Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
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The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Scientific Papers found: Click to Expand⟱
7248- Gink,    Studies on the cytotoxic mechanisms of ginkgetin in a human ovarian adenocarcinoma cell line
- in-vitro, Ovarian, OVCAR-3 - in-vitro, Cerv, HeLa - NA, NA, OV1369
Dose↝, TumCD↑, eff↓, Casp↑, H2O2↑, i-ROS↑,
7250- Gink,    Ginkgetin from Ginkgo biloba: mechanistic insights into anticancer efficacy
- Review, Var, NA
AntiCan↑, toxicity↓, ChemoSen↑, chemoP↑, TumCCA↑, TumCD↑, TumCI↓, angioG↓, Ferroptosis↑, Imm↑, MOMP↑, Cyt‑c↑, Casp↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Apoptosis↑, ROS↑, TumAuto↑, GPx4↓, xCT/SLC7A11↓, RadioS↑, NRF2↓, HO-1↓, HSP90↓, Dose↝, Dose↝, BioAv↓, BioAv↝, CYP3A4↓, *toxicity↑, *toxicity↝,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7283- Gins,    Ginsenoside-Rh2-induced mitochondrial depolarization and apoptosis are associated with reactive oxygen species- and Ca2+-mediated c-Jun NH2-terminal kinase 1 activation in HeLa cells
- in-vitro, Cerv, HeLa - in-vitro, BC, MCF-10AT - in-vitro, BC, MCF7
MMP↓, Casp↑, BAX↑, Ca+2↑, ROS↑, cJun↑,
836- Gra,    Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism
- vitro+vivo, PC, NA
Hif1a↓, NF-kB↓, GLUT1↓, GLUT4↓, HK2↓, LDHA↓, TumCCA↑, TumMeta↓, GlucoseCon↓, ATP↓, necrosis↑, Casp∅, p‑FAK↓, MMP9↓, MUC4↓,
858- Gra,    Annona muricata leaves induce G₁ cell cycle arrest and apoptosis through mitochondria-mediated pathway in human HCT-116 and HT-29 colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116
TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑, BAX↑, Bcl-2↓, TumCMig↓, TumCI↓,
856- Gra,    https://pubmed.ncbi.nlm.nih.gov/33048613/
- in-vitro, BC, MCF7
TumCCA↑, ROS↑, Casp↑,
7335- Gra,    Effect of Annona muricata (Soursop) on Patients with Cancer: A Systematic Review
- Review, Var, NA
TumCG↓, Casp↑, Inflam↓, toxicity↓, other↑, TumCCA↑, Apoptosis↑, TumAuto↑, ATP↓, AIF↑, MMP↓, MOMP↑, Cyt‑c↑, selectivity↑, hepatoP∅,
7353- HibSad,    Hibiscus sabdariffa Leaf Polyphenolic Extract Induces Human Melanoma Cell Death, Apoptosis, and Autophagy
- in-vitro, Melanoma, A375
cl‑Casp↑, Bcl-2↓, Fas↑, FasL↑, ATG5↑, Beclin-1/ATG6↑, LC3B-II↑, TumAuto↑,
7461- HNK,    Honokiol: a potent chemotherapy candidate for human colorectal carcinoma
- vitro+vivo, CRC, RKO
Apoptosis↑, Casp↑, Dose↝, OS↑, *Inflam↓, *AntiThr↑, *antiOx↑, *Half-Life↝, TumCG↓,
5049- HPT,    Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer
- vitro+vivo, PC, Panc02 - vitro+vivo, PC, Bxpc-3
tumCV↓, proCasp↑, ROS↑, Ki-67↓, TOP2↓, TumVol↓,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
4639- HT,    Hydroxytyrosol Induces Apoptosis, Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, p‑Akt↓, p‑STAT3↓, NF-kB↓, AR↓, ROS↑, *BioAv↓, *toxicity∅,
7808- IBC,    Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells
- in-vitro, Tong, Tca8113
TumCP↓, Apoptosis↑, Bcl-2↓, BAX↑, Casp↑, p‑Akt↓, ERK↓, MMP2↓, MMP9↓,
7771- IBC,    Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME
- vitro+vivo, Thyroid, CAL-62
TumCG↓, TumCCA↑, Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, cl‑GSDME↑, TrxR1↓, ROS↑, ER Stress↑, Dose↝,
7674- iod,    Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
- in-vitro, BC, NA
AntiTum↑, selectivity↑, MMP↓, antiOx↑, Thiols↓, Bcl-2↓, BAX↑, eff↓, Casp↑, ROS↓, ROS↑, Cyt‑c↑, AIF↑,
7689- iod,    Uptake and antitumoral effects of iodine and 6-iodolactone in differentiated and undifferentiated human prostate cancer cell lines
