, 5,   TumCP⇅, 1,   TumMeta↓, 3,   TumMeta↑, 1,   Tyro3↓, 1,   uPAR↓, 1,   Vim?, 1,   Vim↓, 2,   Vim↑, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   EGFR↑, 1,   Hif1a↓, 6,   VEGF↓, 8,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

ASC↓, 1,   CD4+↓, 1,   COX2↓, 7,   CRP↓, 1,   CXCR4↓, 2,   ICAM-1↓, 1,   IKKα↓, 1,   IL1↑, 1,   IL10↓, 1,   IL1β↓, 1,   IL2↑, 2,   IL4↑, 1,   IL6↓, 5,   IL8↓, 1,   JAK1↓, 1,   MCP1↓, 1,   NF-kB↓, 8,   p‑NF-kB↓, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 2,   PGE2↓, 2,   T-Cell↓, 1,   Th1 response↑, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 4,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 3,   ChemoSen⇅, 1,   Dose↓, 1,   Dose↝, 4,   eff↓, 1,   eff↑, 7,   Half-Life↑, 1,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   BRCA1↑, 1,   CEA↓, 1,   CRP↓, 1,   EGFR↑, 1,   IL6↓, 5,   Ki-67↓, 1,   LDH↓, 1,   NSE↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 1,   memory↑, 1,   OS↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 268

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 15,   Catalase↑, 5,   GPx↑, 7,   GSH↑, 9,   GSR↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 12,   HO-1⇅, 1,   Keap1↓, 2,   lipid-P↓, 8,   mt-lipid-P↓, 1,   MDA↓, 4,   Mets↝, 1,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 1,   NRF2↑, 10,   ROS↓, 21,   SIRT3↑, 1,   SOD↑, 7,   SOD2↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 2,   MMP↑, 3,   mtDam↓, 2,   PGC-1α↓, 1,   PGC-1α↑, 4,  

Core Metabolism/Glycolysis ⓘ

Acetyl-CoA↓, 1,   ALAT↓, 2,   AMPK↑, 10,   cMyc↑, 1,   p‑CREB↑, 1,   CRM↑, 1,   FAO↑, 1,   G6PD↑, 1,   GlutMet↑, 1,   Glycolysis↝, 1,   LDHA↑, 1,   NADH:NAD↑, 1,   PDK1↓, 1,   PKM2↓, 2,   PKM2↑, 1,   PONs↑, 1,   PPARα↑, 2,   PPARγ↑, 3,   SIRT1↓, 1,   SIRT1↑, 30,   SIRT1∅, 1,  

Cell Death ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 3,   Casp9↓, 1,   Cyt‑c↓, 1,   Cyt‑c∅, 1,   iNOS↓, 3,   JNK↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,  

Protein Folding & ER Stress ⓘ

ATF6↓, 1,   CHOP↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP70/HSPA5↝, 1,   IRE1↓, 1,   PERK↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

CLOCK↝, 1,   FOXO↑, 2,   GSK‐3β↓, 2,   GSK‐3β↑, 1,  

Migration ⓘ

AntiAg↑, 2,   miR-155↓, 1,   MMP3↓, 1,   MMP9↓, 5,   PKA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 2,   NO↓, 2,   PDI↓, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   HMGB1↓, 1,   IL10↑, 1,   IL1β↓, 6,   IL6↓, 4,   Inflam↓, 20,   NF-kB↓, 7,   p65↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   ADAM10↑, 1,   BDNF↑, 2,   PSD95↑, 1,   p‑tau↓, 3,  

Protein Aggregation ⓘ

Aβ↓, 7,   BACE↓, 2,   NLRP3↓, 5,   PP2A↑, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 5,   BioAv↑, 8,   BioAv↝, 2,   Dose↝, 2,   eff↑, 11,   Half-Life↓, 2,   Half-Life↝, 2,   P450↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 1,   BG↓, 1,   BP↓, 2,   creat↓, 1,   IL6↓, 4,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 8,   cognitive↑, 8,   hepatoP↑, 5,   memory↑, 7,   motorD↑, 2,   neuroP↑, 16,   OS↑, 1,   radioP↑, 1,   RenoP↑, 2,   toxicity↓, 2,   toxicity∅, 1,   Weight↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 2,  
Total Targets: 132

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein
34 Resveratrol
9 Capsaicin
7 Quercetin
6 Hydrogen Gas
6 Urolithin
5 nicotinamide adenine dinucleotide
4 Curcumin
4 EGCG (Epigallocatechin Gallate)
4 Luteolin
4 Thymoquinone
3 Calorie Restriction Mimetics
3 Gambogic Acid
3 Shikonin
2 Silver-NanoParticles
2 Alpha-Lipoic-Acid
2 diet FMD Fasting Mimicking Diet
2 Chemotherapy
2 Ellagic acid
2 Electrical Pulses
2 Lycopene
2 Silymarin (Milk Thistle) silibinin
1 Astragalus
1 Magnetic Fields
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Andrographis
1 Artemisinin
1 Baicalein
1 Baicalin
1 Berberine
1 Carnosic acid
1 Carvacrol
1 Hydroxycinnamic-acid
1 Spermidine
1 Aspirin -acetylsalicylic acid
1 HydroxyCitric Acid
1 Garcinol
1 Crocetin
1 Ferulic acid
1 Honokiol
1 Phenylbutyrate
1 Piperine
1 Piperlongumine
1 Pterostilbene
1 Radiotherapy/Radiation
1 Rosmarinic acid
1 Sesame seeds and Oil
1 Salvia miltiorrhiza
1 Vitamin B3,Niacin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:634  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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