eff Cancer Research Results

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4457- SeNPs,    Selenium nanoparticles: a review on synthesis and biomedical applications
- Review, Var, NA - NA, Diabetic, NA
*BioAv↑, *toxicity↓, *eff↑, chemoPv↑, *Inflam↓, antiOx↑, *selenoP↑, *ROS↓, *Dose↝, AntiCan↑, *Bacteria↓, eff↑, DNAdam↑, selectivity↑, *eff↑,
4458- SeNPs,    Selenium Nanoparticles for Antioxidant Activity and Selenium Enrichment in Plants
*Dose↝, *eff↑, *Dose↝,
3198- SFN,    Sulforaphane and TRAIL induce a synergistic elimination of advanced prostate cancer stem-like cells
- in-vitro, Pca, NA
Nanog↓, SOX2↓, E-cadherin↓, Snail↓, VEGFR2↓, Diff↓, TumCMig↓, EMT↓, CXCR4↓, NOTCH1↓, ALDH1A1↓, CSCs↓, eff↑,
2556- SFN,    The role of Sulforaphane in cancer chemoprevention and health benefits: a mini-review
- Review, Var, NA
chemoPv↑, HDAC↓, Hif1a↓, angioG↓, CYP1A1↓, eff↑, BioAv↑,
1728- SFN,    Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
- Review, Nor, NA
eff↑, eff↓,
1729- SFN,    Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
- Review, Nor, NA
eff↑, angioG↓, VEGF↓, MMP9↓, MMP2↓,
1731- SFN,    Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts
- Review, Var, NA
CSCs↓, ChemoSen↑, NF-kB↓, Shh↓, Smo↓, Gli1↓, GLI2↓, PI3K↓, Wnt↓, β-catenin/ZEB1↓, Nanog↓, COX2↓, Zeb1↓, Snail↓, ChemoSideEff↓, eff↑, *BioAv↑,
1727- SFN,    Glucoraphanin, sulforaphane and myrosinase activity in germinating broccoli sprouts as affected by growth temperature and plant organs
- Analysis, Nor, NA
eff↑, eff↓,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1459- SFN,  AF,    Auranofin Enhances Sulforaphane-Mediated Apoptosis in Hepatocellular Carcinoma Hep3B Cells through Inactivation of the PI3K/Akt Signaling Pathway
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
eff↑, TumCCA↑, Apoptosis↑, MMP↓, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, ROS↑, eff↓, PI3K↓, Akt↓, TrxR↓, BAX↑, Bcl-2∅,
1471- SFN,    ROS-mediated activation of AMPK plays a critical role in sulforaphane-induced apoptosis and mitotic arrest in AGS human gastric cancer cells
- in-vitro, GC, AGS
TumCP↓, Apoptosis↑, TumCCA↑, CycB/CCNB1↑, P21↑, p‑H3↑, p‑AMPK↑, eff↓, MMP↓, Cyt‑c↑, ROS↑, eff↓,
1470- SFN,  Rad,    Sulforaphane induces ROS mediated induction of NKG2D ligands in human cancer cell lines and enhances susceptibility to NK cell mediated lysis
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, Lung, A549 - in-vitro, lymphoma, U937
eff↓, ROS↑, NKG2D↑,
1469- SFN,    Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vivo, Pca, NA
eff↑, ROS↑, MMP↓, Casp3↑, Casp9↑, DR4↑, DR5↑, BAX↑, Bak↑, BIM↑, NOXA↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, eff↓, TumCG↓, TumCP↓, eff↑, NF-kB↓, PI3K↓, Akt↓, MEK↓, ERK↓, angioG↓, FOXO3↑,
1467- SFN,    Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells
- in-vitro, AML, U937
Apoptosis↑, ROS↑, MMP↓, Casp3↑, Bcl-2↓, eff↓,
1466- SFN,    Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway
- vitro+vivo, Thyroid, FTC-133
TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, Slug↓, Twist↓, MMP2↓, MMP9↓, TumCG↓, p‑Akt↓, P21↑, ERK↑, p38↑, ROS↑, *toxicity∅, MMP↓, eff↓,
1465- SFN,    TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells
- NA, Bladder, NA
eff↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,
1464- SFN,    d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway
- in-vitro, GBM, NA
Apoptosis↑, Casp3↑, BAX↑, Bcl-2↓, ROS↑, p‑STAT3↓, JAK2↓, eff↓,
1463- SFN,    Sulforaphane induces reactive oxygen species-mediated mitotic arrest and subsequent apoptosis in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
