Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
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Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE/β-secretase↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3660- SFN,    Sulforaphane - role in aging and neurodegeneration
- Review, AD, NA
*antiOx↑, *Inflam↓, *NRF2↑, *NF-kB↓, *HDAC↓, *DNMTs↓, *neuroP↑, *AntiAge↑, *DNMT1↓, *DNMT3A↓, *memory↑, *HO-1↑, *ROS↓, *NO↓, *GSH↑, *NF-kB↓, *TNF-α↓, *IL10↑,
3659- SFN,    Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease
- in-vitro, AD, NA
*NRF2↑, *ROS↓, *MDA↓, *SOD↑, *IL1β↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *iNOS↓, *Inflam↓,
3657- SFN,    Sulforaphane exerts its anti-inflammatory effect against amyloid-β peptide via STAT-1 dephosphorylation and activation of Nrf2/HO-1 cascade in human THP-1 macrophages
- NA, AD, THP1
*NLRP3↓, *Inflam↓, *IL1β↓, *NRF2↑, *HO-1↑,
3656- SFN,    Chronic diseases, inflammation, and spices: how are they linked?
- Review, AD, NA
*AntiCan↑, *cardioP↑, *NRF2↑, *Inflam↓, *NF-kB↓, *STAT3↓, *ERK↓, *MAPK↓, AP-1↑, Bcl-2↓, Casp3↑, Casp9↑,
3187- SFN,    Sulforaphane inhibits the expression of interleukin-6 and interleukin-8 induced in bronchial epithelial IB3-1 cells by exposure to the SARS-CoV-2 Spike protein
- in-vitro, Nor, IB3-1
*IL6↓, *IL8↓, *Inflam↓,
3185- SFN,    Sulforaphane decreases oxidative stress and inhibits NLRP3 inflammasome activation in a mouse model of ulcerative colitis
- in-vivo, Nor, RAW264.7
*IL18↓, *IL1β↓, *NLRP3↓, *Inflam↓,
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
3182- SFN,    Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
- in-vitro, AML, NA
Prx↓, AQPs↓, NOX↓, tumCV↓, AntiCan↑, cardioP↑, neuroP↑, Inflam↓, chemoPv↑, angioG↓, TumMeta↓, selectivity↑, ROS↓,
3189- SFN,    Sulforaphane Inhibits TNF-α-Induced Adhesion Molecule Expression Through the Rho A/ROCK/NF-κB Signaling Pathway
- in-vitro, Nor, ECV304
*ICAM-1↓, *IL1β↓, *IL6↓, *IL8↓, *p‑IKKα↓, *Rho↓, *ROCK1↓, *ERK↓, *Inflam↓,
3190- SFN,    Sulforaphane inhibits TGF-β-induced fibrogenesis and inflammation in human Tenon’s fibroblasts
- in-vitro, Nor, NA
*Fibronectin↓, *α-SMA↓, *ITGB1↓, *ITGA5↓, *IL6↓, *IL8↓, Inflam↓,
2552- SFN,  Chemo,    Chemopreventive activity of sulforaphane
- Review, Var, NA
chemoPv↑, TumCG↓, *ROS↓, *Inflam↓, *Dose↝, *NRF2↑, *HO-1↑, *NQO1↑, NF-kB↓, ROS↑,
2553- SFN,    Mechanistic review of sulforaphane as a chemoprotective agent in bladder cancer
- Review, Bladder, NA
antiOx↓, Inflam↓, ChemoSen↑, ROS⇅, *NRF2↑, *GSH↑, Catalase↑, HO-1↑, NAD↑, chemoP↑,
3946- Shank,    Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies
- Review, AD, NA
*neuroP↑, *cognitive↑, *AChE↓, *antiOx↑, *GSR↑, *SOD↑, *GSH↑, *Inflam↓, *ROS↓, *lipid-P↓, *cardioP↑,
3944- Shank,    Role of Shankhpushpi (Convolvulus pluricaulis) in neurological disorders: An umbrella review covering evidence from ethnopharmacology to clinical studies
- Review, AD, NA
*memory↑, *neuroP↑, *Inflam↓, *5HT↑,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3312- SIL,    Silymarin Alleviates Oxidative Stress and Inflammation Induced by UV and Air Pollution in Human Epidermis and Activates β-Endorphin Release through Cannabinoid Receptor Type 2
