eff Cancer Research Results

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Power to enhance an anti cancer effect
Scientific Papers found: Click to Expand⟱
8206- LCA,    Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways
- in-vivo, GC, BGC-823
ROS?, Casp3↑, cl‑PARP↑, eff↓, ERK↑, JNK↑, MAPK↑, AntiP↑, AntiTum↑, TumCP↓, selectivity↑, GSH/GSSG↓, MDA↑, lipid-P↑, PI3K↓, Akt↓,
8207- LCA,    Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, Apoptosis↑, eff↓, TrxR1↓, cDC2↓, Bcl-2↓, BAX↑, NRF2↓, p‑ASK1↑,
8217- LCA,    Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
- Study, Nor, NA
*CYP1A1↓, *CYP2C19↓, *CYP2C8↓, *CYP2C9↓, *CYP3A4↓, *CYP2E1↓, *CYP2D6↓, *BioEnh↑, eff↑,
8264- LE,  ISL,    Glycyrrhiza glabra L. Extracts with Potential Antiproliferative and Anti-Migration Activities Against Breast and Gynecological Cancer Cell Lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, A2780S - in-vitro, Cerv, HeLa
eff↑, Dose↝, Dose↑,
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, CDK2↓, PI3K↓, cJun↓, mTOR↓, NF-kB↓, VEGF↓, MMP3↓, toxicity↓, Dose↑, chemoP↑, *antiOx↑, *Inflam↓, Dose↝, *COX2/PTGS2↓, *iNOS↓, *IL6↓, *IL10↓, *PGE2↓, *IκB?, *NRF2↑, *HO-1↑, *lipid-P↓, *ROS↓, *Catalase↑, *GPx↑, *SOD↑, Apoptosis↑, ROS↑, TumCP↓, TumCCA↑, cycE/CCNE↓, cycD1/CCND1↓, p‑GSK‐3β↓, PI3K↓, MKK4↓, MKK7↓, HSP90↓, LC3‑Ⅱ/LC3‑Ⅰ↑, Beclin-1/ATG6↑, p62↓, p‑Akt↓, cl‑Casp9↑, cl‑Casp7↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, Cyt‑c↑, P53↑, STAT3↓, E-cadherin↑, Vim↓, N-cadherin↓, CD31/PECAM-1↓, Hif1a↓, iNOS↓, DNAdam↑, MMP↓, BIM↑, APAF1↑, PCNA↓, toxicity↝, eff↑,
1790- LEC,  DHA,    Dietary Crude Lecithin Increases Systemic Availability of Dietary Docosahexaenoic Acid with Combined Intake in Rats
- in-vivo, Nor, NA
*eff↑, other↑,
1791- LEC,    Vegetable lecithins: A review of their compositional diversity, impact on lipid metabolism and potential in cardiometabolic disease prevention
- Review, Nor, NA
*BioEnh↑, *antiOx↑, *BioEnh↑, *LDL↓, *HDL∅, *Obesity↓, eff↑, GutMicro↝,
1795- LEC,  Chit,    Self-assembled lecithin-chitosan nanoparticles improve the oral bioavailability and alter the pharmacokinetics of raloxifene
- in-vivo, Nor, NA
eff↑, BioAv↑,
8125- LF,    Talactoferrin alfa versus placebo in patients with refractory advanced non-small-cell lung cancer (FORTIS-M trial)
- Trial, NSCLC, NA
Dose?, eff∅,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8139- LF,    Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
- vitro+vivo, Pca, NA
Ferroptosis↓, AR↝, Iron↝, Ferritin↑, P53↓, eff↝, other↝, AntiTum↓,
8197- LGE,    Citral induced apoptosis in MDA-MB-231 spheroid cells
- in-vitro, BC, MDA-MB-231
eff↓, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓,
8189- LGE,    Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects
- vitro+vivo, CRC, NA
Apoptosis↑, Dose↝, selectivity↑, eff↑,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
8183- LGE,    Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT-29
TumCG↓, selectivity↑, MMP↓, ROS↑, GSH↓, eff↓, p‑P53↑, BAX↑, Bcl-2↓, Bcl-xL↓, cl‑Casp3↑,
6464- LIN,  1,8-Cin,    Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells
- in-vitro, NSCLC, A549 - in-vitro, Nor, WI38
TumCP↓, TumCCA↑, selectivity↑, ROS↑, MMP↓, eff↓, TumCMig↓, eff↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
2910- LT,  FA,    Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment
- in-vitro, BC, 4T1 - in-vivo, NA, NA
BioAv↓, BioAv↑, eff↑, tumCV↓, e-H2O2↓, i-H2O2∅,
2904- LT,    Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons
- in-vitro, Park, SK-N-SH - in-vitro, AD, NA
*ROS↓, *neuroP↑, *MMP↑, *Catalase↑, *GSH↑, selectivity↑, *eff↑, *Cyt‑c↓,
2903- LT,    Luteolin induces apoptosis by ROS/ER stress and mitochondrial dysfunction in gliomablastoma
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vivo, NA, NA
ER Stress↑, ROS↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, Casp12↑, eff↓, UPR↑, MMP↓, Cyt‑c↑, Bcl-2↓, BAX↑, TumCG↓, Weight∅, ALAT∅, AST∅,
2920- LT,    Formulation, characterization, in vitro and in vivo evaluations of self-nanoemulsifying drug delivery system of luteolin
- in-vitro, Nor, NA - in-vivo, Nor, NA
BioAv↑, eff↑,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
1534- LT,  Api,  EGCG,  RES,    Plant polyphenol induced cell death in human cancer cells involves mobilization of intracellular copper ions and reactive oxygen species generation: a mechanism for cancer chemopreventive action
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, PC, Bxpc-3
TumCP↓, Apoptosis↑, eff↓, *toxicity↑, Dose?, eff↓, eff↓,
3980- Lut,  Zeax,    Supplementation With Carotenoids, Omega-3 Fatty Acids, and Vitamin E Has a Positive Effect on the Symptoms and Progression of Alzheimer's Disease
- Trial, AD, NA
*eff↑, *memory↑, *Mood↑, *QoL↑,
3982- Lut,  Zeax,    Nutritional Intervention to Prevent Alzheimer's Disease: Potential Benefits of Xanthophyll Carotenoids and Omega-3 Fatty Acids Combined
- Trial, AD, NA
*memory↑, *eff↑, *Mood↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2/PTGS2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2/PTGS2↓, *RAGE↓,
3281- Lyco,  Chemo,    Lycopene Supplementation for Patients Under Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, Var, NA
eff↑, cardioP↑, eff?, PSA↓, RenoP↑,
3285- Lyco,    Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study
- in-vitro, Nor, NA
*AntiAg↑, *eff↑,
3287- Lyco,    Recent technological strategies for enhancing the stability of lycopene in processing and production
- Review, NA, NA
*eff↑,
1715- Lyco,    Pro-oxidant Actions of Carotenoids in Triggering Apoptosis of Cancer Cells: A Review of Emerging Evidence
- Review, Var, NA
antiOx↑, ROS↑, ChemoSen↑, selectivity↑, eff↓, Casp3↑, Casp7↑, Casp9↑, P53↑, BAX↑, DNAdam↑, mtDam↑, eff↑,
1713- Lyco,    Lycopene: A Potent Antioxidant with Multiple Health Benefits
- Review, Nor, NA
*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,
1712- Lyco,    Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair
- in-vitro, Lung, A549
ROS↓, ROS↑, eff↑,
1710- Lyco,    Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases
- Review, CardioV, NA
antiOx↓, ROS↓, BP↓, LDL↓, *toxicity∅, eff↑, ROS↑, *Half-Life↑, *BioAv↓, *BioAv↑, *antiOx↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
7742- Lyco,  isoFl,    Lycopene and soy isoflavones in the treatment of prostate cancer
- Trial, Pca, NA
Risk↓, PSA↓, Dose↝, eff↝,
1041- Lyco,  immuno,    Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells
- in-vivo, Lung, NA
TumVol↓, TumW↓, eff↑, IL1↑, IFN-γ↑, IL4↓, IL10↓,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27/CDKN1B↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
4798- Lyco,    Enhancing Anticancer Treatment Efficacy With Lycopene: A Comprehensive Review of Clinical and Preclinical Evidence
- Review, Var, NA
AntiCan↑, ChemoSen↑, eff↑, eff↑,
4792- Lyco,    A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy
- Review, Var, NA
*AntiCan↑, *antiOx↑, Inflam↓, Wnt↓, β-catenin/ZEB1↓, *ROS↓, BioAv↑, ROS↓, Risk↓, PGE2↓, COX2/PTGS2↓, p‑ERK↓, P21↑, MMP7↓, MMP9↓, ChemoSen↑, eff↑,
4790- Lyco,    Role of Lycopene in the Control of ROS-Mediated Cell Growth: Implications in Cancer Prevention
- Review, Var, NA
*antiOx↑, *ROS⇅, TumCP↓, AP-1↓, eff↓,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
2533- M-Blu,  PDT,    Methylene blue-mediated photodynamic therapy enhances apoptosis in lung cancer cells
- in-vitro, Lung, A549
MMP↓, p‑MAPK↑, ROS↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, eff↓,
4528- MAG,    Pharmacology, Toxicity, Bioavailability, and Formulation of Magnolol: An Update
- Review, Nor, NA
*Inflam↑, *cardioP↑, *angioG↓, *antiOx↑, *neuroP↑, *Bacteria↓, AntiTum↑, TumCG↓, TumCMig↓, TumCI↓, Apoptosis↑, E-cadherin↑, NF-kB↓, TumCCA↑, cycD1/CCND1↓, PCNA↓, Ki-67↓, MMP2↓, MMP7↓, MMP9↓, TumCG↓, Casp3↑, NF-kB↓, Akt↓, mTOR↓, LDH↓, Ca+2↑, eff↑, *toxicity↓, *BioAv↝, *PGE2↓, *TLR2↓, *TLR4↓, *MAPK↓, *PPARγ↓,
4517- MAG,    Mitochondrion-targeted magnolol derivatives exert synergistic anticancer activity by modulating energy metabolism and tumor microenvironment
- vitro+vivo, Var, NA
eff↑, AntiCan↑, ROS↑, ER Stress↑, Apoptosis↑,
4525- MAG,  HNK,    Magnolol and Honokiol: Two Natural Compounds with Similar Chemical Structure but Different Physicochemical and Stability Properties
- Study, Nor, NA
*BioAv↝, *eff↑,
2450- Matr,    The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
- Review, Var, NA
HK2↓, eff↓,
7824- MBS,  IVT,  VT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *ROS↓, *Inflam↓, *AChE↓, *BBB↑, *memory↑, *hepatoP↑, *Imm↑, *hyperG↓, *AntiCan↑, *eff↑, *Stroke↓, *BACE/β-secretase↓, *PI3K↓, *Akt↓, *mTOR↓, *Dose↓,
2643- MCT,    Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism
- Review, Nor, NA
*Akt↑, *AMPK↓, *TGF-β↓, eff↑, *BioEnh↑, *ATP↑, *PGC-1α↑, *p‑mTOR↑, *SMAD3↓,
2644- MCT,    The Effects of Medium-Chain Triglyceride Oil Supplementation on Endurance Performance and Substrate Utilization in Healthy Populations: A Systematic Review
- Review, Nor, NA
*KeyT↑, *Dose↝, eff↑,

Showing Research Papers: 1101 to 1150 of 1697
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1697

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiP↑, 1,   EDEM↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   CYP1A1↓, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 2,   GSH↓, 3,   GSH↑, 1,   GSH/GSSG↓, 1,   GSR↓, 1,   GSTs↓, 1,   e-H2O2↓, 1,   i-H2O2∅, 1,   HO-1↓, 1,   HO-1↑, 1,   Iron↝, 2,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 2,   NRF2↑, 1,   OXPHOS↑, 1,   mt-OXPHOS↑, 1,   ROS?, 1,   ROS↓, 4,   ROS↑, 12,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,   SOD2↓, 1,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 6,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT∅, 1,   AMPK↑, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 2,   NADPH↓, 1,   PPARγ↑, 2,   SIRT1↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 8,   p‑ASK1↑, 1,   BAX↑, 7,   Bcl-2↓, 8,   Bcl-xL↓, 1,   BIM↑, 1,   Casp1↓, 1,   Casp12↑, 1,   Casp3↑, 5,   cl‑Casp3↑, 3,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 4,   DR5↑, 1,   Fas↑, 1,   FasL↑, 1,   Ferroptosis↓, 1,   Ferroptosis↑, 1,   HGF/c-Met↓, 