tumCV↓, CycB/CCNB1↑, p‑CDK1↑, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, cl‑PARP↑, ROS↑, eff↓,
1460- SFN,    High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells
- in-vitro, Lung, NA
ROS↑, EGFR↓, eff↓, TumCCA↑, γH2AX↑, DNAdam↑, eff↓,
1458- SFN,    Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
- Review, Bladder, NA
HDAC↓, eff↓, TumW↓, TumW↓, angioG↓, *toxicity↓, GutMicro↝, AntiCan↑, ROS↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, Casp8∅, cl‑PARP↑, TRAIL↑, DR5↑, eff↓, NRF2↑, ER Stress↑, COX2↓, EGFR↓, HER2/EBBR2↓, ChemoSen↑, NF-kB↓, TumCCA?, p‑Akt↓, p‑mTOR↓, p70S6↓, p19↑, P21↑, CD44↓, CSCs↓,
1456- SFN,    Sulforaphane regulates cell proliferation and induces apoptotic cell death mediated by ROS-cell cycle arrest in pancreatic cancer cells
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, TumCP↓, cl‑PARP↑, cl‑Casp3↑, TumCCA↑, ROS↑, MMP↓, γH2AX↑, eff↓, *toxicity↓,
1455- SFN,    Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress
- in-vitro, Cerv, HeLa - in-vitro, Nor, 1321N1
*ROS↓, *BioAv↑, LC3II↑, LAMP1?, TumAuto↑, TFEB↑, ROS↑, eff↓,
1454- SFN,    Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract
- Human, Nor, NA
*HDAC↓, *eff↑, *eff↑, *eff↑, *BioAv↑, *BioAv↑,
1437- SFN,    Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
- Review, NA, NA
HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, HDAC8↓, eff↑, ac‑HSP90↑, DNMT1↓, DNMT3A↓, hTERT/TERT↓, NRF2↑, HO-1↑, NQO1↑, miR-155↓, miR-200c↑, SOX9↓, *toxicity↓,
1474- SFN,    Sulforaphane induces p53‑deficient SW480 cell apoptosis via the ROS‑MAPK signaling pathway
- in-vitro, Colon, SW480
TumCG↓, Apoptosis↑, MMP↓, Bax:Bcl2↑, Casp3↑, Casp7↑, Casp9↑, ROS↑, e-ERK↑, p38↑, P53∅, eff↓, ChemoSen↑,
1509- SFN,    Combination therapy in combating cancer
- Review, NA, NA
NRF2↑, ChemoSideEff↓, eff↑, TumCP↓, Apoptosis↑, TumCCA↑, eff↑, PSA↓, P53↑, Hif1a↓, CAIX↓, chemoR↓, 5HT↓,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
1501- SFN,    The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation
- in-vitro, CRC, T24/HTB-9
Dose↝, NRF2↑, GSH↓, eff↑,
1496- SFN,  VitD3,    Association between histone deacetylase activity and vitamin D-dependent gene expressions in relation to sulforaphane in human colorectal cancer cells
- in-vitro, CRC, Caco-2
eff↑, VDR↑, CYP11A1↓, HDAC↓,
1495- SFN,  doxoR,    Sulforaphane protection against the development of doxorubicin-induced chronic heart failure is associated with Nrf2 Upregulation
- in-vivo, Nor, NA
*CardioT↓, *NRF2↑, *eff↓, *ROS↓,
1494- SFN,  doxoR,    Sulforaphane potentiates anticancer effects of doxorubicin and attenuates its cardiotoxicity in a breast cancer model
- in-vivo, BC, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
CardioT↓, *GSH↑, *ROS↓, *NRF2↑, NRF2∅, HDAC↓, DNMTs↓, Casp3↑, ER-α36↓, Remission↑, eff↑, ROS↑, selectivity?,
1484- SFN,    Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action
- Review, Var, NA - Review, AD, NA
neuroP↑, AntiCan↑, NRF2↑, HDAC↓, eff↑, *ROS↓, neuroP↑, HDAC↓, *toxicity∅, BioAv↑, eff↓, cycD1/CCND1↓, CDK4↓, p‑RB1↓, Glycolysis↓, miR-30a-5p↑, TumCCA↑, TumCG↓, TumMeta↓, eff↑, ChemoSen↑, RadioS↑, CardioT↓, angioG↓, Hif1a↓, VEGF↓, *BioAv?, *Half-Life∅,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1482- SFN,    Sulforaphane induces apoptosis in T24 human urinary bladder cancer cells through a reactive oxygen species-mediated mitochondrial pathway: the involvement of endoplasmic reticulum stress and the Nrf2 signaling pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, Apoptosis↑, Cyt‑c↑, Bax:Bcl2↑, Casp9↑, Casp3↑, Casp8∅, cl‑PARP↑, ROS↑, MMP↓, eff↓, ER Stress↑, p‑NRF2↑, HO-1↑,
