Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1/CCL2↓, *IP-10/CXCL-10↓, *PGE2↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,
3432- TQ,    Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases
- Review, AD, NA - Review, Park, NA
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *antiOx↑, *TLR1↓, *AChE↓, *MMP↑, *neuroP↑, *lipid-P↓, *SOD↑, *GSH↑, *Ach↑,
3425- TQ,    Advances in research on the relationship between thymoquinone and pancreatic cancer
Apoptosis↑, TumCP↓, TumCI↓, TumMeta↓, ChemoSen↑, angioG↓, Inflam↓, NF-kB↓, PI3K↓, Akt↓, TGF-β↓, Jun↓, p38↑, MAPK↑, MMP9↓, PKM2↓, ROS↑, JNK↑, MUC4↓, TGF-β↑, Dose↝, FAK↓, NOTCH↓, PTEN↑, mTOR↓, Warburg↓, XIAP↓, COX2/PTGS2↓, Casp9↑, Ki-67↓, CD34↓, VEGF↓, MCP1/CCL2↓, survivin↓, Cyt‑c↑, Casp3↑, H4↑, HDAC↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2/KDR/Flk1↓, Ki-67↓, COX2/PTGS2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
6452- TUR,    Turmeric Essential Oil Constituents as Potential Drug Candidates: A Comprehensive Overview of Their Individual Bioactivities
- Review, Nor, NA
Dose↝, Casp3↑, MMP9↓, COX2/PTGS2↓, NF-kB↓, PI3K↓, Akt↓, ERK↓, Inflam↓, TNF-α↓, IL6↓, IL17↓, IL22↓, IL23↓,
6459- TUR,    Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis
- in-vivo, Nor, NA - in-vivo, Colon, NA
*NO?, eff↑, eff↑, AntiTum↑, *Inflam↓,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
5934- TV,    Protective Effects of Natural Antioxidants on Inflammatory Bowel Disease: Thymol and Its Pharmacological Properties
- Review, Var, NA
*Inflam↓, *antiOx↑, *Bacteria↓, AntiTum↑, *toxicity∅, *IBI↑, *ZO-1↑, *OCLN↑, *COX1↑, *TLR4↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *TAC↑, *NRF2↑, *GutMicro↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
5018- UA,    Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
- Review, Var, NA
Inflam↓, TumCCA↑, chemoPv↑, TumMeta↓, antiOx↑, AntiViral↑, AntiDiabetic↑,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
3790- UA,    Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools
*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,
3788- UA,  RosA,    Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer’s disease
- in-vivo, AD, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *memory↑, *Inflam↓, *ROS↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4867- Uro,    Urolithin A exhibits a neuroprotective effect against Alzheimer’s disease by inhibiting DYRK1A activity
- in-vivo, AD, NA - in-vitro, AD, HEK293
*neuroP↑, *DYRK1A↓, *memory↑, *p‑tau↓, *Inflam↓,
4864- Uro,    Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease
- Review, AD, NA
*neuroP↑, *Half-Life↝, *BBB↑, *toxicity↓, *Inflam↓, *Strength↑, *BACE/β-secretase↓, *Aβ↓, *MitoP↑, *SIRT1↑, *SIRT3↑, *AMPK↑, *PGC-1α↑, *mTOR↓, *PARK2↑, *Beclin-1/ATG6↑, *ROS↓, *GutMicro↑, *Risk↓,
4860- Uro,    Urolithins–gut Microbial Metabolites with Potential Health Benefits
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*ROS↓, *Inflam↓, TumCG↓, *neuroP↑, *cardioP↑, *LDL↓, *BioAv↝, *BioAv↓, *BioAv↑, *SIRT1↑, *mTOR↑, *BDNF↑, *cognitive↑,
4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *neuroP↑, *Aβ↓, *AMPK↑, *NF-kB↓, *MAPK↓, *BACE/β-secretase↑, *neuroG↑, *Inflam↓, *memory↑,
4872- Uro,    Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity
- in-vitro, AD, HEK293
*DYRK1A↓, *antiOx↑, *Inflam↓, *neuroP↑, *memory↑, *p‑tau↓, *Aβ↓, *neuroP↑,
4875- Uro,    Impact of the Natural Compound Urolithin A on Health, Disease, and Aging
- Review, AD, NA - Review, Stroke, NA - Review, ostP, NA - Review, IBD, NA
