Ferroptosis Cancer Research Results

Ferroptosis, Ferroptosis: Click to Expand ⟱
Source:
Type: type of cell death
Type of programmed cell death dependent on iron.
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides to lethal levels. It is distinct from other forms of cell death, such as apoptosis, necrosis, and autophagy. The process of ferroptosis is heavily dependent on iron metabolism and reactive oxygen species (ROS).
The accumulation of lipid peroxides is a hallmark of ferroptosis. This can occur when the antioxidant defenses, such as glutathione and selenoproteins, are overwhelmed or inhibited. Many cancer cells upregulate GPX4 to evade ferroptosis, making it a potential target for therapy. It has been described that GPX4, xCT and ACSL-4 are the main targets in the regulation of ferroptosis.
Scientific Papers found: Click to Expand⟱
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,
8071- KAE,    Cellular reprogramming and signaling control by kaempferol in colorectal cancer
- Review, CRC, NA
*toxicity↓, Risk↓, MMPs↓, VEGF↓, VEGFR1↓, Wnt↓, β-catenin/ZEB1↑, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, *BioAv↓, TumCCA↑, Apoptosis↑, Hif1a↓, ROS↑, TumCMig↓, TumMeta↓, PKM2↓, Glycolysis↓, DNAdam↑, HO-1↑, Ferroptosis↑, eff↑, Dose↝, BioAv↑,
8073- KAE,    Kaempferol inhibits oxidative stress-induced ferroptosis via the ROS/P38MAPK pathway to delay intervertebral disc degeneration: a combinatorial study of cell, animal, and transcriptomic evidence
- Review, Nor, NA
*Inflam↓, *antiOx↑, *ROS↓, *MAPK↓, *Ferroptosis↓,
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, eff↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8112- LA,    Metabolomics and proteomics reveal the inhibitory effect of Lactobacillus crispatus on cervical cancer
- in-vitro, Cerv, SiHa
HO-1↝, ACSL4↝, Ferroptosis↑, T-cadherin↑, ROS↑, lipid-P↑,
8260- LCA,    Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway
- vitro+vivo, Liver, HepG2 - in-vitro, Liver, HUH7
tumCV↑, xCT/SLC7A11↓, Ferroptosis↑, GPx4↑, ROS↑, TumCP↓, TumCD↑, Iron↑,
8214- LCA,    Licochalcone A decreases cancer cell proliferation and enhances ferroptosis in acute myeloid leukemia through suppressing the IGF2BP3/MDM2 cascade
- vitro+vivo, AML, U937
TumCP↓, Ferroptosis↑, IGF2BP3/IMP3/KOC↓, MDM2↓,
8225- LCA,  Cisplatin,    Licochalcone A protects against cisplatin-induced acute kidney injury via the modulation of Nrf2/Keap1-mediated ferroptosis and apoptosis
- in-vivo, Nor, NA
*RenoP↑, *Urea↓, *BUN↓, *creat↓, *Apoptosis↓, *Ferroptosis↓, *Iron↓, *ROS↓, *lipid-P↓, *mtDam↓, *NRF2↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8139- LF,    Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis
- vitro+vivo, Pca, NA
Ferroptosis↓, AR↝, Iron↝, Ferritin↑, P53↓, eff↝, other↝, AntiTum↓,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
582- MF,  immuno,  VitC,    Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy
- in-vitro, Pca, TRAMP-C1 - in-vivo, NA, NA
Fenton↑, Ferroptosis↑, ROS↑, TumCG↓, Iron↑, GPx4↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
2937- NAD,    High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma Growth through the NAM-Mediated SIRT1-AMPK-ACC Pathway
- in-vitro, Lung, A549
SIRT1↑, Dose↝, TumCP⇅, Ferroptosis↑, lipid-P↑, AMPK↑, ACC↑,
1225- OLST,    Orlistat Induces Ferroptosis in Pancreatic Neuroendocrine Tumors by Inactivating the MAPK Pathway
- vitro+vivo, PC, NA
TumCMig↓, TumCI↓, Ferroptosis↑, MAPK↓,
2054- PB,    Sodium butyrate induces ferroptosis in endometrial cancer cells via the RBM3/SLC7A11 axis
- in-vitro, EC, ISH - in-vitro, EC, HEC1B
Ferroptosis↑, xCT/SLC7A11↓, RBM3↑, HDAC↓, ROS↑,
4925- PEITC,    PEITC triggers multiple forms of cell death by GSH-iron-ROS regulation in K7M2 murine osteosarcoma cells
- in-vitro, OS, NA
tumCV↓, TumCP↓, TumCCA↑, GSH↓, ROS↑, Ferroptosis↑, Apoptosis↑, TumAuto↑, MAPK↑, TumCG↓, Dose⇅,
4927- PEITC,    Targeting ferroptosis in osteosarcoma
- Review, OS, NA
AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,
2956- PL,    Piperlongumine rapidly induces the death of human pancreatic cancer cells mainly through the induction of ferroptosis
- in-vitro, PC, NA
ROS↑, Ferroptosis↓, GSH↓, GPx↓, cl‑PARP∅, cl‑Casp3∅, eff↑, eff↑,
2958- PL,    Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity
- in-vitro, Oral, HSC3
TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,
2954- PL,    The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy
- Review, Var, NA
NRF2↑, ROS↑, ER Stress↑, MAPK↑, CHOP/DDIT3↑, selectivity↑, Keap1↝, HO-1↑, Ferroptosis↑,
4965- PSO,  Cisplatin,    The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis
- vitro+vivo, GC, HGC27 - vitro+vivo, GC, MKN45
TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, eff↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,
5026- QC,    Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes
- in-vitro, GC, NA
SLC1A5↓, ROS↑, Iron↓, NRF2↓, GPx4↓, Ferroptosis↑,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT/SLC7A11↓, GPx4↓, *BioAv↑, COX2/PTGS2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
3023- RosA,    Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis
- in-vivo, Sepsis, NA
*GPx4↑, *Inflam↓, *ER Stress↓, *Ferroptosis↓, *Sepsis↓, *GRP78/BiP↓, *IRE1↓, JNK↓,
3024- RosA,    rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice
- in-vivo, Sepsis, NA
*Ferroptosis↓, *GRP78/BiP↓, *PERK↓, *ATF4↓, *Sepsis↓, *GSH↑, *SOD↑, *Catalase↑,
3039- RosA,    Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
- in-vivo, Nor, NA - in-vivo, Stroke, NA
*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,
4911- Sal,    MUC1-C is a target of salinomycin in inducing ferroptosis of cancer stem cells
- in-vitro, Var, DU145
MUC1-C↓, Ferroptosis↑, CSCs↓, NF-kB↓, GSR↓, GSH↑, Iron↑,
5000- Sal,    Salinomycin kills cancer stem cells by sequestering iron in lysosomes
- vitro+vivo, BC, NA
CSCsMark↓, eff↑, Ferroptosis↑, ROS↑,
4904- Sal,  CUR,    Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition
CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,
5139- SAS,    Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis
- in-vitro, OS, MG63 - in-vitro, OS, U2OS
*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT/SLC7A11↓, GPx4↓, FTH1↓,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT/SLC7A11↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
5039- SAS,    Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer
- vitro+vivo, BC, NA
xCT/SLC7A11↓, ROS↑, GSH↓, Ferroptosis↑, TumCG↓, toxicity↓, lipid-P↑,
4712- Se,    Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
- Review, Var, NA
selenoP↑, Ferroptosis↑, lipid-P↑,
1483- SFN,    Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment
- in-vitro, OS, 143B - in-vitro, Nor, HEK293 - in-vivo, OS, NA
AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,
1479- SFN,    Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
- in-vitro, CRC, HCT116
Ferroptosis↑, SIRT3↑, AMPK↑, mTOR↑, tumCV↓, ROS↑, MDA↑, Iron↑,
3313- SIL,    Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats
- in-vivo, NA, NA
*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,
2201- SK,    Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice
- in-vitro, PSA, HaCaT - in-vivo, NA, NA
*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,
2200- SK,    Shikonin inhibits the growth of anaplastic thyroid carcinoma cells by promoting ferroptosis and inhibiting glycolysis
- in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, 8505C
NF-kB↓, GPx4↓, TrxR1↓, PKM2↓, GLUT1↓, Glycolysis↓, Ferroptosis↑, GlucoseCon↓, lactateProd↓, ROS↑,
2199- SK,    Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
- in-vitro, GC, NA
ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,
2198- SK,    Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis
- in-vitro, OS, MG63 - in-vitro, OS, 143B
TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT/SLC7A11↓, GPx4↓, GSH/GSSG↓, Keap1↑,
2195- SK,    Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis
- in-vitro, OS, NA
TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,
2203- SK,    Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation
- in-vitro, Lung, NA
TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,
2202- SK,    Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification
- in-vitro, Var, NA
Iron↑, Ferroptosis↑, pH↝, H2O2↑, ROS↑, Fenton↑, GSH↓, GPx4↓, lipid-P↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
1068- SM,    Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, BC, NA - Human, BC, NA
TumCG↓, Ferroptosis↑, GPx4↓, TumVol↓, OS↑, GSH/GSSG↓,
4892- Sper,  erastin,    Spermidine inactivates proteasome activity and enhances ferroptosis in prostate cancer
- in-vitro, Pca, PC3 - in-vivo, Pca, NA
Ferroptosis↑, lipid-P↑, Iron↑, eff↑, HO-1↑, NRF2↑, ROS↑, AntiTum↑, eff↓,
1002- SSE,  Osi,  Adag,    Selenite as a dual apoptotic and ferroptotic agent synergizes with EGFR and KRAS inhibitors with epigenetic interference
- in-vitro, Lung, H1975 - in-vitro, Lung, H385
Apoptosis↑, Ferroptosis↑, DNMT1↓, TET1↑, TumCCA↑, cl‑PARP↑, cl‑Casp3↑, Cyt‑c↑, BIM↑, NOXA↑, Apoptosis↑, ROS↑, ER Stress↑, UPR↑,
4727- SSE,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,

