BBB Cancer Research Results

BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
Source:
Type:
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
Scientific Papers found: Click to Expand⟱
3783- FA,    Design, Synthesis, and Biological Evaluation of Ferulic Acid-Piperazine Derivatives Targeting Pathological Hallmarks of Alzheimer’s Disease
- NA, AD, NA
*ROS↓, *IronCh↑, *NLRP3↓, *Aβ↓, *AChE↓, *BChE↓, *antiOx↑, *BBB↑, *MMP↑, *memory↑, *SOD↑, *Catalase↑,
3781- FA,    Therapeutic potential of ferulic acid and its derivatives in Alzheimer’s disease—A systematic review
- Review, AD, NA
*antiOx↑, *Inflam↓, *BBB↑, *AChE↓, *BChE↓,
2854- FIS,    New Perspectives for Fisetin
- Review, Var, NA - Review, Stroke, NA
Inflam↓, ChemoSen↑, chemoPv↑, eff↑, memory↑, neuroP↑, *Dose↑, BioAv↓, BBB↑,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2/PTGS2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
7026- Fuc,    Fucoidan
- Review, AD, NA
*Inflam↓, *ROS↓, *BioAv↓, *GutMicro↑, *neuroP↑, *glucose↝, *AntiThr↑, *chemoP↑, *Half-Life↝, *BBB∅, *AntiAge↑, Risk↑,
7070- GABA,    Neurotransmitters as food supplements: the effects of GABA on brain and behavior
- Review, Nor, NA
*BBB↝, *BBB↓, *fatigue↓, *other↝,
7069- GABA,    United States Pharmacopeia (USP) Safety Review of Gamma-Aminobutyric Acid (GABA)
- Review, Nor, NA
*toxicity↓, *BP↓, *AntiDiabetic↑, *AntiCan↑, *antiOx↑, *Inflam↓, *AntiBio↑, *other↝, *cognitive↑, *GH↑, *Sleep↑, *BioAv↑, *Half-Life↝, *BBB↓, *eff↑,
7080- GABA,    The Effect of Oral GABA on the Nervous System: Potential for Therapeutic Intervention
- Review, AD, NA
*BBB↝, *cognitive↑, *Dose↝, *toxicity↓, *Stress↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL1β↓, *TNF-α↓, *Sleep↑, *Pain↓, *neuroP↑, *eff↑, *Ach↑, *AST↓, *ALAT↓, *BP↓, *other↝,
5148- GamB,    Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics
- Review, Var, NA
AntiCan↑, angioG↓, ChemoSen↑, RadioS↑, VEGF↓, MMP2↓, MMP9↓, Telomerase↓, TrxR↓, ERK↓, HSP90↓, ROS↑, SIRT1↑, survivin↓, cFLIP↓, Casp3↑, Casp8↑, Casp9↑, BAD↓, BID↓, Bcl-2↓, BAX↑, STAT3↓, hTERT/TERT↓, NF-kB↓, Myc↓, Hif1a↓, FOXD3↑, BioAv↓, BioAv↑, P53↑, eff↓, OCR↓, MMP↓, PI3K↓, Akt↓, BBB↑, TumCG↓, TumMeta↓, BioAv↑,
6572- Ger,    Pharmacokinetics of Geraniol and Its Metabolites in Mice After Oral Administration
- in-vivo, Nor, NA
BioAv↝, BBB↑, BioAv↝, Half-Life↝,
7302- GlaB,    Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma
- vitro+vivo, MB, NA
BioAv↑, Gli1↓, TumCG↓, Dose↝, BBB↑, HH↓,
6062- GoldNP,  SeNPs,    Nanotechnology-based Targeting of Neurodegenerative Disorders: A Promising Tool for Efficient Delivery of Neuromedicines
- Review, AD, NA
*DDS↑, *BBB↑, *eff↑,
7487- H2,    A comprehensive review of molecular hydrogen as a novel nutrition therapy in relieving oxidative stress and diseases: Mechanisms and perspectives
- Review, Nor, NA
*Inflam↓, *antiOx↓, *Stress↓, *Dose↝, *cardioP↑, *GastroP↑, *BBB↑, *eff↑, *toxicity↓, *Dose↝, *hepatoP↑, *ROS↓, *SOD↑, *TBARS↓, *HDL↑, *LDL↓, *Obesity↓, *GSH↑, *TNF-α↓, *GutMicro↑, *DNAdam↓, *γH2AX↓, *p‑p38↓, *NF-kB↓,
4307- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *neuroP↑, *memory↑, *BBB↑, *BDNF↑, *TNF-α↓, *Catalase↑, *IL6↓, *Aβ↓, *GABA↓, *Dose↝,
2511- H2,    Molecular hydrogen suppresses glioblastoma growth via inducing the glioma stem-like cell differentiation
- in-vivo, GBM, U87MG
TumCG↓, OS↑, CD133↓, Ki-67↓, angioG↓, Diff↑, TumCMig↓, TumCI↓, Dose↝, BBB↑, mt-ROS↑,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2513- H2,    Hydrogen therapy: from mechanism to cerebral diseases