- Human, Nor, NA
*antiOx↑, *Inflam↓, *ROS↓, *IL1α↓, *AhR↑, *NRF2↑, *IL8↓,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2/PTGS2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3305- SIL,    Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,
3306- SIL,  Rad,    Radioprotective and radiosensitizing properties of silymarin/silibinin in response to ionizing radiation
- Review, Var, NA
radioP↑, RadioS↑, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, DNAdam↓, ROS↑, *ROS↓, *Inflam↓,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, eff↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, eff↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
3311- SIL,    Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells
- in-vitro, Nor, PC12
*antiOx↑, *Inflam↓, AntiCan↑, *ROS↓, *MDA↓, *GSH↓, *NRF2↑, *GPx↑, *GCLC↑, *GCLM↑,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, NA, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2/PTGS2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,
3294- SIL,    Silymarin: a review on paving the way towards promising pharmacological agent
- Review, Nor, NA - Review, Arthritis, NA
*hepatoP↑, *Inflam↓, *chemoP↑, *glucose↓, *antiOx↑, *ROS↓, *ACC↓, *FASN↓, *radioP↑, *NF-kB↓, *TGF-β↓, *AST↓, *α-SMA↝, *eff↑, *neuroP↑, eff↑, ROS↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27/CDKN1B↑, COX2/PTGS2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1/SREBF1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
3647- SIL,    Silymarin Modulates Microbiota in the Gut to Improve the Health of Sow from Late Gestation to Lactation
- in-vivo, NA, NA
*IL1β↓, *GutMicro↝, *Inflam↓,
3653- SIL,    Silibinin ameliorates Aβ25-35-induced memory deficits in rats by modulating autophagy and attenuating neuroinflammation as well as oxidative stress
- in-vivo, AD, NA
*hepatoP↑, *neuroP↑, *cognitive↑, *memory↑, *Inflam↓, *GSH↑, *MDA↓, *Inflam↓, *antiOx↓,
3649- SIL,    Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis
*Inflam↓, *NF-kB↓, *cJun↓, *Casp↓, *ROS↓, *lipid-P↓,
3648- SIL,    Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years
- Review, NA, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *necrosis↓, *hepatoP↑, *IL1↓, *IL6↓, *TNF-α↓, *IFN-γ↓, MAPK↓, Apoptosis↑, Cyt‑c↑, Casp3↑, Casp9↑, *PPARγ↑, *GLUT4↑, *HSPs↓, *HSP27↑, *Trx↑, *SIRT1↑, *ALAT↓, *GSH↑, *lipid-P↓, *TNF-α↓, TumCG↓, P21↑, CDK4↑,
3646- SIL,    "Silymarin", a promising pharmacological agent for treatment of diseases
- Review, NA, NA
*P-gp/ABCB1↓, *Inflam↓, *hepatoP↑, *antiOx↑, *GSH↑, *BioAv↑, *SOD↑, *IFN-γ↓, *IL4↓, *IL10↓, *Half-Life↓, *TNF-α↓, *ALAT↓, *AST↓, Akt↓, chemoP↑, β-catenin/ZEB1↓, TumCP↓, MMP↓, Cyt‑c↑, *RenoP↑, *BBB↑,
3331- SIL,    The clinical anti-inflammatory effects and underlying mechanisms of silymarin
- Review, NA, NA
*Inflam↓, *NF-kB↓, *NLRP3↓, *COX2/PTGS2↓, *iNOS↓, *neuroP↑, *p‑ERK↓, *p38↓, *MAPK↓, *EGFR↓, *ROS↓, *lipid-P?, *5LO↓,
3325- SIL,    Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury
- in-vivo, Nor, NA
*Inflam↓, *ROS↓, *Casp3↑, *Casp9↑, *Hif1a↓, *iNOS↓, *SOD↑, *MDA↓,