- in-vitro, Nor, RWPE-1 - in-vitro, Pca, LNCaP - vitro+vivo, Pca, DU145
Bax:Bcl2↑, Casp↑, TumCG↓,
7763- ISL,    Harnessing Liquiritigenin: A Flavonoid-Based Approach for the Prevention and Treatment of Cancer
AntiCan↑, *antiOx↓, *Inflam↓, TumCP↓, Apoptosis↑, NF-kB↓, PI3K↓, Akt↓, mTOR↓, *AntiArt↑, Casp8↑, Cyt‑c↑, Casp↑, cl‑PARP↑, GutMicro↑, BioAv↑, BioAv↓, Half-Life↓,
7853- isoO,    Natural flavonoid isoorientin and its anticancer mechanisms: a systematic review
- Review, Var, NA
Apoptosis↑, TumCCA↑, MAPK?, PI3K↓, Akt↓, AMPK?, NF-kB?, Wnt↓, β-catenin/ZEB1↓, Bcl-2↓, Mcl-1↓, BAX↑, Cyt‑c↑, Casp↑, TumCP↓, TumMeta↓,
7793- ISQ,    Apoptosis triggered by isoquercitrin in bladder cancer cells by activating the AMPK-activated protein kinase pathway
- in-vitro, Bladder, T24/HTB-9
tumCV↓, ROS↑, AMPK↑, Glycolysis↓, p‑PI3K↓, p‑Akt↓, Casp↑, mTOR↓, ACC↓, FASN↓,
7797- ISQ,    Isoquercitrin Suppresses Esophageal Squamous Cell Carcinoma (ESCC) by Inducing Excessive Autophagy and Promoting Apoptosis via the AKT/mTOR Signaling Pathway
- vitro+vivo, ESCC, KYSE-510 - in-vitro, ESCC, KYSE450
TumCG↓, Apoptosis↓, Casp↑, Bcl-2↓, EMT↓, TumAuto↑, ROS↑, Akt↓, PI3K↓, Catalase↓, SOD1↓, SOD2↓, eff↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8085- KAE,    Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, PI3K↓, Akt↓, STAT3↓, AP-1↓, NRF2↓, BioAv↑, Inflam↓, NF-kB↓, TNF-α↓, VEGF↓, BAX↑, Casp↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, NRF2↓, ROS↑, DR5↑, ERK↑, CHOP/DDIT3↑, DR4↑, JNK↑, Ki-67↓, ChemoSen↑,
8060- KAE,    Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells
- in-vitro, CRC, HT-29
TumCCA↑, DNAdam↑, ChrCon↑, cl‑Casp9↑, cl‑Casp3↑, cl‑Casp7↑, cl‑PARP↑, MPT↑, Cyt‑c↑, Bcl-xL↓, Bak↑, Akt↓, BAD↑, Casp↑, MMP↓,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8254- LCA,  Geld,    Licochalcone A enhances geldanamycin-induced apoptosis through reactive oxygen species-mediated caspase activation
- in-vitro, Ovarian, NA
MMP↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, ROS↑, GSH↓, eff↓,
8209- LCA,    Licochalcone A Exerts Anti-Cancer Activity by Inhibiting STAT3 in SKOV3 Human Ovarian Cancer Cells
- in-vitro, Ovarian, SKOV3
tumCV↓, TumCCA↑, ROS↑, MMP↓, Apoptosis↑, cl‑Casp↑, Cyt‑c↑, STAT3↓, TumCP↓, Dose↝, p‑STAT3↓,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
5795- MET,    Metformin: A Review of Potential Mechanism and Therapeutic Utility Beyond Diabetes
- Review, AD, NA - Review, Park, NA - Review, Diabetic, NA
*AntiDiabetic↑, *AMPK↑, *glyC↓, *ROS↓, *cardioP↑, *neuroP↑, *Half-Life↝, *toxicity↝, *BioAv↑, *glucose↓, *AGEs↓, AntiCan↑, Risk↓, TumCP↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, pRB↓, p27/CDKN1B↓, mTOR↓, Casp↑, ROS↑, MMP↓, ChemoSen↑, *hepatoP↑, *CRM↑, *Insulin↓,
4353- MF,  Chemo,    Pulsed Electromagnetic Field Enhances Doxorubicin-induced Reduction in the Viability of MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
TumCCA↑, Apoptosis↑, eff↑, TumCCA↑, Casp↝, p‑CDK2↓, cycE/CCNE↓, Fas↑, BAX↑, survivin↓, Mcl-1↓, cl‑PARP↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑,
1762- MF,  Fe,    Triggering the apoptosis of targeted human renal cancer cells by the vibration of anisotropic magnetic particles attached to the cell membrane
- in-vitro, RCC, NA
Dose∅, Apoptosis↑, Casp↑, tumCV↓, Casp3↑, Casp7↑, Ca+2↑, Cyt‑c↑,
7382- MFrot,    Inhibition of mitochondrial NADH:ubiquinone oxidoreductase by spinning oscillating magnetic fields causes toxicity in cancer cells
- vitro+vivo, GBM, NA