*MitoP↓, *Strength↑, *PINK1↑, *PARK2↑, *Inflam↓, *COX2/PTGS2↓, *IL1β↓, *IL6↓, *TNF-α↓, *OS↑, *cardioP↑, *memory↑, *neuroG↑, *neuroP↑, *Cartilage↑, *Inflam↓, *RenoP↑, *eff↑, *Dose↝, *Half-Life↑, *NRF2↑, *GutMicro↑,
4876- Uro,    Urolithin A in Health and Diseases: Prospects for Parkinson’s Disease Management
- Review, Park, NA - Review, AD, NA
*Inflam↓, *antiOx↓, *neuroP↑, *p‑tau↓, *Aβ↓, *eff↑, *BioAv↓, *BioAv↑, *GSH↑, *SOD↑, *lipid-P↓, *Catalase↑, *GSR↑, *GPx↑, *ROS↓, *NRF2↑, *GutMicro↑, *Risk↓, *BBB↓, *NLRP3↓, *MAOA↓,
4877- Uro,    Urolithin-A Derivative UAS03 Improves Cognitive Deficits and Memory by Activating Nrf2 Pathways to Alleviate Oxidative Stress and Neuroinflammation
- in-vivo, AD, NA
*cognitive↑, *memory↑, *neuroP↑, *NRF2↑, *ROS↓, *Inflam↓, *IL1β↓, *TNF-α↓, *COX2/PTGS2↓,
4880- Uro,    Urolithins: A Prospective Alternative against Brain Aging
- Review, AD, NA
*cognitive↑, *memory↑, *antiOx↑, *BBB↑, *ROS↓, *lipid-P↓, *Catalase↑, *SOD↑, *GSR↑, *GPx↑, *CREB↑, *BDNF↑, *neuroP↑, *Inflam↓, *MitoP↑, *Aβ↓, *tau↓, *NLRP3↓, *SIRT1↑, *SIRT3↑,
4884- Uro,    A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease
- Review, AD, NA
*antiOx↑, *neuroG↑, *Inflam↓, *cognitive↑,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4838- Uro,    The Therapeutic Potential of Urolithin A for Cancer Treatment and Prevention
- Review, Var, NA
BioAv↑, Inflam↓, IL6↓, IL1β↓, NOS2↓, p53 Wildtype↑, MDM2↑, Snail↓, E-cadherin↑, N-cadherin↓, Vim↓, NF-kB↓, mTOR↓, p‑Akt↓, selectivity↑, EMT↓,
4842- Uro,    Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MCF7 - in-vitro, BC, 4T1
Inflam↓, IL6↓, TNF-α↓, eff↑, STAT3↓, TumCP↓, TumCMig↓,
4852- Uro,    Dietary Urolithin B Suppresses Lung Tumorigenesis Correlating with Autophagy Induction and Gut Microbiota Remodeling
- vitro+vivo, Lung, NA
TumCG↓, *GutMicro↑, *Inflam↓, *antiOx↑, AntiTum↑, TumCCA↑, Apoptosis↑,
4313- VitA,RetA,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*neuroP↑, memory↑, *Inflam↓, *neuroG↑, *cognitive↑, *Aβ↓, p‑tau↓, *BACE/β-secretase↓,
4312- VitB1/Thiamine,    Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease
- Review, AD, NA
*eff↑, *cognitive↑, *memory↑, *GlucoseCon↑, *Aβ↓, *Inflam↓, *antiOx↑, *p‑tau↓, *AGEs↓, *Dose↝,
4310- VitB1/Thiamine,    Pharmacological thiamine (Vitamin B1) as a treatment for alzheimer’s disease
- Review, AD, NA
*other↝, *memory↑, *Inflam↓, *p‑tau↓,
4311- VitB1/Thiamine,    Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy
- in-vivo, AD, NA
*Aβ↓, *p‑tau↓, *ROS↓, *cognitive↑, *OS↑, *Mood↑, *neuroP↑, *Inflam↓, *NRF2↑, *PGC-1α↑, *AGEs↓, *4-HNE↓, *NQO1↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *GSK‐3β↓,
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE/β-secretase↓, *ATP↑, *neuroP↑,
4315- VitB2,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
*GlucoseCon↑, *ATP↑, *Hcy/homoC↓, *ROS↓, *Aβ↓, *Aβ↓, *Inflam↓,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE/β-secretase↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
4032- VitB3,    Modulation of cGAS-STING Pathway by Nicotinamide Riboside in Alzheimer's Disease
- in-vivo, AD, NA
*DNAdam↓, *Inflam↓, *other↓, *cognitive↑, *Mood↑,
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, NA, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,
4317- VitB5,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Ach↑, *ROS↓, *Inflam↓, *p‑tau↓, *Aβ↓, *Acetyl-CoA↑, *ATP↑, *ChAT↑, *memory↑,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,
4329- VitB5,    Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer's Disease Pathogenesis in a Transgenic Mouse Model
- in-vivo, AD, NA
