Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3684- BBR,    Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies
- Review, AD, NA
*Inflam↓, *antiOx↓, *AChE↓, *BChE↓, *MAOA↓, *MAOB↓, *lipid-P↓, *GSH↑, *ROS↓, *APP↓, *BACE/β-secretase↓, *p‑tau↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *MAPK↓, *PI3K↓, *Akt↓, *neuroP↑, *memory↑,
5548- BBR,    Berbamine induces SMMC-7721 cell apoptosis via upregulating p53, downregulating survivin expression and activating mitochondria signaling pathway
- in-vitro, HCC, SMMC-7721 cell
TumCG↓, Apoptosis↑, Cyt‑c↑, BAX↑, P53↑, Bcl-2↓, survivin↓,
5545- BBR,    Improving the oral bioavailability of berberine: A crystal engineering approach
- in-vivo, Nor, NA
BioAv↑,
5182- BBR,    Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9
- in-vitro, SCC, SCC4
TumCMig↓, TumCI↓, p‑JNK↝, p‑ERK↝, p‑p38↝, IKKα↝, NF-kB↝, MMP2↓, MMP9↓,
6424- BBR,    Berberine Protects Glomerular Podocytes via Inhibiting Drp1-Mediated Mitochondrial Fission and Dysfunction
- in-vivo, Nor, NA
*mt-ROS↓, *DRP1/DNM1L↓,
6764- BBR,    Berberine as a therapeutic alkaloid against ESKAPE and multiple drug-resistant bacteria: a comprehensive review
- Review, Nor, NA
*AntiBio↑, *BioAv↓,
4274- BBR,    Berberine exerts antidepressant effects in vivo and in vitro through the PI3K/AKT/CREB/BDNF signaling pathway
- in-vivo, NA, NA
*IL1β↓, *IL6↓, *TNF-α↓, *CRP↓, *CREB↑, *BDNF↑,
4275- BBR,    Pharmacological effects of berberine on mood disorders
- Review, NA, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *eff↑, *5HT↑, *Mood↑, *BDNF↑,
4298- BBR,    Berberine mitigates cognitive decline in an Alzheimer’s Disease Mouse Model by targeting both tau hyperphosphorylation and autophagic clearance
- in-vivo, AD, NA
*cognitive↑, *p‑tau↓, *GSK‐3β↓, *PP2A↑, *memory↑, *Akt↑, *LC3II↑, *Beclin-1/ATG6↑,
4299- BBR,    Berberine attenuates cognitive impairment and ameliorates tau hyperphosphorylation by limiting the self-perpetuating pathogenic cycle between NF-κB signaling, oxidative stress and neuroinflammation
- in-vivo, AD, NA
*memory↑, *p‑tau↓, *NF-kB↓, *GSH↑, *lipid-P↓, *cognitive↑, *ROS↓, *Inflam↓,
4300- BBR,    Effect of berberine on cognitive function and β-amyloid precursor protein in Alzheimer’s disease models: a systematic review and meta-analysis
- Review, AD, NA
*APP↓, *cognitive↑, *Aβ↓, *BACE/β-secretase↓, *tau?,
4340- BBR,    Agonist-dependent differential effects of berberine in human platelet aggregation
- Human, NA, NA
*AntiAg↑, *other?,
4658- BBR,    Berberine Suppresses Stemness and Tumorigenicity of Colorectal Cancer Stem-Like Cells by Inhibiting m6A Methylation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
CSCs↓, TumCP↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, TumCCA↑, Apoptosis↑, ChemoSen↑, β-catenin/ZEB1↓, FTO↑, CD44↓, CD133↓, ChemoSen↑,
5181- BBR,  Cisplatin,    Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
- in-vitro, GC, SGC-7901 - in-vitro, GC, BGC-823
tumCV↓, MDR1↓, ChemoSen↑, PI3K↓, Akt↓, mTOR↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5178- BBR,    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,
5177- BBR,    Berberine induces apoptosis in human HSC-3 oral cancer cells via simultaneous activation of the death receptor-mediated and mitochondrial pathway
- in-vitro, Oral, HMC3
TumCCA↑, Apoptosis↑, TumCG↓, Casp3↑, TumCCA↑, ROS↑, Ca+2↑, MMP↓, ER Stress↑, Cyt‑c↑,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
1031- BCA,    Biochanin A Suppresses Tumor Progression and PD-L1 Expression via Inhibiting ZEB1 Expression in Colorectal Cancer
- vitro+vivo, CRC, HCT116 - vitro+vivo, CRC, SW-620
PD-L1↓, TumCG↓, Zeb1↓, E-cadherin↑, N-cadherin↓, EMT↓,
1473- BCA,  SFN,    An Insight on Synergistic Anti-cancer Efficacy of Biochanin A and Sulforaphane Combination Against Breast Cancer
- in-vitro, BC, MCF7
eff↑, ROS↑, other↑, ERK↓, Apoptosis↑,
5644- BCA,    Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways
- Review, Var, NA
P-gp/ABCB1↓,
5643- BCA,  GEN,  QC,  SIL,  KAE  P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review
- in-vitro, NA, NA
P-gp/ABCB1↓,
5642- BCA,    Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo
- vitro+vivo, Nor, NA
P-gp/ABCB1↓, BioAv↓,
5641- BCA,    Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
- in-vitro, Nor, NA