Showing Research Papers: 101 to 150 of 160
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 160

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IGF2BP3/IMP3/KOC↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   ATF3↑, 1,   Fenton↑, 2,   Ferroptosis↓, 3,   Ferroptosis↑, 38,   GPx↓, 1,   GPx4↓, 19,   GPx4↑, 1,   GSH↓, 13,   GSH↑, 1,   GSH/GSSG↓, 3,   GSR↓, 1,   H2O2↑, 1,   HO-1↑, 5,   HO-1↝, 1,   Iron↓, 1,   Iron↑, 16,   Iron↝, 2,   i-Iron↑, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↑, 15,   MDA↓, 1,   MDA↑, 10,   NOX4↑, 1,   NRF2↓, 4,   NRF2↑, 2,   ROS↓, 1,   ROS↑, 29,   selenoP↑, 1,   SIRT3↑, 1,   SOD↓, 3,   TrxR1↓, 1,   xCT/SLC7A11↓, 7,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   Ferritin↑, 1,   FTH1↓, 2,   IronCh↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,   MPT↑, 1,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ACSL4↑, 1,   ACSL4↝, 1,   AMPK↑, 3,   GlucoseCon↓, 1,   Glycolysis↓, 3,   ac‑Histones↑, 1,   lactateProd↓, 1,   LDH↓, 1,   PKM2↓, 2,   PKM2↑, 1,   SIRT1↑, 1,   SLC1A5↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 5,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   cl‑Casp3↑, 1,   cl‑Casp3∅, 1,   Cyt‑c↑, 2,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   FasL↓, 1,   Ferroptosis↓, 3,   Ferroptosis↑, 38,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   MDM2↓, 1,   NOXA↑, 1,   Pyro↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