1480- SFN,    Sulforaphane Induces Cell Death Through G2/M Phase Arrest and Triggers Apoptosis in HCT 116 Human Colon Cancer Cells
- in-vitro, CRC, HCT116
tumCV↓, TumCCA↑, Apoptosis↑, cycA1/CCNA1↑, CycB/CCNB1↑, CDC25↓, CDK1↓, ROS↑, eff↓, Cyt‑c↑, AIF↑, ER Stress↑,
1478- SFN,  acet,    Anti-inflammatory and anti-oxidant effects of combination between sulforaphane and acetaminophen in LPS-stimulated RAW 264.7 macrophage cells
- in-vitro, Nor, NA
eff↑, NO↓, iNOS↓, COX2↓, IL1β↓, ROS↓,
1476- SFN,  PDT,    Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane
- in-vitro, HNSCC, NA
eff↑, tumCV↓, ROS↑, eff↓, Casp↑,
1475- SFN,  Form,    Combination of Formononetin and Sulforaphane Natural Drug Repress the Proliferation of Cervical Cancer Cells via Impeding PI3K/AKT/mTOR Pathway
- in-vitro, Cerv, HeLa
TumCP↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↑,
1513- SFN,  acetaz,    Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis
- in-vitro, BrCC, H720 - in-vivo, BrCC, NA - in-vitro, BrCC, H727
eff↑, tumCV↓, Apoptosis↑, P21↑, PI3K↓, Akt↓, mTOR↓, 5HT↓, NRF2↑,
3301- SIL,    Critical review of therapeutic potential of silymarin in cancer: A bioactive polyphenolic flavonoid
- Review, Var, NA
Inflam↓, TumCCA↑, Apoptosis↓, TumMeta↓, TumCG↓, angioG↓, chemoP↑, radioP↑, p‑ERK↓, p‑p38↓, p‑JNK↓, P53↑, Bcl-2↓, Bcl-xL↓, TGF-β↓, MMP2↓, MMP9↓, E-cadherin↑, Wnt↓, Vim↓, VEGF↓, IL6↓, STAT3↓, *ROS↓, IL1β↓, PGE2↓, CDK1↓, CycB/CCNB1↓, survivin↓, Mcl-1↓, Casp3↑, Casp9↑, cMyc↓, COX2↓, Hif1a↓, CXCR4↓, CSCs↓, EMT↓, N-cadherin↓, PCNA↓, cycD1/CCND1↓, ROS↑, eff↑, eff↑, eff↑, HER2/EBBR2↓,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, eff↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, eff↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3298- SIL,    Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells
- in-vitro, BC, MCF-7
LC3II↑, Beclin-1↑, Bcl-2↓, ROS↑, MMP↓, ATP↓, eff↓, BNIP3?, TumAuto↑, eff↑,
3294- SIL,    Silymarin: a review on paving the way towards promising pharmacological agent
- Review, Nor, NA - Review, Arthritis, NA
*hepatoP↑, *Inflam↓, *chemoP↑, *glucose↓, *antiOx↑, *ROS↓, *ACC↓, *FASN↓, *radioP↑, *NF-kB↓, *TGF-β↓, *AST↓, *α-SMA↝, *eff↑, *neuroP↑, eff↑, ROS↓,
3293- SIL,    Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer
- Review, Var, NA
hepatoP↑, TumMeta↓, Inflam↓, chemoP↑, radioP↑, Half-Life↝, *GSTs↑, p‑JNK↑, BAX↑, p‑p38↑, cl‑PARP↑, Bcl-2↓, p‑ERK↓, TumVol↓, eff↑, TumCCA↑, STAT3↓, Mcl-1↓, survivin↓, Bcl-xL↓, Casp3↑, Casp9↑, eff↑, CXCR4↓, Dose↝,
3292- SIL,  Fe,    Anti-tumor activity of silymarin nanoliposomes in combination with iron: In vitro and in vivo study
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
*antiOx↑, ROS↑, OS↑, Weight↑, TumVol↓, eff↑, Fenton↑,
3289- SIL,    Silymarin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
*BioAv↝, *BioAv↓, Fas↑, FasL↑, FADD↑, pro‑Casp8↑, Apoptosis↑, DR5↑, Bcl-2↑, BAX↑, Casp3↑, PI3K↓, FOXM1↓, p‑mTOR↓, p‑P70S6K↓, Hif1a↓, Akt↑, angioG↓, STAT3↓, NF-kB↓, lipid-P↓, eff↑, CDK1↓, survivin↓, CycB/CCNB1↓, Mcl-1↓, Casp9↑, AP-1↓, BioAv↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,
2358- SK,    SIRT1 improves lactate homeostasis in the brain to alleviate parkinsonism via deacetylation and inhibition of PKM2
- in-vivo, Park, NA
*eff↑, *PKM2↓, *motorD↑, *lactateProd↓,
2364- SK,    Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation
- in-vivo, PSA, NA
eff↑, lactateProd↓, PKM2↓,
2230- SK,    Shikonin induces ROS-based mitochondria-mediated apoptosis in colon cancer
- in-vitro, CRC, HCT116 - in-vivo, NA, NA
TumCG↓, Bcl-2↓, ROS↑, Bcl-xL↓, MMP↓, Casp↑, selectivity↑, cycD1/CCND1↓, TumCCA↑, eff↓,