3324- SIL,    Silymarin prevents NLRP3 inflammasome activation and protects against intracerebral hemorrhage
*ROS↓, *TAC↑, *NF-kB↓, *IL2↓, *NRF2↑, *HO-1↑, *neuroP↑, *Inflam↓, *NLRP3↓,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3321- SIL,    Silymarin (Milk thistle)
- Review, AD, NA
*neuroP↝, *Dose↝, *Half-Life?, *BioAv↝, *cognitive↑, *Aβ↓, *Inflam↓, *OS↑, *memory↑,
3320- SIL,    Neuroprotective Potential of Silymarin against CNS Disorders: Insight into the Pathways and Molecular Mechanisms of Action
- Review, AD, NA
*hepatoP↑, *neuroP↑, *ROS↓, *β-Amyloid↓, *Inflam↓, *Aβ↓, *NF-kB↓, *TNF-α↓, *LTA/TNF-β↓, *iNOS↓, *NO↓, *COX2/PTGS2↓,
3319- SIL,    Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *BBB?, *tau↓, *NF-kB↓, *IL1β↓, *TNF-α↓, *IL4↓, *MAPK↓, *memory↑, *cognitive↑, *Aβ↓, *ROS↓, *lipid-P↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *AChE↓, *BChE↓, *p‑ERK↓, *p‑JNK↓, *p‑p38↓, *GutMicro↑, *COX2/PTGS2↓, *iNOS↓, *TLR4↓, *neuroP↑, *Strength↑, *AMPK↑, *MMP↑, *necrosis↓, *NRF2↑, *HO-1↑,
3316- SIL,  Chemo,    Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis
Inflam↓, antiOx↓, neuroP↑, cognitive↑, NRF2↑, HO-1↑, memory↑, AChE↓, Casp3↓,
3314- SIL,    Silymarin: Unveiling its pharmacological spectrum and therapeutic potential in liver diseases—A comprehensive narrative review
- Review, NA, NA
*antiOx↑, *hepatoP↑, *Half-Life↑, *ROS↓, *GSH↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *IFN-γ↓, *IL2↓, *IL4↓, *NF-kB↓, *iNOS↓, *OATPs↓, *OCT4↓, *Inflam↓, *PGE2↓, MMPs↓, VEGF↓, angioG↓, STAT3↓, *ALAT↓, *AST↓, Dose↝,
4126- Silicon,  H2,    Oral Administration of Si-Based Agent Attenuates Oxidative Stress and Ischemia-Reperfusion Injury in a Rat Model: A Novel Hydrogen Administration Method
- in-vivo, NA, NA
*creat↓, *ROS↓, *other↑, *MDA↓, *other↑, *Inflam↓,
2415- SK,    Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways
- in-vivo, Arthritis, NA
Apoptosis?, TumAuto↑, ROS↑, ATP↓, Glycolysis↓, PI3K↓, Akt↓, mTOR↓, *Apoptosis↓, *Inflam↓, *TNF-α↓, *IL6↓, *IL8↓, *IL10↓, *IL17↓, *hepatoP↑, *RenoP↑, PKM2↓, GLUT1↓, HK2↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2196- SK,    Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species
- Review, Var, NA
*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,
2215- SK,  doxoR,    Shikonin alleviates doxorubicin-induced cardiotoxicity via Mst1/Nrf2 pathway in mice
- in-vivo, Nor, NA
*cardioP↑, *ROS↓, *Inflam↓, *Mst1↓, *NRF2↑, *eff↓, *antiOx↑, *SOD↑, *GSH↑, *TNF-α↓, BAX↓, Bcl-2↑,
2213- SK,    Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation
- in-vivo, Stroke, NA
*neuroP↑, *Inflam↓, *iNOS↓, *TNF-α↓, *IL1β↓, *IL6↓, *ARG1/2↑, *TGF-β↑, *IL10↑, *NF-kB↓, *eff↓,

Showing Research Papers: 1001 to 1050 of 1166
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1166