DLEU1↓, 1,   other↝, 2,   tumCV↓, 2,   tumCV↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   ER Stress↑, 4,   UPR↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3B↑, 1,   p62↑, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNMT1↓, 1,   DNMT1↑, 1,   P53↓, 1,   cl‑PARP↑, 1,   cl‑PARP∅, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 3,   CSCsMark↓, 1,   EMT↓, 2,   ERK↓, 1,   ERK↑, 1,   FOSL1↑, 1,   GDF15↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   mTOR↓, 3,   mTOR↑, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 2,   STAT3↓, 1,   TumCG↓, 7,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   HLA↑, 1,   Ki-67↓, 1,   MALAT1↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   MUC1-C↓, 1,   SOX4↓, 2,   T-cadherin↑, 1,   TET1↑, 1,   TIMP2↓, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 9,   TumCP⇅, 1,   TumMeta↓, 1,   VEGFR1↓, 1,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↓, 1,   Hif1a↑, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   FOXP3↓, 1,   HMGB1↓, 1,   IL1↓, 1,   IL2↓, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   p‑NF-kB↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   ChemoSen↑, 6,   Dose⇅, 1,   Dose↝, 2,   eff↓, 4,   eff↑, 8,   eff↝, 1,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   Ferritin↓, 1,   Ferritin↑, 1,   Ki-67↓, 1,   LDH↓, 1,   RBM3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 3,   chemoP↑, 1,   OS↑, 1,   Risk↓, 1,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 185

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,   anemia↓, 1,   Aβ42↓, 1,   FPN↑, 1,   RBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   Fenton↓, 1,   Ferroptosis↓, 10,   GPx↑, 1,   GPx4↓, 1,   GPx4↑, 6,   GSH↑, 4,   GSR↓, 1,   GSTs↓, 1,   HO-1↑, 2,   HO-1↝, 1,   Iron↓, 2,   i-Iron↓, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 3,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 5,   ROS↓, 6,   SOD↑, 4,   TAC↑, 1,   TBARS↓, 1,   xCT/SLC7A11↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   NCOA4↝, 1,   TfR1/CD71↓, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↓, 1,   BUN↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 2,   Casp3↓, 2,   Cyt‑c↓, 1,   Ferroptosis↓, 10,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 2,   IRE1↓, 1,   PERK↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PTEN↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL17↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 5,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 1,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

creat↓, 2,   Ferritin↓, 1,   GutMicro↑, 2,   HemoG↑, 1,   IL6↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   neuroP↑, 1,   RenoP↑, 2,   toxicity↓, 3,   toxicity∅, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 3,  
Total Targets: 80

Scientific Paper Hit Count for: Ferroptosis, Ferroptosis
19 Artemisinin
8 Shikonin
7 erastin
7 Curcumin
7 Selenite (Sodium)
6 Cisplatin
4 Ashwagandha(Withaferin A)
4 Baicalein
4 Copper and Cu NanoParticles
4 Sulfasalazine
4 Honokiol
4 Kaempferol
3 Boron
3 immunotherapy
3 Docosahexaenoic Acid
3 Isoliquiritigenin
3 Licochalcone A
3 Piperlongumine
3 Rosmarinic acid
3 salinomycin
2 Andrographis
2 doxorubicin
2 Luteolin
2 Berberine
2 Betulinic acid
2 brusatol
2 Chlorogenic acid
2 Citric Acid
2 Coenzyme Q10
2 Disulfiram
2 Formononetin
2 Gambogic Acid
2 Ginkgo biloba
2 Ginkgetin
2 Hyperoside
2 isoquercitrin
2 Juglone
2 Lactoferrin/Talactoferrin
2 Vitamin C (Ascorbic Acid)
2 Phenethyl isothiocyanate
2 Sulforaphane (mainly Broccoli)
1 3-bromopyruvate
1 cetuximab
1 Astragalus
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 5-fluorouracil
1 Docetaxel
1 Astaxanthin
1 Radiotherapy/Radiation
1 Atorvastatin
1 Ras-selective lethal 3
1 Boswellia (frankincense)
1 Carvacrol
1 Celastrol
1 Vitamin K2
1 Crocetin
1 Cucurbitacin
1 diet Methionine-Restricted Diet
1 Dipyridamole
1 EGCG (Epigallocatechin Gallate)
1 Fenbendazole
1 ferumoxytol
1 Gallic acid
1 Hydrogen Gas
1 HydroxyTyrosol
1 isoorientin
1 Lactobacillus
1 Magnetic Fields
1 Myricetin
1 nicotinamide adenine dinucleotide
1 Orlistat
1 Phenylbutyrate
1 Psoralidin
1 Quercetin
1 Resveratrol
1 Selenium
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Spermidine
1 Osimertinib
1 Adagrasib
1 Aflavin-3,3′-digallate
1 Urolithin
1 Vitexin
1 Isovitexin
1 Zinc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:114  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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