Showing Research Papers: 1101 to 1150 of 1301
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1301

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   CYP1A1↓, 1,   Fenton↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 3,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 8,   NRF2∅, 1,   p‑NRF2↑, 1,   ROS?, 1,   ROS↓, 3,   ROS↑, 24,   SOD↑, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 2,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 13,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   CAIX↓, 1,   cMyc↓, 2,   Glycolysis↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   SIRT1↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 13,   Bak↑, 1,   BAX↑, 6,   Bax:Bcl2↑, 4,   Bcl-2↓, 8,   Bcl-2↑, 1,   Bcl-2∅, 1,   Bcl-xL↓, 4,   BID↑, 1,   BIM↑, 1,   Casp↑, 4,   Casp12?, 1,   Casp3↑, 14,   cl‑Casp3↑, 1,   Casp7↑, 2,   Casp8↑, 3,   Casp8∅, 2,   pro‑Casp8↑, 1,   Casp9↑, 11,   Cyt‑c↑, 6,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 4,   FADD↑, 1,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 1,   iNOS↓, 1,   p‑JNK↓, 1,   p‑JNK↑, 1,   Mcl-1↓, 4,   NOXA↑, 1,   p27↑, 1,   p38↑, 3,   p‑p38↓, 1,   p‑p38↑, 1,   PUMA↑, 1,   survivin↓, 4,   Telomerase↓, 2,   TRAIL↑, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   p70S6↓, 1,   SOX9↓, 1,  