P-gp/ABCB1↑,
5640- BCA,    Improved effectiveness of biochanin A as a P-gp inhibitor in solid dispersion
- in-vitro, Nor, NA
*P-gp/ABCB1↓, BioAv↑, other↝, other↑,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
5632- BCA,    Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats
- in-vivo, Var, NA
chemoPv↑, *BioAv↓,
5633- BCA,    Mechanisms Behind the Pharmacological Application of Biochanin-A: A review
- Review, Var, NA - Review, AD, NA
*AntiDiabetic↑, *neuroP↑, *toxicity↓, *CYP19↓, p‑Akt↓, mTOR↓, TumCCA↑, P21↑, Casp3↑, Bcl-2↑, Apoptosis↑, E-cadherin↓, TumMeta↓, eff↑, GSK‐3β↓, β-catenin/ZEB1↓, RadioS↑, ROS↑, Casp1↑, MMP2↓, MMP9↓, EGFR↓, ChemoSen↑, PI3K↓, MMPs↓, Hif1a↓, VEGF↓, *ROS↓, *Obesity↓, *cardioP↑, *NRF2↑, *NF-kB↓, *Inflam↓, *lipid-P↓, *hepatoP↑, *AST↓, *ALP↓, *Bacteria↓, *neuroP↑, *SOD↑, *GPx↑, *AChE↓, *BACE/β-secretase↓, *memory↑, *BioAv↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5635- BCA,    Biochanin A inhibits lung adenocarcinoma progression by targeting ZEB1
- vitro+vivo, Lung, NA
AntiCan↑, ChemoSen↑, Zeb1↓, TumMeta↓,
5636- BCA,    Biochanin A Induces S Phase Arrest and Apoptosis in Lung Cancer Cells
- vitro+vivo, Lung, A549
tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, TumCG↓, P21↑, Casp3↑, Bcl-2↑,
5637- BCA,  ATV,    Combination Treatment of Biochanin A and Atorvastatin Alters Mitochondrial Bioenergetics, Modulating Cell Metabolism and Inducing Cell Cycle Arrest in Pancreatic Cancer Cells
- in-vitro, PC, AsPC-1 - in-vitro, PC, PANC1 - in-vitro, PC, MIA PaCa-2
eff↑, TumCI↓, STAT3↓, Apoptosis↑,
5638- BCA,    Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway
- in-vitro, Oral, NA
tumCV↓, ROS↑, MMP↓, TumCMig↓, TAC↓, lipid-P↓, NF-kB↓, Apoptosis↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
6511- BCP,    Improvement of Oxidative Stress and Mitochondrial Dysfunction by β-Caryophyllene: A Focus on the Nervous System
- Review, AD, NA
*CB2 / CNR2↑, *Bacteria↓, *antiOx↑, *Inflam↓, *NP/CIPN↓, *neuroP↑, AntiCan↑, *ROS↓, *mtDam↓, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *IL1β↓, *IL6↓, *TNF-α↓, *COX2/PTGS2↓, *iNOS↓, *NRF2↑, *HO-1↑, *AChE↓,
6519- BCP,    beta-Caryophyllene: A Sesquiterpene with Countless Biological Properties
- Review, Nor, NA
*CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *BioEnh↑,
6518- BCP,    beta-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116
angioG↓, VEGF↓, TumVol↓, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, TumCP↓, TumCMig↓, TumCG↓, Dose↝,
6517- BCP,    β-Caryophyllene Ameliorates Cyclophosphamide Induced Cardiac Injury: The Association of TLR4/NFκB and Nrf2/HO1/NQO1 Pathways
- in-vivo, Nor, NA
*cardioP↑, *lipid-P↓, *antiOx↑, *NRF2↑, *HO-1↑, *NQO1↑, *TLR4↓, *NF-kB↓, *Inflam↓, *Apoptosis↓,
6516- BCP,    β-Caryophyllene, a CB2-Receptor-Selective Phytocannabinoid, Suppresses Mechanical Allodynia in a Mouse Model of Antiretroviral-Induced Neuropathic Pain
- in-vivo, Nor, NA
*NP/CIPN↓, *Inflam↓, *CB2 / CNR2↑,
6515- BCP,  Xan,    Advancing Brain Health Naturally: β-Caryophyllene and Xanthohumol as Neuroprotective Agents
- Review, AD, NA
*neuroP↑, *BioAv↝, *CB2 / CNR2↑, *Inflam↓, *iNOS↓, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *COX1↓, *COX2/PTGS2↓, *PPARα↑, *PPARγ↑, *ROS↓, *tau↓, *NRF2↑, *HO-1↑, *AChE↓, *BChE↓, *BioAv↓,
6514- BCP,    Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells
- in-vitro, BC, NA
TumCP↓, CB2 / CNR2↓, STAT3↓, mTOR↓, Akt↓, Hypoxia↓,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
6495- BCP,    Beta-caryophyllene is a dietary cannabinoid
*CB2 / CNR2↑, *other↝, *Inflam↓, *TNF-α↓, *IL1β↓, *ERK↓, *JNK↓,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2/PTGS2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
6497- BCP,  Cisplatin,    Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
- in-vitro, Lung, NA
TumCG↓, TumCP↓, Apoptosis↑, toxicity↓, ChemoSen↑, P21↑, Bcl-xL↑, Bcl-2↓, EMT↓, E-cadherin↑, eff↑, MMP↓,
6498- BCP,    β-Caryophyllene induces apoptosis and inhibits cell proliferation by deregulation of STAT-3/mTOR/AKT signaling in human bladder cancer cells: An in vitro study
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, 5637
tumCV↓, ROS↑, Apoptosis↑, MMP↓, TumCMig↓, STAT3↓, mTOR↓, Akt↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,