- Review, Stroke, NA
*BBB?, *antiOx↑, *Inflam↓, *Apoptosis↓, *NF-kB↓, *Dose↝,
3761- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer's Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Human, AD, NA
*cognitive↑, *BBB↑, *ROS↓, *NRF2↑, *Inflam↓, *NFAT↓, *FAO↓, *4-HNE↓, *PGC-1α↑, *Ferroptosis↓,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3765- H2,    Therapeutic Inhalation of Hydrogen Gas for Alzheimer’s Disease Patients and Subsequent Long-Term Follow-Up as a Disease-Modifying Treatment: An Open Label Pilot Study
- Study, AD, NA
*antiOx↑, *Inflam↓, *cognitive↑, *BBB↑,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *BP∅, *BBB↑,
6869- HCAs,  FA,  CA,  RosA,    Exploring the potential of cinnamic acid analogues in alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↓, *Inflam↓, *tau↓, *BioAv↓, *BBB↓, *BioAv↑,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2873- HNK,    Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- in-vitro, Nor, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,
2872- HNK,    Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis
- in-vivo, ALS, NA - NA, Stroke, NA - NA, AD, NA - NA, Park, NA
*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *eff↑, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,
2866- HNK,    Honokiol and its analogues as anticancer compounds: Current mechanistic insights and structure-activity relationship
- Review, Var, NA
EMT↓, TumMeta↓, BioAv↑, BBB↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE/β-secretase↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7804- IBC,    Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms
- Review, Nor, NA
*BioAv↓, *BBB↑, *hepatoP↓, ROS↑, *NA↓, ERK↓, Wnt↓, Apoptosis↑, *NF-kB↓, *NRF2↑, *HO-1↑, *Inflam↓,
7710- IBC,    Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice
- vitro+vivo, AD, NA
*p‑AMPK↑, *NLRP3↓, *NA↝, *cognitive↑, *memory↑, *motorD↑, *Aβ↓, *Inflam↓, *BBB↑,
7641- Ins,    Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
- Review, CRC, NA
AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,
7765- ISL,    Isoliquiritigenin as a modulator of the Nrf2 signaling pathway: potential therapeutic implications
- Review, Var, NA
*antiOx↑, *AntiCan↑, *AntiTum↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *NRF2↑, *NQO1↝, *HO-1↑, *SOD↑, *toxicity↓, *BioAv↓, *Half-Life↓, *BBB↑, *neuroP↑, *Stroke↓, *GSK‐3β↓, *p‑GSK‐3β↑, *hepatoP↑, *Inflam↓, *ROS↓, *MPO↓, *MDA↓,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7732- isoFl,    Biological activities and therapeutic potential of soy isoflavones: a focus on anticancer activity
*Inflam↓, *ROS↓, Apoptosis↑, NOS2↑, *Aβ↓, *BioAv↓, *BioAv↑, *BioAv↝, *neuroP↑, *BBB↑, TNF-α↓, ROS↑, selectivity↑, ChemoSen↑, eff↝,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *eff↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7836- ISQ,    An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*AChE↓, *Aβ↓, *BBB↑, *Ach↑, *cognitive↑, *APP↓, *tau↓, *eff↑,
8039- IVM,    Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy
- NA, neuroblastoma, SH-SY5Y
*toxicity↑, TumCD↑, ROS↑, mtDam↑, Apoptosis↑, MitoP↑, TumAuto↑, p‑Akt↓, p‑mTOR↓, LC3II↑, Beclin-1/ATG6↑, ATG5↑, PINK1↑, PARK2↑, tumCV↓, MDA↑, SOD↑, Catalase↑, eff↓, MMP↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Cyt‑c↑, Bcl-2↓, proCasp3↓, Bax:Bcl2↑, eff↑, *AntiP↑, *Inflam↓, *AntiDiabetic↑, *AntiViral↑, BBB∅, toxicity↝,
8029- IVM,    Ivermectin in Cancer Treatment: Should Healthcare Providers Caution or Explore Its Therapeutic Potential?