1,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 1,   p‑MDM2↓, 1,   p27/CDKN1B↑, 2,   p‑p38↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   H3↓, 1,   H4↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   eIF2α↑, 2,   p‑eIF2α↑, 1,   ER Stress↑, 3,   HSP90↓, 1,   HSP90↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3II↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   GADD45A↑, 1,   P53↓, 1,   P53↑, 4,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 3,   CDK4↓, 2,   cycD1/CCND1↓, 4,   CycD3↓, 1,   cycE/CCNE↓, 2,   P21↑, 3,   TumCCA↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   cDC2↓, 1,   cFos↑, 1,   EMT↓, 1,   ERK↑, 1,   p‑ERK↓, 1,   FOXO3↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 4,   NOTCH1↓, 1,   PI3K↓, 4,   p‑PI3K↓, 1,   PTEN↓, 1,   p‑Src↓, 1,   STAT3↓, 3,   p‑STAT6↓, 1,   TumCG↓, 4,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   AXL↓, 1,   Ca+2↑, 1,   CD31/PECAM-1↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FAK↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 3,   N-cadherin↓, 2,   PDGF↓, 1,   Rac1↓, 1,   Rho↓, 2,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 8,   TumMeta↓, 1,   Tyro3↓, 1,   Vim↓, 1,   Vim↑, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   ATF4↑, 2,   EGFR↑, 1,   Hif1a↓, 2,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 2,   ICAM-1↓, 1,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 6,   p‑p65↓, 1,   PD-1↓, 1,   PGE2↓, 2,   PSA↓, 2,   PSA∅, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   AR↝, 1,   GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 5,   ChemoSen↑, 5,   Dose?, 2,   Dose↑, 2,   Dose↝, 4,   eff?, 1,   eff↓, 14,   eff↑, 26,   eff↝, 2,   eff∅, 1,   RadioS↑, 1,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT∅, 1,   AR↓, 1,   AR↝, 1,   AST∅, 1,   BP↓, 1,   CEA↓, 1,   EGFR↑, 1,   Ferritin↑, 1,   GutMicro↝, 1,   IL6↓, 2,   Ki-67↓, 1,   LDH↓, 1,   NSE↓, 1,   PSA↓, 2,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↓, 1,   AntiTum↑, 2,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 2,   neuroP↑, 2,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,   TumW↓, 1,   Weight∅, 1,  
Total Targets: 253

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

anemia↓, 1,   Aβ42↓, 1,   CYP2C19↓, 1,   CYP2C8↓, 1,   CYP2D6↓, 1,   FPN↑, 1,   RBC↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 11,   mt-antiOx↑, 1,   Catalase↑, 5,   CYP1A1↓, 1,   CYP2E1↓, 1,   Fenton↓, 1,   GPx↑, 4,   GSH↑, 4,   GSTs↑, 1,   HDL∅, 1,   HO-1↑, 3,   hyperG↓, 1,   lipid-P↓, 3,   NRF2↑, 2,   ROS↓, 8,   ROS⇅, 2,   SOD↑, 6,   TAC↑, 1,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   MMP↑, 1,   mtDam↓, 1,   OCR↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↓, 1,   CREB↑, 1,   CYP3A4↓, 1,   ECAR↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   KeyT↑, 1,   LDL↓, 3,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 2,   Apoptosis↓, 1,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp3↓, 4,   Casp9↓, 1,   Casp9↑, 1,   Cyt‑c↓, 1,   iNOS↓, 1,   MAPK↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↑, 1,   UPR↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,   mTOR↓, 2,   p‑mTOR↑, 1,   PI3K↓, 1,   PTEN↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   MMPs↓, 1,   RAGE↓, 1,   SMAD3↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   IL10↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL33↓, 