Showing Research Papers: 1351 to 1400 of 8263
Prev Page 28 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8263

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 2,   HTRA↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

lipid-P↓, 1,   ROS↑, 9,   TAC↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MEK↓, 1,   MMP↓, 7,   MMP↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   AMPK↑, 2,   cMyc↓, 2,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   p‑Akt↓, 2,   Apoptosis↑, 18,   BAX↑, 4,   Bax:Bcl2↑, 2,   Bcl-2↓, 7,   Bcl-2↑, 2,   Bcl-xL↓, 1,   Bcl-xL↑, 1,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp3↑, 8,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 5,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   p‑JNK↝, 1,   Mcl-1↓, 1,   Myc↓, 1,   p27/CDKN1B↑, 3,   p‑p38↝, 1,   survivin↓, 5,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   ER Stress↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNMT1↓, 1,   DNMT3A↓, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↑, 2,   PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 9,   TFAP2A↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CD44↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 2,   p‑ERK↓, 1,   p‑ERK↝, 1,   GSK‐3β↓, 1,   IGFBP1↑, 1,   mTOR↓, 7,   PI3K↓, 5,   p‑PI3K↓, 1,   STAT3↓, 5,   STAT3↑, 1,   TumCG↓, 8,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 2,   FTO↑, 1,   Ki-67↓, 1,   miR-29b↓, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 2,   N-cadherin↓, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 10,   TumCP↑, 1,   TumMeta↓, 4,   TXNIP↑, 1,   Zeb1↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   EGFR↓, 1,   Hif1a↓, 3,   Hypoxia↓, 1,   VEGF↓, 6,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 3,   P-gp/ABCB1↑, 1,   P-gp/ABCB1⇅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↓, 1,   CB2 / CNR2↑, 2,   COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IKKα↝, 1,   IL6↓, 1,   Inflam↓, 3,   JAK1↑, 1,   NF-kB↓, 6,   NF-kB↝, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   ChemoSen↑, 8,   Dose↝, 2,   eff↑, 5,   Half-Life↓, 1,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 1,   Myc↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   chemoPv↑, 4,   neuroP↑, 1,   toxicity↓, 1,   TumVol↓, 3,  
Total Targets: 138

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 5,   Catalase↑, 1,   GPx↑, 1,   GSH↑, 3,   HO-1↑, 3,   lipid-P↓, 5,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 5,   PARK2↑, 1,   ROS↓, 7,   ROS↑, 1,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   Insulin↑, 1,   MMP↓, 1,   mtDam↓, 1,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   CREB↑, 1,   PPARα↑, 2,   PPARγ↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   iNOS↓, 4,   JNK↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,   other↝, 1,   TFAM↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3B↑, 1,   LC3II↑, 1,   p62↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   GSK‐3β↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   APP↓, 2,   MMP9↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 5,   COX1↓, 2,   COX2/PTGS2↓, 6,   CRP↓, 1,   IL1β↓, 7,   IL6↓, 5,   Inflam↓, 14,   NF-kB↓, 7,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 4,   BChE↓, 2,   BDNF↑, 2,   MAOA↓, 1,   tau?, 1,   tau↓, 1,   p‑tau↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 4,   MAOB↓, 1,   NLRP3↓, 1,   PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5,   BioAv↑, 1,   BioAv↝, 2,   BioEnh↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALP↓, 1,   AST↓, 1,   BloodF↑, 1,   CRP↓, 1,   IL6↓, 5,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   cardioP↑, 3,   cognitive↑, 3,   hepatoP↑, 2,   memory↑, 4,   Mood↑, 1,   neuroP↑, 8,   NP/CIPN↓, 3,   Obesity↓, 1,   Pain↓, 1,   toxicity↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 2,  
Total Targets: 95

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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