- Review, Var, NA
TumCP↓, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, Akt↓, mTOR↓, BBB∅, ROS↑, MMP↓, Casp3↓, Casp9↑, TumCCA↑, P53↑, cMyc↓, MMP9↓, HSP27↓, ICD↑, eff↑, *AntiP↑,
8234- LCA,    Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
- Review, AD, NA
*neuroP↑, *PTP1B↓, *cognitive↑, *BDNF↑, *TrkB↝, *cJun↓, *p‑tau↓, *AChE↓, *Ach↑, *Aβ↓, *antiOx↑, *NRF2↑, *AntiViral↑, *Obesity↓, *PI3K↑, *Akt↑, *mTOR↑, *memory↑, *BBB↑,
8226- LCA,    Licochalcone A as a Potential Anti- Toxoplasma Agent: A Target Identification and Pharmacokinetic Study
- Study, Nor, NA
*BBB↑,
8228- LCA,    Detection and pharmacokinetics of licochalcone A in brains of neuroinflammatory mouse model
- in-vivo, AD, NA
*Inflam↓, *neuroP?, *BBB↑, *memory↑, *cognitive↑,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
4295- LT,    Luteolin Reduces Alzheimer’s Disease Pathologies Induced by Traumatic Brain Injury
- in-vivo, AD, NA
*Aβ↓, *GSK‐3β↓, *p‑tau↓, *BBB↑,
4292- LT,    Luteolin for neurodegenerative diseases: a review
- Review, AD, NA - Review, Park, NA - Review, MS, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE/β-secretase↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
2916- LT,    Antioxidative and Anticancer Potential of Luteolin: A Comprehensive Approach Against Wide Range of Human Malignancies
- Review, Var, NA - Review, AD, NA - Review, Park, NA
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1/ATG6↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,

Showing Research Papers: 101 to 150 of 221
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 221

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

BMP7/OP1↓, 1,   CTSK↓, 1,   TF-Ag↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 2,   Catalase↑, 1,   Ferroptosis↑, 1,   GSH↓, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 1,   ICD↑, 1,   Iron↝, 1,   MDA↑, 2,   NRF2↓, 1,   NRF2↑, 2,   PARK2↑, 1,   ROS↓, 2,   ROS↑, 8,   mt-ROS↑, 2,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   mitResp↓, 1,   MMP↓, 5,   mtDam↑, 1,   OCR↓, 2,   OCR↑, 1,   PINK1↑, 1,   c-Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 2,   ECAR↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 4,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 6,   BAD↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   BID↓, 1,   Casp3↓, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   proCasp3↓, 1,   Casp8↑, 3,   Casp9↑, 5,   cl‑Casp9↑, 1,   proCasp9↓, 1,   cFLIP↓, 2,   Cyt‑c↑, 4,   DR5↑, 2,   Ferroptosis↑, 1,   hTERT/TERT↓, 2,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↑, 1,   MDM2↓, 1,   Myc↓, 1,   p27/CDKN1B↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 2,   BNIP3↑, 1,   LC3II↑, 2,   MitoP↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53?, 1,   P53↑, 4,   cl‑PARP↑, 3,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 4,   CDK4↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 2,   cycD1/CCND1↑, 1,   P21?, 1,   P21↑, 1,   p‑RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 2,   cFos↓, 1,   CSCs↓, 2,   Diff↑, 1,   EMT↓, 4,   ERK↓, 3,   p‑ERK↓, 1,   FOXM1↓, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 1,   PI3K↓, 7,   