Transcription & Epigenetics ⓘ

p‑H3↑, 1,   HATs↑, 1,   miR-30a-5p↑, 1,   tumCV↓, 6,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 3,   HSP70/HSPA5↓, 1,   HSP90↓, 1,   ac‑HSP90↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,   BNIP3?, 1,   LC3B↑, 1,   LC3II↑, 2,   p62↑, 1,   TFEB↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   DNMT1↓, 1,   DNMT3A↓, 1,   DNMTs↓, 2,   P53↑, 3,   P53∅, 1,   cl‑PARP↑, 8,   PCNA↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence ⓘ

CDK1↓, 3,   p‑CDK1↑, 1,   CDK4↓, 3,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 3,   CycB/CCNB1↑, 3,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   p19↑, 1,   P21↑, 6,   p‑RB1↓, 1,   TumCCA?, 1,   TumCCA↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

ALDH1A1↓, 1,   CD44↓, 4,   cMYB↓, 1,   CSCs↓, 5,   Diff↓, 1,   EMT↓, 4,   ERK↓, 3,   ERK↑, 2,   p‑ERK↓, 2,   e-ERK↑, 1,   FOXM1↓, 1,   FOXO3↑, 1,   Gli1↓, 1,   HDAC↓, 9,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   mTOR↓, 3,   p‑mTOR↓, 2,   Nanog↓, 2,   NOTCH↓, 1,   NOTCH1↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 7,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 4,   p‑STAT3↓, 1,   TumCG↓, 7,   VDR↑, 1,   Wnt↓, 4,  

Migration ⓘ

AP-1↓, 1,   CA↓, 1,   Ca+2↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 4,   ER-α36↓, 1,   FAK↓, 1,   GLI2↓, 1,   Ki-67↓, 1,   LAMP1?, 1,   miR-155↓, 1,   miR-200c↑, 1,   miR-203↑, 1,   MMP1↓, 1,   MMP2↓, 7,   MMP9↓, 6,   N-cadherin↓, 2,   PDGF↓, 1,   Slug↓, 1,   Snail↓, 3,   TGF-β↓, 2,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 6,   TumMeta↓, 3,   Twist↓, 2,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 3,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 9,   EGFR↓, 3,   Hif1a↓, 8,   NO↓, 1,   VEGF↓, 7,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

NHE1↓, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   CXCR4↓, 4,   IFN-γ↑, 1,   IKKα↓, 1,   IL1↓, 1,   IL12↓, 1,   IL1β↓, 4,   IL2↑, 1,   IL6↓, 4,   Inflam↓, 2,   JAK2↓, 1,   NF-kB↓, 7,   p50↓, 1,   PD-L1↓, 1,   PGE2↓, 2,   PSA↓, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission ⓘ