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   Catalase↑, 2,   CYP1A1↓, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 1,   HO-1↑, 4,   lipid-P↓, 2,   MDA↑, 1,   MPO↓, 1,   NRF2↑, 2,   Prx↓, 1,   ROS?, 1,   ROS↓, 4,   ROS↑, 5,   ROS⇅, 1,   SOD↑, 1,   TrxR1↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   MEK↓, 1,   MMP↓, 4,   Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   cMyc↓, 3,   Glycolysis↓, 2,   HK2↓, 1,   NAD↑, 1,   NADPH↑, 1,   PKM2↓, 2,   SIRT1↓, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 4,   BAX↓, 1,   BAX↑, 4,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 3,   BIM↓, 1,   Casp↑, 2,   Casp3↓, 1,   Casp3↑, 5,   Casp9↑, 5,   Cyt‑c↑, 5,   DR5↑, 1,   iNOS↓, 2,   JNK↑, 1,   p‑JNK↓, 1,   p‑JNK↑, 2,   MAPK↓, 2,   Mcl-1↓, 2,   p27/CDKN1B↑, 2,   p‑p38↓, 2,   p‑p38↑, 1,   survivin↓, 4,   Telomerase↓, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↑, 2,   p‑pRB↓, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↑, 3,   cl‑PARP↑, 2,   PCNA↓, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 3,   CDK4↑, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↑, 3,   RB1↑, 1,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 4,   p‑ERK↓, 3,   HDAC↓, 2,   IGFBP3↑, 1,   mTOR↓, 2,   NOTCH↓, 1,   NOTCH1↓, 1,   PI3K↓, 3,   STAT3↓, 5,   p‑STAT3↓, 1,   TumCG↓, 4,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↑, 1,   CA↓, 1,   Ca+2↑, 1,   CD31/PECAM-1↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   miR-203↑, 1,   MMP2↓, 3,   MMP9↓, 2,   MMPs↓, 2,   N-cadherin↓, 1,   PDGF↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 2,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 3,   TumMeta↓, 5,   uPA↓, 2,   Vim↓, 2,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 7,   ATF4↑, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 4,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   GLUT1↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   CXCR4↓, 3,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 2,   IL10↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 3,   Inflam↓, 12,   JAK2↓, 1,   MDSCs↓, 1,   NF-kB↓, 5,   PD-L1↓, 2,   PGE2↓, 3,   PSA↓, 2,   TNF-α↓, 3,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   ChemoSen↑, 3,   Dose↝, 4,   eff↑, 8,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 2,   RadioS↑, 1,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 1,   AST↓, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 3,   PD-L1↓, 2,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   cardioP↑, 3,   chemoP↑, 7,   chemoPv↑, 2,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   neuroP↑, 3,   radioP↑, 3,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 1,  
Total Targets: 192

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 13,   Catalase↑, 4,   Ferroptosis↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 4,   GPx4↓, 1,   GSH↓, 1,   GSH↑, 14,   GSR↑, 2,   GSTs↑, 2,   HO-1↑, 8,   HO-1↝, 1,   Iron↓, 1,   lipid-P?, 1,   lipid-P↓, 8,   lipid-P↑, 1,   MDA↓, 7,   NQO1↑, 4,   NRF2↓, 1,   NRF2↑, 15,   ROS↓, 27,   ROS↑, 1,   SOD↑, 10,   TAC↑, 1,   Trx↑, 2,   TrxR↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   NCOA4↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALAT↓, 6,   AMPK↑, 1,   FASN↓, 1,   glucose↓, 1,   LDH↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PPARγ↑, 1,   SIRT1↑, 2,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Apoptosis↓, 2,   Casp↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Ferroptosis↓, 1,   iNOS↓, 9,   p‑JNK↓, 1,   MAPK↓, 3,   necrosis↓, 2,   p38↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↑, 