PTEN↑, 1,   RAS↓, 3,   SOX2↓, 1,   STAT3↓, 3,   p‑STAT3↓, 2,   TOP2↑, 1,   TumCG↓, 4,   Wnt↓, 3,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 2,   FAK↓, 1,   Ki-67↓, 1,   MMP2↓, 4,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 2,   Rho↑, 1,   ROCK1↑, 1,   Snail↓, 2,   SOX4↓, 1,   TIMP1↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 4,   Twist↓, 2,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 2,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   EGFR↓, 2,   p‑EGFR↓, 1,   Hif1a↓, 4,   NO↝, 1,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 8,   BBB∅, 2,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   ICAM-1↓, 1,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL1β↓, 3,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 3,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 9,   p65↓, 1,   PGE2↓, 3,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 4,   BioAv↝, 4,   ChemoSen↑, 8,   Dose↓, 1,   Dose↝, 3,   eff↓, 2,   eff↑, 4,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 4,   RadioS↑, 3,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

BMPs↑, 1,   EGFR↓, 2,   p‑EGFR↓, 1,   FOXM1↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 2,   IL6↓, 3,   Ki-67↓, 1,   Myc↓, 1,   NOS2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   cardioP↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   cognitive↑, 1,   memory↑, 1,   neuroP↓, 1,   neuroP↑, 1,   OS↑, 3,   Risk↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 223

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

anemia↓, 1,   AntiBio↑, 2,   AntiP↑, 2,   APOE4↓, 1,   Aβ42↓, 1,   FPN↑, 1,   Learn↑, 1,   NA↓, 1,   NA↝, 1,   PSEN1/PS1↑, 1,   RBC↑, 1,   Stress↓, 2,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↓, 2,   antiOx↑, 17,   Catalase↑, 6,   Fenton↓, 1,   Ferroptosis↓, 1,   GPx↑, 2,   GSH↑, 6,   GSR↑, 1,   GSTs↑, 1,   HDL↑, 1,   HO-1↑, 6,   Keap1↑, 1,   lipid-P↓, 3,   MDA↓, 5,   MDA↑, 1,   MPO↓, 1,   NQO1↝, 1,   NRF2↑, 12,   ROS↓, 22,   SIRT3↑, 1,   SOD↑, 10,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 2,   Trx1↑, 1,   TrxR1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 3,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   MMP↑, 2,   mtDam↓, 1,   PGC-1α↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ALAT↓, 2,   AMPK↑, 2,   p‑AMPK↑, 1,   CREB↑, 1,   FAO↓, 1,   glucose↝, 1,   LDL↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PPARγ↑, 2,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↓, 4,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↑, 1,   Casp1↓, 1,   Casp3↓, 4,   Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 3,   AntiThr↑, 1,   cJun↓, 1,   other↑, 1,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↑, 1,   UPR↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,   γH2AX↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   FOXO3↑, 1,   GH↑, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   mTOR↑, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   APP↓, 3,   cl‑APP↑, 1,   BACH1↓, 1,   Ca+2↓, 1,   NFAT↓, 1,   PTP1B↓, 1,   Rho↓, 1,   VCAM-1↓, 1,   ZO-1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB?, 1,   BBB↓, 