ROS↑, compI↓, DNAdam↑, TumCCA↑, Casp↓, Apoptosis↑, mt-NADH↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2/PTGS2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp/ABCB1↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
6487- Nimb,    Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development
- Review, Var, NA
TumCP↓, Apoptosis↓, TumMeta↑, angioG↓, *antiOx↑, *eff↑, Apoptosis↑, MOMP↑, CDK1↓, TumCCA↑, MAPK↓, JAK2↓, STAT3↓, PI3K↓, Akt↓, TumCP↓, *NRF2↑, NF-kB↓, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, chemoPv↑, Bcl-xL↓, Bcl-2↓, survivin↓, Cyt‑c↑, BAX↑, BID↑, cl‑Casp↑, P53↑, DR5↑, DR4↑, ROS↑, lipid-P↑, MDA↑, MMP2↓, MMP9↓, uPA↓, ICAM-1↓, CXCR4↓, CXCR2↓, angioG↓, BBB↑,
4974- Nimb,    Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma
- in-vitro, OS, NA
Apoptosis↑, ER Stress↑, mtDam↑, ROS↑, Casp↑, TumCMig↓, TumMeta↓,
4975- Nimb,    Nimbolide Induces Cell Apoptosis via Mediating ER Stress-Regulated Apoptotic Signaling in Human Oral Squamous Cell Carcinoma
- in-vitro, Oral, NA
Apoptosis↑, ROS↑, Ca+2↑, ER Stress↑, Casp↑, MMP↓, tumCV↓,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
1663- PBG,    Propolis and Their Active Constituents for Chronic Diseases
- Review, Var, NA
NF-kB↓, Casp↓, Fas↓, DNAdam↑, Casp3↑, P53↝, MMP↝, ROS↑, mtDam↑, Dose?, angioG↓, TumCP↓, TumCMig↓, BAX↑, selectivity↑, MMP↓, LDH↓, IL6↓, IL1β↓, TNF-α↓,
1668- PBG,    Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
- Review, Var, NA
antiOx↑, Inflam↓, AntiCan↑, TumCP↓, Apoptosis↑, eff↝, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, IL1β↑, *BioAv↓, BAX↑, Casp3↑, Cyt‑c↑, Bcl-2↓, eff↑, selectivity↑, P53↑, ROS↑, Casp↑, eff↑, ERK↓, Dose∅, TRAIL↑, NF-kB↑, ROS↑, Dose↑, MMP↓, DNAdam↑, TumAuto↑, LC3II↑, p62↓, EGF↓, Hif1a↓, VEGF↓, TLR4↓, GSK‐3β↓, NF-kB↓, Telomerase↓, ChemoSen↑, ChemoSideEff↓,
5183- PEITC,  Cisplatin,    Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, HaCaT
DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,
1989- PTL,    Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
- Review, Var, NA
eff↑, NF-kB↓, STAT↓, ROS↑, Inflam↓, Wnt↓, TCF-4↓, LEF1↓, GSH↓, MMP↓, Casp↑, eff↓, CSCs↓,
1992- PTL,    Parthenolide induces ROS-dependent cell death in human gastric cancer cell
- in-vitro, BC, MGC803
TumCCA↑, Casp↑, Apoptosis↑, Necroptosis↑, RIP1↓, RIP3↑, MLKL↑, ROS↑, eff↓,
4694- PTS,    Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions
BioAv↑, AntiCan↑, Casp↑, TumCCA↑, angioG↓, TumMeta↓, MMP9↓, VEGF↓, CSCs↓, CD44↓, cMyc↓, ChemoSen↑, mTOR↓,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
40- QC,    Quercetin arrests G2/M phase and induces caspase-dependent cell death in U937 cells
- in-vitro, lymphoma, U937
cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, CycB/CCNB1↑, Casp↑, Apoptosis↑, TumCCA↑, TumCP↓,
7149- Rhe,    Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
- in-vitro, PC, NA
TumCCA↑, Casp↑, mt-Apoptosis↑, PI3K↓, Akt↓, ChemoSen↑, ROS↑, eff↓,
1746- RosA,    Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
- in-vitro, AML, U937
TNF-α↓, ROS↓, Casp↑, NF-kB↓, IκB↓, p50↓, p65↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, Apoptosis↑,
4903- Sal,    Salinomycin: A new paradigm in cancer therapy
- Review, Var, NA
TumCG↓, ATP↓, CSCs↓, ROS↑, Casp↑, MMP↓, selectivity↑, OXPHOS↓, STAT3↓, P53↑, γH2AX↑, cycD1/CCND1↓, TumCCA↑, DNAdam↑, ChemoSen↑,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
6449- SAO,    Skin cancer chemoprevention by α-santalol
- Review, Melanoma, A431
*chemoPv↑, Apoptosis↑, Casp↑, MMP↓, Cyt‑c↑, TumCCA↑, TumCG↓,

