| Source: |
| Type: |
| AChE is an enzyme that rapidly hydrolyzes the neurotransmitter acetylcholine into choline and acetate, terminating cholinergic signals. - In some cancers, studies have reported reduced AChE activity, which may contribute to an accumulation of acetylcholine. - Lower levels or loss of AChE expression/activity have been associated with more aggressive tumor behavior and poor prognosis, possibly due to unchecked cholinergic signaling. For AD (Alzheimer's), AChE inhibitors are used, to allow ACh, and ChAT to increase along with acetyl-CoA -Natural AChE inhibitors: Ferulic Acid, Caffeic Acid, Rosmarinic Acid, Sage -AChE inhibitors only temporarily relieve some of the disease’s cognitive symptoms and do not stop the patient’s cognitive loss -adverse effects such as disorientation, falls, dizziness, and fatigue may occur with these medications and should be used only as recommended - Natural AChE inhibitors paper |
| 3347- | QC, | Recent Advances in Potential Health Benefits of Quercetin |
| - | Review, | Var, | NA | - | Review, | AD, | NA |
| 3341- | QC, | Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA |
| 3336- | QC, | Neuroprotective Effects of Quercetin in Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 3616- | RosA, | Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders |
| - | Review, | AD, | NA |
| 3622- | RosA, | Rosmarinic acid prevents lipid peroxidation and increase in acetylcholinesterase activity in brain of streptozotocin-induced diabetic rats |
| - | in-vivo, | Diabetic, | NA |
| 3623- | RosA, | Rosmarinic acid inhibits some metabolic enzymes including glutathione S-transferase, lactoperoxidase, acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase isoenzymes |
| - | in-vitro, | AD, | NA |
| 3632- | RosA, | CA, | QC, | Evolving Role of Natural Products from Traditional Medicinal Herbs in the Treatment of Alzheimer's Disease |
| - | Review, | AD, | NA |
| 3757- | RosA, | Sage, | Cro, | NarG, | Caff | Food-derived Acetylcholinesterase Inhibitors as Potential Agents against Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 3755- | RosA, | CUR, | Development of Acetylcholinesterase (AChE) Inhibitor |
| - | Study, | AD, | NA |
| 3641- | Sage, | Systematic Review of Clinical Trials Assessing Pharmacological Properties of Salvia Species on Memory, Cognitive Impairment and Alzheimer's Disease |
| - | Review, | AD, | NA |
| 3643- | Sage, | Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery |
| - | Human, | Nor, | NA |
| 3645- | Sage, | RosA, | Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family |
| - | Study, | AD, | NA |
| 4217- | Sage, | RosA, | Aroma, | Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4085- | Se, | Role of micronutrients in Alzheimer's disease: Review of available evidence |
| - | Review, | AD, | NA |
| - | Review, | AD, | NA |
| 6055- | SeNPs, | CUR, | RES, | Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems |
| - | NA, | AD, | NA |
| 6046- | SeNPs, | CGA, | Anti-amyloidogenic properties of 5‑caffeoylquinic acid-capped selenium nanoparticles |
| - | Study, | AD, | NA |
| 4190- | Sesame, | Sesame Seeds: A Nutrient-Rich Superfood |
| - | Review, | NA, | NA |
| 3947- | Shank, | Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer's disease Drosophila model |
| - | in-vivo, | AD, | NA |
| 3948- | Shank, | Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain |
| - | in-vivo, | AD, | NA |
| 3946- | Shank, | Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies |
| - | Review, | AD, | NA |
| 3945- | Shank, | Novel insights on acetylcholinesterase inhibition by Convolvuluspluricaulis, scopolamine and their combination in zebrafish |
| - | in-vivo, | AD, | NA |
| 3943- | Shank, | Protective Mechanisms of Nootropic Herb Shankhpushpi (Convolvulus pluricaulis) against Dementia: Network Pharmacology and Computational Approach |
| - | Review, | AD, | NA |
| 3330- | SIL, | Mechanistic Insights into the Pharmacological Significance of Silymarin |
| - | Review, | Var, | NA |
| 3319- | SIL, | Silymarin and neurodegenerative diseases: Therapeutic potential and basic molecular mechanisms |
| - | Review, | AD, | NA | - | Review, | Park, | NA | - | Review, | Stroke, | NA |
| 3318- | SIL, | Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3316- | SIL, | Chemo, | Silymarin Nanoparticles Counteract Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights into Mitochondrial Dysfunction and Nrf2/HO-1 Axis |
| 4215- | SY, | Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway |
| - | in-vivo, | NA, | NA |
| 3432- | TQ, | Thymoquinone: Review of Its Potential in the Treatment of Neurological Diseases |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3562- | TQ, | ACETYLCHOLINESTERASE AND GROWTH INHIBITORY EFFECTS–VARIOUS GRADES OF N. SATIVA OILS |
| - | Review, | AD, | NA | - | Review, | Var, | NA |
| 3555- | TQ, | Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model |
| - | in-vivo, | AD, | NA |
| 3557- | TQ, | Thymoquinone protects against lipopolysaccharides-induced neurodegeneration and Alzheimer-like model in mice. |
| - | in-vivo, | AD, | NA |
| 3559- | TQ, | Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease |
| - | Review, | AD, | NA | - | Review, | Var, | NA |
| 3560- | TQ, | Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes |
| - | in-vivo, | AD, | NA |
| 3561- | TQ, | Studi In Silico Potensi Piperine, Piperlongumine, dan Thymoquinone Sebagai Obat Alzheimer |
| - | NA, | AD, | NA |
| 3565- | TQ, | Thymoquinone as a potential therapeutic for Alzheimer’s disease in transgenic Drosophila melanogaster model |
| 5904- | TV, | Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development |
| - | Review, | Var, | NA | - | Review, | Stroke, | NA | - | Review, | Diabetic, | NA | - | Review, | Obesity, | NA | - | Review, | AD, | NA | - | Review, | Arthritis, | NA |
| 4084- | Z, | Role of micronutrients in Alzheimer's disease: Review of available evidence |
| - | Review, | AD, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:1329 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid