| 5553- | BBM, | A review on berbamine–a potential anticancer drug |
| - | Review, | Var, | NA |
| 1242- | BBM, | Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways |
| - | in-vivo, | Nor, | NA |
| 2023- | BBR, | Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor |
| - | in-vitro, | Colon, | NA | - | in-vitro, | Nor, | YAMC |
| 2022- | BBR, | GoldNP, | Rad, | Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition |
| - | in-vitro, | Liver, | SMMC-7721 cell | - | in-vitro, | Nor, | HL7702 |
| 2021- | BBR, | Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways |
| - | Review, | NA, | NA |
| 1385- | BBR, | 5-FU, | Low-Dose Berberine Attenuates the Anti-Breast Cancer Activity of Chemotherapeutic Agents via Induction of Autophagy and Antioxidation |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 |
| 1398- | BBR, | Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage |
| - | in-vitro, | Kidney, | NA |
| 1397- | BBR, | Chemo, | Effects of Coptis extract combined with chemotherapeutic agents on ROS production, multidrug resistance, and cell growth in A549 human lung cancer cells |
| - | in-vitro, | Lung, | A549 |
| 1395- | BBR, | Analysis of the mechanism of berberine against stomach carcinoma based on network pharmacology and experimental validation |
| - | in-vitro, | GC, | NA |
| 1394- | BBR, | DL, | Synergistic Inhibitory Effect of Berberine and d-Limonene on Human Gastric Carcinoma Cell Line MGC803 |
| - | in-vitro, | GC, | MGC803 |
| 1393- | BBR, | EPI, | Berberine promotes antiproliferative effects of epirubicin in T24 bladder cancer cells by enhancing apoptosis and cell cycle arrest |
| - | in-vitro, | Bladder, | T24/HTB-9 |
| 1392- | BBR, | Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress |
| - | in-vitro, | GC, | AGS | - | in-vitro, | GC, | MKN45 |
| 1390- | BBR, | Rad, | Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells |
| - | in-vitro, | Pca, | PC3 |
| 1389- | BBR, | Lap, | Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS |
| - | in-vitro, | BC, | BT474 | - | in-vitro, | BC, | AU-565 |
| 1299- | BBR, | Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review |
| - | Review, | NA, | NA |
| 1387- | BBR, | Antitumor Activity of Berberine by Activating Autophagy and Apoptosis in CAL-62 and BHT-101 Anaplastic Thyroid Carcinoma Cell Lines |
| - | in-vitro, | Thyroid, | CAL-62 |
| 1386- | BBR, | Berberine-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species generation and mitochondrial-related apoptotic pathway |
| - | in-vitro, | BC, | MCF7 | - | in-vitro, | BC, | MDA-MB-231 |
| 1396- | BBR, | Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro |
| - | in-vitro, | GC, | SNU1041 | - | in-vitro, | GC, | SNU5 |
| 1384- | BBR, | Berberine induces apoptosis via ROS generation in PANC-1 and MIA-PaCa2 pancreatic cell lines |
| - | in-vitro, | PC, | PANC1 |
| 1374- | BBR, | PDT, | Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells |
| - | in-vitro, | RCC, | 786-O | - | in-vitro, | RCC, | HK-2 |
| 1375- | BBR, | 13-[CH2CO-Cys-(Bzl)-OBzl]-Berberine: Exploring The Correlation Of Anti-Tumor Efficacy With ROS And Apoptosis Protein |
| - | in-vitro, | CRC, | HCT8 | - | in-vivo, | NA, | NA |
| 1376- | BBR, | immuno, | Berberine sensitizes immune checkpoint blockade therapy in melanoma by NQO1 inhibition and ROS activation |
| - | in-vivo, | Melanoma, | NA |
| 1377- | BBR, | Berberine inhibits autophagy and promotes apoptosis of fibroblast-like synovial cells from rheumatoid arthritis patients through the ROS/mTOR signaling pathway |
| - | in-vitro, | Arthritis, | NA |
| 1378- | BBR, | Berberine induces non-small cell lung cancer apoptosis via the activation of the ROS/ASK1/JNK pathway |
| - | in-vitro, | Lung, | NA |
| 1379- | BBR, | Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells |
| - | in-vitro, | lymphoma, | NA |
