Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱
Source:
Type: pro-survival proteins
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
Scientific Papers found: Click to Expand⟱
2095- TQ,    Review on the Potential Therapeutic Roles of Nigella sativa in the Treatment of Patients with Cancer: Involvement of Apoptosis
- Review, Var, NA
TumCCA↑, Apoptosis↑, ROS↑, Cyt‑c↑, Bax:Bcl2↑, Casp3↑, Casp9↑, cl‑PARP↑, P53↑, P21↑, cMyc↓, hTERT/TERT↓, cycD1/CCND1↓, CDK4↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, eff↑,
2100- TQ,    Dual properties of Nigella Sative: Anti-oxidant and Pro-oxidant
- Review, NA, NA
ROS⇅, *antiOx↑, *SOD↑, *MPO↑, *neuroP↑, *chemoP↑, *radioP↑, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, Bcl-xL↓, survivin↓, COX2↓, MMP9↓, VEGF↓, ROS↑, P21↑, HDAC↓, GSH↓, GADD45A↑, AIF↑, STAT3↓,
2102- TQ,    A review on therapeutic potential of Nigella sativa: A miracle herb
- Review, Var, NA
angioG↓, NF-kB↓, PPARγ↓, Bcl-2↓, Bcl-xL↓, MUC4↓, cJun↑, p38↑, P21↑, HDAC↓, *radioP↑, hepatoP↑,
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2↓, XIAP↓, survivin↓, COX2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
3414- TQ,    Thymoquinone induces apoptosis through inhibition of JAK2/STAT3 signaling via production of ROS in human renal cancer Caki cells
- in-vitro, RCC, Caki-1
tumCV↓, Apoptosis↑, P53↑, BAX↑, Cyt‑c↑, cl‑Casp9↑, cl‑Casp3↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, p‑STAT3↓, p‑JAK2↓, STAT3↓, survivin↓, cycD1/CCND1↓, ROS↑, eff↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, BioAv↝, TumCG↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

Showing Research Papers: 101 to 110 of 110
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 110

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 1,   ROS↑, 7,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 3,   FAO↑, 1,   FASN↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   PPARγ↓, 2,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 5,   Bak↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 6,   Bcl-xL↓, 9,   Bcl-xL↑, 1,   Casp↑, 2,   Casp3↑, 4,   cl‑Casp3↑, 2,   Casp7↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 2,   Cyt‑c↑, 4,   hTERT/TERT↓, 1,   IAP1↓, 3,   IAP2↓, 3,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   p27↑, 1,   p38↑, 1,   survivin↓, 5,  

Kinase & Signal Transduction ⓘ

cSrc↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   EZH2↓, 1,   tumCV↓, 2,  

DNA Damage & Repair ⓘ

ATM↑, 1,   BRCA1↑, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   GADD45A↑, 1,   p16↑, 1,   P53↑, 6,   cl‑PARP↑, 4,  

Cell Cycle & Senescence ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 6,   P21↓, 1,   P21↑, 4,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   ERK↓, 1,   p‑ERK↓, 2,   HDAC↓, 5,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PTEN↑, 2,   STAT3↓, 4,   p‑STAT3↓, 2,   TumCG↓, 2,  

Migration ⓘ

5LO↓, 1,   CD31↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   Ki-67↓, 2,   MMP9↓, 3,   MMPs↓, 1,   MUC4↓, 1,   N-cadherin↓, 1,   TumMeta↓, 1,   Twist↓, 2,   Vim↓, 1,   Zeb1↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 1,   NO↑, 1,   VEGF↓, 3,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CXCR4↓, 1,   Inflam↓, 2,   JAK2↓, 1,   p‑JAK2↓, 1,   NF-kB↓, 7,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 2,   ChemoSen↑, 1,   eff↓, 1,   eff↑, 5,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BRCA1↑, 1,   EGFR↓, 1,   EZH2↓, 1,   hTERT/TERT↓, 1,   Ki-67↓, 2,   Maspin↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   hepatoP↑, 3,   neuroP↑, 1,   RenoP↑, 1,  
Total Targets: 115

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 2,   GSTs↑, 1,   MDA↓, 1,   MPO↑, 1,   SOD↑, 3,  

Core Metabolism/Glycolysis ⓘ

NAD↑, 1,   SIRT1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling ⓘ

CRP↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   neuroP↑, 1,   radioP↑, 2,  
Total Targets: 23

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
3 Boswellia (frankincense)
3 Sulforaphane (mainly Broccoli)
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Artemisinin
2 Berbamine
2 Boron
2 Butyrate
2 Carnosic acid
2 Capsaicin
2 Ursolic acid
2 Ellagic acid
2 Fisetin
2 Garcinol
2 Luteolin
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Silver-NanoParticles
1 Camptothecin
1 Paclitaxel
1 Cisplatin
1 Berberine
1 Betulinic acid
1 brusatol
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Docetaxel
1 Dichloroacetophenone(2,2-)
1 Evodiamine
1 Emodin
1 Gambogic Acid
1 Honokiol
1 Hyperthermia
1 Juglone
1 Magnolol
1 Magnetic Fields
1 Niclosamide (Niclocide)
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page