Showing Research Papers: 101 to 150 of 177
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 177

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ATG13↑, 1,   ATG16L1↑, 1,   ChrCon↑, 1,   RUBCN↓, 1,   TFE3↑, 1,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   ULK1/ATG1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   antiOx⇅, 1,   Catalase↓, 1,   compI↓, 2,   CYP1A1↓, 1,   CYP1A1↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 3,   H2O2↑, 1,   HO-1↓, 1,   ICD↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↑, 1,   mt-NADH↓, 1,   NRF2↓, 3,   NRF2↑, 1,   OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 33,   i-ROS?, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   SOD2↑, 1,   Thiols↓, 1,   TrxR1↓, 2,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 6,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   mitResp↓, 1,   MMP?, 1,   MMP↓, 17,   MMP↝, 1,   MPT↑, 1,   mtDam↑, 4,   OCR↓, 1,   e-Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK?, 1,   AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 1,   CYP3A4↓, 1,   FASN↓, 2,   GLO-I↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   LDH↓, 1,   LDHA↓, 1,   PDK1 / PDPK1↓, 1,   PI3K/Akt↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   p‑Akt↓, 4,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 28,   mt-Apoptosis↑, 2,   BAD↑, 2,   Bak↑, 1,   BAX↑, 15,   Bax:Bcl2↑, 4,   Bcl-2↓, 13,   Bcl-xL↓, 4,   BID↑, 1,   Casp↓, 2,   Casp↑, 42,   Casp↝, 1,   Casp∅, 1,   cl‑Casp↑, 3,   proCasp↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 2,   Casp6↑, 1,   Casp7↑, 2,   cl‑Casp7↑, 2,   Casp8↑, 2,   cl‑Casp8↑, 1,   cl‑Casp9↑, 3,   Cyt‑c↑, 15,   DR4↑, 2,   DR5↑, 4,   Fas↓, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 1,   cl‑GSDME↑, 1,   Hippo↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 2,   JNK↑, 2,   MAPK?, 1,   MAPK↓, 2,   MAPK↑, 2,   Mcl-1↓, 3,   MDM2↓, 1,   MLKL↑, 1,   MOMP↑, 3,   Necroptosis↑, 1,   necrosis↑, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   p38↓, 1,   Pyro↑, 1,   RIP1↓, 1,   survivin↓, 4,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 3,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↑, 1,   pRB↓, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   eIF2α↓, 1,   ER Stress↑, 4,   HSP90↓, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   ATG5↑, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↑, 1,   p62↓, 1,   p62↑, 1,   TumAuto↑, 7,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 7,   DNArepair↓, 1,   P53↑, 7,   P53↝, 1,   cl‑PARP↑, 9,   cl‑PARP1↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 4,   p‑CDK2↓, 1,   CDK4↓, 3,   CycB/CCNB1↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 4,   E2Fs↓, 1,   mitA↓, 1,   P21↑, 2,   TumCCA↑, 29,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   CD44↓, 1,   p‑cMET↑, 1,   CSCs↓, 4,   EMT↓, 1,   ERK↓, 4,   ERK↑, 2,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↓, 1,   mTOR↓, 7,   p‑mTOR↓, 1,   mTORC1↓, 1,   NOTCH1↓, 1,   P70S6K↓, 2,   PI3K↓, 8,   p‑PI3K↓, 1,   PTEN↑, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 7,   p‑STAT3↓, 2,   TCF↝, 1,   TCF-4↓, 1,   TOP1↓, 1,   TOP2↓, 2,   TumCG↓, 7,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 1,   Ca+2↑, 4,   FAK↓, 1,   p‑FAK↓, 1,   Ki-67↓, 2,   LEF1↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 4,   MMP3↓, 1,   MMP9↓, 6,   MMPs↓, 1,   MUC4↓, 1,   PAK1↑, 1,   PDGF↓, 1,   PKCδ↓, 2,   RIP3↑, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TSC1↑, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 