1,   HSP70/HSPA5↑, 1,   HSPs↓, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   ERK↓, 2,   p‑ERK↓, 2,   HDAC↓, 1,   Mst1↓, 1,   OCT4↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   ARG1/2↑, 1,   Fibronectin↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   MMP9↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   α-SMA↓, 2,   α-SMA↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,   Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↑, 2,   GLUT4↑, 1,   OATPs↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IFN-γ↓, 4,   p‑IKKα↓, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 3,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 8,   IL2↓, 3,   IL4↓, 4,   IL6↓, 10,   IL8↓, 6,   Inflam?, 1,   Inflam↓, 38,   LTA/TNF-β↓, 1,   NF-kB↓, 15,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 13,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 2,   BChE↓, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE/β-secretase↓, 1,   NLRP3↓, 4,   β-Amyloid↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 6,   Dose↝, 3,   eff↓, 2,   eff↑, 2,   Half-Life?, 1,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   AST↓, 6,   creat↓, 1,   EGFR↓, 1,   GutMicro↑, 1,   GutMicro↝, 1,   IL6↓, 10,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   cardioP↑, 4,   chemoP↑, 2,   cognitive↑, 5,   hepatoP↑, 14,   memory↑, 5,   neuroP↑, 13,   neuroP↝, 1,   OS↑, 1,   radioP↑, 1,   RenoP↑, 2,   Strength↑, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 154

Scientific Paper Hit Count for: Inflam, inflammation
43 Hydrogen Gas
40 Curcumin
33 Thymoquinone
32 Quercetin
31 Magnetic Fields
30 Silymarin (Milk Thistle) silibinin
23 Resveratrol
18 Alpha-Lipoic-Acid
18 Berberine
18 Selenium NanoParticles
18 Fisetin
18 Rosmarinic acid
17 Lycopene
16 Ashwagandha(Withaferin A)
16 Ferulic acid
15 Capsaicin
15 Carvacrol
15 Kaempferol
15 Sulforaphane (mainly Broccoli)
15 Urolithin
14 Apigenin (mainly Parsley)
14 Propolis -bee glue
14 Emodin
14 Eugenol
14 Honokiol
13 Silver-NanoParticles
13 Beta-Caryophyllene
13 Licochalcone A
12 Radiotherapy/Radiation
12 Baicalein
12 Chlorogenic acid
12 Chrysin
11 Cinnamon
11 Isoliquiritigenin
10 Crocetin
10 Chemotherapy
10 Dandelion Root
10 EGCG (Epigallocatechin Gallate)
10 Pterostilbene
9 Selenite (Sodium)
9 Isovitexin
9 Boron
9 Ginger/6-Shogaol/Gingerol
8 Astaxanthin
8 Boswellia (frankincense)
8 α-Bisabolol / Chamomile oil
8 Rutin
8 Diclofenac
8 Fucoidan
8 Piperlongumine
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Allicin (mainly Garlic)
7 Betulinic acid
7 Vitamin B3,Niacin
7 Butyrate
7 Centella asiatica / Gotu kola → asiaticoside
7 D-limonene
7 Gallic acid
7 Hyperoside
6 1,8-Cineole
6 Artemisinin
6 Aspirin
6 Caffeic acid
6 Thymol-Thymus vulgaris
6 Hydroxycinnamic-acid
6 Garcinol
6 HydroxyTyrosol
6 isoorientin
6 Vitexin
6 Luteolin
6 Magnolol
6 Piperine
5 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
5 Folic Acid, Vit B9
5 Cisplatin
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Celastrol
5 chitosan
5 Chocolate
5 Coenzyme Q10
5 Ellagic acid
5 Shilajit/Fulvic Acid
5 isoquercitrin
5 Lactoferrin/Talactoferrin
5 Magnetic Field Rotating