5HT↓, 2,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,   CYP11A1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 3,   chemoR↓, 1,   ChemoSen↑, 4,   Dose↝, 4,   eff↓, 28,   eff↑, 37,   eff↝, 2,   Half-Life↓, 1,   Half-Life↝, 2,   RadioS↑, 2,   selectivity?, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 3,   FOXM1↓, 1,   GutMicro↝, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 2,   IL6↓, 4,   Ki-67↓, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 5,   cardioP↑, 1,   CardioT↓, 2,   chemoP↑, 3,   chemoPv↑, 2,   ChemoSideEff↓, 3,   hepatoP↑, 2,   neuroP↑, 2,   NKG2D↑, 1,   OS↑, 1,   radioP↑, 2,   Remission↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 3,   TumW↓, 3,   Weight↑, 1,  
Total Targets: 261

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 8,   selenoP↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   FASN↓, 1,   glucose↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   SIRT1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

TGF-β↓, 1,   TIMP1↓, 1,   α-SMA↝, 1,  

Immune & Inflammatory Signaling ⓘ

IL8↓, 1,   Inflam↓, 4,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv?, 1,   BioAv↓, 1,   BioAv↑, 7,   BioAv↝, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 8,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

AST↓, 1,  

Functional Outcomes ⓘ

CardioT↓, 1,   chemoP↑, 2,   hepatoP↑, 2,   motorD↑, 1,   neuroP↑, 2,   radioP↑, 1,   toxicity↓, 4,   toxicity∅, 3,   Weight∅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 44

