LC3II Cancer Research Results

LC3II, Microtubule-associated protein 1A/1B light chain 3: Click to Expand ⟱
Source:
Type:
LC3II (Microtubule-associated protein 1A/1B light chain 3, also known as LC3) is a protein that plays a crucial role in the process of autophagy. Autophagy is a cellular process in which cells recycle and remove damaged or dysfunctional components.
LC3II is often used as a marker for autophagy, as its levels increase during autophagic activity.
LC3II is overexpressed in certain types of cancer, including breast, lung, and colon cancer.
LC3II is also known by other names, including:
    MAP1LC3B (Microtubule-associated protein 1 light chain 3 beta)
    LC3B (Microtubule-associated protein 1 light chain 3 beta)
    ATG8F (Autophagy-related protein 8F)
: In many cancers, increased LC3-II expression indicates enhanced autophagy, which can support tumor cell survival, especially under stress conditions (e.g., nutrient deprivation, hypoxia). This is often associated with poor prognosis and treatment resistance.
Scientific Papers found: Click to Expand⟱
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
227- MFrot,  MF,    Low Frequency Magnetic Fields Induce Autophagy-associated Cell Death in Lung Cancer through miR-486-mediated Inhibition of Akt/mTOR Signaling Pathway
- in-vivo, Lung, A549 - in-vitro, Lung, A549
TumCG↓, miR-486↑, BCAP↓, Apoptosis↑, ROS↑, TumAuto↑, LC3II↑, ATG5↑, Beclin-1/ATG6↑, p62↑, TumCP↓,
1672- PBG,    The Potential Use of Propolis as an Adjunctive Therapy in Breast Cancers
- Review, BC, NA
ChemoSen↓, RadioS↑, Inflam↓, AntiCan↑, Dose∅, mtDam↑, Apoptosis?, OCR↓, ATP↓, ROS↑, ROS↑, LDH↓, TP53↓, Casp3↓, BAX↓, P21↓, ROS↑, eNOS↑, iNOS↑, eff↑, hTERT/TERT↓, cycD1/CCND1↓, eff↑, eff↑, eff↑, eff↑, STAT3↓, TIMP1↓, IL4↓, IL10↓, OS↑, Dose∅, ER Stress↑, ROS↑, NF-kB↓, p65↓, MMP↓, TumAuto↑, LC3II↑, p62↓, TLR4↓, mtDam↑, LDH↓, ROS↑, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDH↓, IL10↓, HDAC8↓, eff↑, eff↑, P21↑,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,
1455- SFN,    Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
- in-vitro, Cerv, HeLa - in-vitro, Nor, 1321N1
*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF7
LC3II↑, Beclin-1/ATG6↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
7916- VT,    Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway
- in-vitro, HCC, NA
*antiOx↑, *Inflam↓, *AntiTum↑, Apoptosis↑, Casp3↑, Bcl-2↓, LC3II↓, p‑JNK↑, p‑ERK↓,

Showing Research Papers: 51 to 63 of 63
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 63