*Aβ↓, *Mood↑, *neuroP↑, *Inflam↓, *TNF-α↓, *BBB↝, *other↝, *Dose↝,
4328- VitB5,    Pantethine
- Review, AD, NA
*BBB↝, *LDL↓, *lipid-P↓, *AST↓, *ALAT↓, *TGF-β↓, *adiP↑, *Inflam↓, TumCG↓, FASN↓,
4319- VitC,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, *Inflam↓, *Risk↓, *cognitive↑,
3146- VitC,    Vitamin C protects against hypoxia, inflammation, and ER stress in primary human preadipocytes and adipocytes
- in-vivo, Nor, NA
*Obesity↓, *ER Stress↓, *Inflam↓, Hif1a↓, VEGF↓, GLUT1↓, GRP78/BiP↓,
3149- VitC,    Hepatoprotective benefits of vitamin C against perfluorooctane sulfonate-induced liver damage in mice through suppressing inflammatory reaction and ER stress
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *TNF-α↓, *IL6↓, *ER Stress↓, *ATF6↓, *eIF2α↓, *GRP78/BiP↓, *XBP-1↓, *Inflam↓,
3111- VitC,    https://pmc.ncbi.nlm.nih.gov/articles/PMC4492638/
- Trial, Nor, NA
Inflam↓, CRP↓, IL6↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,
3125- VitC,    Vitamin C inhibits NLRP3 inflammasome activation and delays the development of age-related hearing loss in male C57BL/6 mice
- in-vivo, Nor, NA
*Hear↑, *Inflam↓, *NLRP3↓,

Showing Research Papers: 1101 to 1150 of 1166
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1166

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   H2O2↑, 1,   lipid-P↑, 1,   ROS↑, 4,   ROS⇅, 1,   i-ROS↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   MMP↓, 3,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 1,   cMyc↓, 2,   cMyc↑, 1,   FAO↑, 1,   FASN↓, 2,   Glycolysis↓, 1,   HK2↓, 2,   lactateProd↓, 2,   PKM2↓, 2,   PPARγ↓, 1,   SIRT1↓, 1,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 7,   Bak↑, 1,   BAX↑, 6,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 3,   Casp↑, 2,   Casp3↑, 8,   Casp7↑, 2,   Casp8↑, 3,   Casp9↑, 6,   Cyt‑c↑, 3,   DR5↑, 1,   JNK↑, 3,   MAPK↓, 1,   MAPK↑, 1,   MDM2↑, 1,   p27/CDKN1B↑, 2,   p38↑, 3,   survivin↓, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   H4↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   DNAdam↑, 2,   DNMT1↓, 2,   DNMT3A↓, 1,   P53↑, 5,   p53 Wildtype↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 1,   P21↓, 1,   P21↑, 2,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   EMT↓, 4,   ERK↓, 4,   p‑ERK↓, 2,   FOXO1↑, 1,   GSK‐3β↓, 1,   HDAC↓, 3,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   Jun↓, 1,   mTOR↓, 4,   NOTCH↓, 1,   PI3K↓, 6,   PTEN↑, 4,   STAT3↓, 3,   p‑STAT3↓, 1,   TumCG↓, 4,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   CD31/PECAM-1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 2,   Ki-67↓, 3,   MMP2↓, 1,   MMP9↓, 4,   MMPs↓, 2,   MUC4↓, 1,   N-cadherin↓, 2,   PKA↓, 1,   PKCδ↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 7,   TumMeta↓, 5,   Twist↓, 3,   Vim↓, 2,   Zeb1↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   angioG↑, 1,   EGFR↓, 1,   Hif1a↓, 1,   NO↑, 1,   VEGF↓, 4,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 6,   CRP↓, 1,   CXCR4↓, 1,   IFN-γ↓, 1,   IL17↓, 2,   IL1β↓, 1,   IL22↓, 1,   IL23↓, 1,   IL6↓, 5,   Imm↑, 1,   Inflam↓, 9,   JAK2↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   p‑NF-kB↑, 1,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 2,   ChemoSen↑, 7,   Dose↝, 2,   eff↓, 1,   eff↑, 9,   RadioS↑, 2,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 1,   EZH2↓, 1,   GutMicro↑, 1,   IL6↓, 5,   Ki-67↓, 3,   Maspin↑, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 3,   AntiDiabetic↑, 1,   AntiTum↑, 4,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 1,   radioP↑, 1,   RenoP↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 172