Scientific Paper Hit Count for: eff, efficacy
69 Silver-NanoParticles
58 Magnetic Fields
43 Sulforaphane (mainly Broccoli)
40 Curcumin
35 Vitamin C (Ascorbic Acid)
32 Thymoquinone
31 Chemotherapy
29 immunotherapy
28 Shikonin
26 chitosan
25 EGCG (Epigallocatechin Gallate)
25 Piperlongumine
24 Artemisinin
23 Selenium NanoParticles
23 Quercetin
23 Selenite (Sodium)
22 Resveratrol
22 Baicalein
20 Copper and Cu NanoParticles
20 Ashwagandha(Withaferin A)
20 Berberine
19 Radiotherapy/Radiation
18 Capsaicin
18 Chrysin
18 Magnetic Field Rotating
17 Apigenin (mainly Parsley)
17 Phenylbutyrate
17 Chlorogenic acid
17 Dichloroacetate
16 diet FMD Fasting Mimicking Diet
16 Gambogic Acid
16 Bicarbonate(Sodium)
15 Selenium
15 Lycopene
14 Citric Acid
14 Metformin
14 Propolis -bee glue
14 Exercise
14 Phenethyl isothiocyanate
13 3-bromopyruvate
13 Caffeic acid
12 Betulinic acid
12 Fisetin
11 Folic Acid, Vit B9
11 Auranofin
11 borneol
11 salinomycin
11 Rosmarinic acid
10 Alpha-Lipoic-Acid
10 Melatonin
10 Luteolin
10 Cisplatin
10 Atorvastatin
10 Boron
10 Choline
10 Vitamin K2
10 Silymarin (Milk Thistle) silibinin
10 diet Methionine-Restricted Diet
10 doxorubicin
10 Honokiol
10 VitK3,menadione
9 Gold NanoParticles
9 SonoDynamic Therapy UltraSound
9 Vitamin D3
9 Ellagic acid
9 Carvacrol
9 Disulfiram
9 Hydrogen Gas
9 Urolithin
8 Photodynamic Therapy
8 Hyperthermia
8 Chlorophyllin
8 Electrical Pulses
8 Plumbagin
8 Parthenolide
7 Carnosic acid
7 Piperine
6 5-fluorouracil
6 Coenzyme Q10
6 Vitamin B12
6 Fenbendazole
6 Allicin (mainly Garlic)
6 Docetaxel
6 beta-glucans
6 Bifidobacterium
6 Celastrol
6 HydroxyCitric Acid
6 Spermidine
6 Juglone
5 Astragalus
5 chemodynamic therapy
5 Akkermansia
5 Bevacizumab (brand Avastin)
5 Ascorbyl Palmitate
5 Astaxanthin
5 Berbamine
5 beta-carotene(VitA)
5 Bortezomib
5 Boswellia (frankincense)
5 Thymol-Thymus vulgaris
5 diet Plant based
5 MCToil
5 Magnolol
5 Moringa oleifera
4 2-DeoxyGlucose
4 almonertinib
4 Andrographis
4 Gemcitabine (Gemzar)
4 Aspirin -acetylsalicylic acid
4 Dipyridamole
4 Butyrate
4 capecitabine
4 Cat’s Claw
4 Cannabidiol
4 diet Short Term Fasting
4 Propyl gallate
4 Pterostilbene
4 Sulfasalazine
4 Whole Body Vibration
3 cetuximab
3 Anthocyanins
3 Zinc
3 Anti-oxidants
3 Aloe anthraquinones
3 Biochanin A
3 bempedoic acid
3 Lutein
3 Zeaxanthin
3 Bufalin/Huachansu
3 temozolomide
3 hydroxychloroquine
3 Chocolate
3 Calorie Restriction Mimetics
3 erastin
3 Ginseng
3 Lecithin
3 nicotinamide adenine dinucleotide
3 Naringin
3 Radio Frequency
3 Taurine
3 Vitamin B1/Thiamine
2 5-Aminolevulinic acid
2 Glucose
2 Aromatherapy
2 Sorafenib (brand name Nexavar)
2 Trastuzumab
2 Arsenic trioxide
2 Baicalin
2 brusatol
2 Rutin
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Caffeine
2 Calcium
2 carboplatin
2 Celecoxib
2 Cinnamon
2 Hydroxycinnamic-acid
2 Oxygen, Hyperbaric
2 Emodin
2 ferumoxytol
2 Kaempferol
2 Genistein (soy isoflavone)
2 γ-linolenic acid (Borage Oil)
2 Orlistat
2 Potassium
2 Methylene blue
2 metronomic chemo
2 Methylsulfonylmethane
2 Mushroom Lion’s Mane
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phosphatidylserine
2 Aflavin-3,3′-digallate
1 Serotonin, 5-hydroxytryptamine
1 dietMediterranean
1 EMF
1 Anzaroot, Astragalus fasciculifolius Bioss
1 Trichostatin A
1 wortmannin
1 Resiquimod
1 Ajoene (compound of Garlic)
1 Acetyl-l-carnitine
1 Amodiaquine
1 Vitamin A, Retinoic Acid
1 D-limonene
1 Huperzine A/Huperzia serrata
1 probiotics
1 Brucea javanica
1 Bacopa monnieri
1 Bromelain
1 Bruteridin(bergamot juice)
1 urea
1 Carnosine
1 Cannabichromene
1 Beta‐Lapachone
1 Camptothecin
1 irinotecan
1 Black phosphorus
1 Dichloroacetophenone(2,2-)
1 Date Fruit Extract
1 diet Fermented Foods
1 diet Ketogenic
1 PXD, phenoxodiol
1 Ferulic acid
1 Vitamin E
1 flavonoids
1 Flickering Light Stimulation
1 verapamil
1 Garcinol
1 tamoxifen
1 HydroxyTyrosol
1 itraconazole
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Docosahexaenoic Acid
1 Matrine
1 Methyl Jasmonate
1 methotrexate
1 Magnesium
1 Methylglyoxal
1 Mushroom Reishi
1 Myricetin
1 Oleocanthal
1 Peppermint
1 sericin
1 Paclitaxel
1 Psoralidin
1 enzalutamide
1 Oxaliplatin
1 Scoulerine
1 polyethylene glycol
1 acetaminophen
1 Formononetin
1 acetazolamide
1 Iron
1 Squalene
1 Glutathione
1 statins
1 Sutherlandioside D
1 triptolide
1 Tumor Treating Fields
1 Ursolic acid
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
1 Vitamin B6,pyridoxine
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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