| 1380- | BBR, | doxoR, | treatment with ROS scavenger N-acetylcysteine (NAC) and JNK inhibitor SP600125 could partially attenuate apoptosis and DNA damage triggered by DCZ0358. |
| - | in-vivo, | Nor, | NA |
| 1381- | BBR, | Rad, | Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3) |
| - | in-vitro, | Ovarian, | SKOV3 |
| 1382- | BBR, | Berberine increases the expression of cytokines and proteins linked to apoptosis in human melanoma cells |
| - | in-vitro, | Melanoma, | SK-MEL-28 |
| 1400- | BBR, | Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells |
| - | in-vitro, | Melanoma, | U266 |
| 1401- | BBR, | Berberine induces apoptosis in glioblastoma multiforme U87MG cells via oxidative stress and independent of AMPK activity |
| - | in-vitro, | GBM, | U87MG |
| 1399- | BBR, | Rad, | Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review |
| - | Review, | NA, | NA |
| 1402- | BBR, | Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction |
| - | in-vitro, | GBM, | T98G |
| 1404- | BBR, | Berberine-induced apoptosis in human prostate cancer cells is initiated by reactive oxygen species generation |
| - | in-vitro, | Pca, | PC3 |
| 1405- | BBR, | Chit, | Chitosan/alginate nanogel potentiate berberine uptake and enhance oxidative stress mediated apoptotic cell death in HepG2 cells |
| - | in-vitro, | Liver, | HepG2 |
| 2335- | BBR, | Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer |
| - | in-vitro, | CRC, | HT29 | - | in-vitro, | CRC, | HCT116 | - | in-vivo, | NA, | NA |
| 2336- | BBR, | Berberine Targets PKM2 to Activate the t-PA-Induced Fibrinolytic System and Improves Thrombosis |
| - | in-vivo, | Nor, | NA |
| 2337- | BBR, | Berberine Inhibited the Proliferation of Cancer Cells by Suppressing the Activity of Tumor Pyruvate Kinase M2 |
| - | in-vitro, | CRC, | HCT116 | - | in-vitro, | Cerv, | HeLa |
| 2701- | BBR, | Berberine Inhibits KLF4 Promoter Methylation and Ferroptosis to Ameliorate Diabetic Nephropathy in Mice |
| - | in-vivo, | Diabetic, | NA |
| 2698- | BBR, | A gene expression signature-based approach reveals the mechanisms of action of the Chinese herbal medicine berberine |
| - | Analysis, | BC, | MDA-MB-231 |
| 2689- | BBR, | Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells |
| - | in-vitro, | Nor, | PC12 | - | in-vitro, | AD, | NA | - | in-vitro, | Stroke, | NA |
| 2699- | BBR, | Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line |
| - | in-vitro, | Lung, | A549 |
| 2700- | BBR, | Cell-specific pattern of berberine pleiotropic effects on different human cell lines |
| - | in-vitro, | GBM, | U343 | - | in-vitro, | GBM, | MIA PaCa-2 | - | in-vitro, | Nor, | HDFa |
| 2690- | BBR, | Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice |
| - | in-vivo, | Diabetic, | NA |
| 2680- | BBR, | PDT, | Photodynamic therapy-triggered nuclear translocation of berberine from mitochondria leads to liver cancer cell death |
| - | in-vitro, | Liver, | HUH7 |
| 2697- | BBR, | Structural exploration of common pharmacophore based berberine derivatives as novel histone deacetylase inhibitor targeting HDACs enzymes |
| - | Analysis, | Var, | NA |
| 2696- | BBR, | Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway |
| - | in-vivo, | Nor, | NA |
| - | Trial, | BC, | NA |
| 2694- | BBR, | Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells |
| - | in-vitro, | BC, | NA |
| 2693- | BBR, | Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 Release |
| - | in-vitro, | GBM, | U251 | - | in-vitro, | GBM, | U87MG |
| 2692- | BBR, | Berberine affects osteosarcoma via downregulating the caspase-1/IL-1β signaling axis |
| - | in-vitro, | OS, | MG63 | - | in-vitro, | OS, | SaOS2 | - | in-vivo, | NA, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:% State#:% Dir#:%
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