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 2,   antiOx↑, 14,   Catalase↑, 9,   Ferroptosis↓, 1,   GPx↑, 9,   GSH↑, 7,   GSR↑, 2,   GSTA1↑, 1,   GSTs↑, 2,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 6,   MDA↓, 3,   NADH↓, 1,   NQO1↑, 1,   NRF2↑, 8,   PARK2↑, 3,   RNS↓, 1,   ROS↓, 20,   SIRT3↑, 2,   SOD↑, 12,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 5,   MMP↑, 4,   PGC-1α↑, 3,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↑, 1,   adiP↑, 1,   ALAT↓, 2,   AMPK↑, 3,   CREB↑, 1,   G6PD↑, 1,   GlucoseCon↑, 2,   LDL↓, 3,   NAD↑, 2,   NADPH↑, 2,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 2,   other↓, 2,   other↑, 4,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↓, 1,   eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   DYRK1A↓, 2,   MitoP↓, 1,   MitoP↑, 3,   p62↓, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   mTOR↓, 2,   mTOR↑, 1,   neuroG↑, 4,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↑, 1,   APP↓, 1,   Cartilage↑, 2,   MMP13↓, 1,   TGF-β↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO?, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 4,   BBB↝, 2,   GastroP↑, 1,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX1↑, 1,   COX2/PTGS2↓, 5,   CRP↓, 3,   IL12↓, 1,   IL1β↓, 9,   IL2↓, 1,   IL5↓, 1,   IL6↓, 8,   Imm↑, 1,   Inflam↓, 42,   IP-10/CXCL-10↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   PGE2↓, 2,   TLR1↓, 1,   TLR4↓, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↑, 3,   ChAT↑, 1,   MAOA↓, 1,   tau↓, 1,   p‑tau↓, 10,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2,   Aβ↓, 16,   BACE/β-secretase↓, 4,   BACE/β-secretase↑, 1,   NLRP3↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 5,   BioAv↝, 4,   Dose↝, 4,   eff↑, 7,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BP↓, 1,   CRP↓, 3,   GutMicro↑, 6,   Hcy/homoC↓, 1,   IL6↓, 8,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   cardioP↑, 7,   cognitive↑, 15,   Hear↑, 1,   hepatoP↑, 5,   memory↑, 13,   Mood↑, 3,   motorD↑, 1,   neuroP↑, 23,   Obesity↓, 2,   OS↑, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 4,   Strength↑, 3,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 147

Scientific Paper Hit Count for: Inflam, inflammation
43 Hydrogen Gas
40 Curcumin
33 Thymoquinone
32 Quercetin
31 Magnetic Fields
30 Silymarin (Milk Thistle) silibinin
23 Resveratrol
18 Alpha-Lipoic-Acid
18 Berberine
18 Selenium NanoParticles
18 Fisetin
18 Rosmarinic acid
17 Lycopene
16 Ashwagandha(Withaferin A)
16 Ferulic acid
15 Capsaicin
15 Carvacrol
15 Kaempferol
15 Sulforaphane (mainly Broccoli)
15 Urolithin
14 Apigenin (mainly Parsley)
14 Propolis -bee glue
14 Emodin
14 Eugenol
14 Honokiol
13 Silver-NanoParticles
13 Beta-Caryophyllene
13 Licochalcone A
12 Radiotherapy/Radiation
12 Baicalein
12 Chlorogenic acid
12 Chrysin
11 Cinnamon
11 Isoliquiritigenin
10 Crocetin
10 Chemotherapy
10 Dandelion Root
10 EGCG (Epigallocatechin Gallate)
10 Pterostilbene
9 Selenite (Sodium)
9 Isovitexin
9 Boron
9 Ginger/6-Shogaol/Gingerol
8 Astaxanthin
8 Boswellia (frankincense)
8 α-Bisabolol / Chamomile oil
8 Rutin
8 Diclofenac
8 Fucoidan
8 Piperlongumine
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Allicin (mainly Garlic)
7 Betulinic acid
7 Vitamin B3,Niacin
7 Butyrate
7 Centella asiatica / Gotu kola → asiaticoside
7 D-limonene
7 Gallic acid
7 Hyperoside
6 1,8-Cineole
6 Artemisinin
6 Aspirin
6 Caffeic acid
6 Thymol-Thymus vulgaris
6 Hydroxycinnamic-acid
6 Garcinol
6 HydroxyTyrosol
6 isoorientin
6 Vitexin