19,   TumMeta↓, 5,   TumMeta↑, 1,   Twist↓, 1,   uPA↓, 1,   VCAM-1↓, 1,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 9,   ATF4↑, 1,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 4,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT1↓, 2,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 3,   CXCR2↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL1β↑, 1,   IL6↓, 2,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 4,   IκB↓, 1,   JAK2↓, 2,   M2 MC↓, 1,   NF-kB?, 1,   NF-kB↓, 12,   NF-kB↑, 1,   p50↓, 1,   p65↓, 1,   PD-L1↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 9,   CYP1A2↓, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 7,   Dose∅, 2,   eff↓, 9,   eff↑, 6,   eff↝, 1,   Half-Life↓, 1,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   EGFR↓, 2,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 2,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 7,   AntiTum↑, 2,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP∅, 1,   OS↑, 1,   PRAS40↑, 1,   Risk↓, 1,   toxicity↓, 3,   TumVol↓, 2,  
Total Targets: 301

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiP↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 2,   Catalase↑, 2,   GPx↑, 1,   GSR↑, 1,   GSTA1↑, 1,   HO-1↑, 1,   Keap1↓, 2,   lipid-P↓, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS↓, 3,   ROS∅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   CRM↑, 1,   glucose↓, 1,   glyC↓, 1,  

Cell Death(tgid=5) ⓘ

MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,   NF-kB↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 1,   eff↑, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 44

Scientific Paper Hit Count for: Casp, caspase
7 Thymoquinone
6 Betulinic acid
6 Capsaicin
6 Fisetin
4 Silver-NanoParticles
4 Apigenin (mainly Parsley)
4 Boswellia (frankincense)
4 Propolis -bee glue
4 Carvacrol
4 Curcumin
4 Graviola
4 Shikonin
3 Allicin (mainly Garlic)
3 Alpha-Lipoic-Acid
3 Anethole/trans-Anethole
3 Cisplatin
3 Cucurbitacin
3 Dichloroacetate
3 Gambogic Acid
3 Ginkgetin
3 Licochalcone A
3 Nimbolide
3 α-Santalol/Sandalwood oil
3 Selenite (Sodium)
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
2 Berberine
2 Rosmarinic acid
2 Thymol-Thymus vulgaris
2 chaetocin
2 Selenium
2 Chrysin
2 Gemcitabine (Gemzar)
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Isoliquiritigenin
2 Garcinol
2 HydroxyTyrosol
2 Isobavachalcone
2 iodine
2 isoquercitrin
2 Kaempferol
2 Magnetic Fields
2 Parthenolide
2 Quercetin
2 Selenium NanoParticles
2 Urolithin
1 3-bromopyruvate
1 Astragalus
1 alpha Linolenic acid
1 Isovitexin
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Atorvastatin
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 chitosan
1 Selenate
1 Chlorophyllin
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Deguelin
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Eugenol
1 Ferulic acid
1 Fenbendazole
1 Formononetin
1 Fucoidan
1 verapamil
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginseng
1 Hibiscus sabdariffa
1 Honokiol
1 Hyperthermia
1 isoorientin
1 Ivermectin
1 Geldanamycin
1 Luteolin
1 Metformin
1 Chemotherapy
1 Iron
1 Magnetic Field Rotating
1 Naringin
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Pterostilbene
1 Rhein
1 salinomycin
1 irinotecan
1 Photodynamic Therapy
1 doxorubicin
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:443  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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