4,   BBB↑, 30,   BBB↝, 4,   BBB∅, 1,   GastroP↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 4,   ICAM-1↓, 1,   IL1β↓, 6,   IL33↓, 1,   IL6↓, 8,   IL6↑, 1,   IL8↓, 2,   Imm↑, 1,   Inflam↓, 25,   NF-kB↓, 8,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 6,   ADAM10↑, 1,   BChE↓, 2,   BDNF↑, 6,   GABA↓, 1,   NGF↑, 1,   tau↓, 4,   p‑tau↓, 3,   TrkB↑, 2,   TrkB↝, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 12,   BACE/β-secretase↓, 4,   NLRP3↓, 5,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 8,   BioAv↝, 5,   ChemoSen↑, 1,   DDS↑, 1,   Dose↑, 1,   Dose↝, 7,   eff↑, 11,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 3,   BloodF↑, 1,   BP↓, 2,   BP∅, 1,   Ferritin↓, 1,   GutMicro↑, 3,   HemoG↑, 1,   IL6↓, 8,   IL6↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 4,   chemoP↑, 1,   cognitive↑, 15,   fatigue↓, 1,   hepatoP↓, 1,   hepatoP↑, 3,   memory↑, 9,   motorD↑, 2,   neuroP?, 1,   neuroP↑, 22,   Obesity↓, 2,   OS↑, 2,   Pain↓, 1,   RenoP↓, 1,   RenoP↑, 2,   Sleep↑, 2,   toxicity↓, 6,   toxicity↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Sepsis↓, 2,  
Total Targets: 188

Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
14 Selenium NanoParticles
13 Alpha-Lipoic-Acid
11 borneol
10 Curcumin
10 Hydrogen Gas
7 Honokiol
6 Urolithin
5 Chlorogenic acid
5 Carvacrol
5 EGCG (Epigallocatechin Gallate)
5 Pterostilbene
4 Silver-NanoParticles
4 Berberine
4 Mung Bean Sprouts
4 Ferulic acid
4 Quercetin
4 Resveratrol
3 5-Hydroxytryptophan
3 Apigenin (mainly Parsley)
3 Choline
3 Gamma-aminobutyric acid
3 Rosmarinic acid
3 Licochalcone A
3 Luteolin
3 Lycopene
3 Mushroom Lion’s Mane
3 Rutin
3 Sulforaphane (mainly Broccoli)
2 almonertinib
2 Baicalein
2 beta-carotene(VitA)
2 Bacopa monnieri
2 Carnosic acid
2 Caffeic acid
2 Cinnamon
2 Fisetin
2 Isobavachalcone
2 Isoliquiritigenin
2 Ivermectin
2 Lactoferrin/Talactoferrin
2 Methylene blue
2 Vitamin B3,Niacin
2 S-adenosyl-L-methionine
2 Silymarin (Milk Thistle) silibinin
2 Thymoquinone
2 Turmerones
2 Vitamin B5,Pantothenic Acid
1 1,8-Cineole
1 acetaminophen
1 Anthocyanins
1 Allicin (mainly Garlic)
1 Acetyl-l-carnitine
1 Bevacizumab (brand Avastin)
1 Aromatherapy
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Brucea javanica
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 chitosan
1 Chrysin
1 Propolis -bee glue
1 Coenzyme Q10
1 Crocetin
1 Galantamine
1 Cysteamine
1 Deguelin
1 Diclofenac
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Evodiamine
1 Fucoidan
1 Gambogic Acid
1 Geraniol
1 Glabrescione B
1 Gold NanoParticles
1 Hydroxycinnamic-acid
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 Inositol
1 isoflavones
1 isoorientin
1 isoquercitrin
1 Magnolol
1 Isovitexin
1 Vitexin
1 MCToil
1 Melatonin
1 Magnetic Fields
1 Moringa oleifera
1 Methylsulfonylmethane
1 Myricetin
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Nimbolide
1 Olive Oil
1 HydroxyTyrosol
1 Oleuropein
1 Protocatechuic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 Metformin
1 Taurine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1123  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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