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

MYCN↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   CYP1A1↓, 1,   GPx↓, 1,   GSH↓, 3,   GSH↑, 1,   GSR↓, 1,   GSTs↓, 1,   HO-1↓, 1,   lipid-P↓, 1,   NQO1↓, 1,   NRF2↓, 1,   ROS↑, 14,   ROS⇅, 1,   SOD↓, 2,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   BOK↑, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   MEK↓, 1,   mitResp↓, 1,   MMP↓, 6,   mtDam↑, 3,   OCR↓, 1,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 2,   ATG7↑, 1,   BCAP↓, 1,   cMyc↓, 2,   Glycolysis↓, 2,   HK2↓, 1,   LDH↓, 3,   PFK↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Akt↑, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↑, 4,   BAD↑, 1,   BAX↓, 1,   BAX↑, 4,   Bcl-2↓, 7,   Bcl-xL↓, 1,   BID↓, 1,   BID↑, 1,   BIM↓, 1,   Casp↑, 3,   Casp1↓, 1,   cl‑Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 7,   Casp8↑, 3,   Casp9↑, 3,   Chk2↓, 1,   Cyt‑c↑, 4,   DR5↑, 3,   FADD↑, 1,   Fas↑, 3,   FasL↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 2,   iNOS↓, 4,   iNOS↑, 1,   JNK↑, 1,   p‑JNK↑, 2,   MAPK↓, 5,   MAPK↑, 1,   Mcl-1↓, 2,   p‑MDM2↓, 1,   Myc↓, 1,   NAIP↓, 1,   p27/CDKN1B↑, 1,   p38↑, 1,   p‑p38↑, 1,   survivin↓, 2,   Telomerase↓, 2,   TRAIL↑, 2,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   H4↓, 1,   HATs↑, 1,   other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   autoF↓, 1,   Beclin-1/ATG6↑, 5,   BNIP3?, 1,   LC3II↓, 1,   LC3II↑, 12,   lysosome↓, 1,   p62↓, 3,   p62↑, 1,   TFEB↑, 1,   TumAuto↓, 1,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 1,   CYP1B1↑, 1,   DNAdam↑, 2,   DNMT1↓, 2,   p16↑, 1,   P53↑, 4,   PARP↑, 2,   PCNA↓, 2,   TP53↓, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 2,   CDK4↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   E2Fs↓, 1,   E2Fs↑, 1,   P21↓, 1,   P21↑, 4,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   cFos↑, 1,   cMET↓, 2,   CSCs↓, 2,   CTSB↓, 1,   CTSL↓, 1,   CTSS↓, 1,   EMT↓, 3,   ERK↓, 4,   p‑ERK↓, 1,   FOXO↑, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC8↓, 1,   mTOR↓, 4,   NOTCH↓, 1,   NOTCH1↓, 1,   P70S6K↓, 1,   PI3K↓, 4,   p‑PI3K↓, 1,   PTEN↓, 1,   p‑Src↓, 1,   STAT3↓, 5,   p‑STAT6↓, 1,   TumCG↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   Akt2↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 1,   CD31/PECAM-1↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   LAMP1?, 1,   MET↓, 1,   p‑MET↓, 1,   miR-486↑, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 1,   MMPs↓, 3,   N-cadherin↓, 4,   Rac1↓, 1,   Rho↓, 1,   Slug↓, 1,   Snail↓, 2,   TIMP1↓, 1,   TumCP↓, 5,   TumMeta↓, 2,   Twist↓, 1,   Tyro3↓, 1,   uPA↓, 1,   Vim↓, 3,   Vim↑, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   ATF4↑, 1,   EGFR↑, 1,   eNOS↑, 1,   Hif1a↓, 4,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 3,   CTSZ↓, 1,   CXCL1↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 4,   IL12↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL2↑, 3,   IL4↓, 1,   IL6↓, 2,   Inflam↓, 3,   JAK2↓, 1,   MDSCs↓, 1,   NF-kB↓, 6,   NF-kB↑, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 1,   TLR4↓, 2,   TNF-α↓, 3,   TNF-α↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 1,   BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 4,   Dose↑, 1,   Dose∅, 3,   eff↓, 2,   eff↑, 10,   eff↝, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 2,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRCA1↓, 1,   CEA↓, 1,   EGFR↑, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 2,   LDH↓, 3,   Myc↓, 1,   NSE↓, 1,   TP53↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   RenoP↑, 1,   Risk↓, 1,  
Total Targets: 277

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   lipid-P↓, 1,   MDA↓, 1,   ROS↓, 3,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDHA↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 2,   Casp9↓, 1,   JNK↓, 1,   MAPK↓, 1,   p38↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 1,   IL10↑, 1,   IL1β↓, 1,   Inflam↓, 1,   TNF-α↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 1,   BioAv↝, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   radioP↑, 1,   toxicity↓, 1,  
Total Targets: 36

Scientific Paper Hit Count for: LC3II, Microtubule-associated protein 1A/1B light chain 3
4 Curcumin
3 Berberine
3 Propolis -bee glue
3 Ferulic acid
3 Licochalcone A
2 Artemisinin
2 Capsaicin
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Formononetin
2 Honokiol
2 itraconazole
2 Ivermectin
2 Juglone
2 Luteolin
2 Silymarin (Milk Thistle) silibinin
1 Silver-NanoParticles
1 Betulinic acid
1 Boron
1 Butyrate
1 Caffeic acid
1 Coenzyme Q10
1 Dichloroacetate
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Evodiamine
1 Fisetin
1 Gambogic Acid
1 hydroxychloroquine
1 Genistein (soy isoflavone)
1 Hibiscus sabdariffa
1 Hyperoside
1 isoorientin
1 isoquercitrin
1 Isovitexin
1 Kaempferol
1 Magnetic Field Rotating
1 Magnetic Fields
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
1 Ursolic acid
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:721  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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