1,   IL6↓, 3,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 5,   Inflam↑, 1,   IκB?, 1,   NF-kB↓, 2,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   tau↓, 2,   p‑tau↓, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,   BACE/β-secretase↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 4,   BioEnh↑, 4,   ChemoSen↑, 1,   CYP2C9↓, 1,   Dose↓, 1,   Dose↝, 2,   eff↑, 14,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 1,   Ferritin↓, 1,   GutMicro↑, 1,   HemoG↑, 1,   IL6↓, 3,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   cardioP↑, 3,   cognitive↑, 2,   hepatoP↑, 1,   memory↑, 5,   Mood↑, 2,   neuroP↑, 4,   Obesity↓, 1,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 130

Scientific Paper Hit Count for: eff, efficacy
70 Silver-NanoParticles
65 Magnetic Fields
49 Curcumin
43 Sulforaphane (mainly Broccoli)
38 Vitamin C (Ascorbic Acid)
35 Thymoquinone
33 Chemotherapy
30 immunotherapy
29 EGCG (Epigallocatechin Gallate)
28 Shikonin
26 chitosan
26 Quercetin
25 Radiotherapy/Radiation
25 Piperlongumine
24 Artemisinin
23 Resveratrol
23 Selenium NanoParticles
23 Selenite (Sodium)
22 Copper and Cu NanoParticles
22 Baicalein
22 Dichloroacetate
20 Ashwagandha(Withaferin A)
20 Berberine
18 Metformin
18 Chlorogenic acid
18 Capsaicin
18 Chrysin
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
17 Gambogic Acid
16 Lycopene
16 diet FMD Fasting Mimicking Diet
16 Exercise
16 Bicarbonate(Sodium)
15 Selenium
15 Fisetin
14 3-bromopyruvate
14 Folic Acid, Vit B9
14 Hyperthermia
14 Citric Acid
14 Caffeic acid
14 Propolis -bee glue
14 Hydrogen Gas
14 Phenethyl isothiocyanate
13 Gold NanoParticles
13 Cisplatin
13 Formononetin
13 Honokiol
13 Ivermectin
12 Betulinic acid
12 Disulfiram
11 Auranofin
11 Fenbendazole
11 Melatonin
11 borneol
11 Vitamin D3
11 chaetocin
11 doxorubicin
11 salinomycin
11 diet Methionine-Restricted Diet
11 Dandelion Root
11 VitK3,menadione
11 Rosmarinic acid
10 Alpha-Lipoic-Acid
10 Luteolin
10 Atorvastatin
10 Boron
10 Choline
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 Juglone
10 Urolithin
9 Coenzyme Q10
9 Photodynamic Therapy
9 SonoDynamic Therapy UltraSound
9 Ellagic acid
9 Carvacrol
9 Electrical Pulses
9 Eugenol
8 Vitamin B12
8 isoquercitrin
8 Chlorophyllin
8 Docosahexaenoic Acid
8 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
8 Plumbagin
8 Parthenolide
7 5-fluorouracil
7 Gemcitabine (Gemzar)
7 Docetaxel
7 buckwheat sprouts
7 isoorientin
7 Carnosic acid
7 Piperine
7 Kaempferol
7 Gossypol/AT-101
6 Allicin (mainly Garlic)
6 Dipyridamole
6 beta-glucans
6 Bifidobacterium
6 Bortezomib
6 Celastrol
6 Diclofenac
6 Fucoidan
6 Ginger/6-Shogaol/Gingerol
6 HydroxyCitric Acid
6 Spermidine
6 Inositol
6 Terpinen-4-ol / Tea Tree Oil
5 1,8-Cineole
5 Astragalus
5 chemodynamic therapy
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Aspirin
5 Ascorbyl Palmitate
5 Astaxanthin
5 Berbamine
5 beta-carotene(VitA)
5 Boswellia (frankincense)
5 Thymol-Thymus vulgaris
5 Centella asiatica / Gotu kola → asiaticoside
5 Cynaropicrin
5 eicosapentaenoic acid
5 diet Plant based
5 Lemongrass Extract/Citral
5 Echinacea
5 Ginkgo biloba-EGb 761
5 Emodin
5 MCToil
5 Gallic acid
5 Gamma-aminobutyric acid
5 Ginkgolide B
5 Magnolol
5 Licochalcone A
5 Moringa oleifera
5 Nimbolide
4 2-DeoxyGlucose
4 cetuximab
4 EMF
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 almonertinib
4 Andrographis
4 Vitamin A, Retinoic Acid