6 Luteolin
6 Magnolol
6 Piperine
5 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
5 Folic Acid, Vit B9
5 Cisplatin
5 Caffeic Acid Phenethyl Ester (CAPE)
5 Celastrol
5 chitosan
5 Chocolate
5 Coenzyme Q10
5 Ellagic acid
5 Shilajit/Fulvic Acid
5 isoquercitrin
5 Lactoferrin/Talactoferrin
5 Magnetic Field Rotating
5 Ursolic acid
4 Bacopa monnieri
4 Cichoric acid / Chicoric acid
4 Carvone
4 Ginkgo biloba-EGb 761
4 Formononetin
4 Ginkgo biloba
4 Geraniol
4 Ginkgetin
4 Isobavachalcone
4 Mung Bean Sprouts
4 Lemongrass Extract/Citral
4 Moringa oleifera
4 nicotinamide adenine dinucleotide
4 Nimbolide
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin D3
4 Vitamin K2
3 Anethole/trans-Anethole
3 Lutein
3 Naringin
3 Baicalin
3 Biochanin A
3 Vitamin B12
3 Bromelain
3 doxorubicin
3 Lecithin
3 Carnosine
3 Chyawanprash
3 Spermidine
3 Cucurbitacin
3 Date Fruit Extract
3 Docosahexaenoic Acid
3 eicosapentaenoic acid
3 diet Fermented Foods
3 Exercise
3 Gamma-aminobutyric acid
3 Genistein (soy isoflavone)
3 HydroxyCitric Acid
3 Inositol
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Licorice
3 Methylsulfonylmethane
3 α-Santalol/Sandalwood oil
3 Sulfasalazine
3 Vitamin B1/Thiamine
2 Anthocyanins
2 alpha Linolenic acid
2 Fennel Oil/Foeniculum vulgare
2 Melatonin
2 brusatol
2 borneol
2 buckwheat sprouts
2 Paclitaxel/Taxol
2 Cat’s Claw
2 Celecoxib
2 Chlorophyllin
2 Choline
2 methotrexate
2 Selenium
2 Vitamin E
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Galantamine
2 Huperzine A/Huperzia serrata
2 diet Short Term Fasting
2 Dipyridamole
2 Echinacea
2 Eurycomanone
2 flavonoids
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Ginkgolide B
2 Ginseng
2 Grapeseed extract
2 hydrogen sulfide
2 Orlistat
2 Hibiscus sabdariffa
2 Oleuropein
2 iodine
2 Inulin Prebiotic
2 isoflavones
2 Ivermectin
2 Juglone
2 Potassium
2 probiotics
2 Methyl salicylate / Sweet Birch oil
2 Mushroom Lion’s Mane
2 Oleocanthal
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Salvia miltiorrhiza
2 Terpinen-4-ol / Tea Tree Oil
2 Aflavin-3,3′-digallate
2 Turmerones
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Annona atemoya Seed Extract
1 Astragalus
1 Acetyl-l-carnitine
1 Morin
1 Aloe anthraquinones
1 beta-glucans
1 xanthohumol
1 Cannabidiol
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Brucea javanica
1 Bruteridin(bergamot juice)
1 Black Seed Oil/Nigella sativa
1 Carnosic acid
1 Cannabichromene
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chaetocin
1 Prebiotic
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Copper and Cu NanoParticles
1 Rivastigmine
1 Cynaropicrin
1 Deguelin
1 Dihydrocaffeic Acid
1 Disulfiram
1 immunotherapy
1 Electrical Pulses
1 Evodiamine
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Galloflavin
1 Gambogic Acid
1 Ginkgolic acids
1 Bifidobacterium animalis subsp. lactis GCL2505
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 Graviola
1 Germacranolide sesquiterpene lactone
1 Siegesbeckia glabrescens
1 Helleborus niger extracts – Christmas Rose
1 Hops (Humulus lupulus)
1 Indole-3-carbinol
1 Butein
1 Scopoletin
1 Lactobacillus
1 Linalool
1 Zeaxanthin
1 5-fluorouracil
1 MCToil
1 Metformin
1 Neem
1 Oregano
1 Peppermint
1 Propyl gallate
1 Phenolic Acids
1 Psoralidin
1 Parthenolide
1 EMF
1 Radio Frequency
1 Aromatherapy
1 Gold NanoParticles
1 Sesame seeds and Oil
1 Silicic Acid
1 cetuximab
1 Terminalia bellirica
1 Thyme
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:953  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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