5 Ursolic acid
4 Bacopa monnieri
4 Cichoric acid / Chicoric acid
4 Carvone
4 Ginkgo biloba-EGb 761
4 Formononetin
4 Ginkgo biloba
4 Geraniol
4 Ginkgetin
4 Isobavachalcone
4 Mung Bean Sprouts
4 Lemongrass Extract/Citral
4 Moringa oleifera
4 nicotinamide adenine dinucleotide
4 Nimbolide
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin D3
4 Vitamin K2
3 Anethole/trans-Anethole
3 Lutein
3 Naringin
3 Baicalin
3 Biochanin A
3 Vitamin B12
3 Bromelain
3 doxorubicin
3 Lecithin
3 Carnosine
3 Chyawanprash
3 Spermidine
3 Cucurbitacin
3 Date Fruit Extract
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 diet Fermented Foods
3 Exercise
3 Gamma-aminobutyric acid
3 Genistein (soy isoflavone)
3 HydroxyCitric Acid
3 Inositol
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Licorice
3 Methylsulfonylmethane
3 α-Santalol/Sandalwood oil
3 Sulfasalazine
3 Vitamin B1/Thiamine
2 Anthocyanins
2 alpha Linolenic acid
2 Fennel Oil/Foeniculum vulgare
2 Melatonin
2 brusatol
2 borneol
2 buckwheat sprouts
2 Paclitaxel/Taxol
2 Cat’s Claw
2 Celecoxib
2 Chlorophyllin
2 Choline
2 methotrexate
2 Selenium
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Galantamine
2 Huperzine A/Huperzia serrata
2 diet Short Term Fasting
2 Dipyridamole
2 Echinacea
2 Eurycomanone
2 flavonoids
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Ginkgolide B
2 Ginseng
2 Grapeseed extract
2 hydrogen sulfide
2 Orlistat
2 Hibiscus sabdariffa
2 Oleuropein
2 iodine
2 Inulin Prebiotic
2 isoflavones
2 Ivermectin
2 Juglone
2 Potassium
2 probiotics
2 Methyl salicylate / Sweet Birch oil
2 Mushroom Lion’s Mane
2 Oleocanthal
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Salvia miltiorrhiza
2 Terpinen-4-ol / Tea Tree Oil
2 Aflavin-3,3′-digallate
2 Turmerones
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Annona atemoya Seed Extract
1 Astragalus
1 Acetyl-l-carnitine
1 Morin
1 Aloe anthraquinones
1 beta-glucans
1 xanthohumol
1 Cannabidiol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Brucea javanica
1 Bruteridin(bergamot juice)
1 Black Seed Oil/Nigella sativa
1 Carnosic acid
1 Cannabichromene
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Prebiotic
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Copper and Cu NanoParticles
1 Rivastigmine
1 Cynaropicrin
1 Deguelin
1 Dihydrocaffeic Acid
1 Disulfiram
1 immunotherapy
1 Electrical Pulses
1 Evodiamine
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Galloflavin
1 Gambogic Acid
1 Ginkgolic acids
1 Bifidobacterium animalis subsp. lactis GCL2505
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 Helleborus niger extracts – Christmas Rose
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Butein
1 Scopoletin
1 Lactobacillus
1 Linalool
1 Zeaxanthin
1 5-fluorouracil
1 MCToil
1 Metformin
1 Neem
1 Oregano
1 Peppermint
1 Propyl gallate
1 Phenolic Acids
1 Psoralidin
1 Parthenolide
1 EMF
1 Radio Frequency
1 Aromatherapy
1 Gold NanoParticles
1 Sesame seeds and Oil
1 Silicic Acid
1 cetuximab
1 Terminalia bellirica
1 Thyme
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:953  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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