4 α-Bisabolol / Chamomile oil
4 Butyrate
4 capecitabine
4 hydroxychloroquine
4 Cat’s Claw
4 Cannabidiol
4 CUSP9
4 erastin
4 diet Short Term Fasting
4 ferumoxytol
4 Ginseng
4 Isobavachalcone
4 iodine
4 Inulin Prebiotic
4 Isoliquiritigenin
4 itraconazole
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 Anthocyanins
3 Zinc
3 Anti-oxidants
3 Sorafenib (brand name Nexavar)
3 Arsenic trioxide
3 Aloe anthraquinones
3 D-limonene
3 Biochanin A
3 Beta-Caryophyllene
3 bempedoic acid
3 Lutein
3 Zeaxanthin
3 Bufalin/Huachansu
3 temozolomide
3 Vitexin
3 Rutin
3 Bullatacin
3 Chocolate
3 Cichoric acid / Chicoric acid
3 Calorie Restriction Mimetics
3 Cysteamine
3 Oxygen, Hyperbaric
3 Geldanamycin
3 Paclitaxel/Taxol
3 Garcinol
3 Ginkgo biloba
3 Germanium Organic/Ge-132 / propagermanium (organogermanium)
3 Genistein (soy isoflavone)
3 Ginkgetin
3 Hibiscus sabdariffa
3 HydroxyTyrosol
3 isoflavones
3 lambertianic acid
3 Lecithin
3 Lactoferrin/Talactoferrin
3 nicotinamide adenine dinucleotide
3 Naringin
3 Radio Frequency
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Trichostatin A
2 Glucose
2 Anethole/trans-Anethole
2 Aromatherapy
2 Trastuzumab
2 Baicalin
2 Huperzine A/Huperzia serrata
2 probiotics
2 brusatol
2 Isovitexin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Caffeine
2 Calcium
2 carboplatin
2 Celecoxib
2 Cinnamon
2 Hydroxycinnamic-acid
2 Crocetin
2 Cucurbitacin
2 Cyclopamine
2 Dichloroacetophenone(2,2-)
2 Dasatinib/Phyrago
2 Deguelin
2 Date Fruit Extract
2 statins
2 Ferulic acid
2 Vitamin E
2 Galloflavin
2 γ-linolenic acid (Borage Oil)
2 Grapeseed extract
2 Orlistat
2 Helleborus niger extracts – Christmas Rose
2 Hyperoside
2 Potassium
2 Lapatinib
2 Lapachol
2 Licorice
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 Niclosamide (Niclocide)
2 Phosphatidylserine
2 Rauwolfia serpentina/Indian Snakeroot
2 Aflavin-3,3′-digallate
2 tetrathiomolybdate
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 Anzaroot, Astragalus fasciculifolius Bioss
1 wortmannin
1 Resiquimod
1 Aidi injection
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Amodiaquine
1 DTS(dibenzyl trisulphide) from Anamu
1 Fennel Oil/Foeniculum vulgare
1 Acer okamotoanum
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 urea
1 Carnosine
1 Cannabichromene
1 Beta‐Lapachone
1 Carica papaya leaf extract
1 Camptothecin
1 irinotecan
1 Carvone
1 Polyphenols
1 Black phosphorus
1 gefitinib, erlotinib
1 Dihydrocaffeic Acid
1 diet Fermented Foods
1 diet Ketogenic
1 Mistletoe/Viscum album Extracts
1 Protocatechuic acid
1 PXD, phenoxodiol
1 Eurycomanone
1 Radicicol/monorden
1 flavonoids
1 Flickering Light Stimulation
1 olaparib/LYNPARZA
1 verapamil
1 Germanium inorganic
1 Geraniol
1 Germanium-Spirogermanium
1 Glabrescione B
1 Graviola
1 tamoxifen
1 High-Ozonide Oil
1 Indole-3-carbinol
1 entinostat
1 Recombinant Methioninase
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactobacillus
1 Laetrile B17 Amygdalin
1 Linalool
1 Matrine
1 Mung Bean Sprouts
1 Methyl Jasmonate
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 No Product/Mechanism Only
1 Oleocanthal
1 Peppermint
1 sericin
1 Psoralidin
1 enzalutamide
1 Rhein
1 Oxaliplatin
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 Sutherlandioside D
1 triptolide
1 Triphala
1 Tumor Treating Fields
1 Turmerones
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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