CDK2 Cancer Research Results

CDK2, Cyclin-dependent kinase 2: Click to Expand ⟱
Source:
Type:
(CDK2) complex is significantly over-activated in many cancers.
CDK2 (Cyclin-Dependent Kinase 2) is a serine/threonine kinase that regulates late G1 and S phase of the cell cycle.
CDK2 interacts with and phosphorylates proteins in pathways such as DNA damage, intracellular transport, protein degradation, signal transduction, DNA and RNA metabolism and translation.
Scientific Papers found: Click to Expand⟱
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1/CCL2↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp/ABCB1↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP/DDIT3↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2/KDR/Flk1↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1/ATG6↑, IL1β↓, CRP↓, IL10↓, COX2/PTGS2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
91- QC,    The roles of endoplasmic reticulum stress and mitochondrial apoptotic signaling pathway in quercetin-mediated cell death of human prostate cancer PC-3 cells
- in-vitro, Pca, PC3
CDK2↓, cycE/CCNE↓, cycD1/CCND1↓, ATFs↑, GRP78/BiP↑, Bcl-2↓, BAX↑, Casp3↑, Casp8↑, Casp9↑, ER Stress↑, CHOP/DDIT3↑, TumCCA↑, DNAdam↑, AIF↑, Ca+2↑, MMP↓,
100- QC,    Inhibition of Prostate Cancer Cell Colony Formation by the Flavonoid Quercetin Correlates with Modulation of Specific Regulatory Genes
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP
cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4/6↓, E2Fs↓, PCNA↓, cDC2↓, PTEN↑, MSH2↑, P21↑, EP300↑, BRCA1↑, NF2↑, TSC1↑, TGFβR1↑, P53↑, RB1↑, AKT1↓, cMyc↓, CDC7↓, cycF↓, CDC16↓, CUL4B↑, CBP↑, TSC2↑, HER2/EBBR2↓, BCR↓, TumCCA↑, chemoPv↑,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoPv↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2/PTGS2↓, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,
3035- RosA,    Rosmarinic Acid Decreases the Malignancy of Pancreatic Cancer Through Inhibiting Gli1 Signaling
- in-vitro, PC, NA - in-vivo, NA, NA
Gli1↓, TumCCA↑, TumCMig↓, TumCI↓, CDK2↓, cycE/CCNE↓, P21↑, p27/CDKN1B↑,
4190- Sesame,    Sesame Seeds: A Nutrient-Rich Superfood
- Review, NA, NA
*antiOx↑, *LDL↓, *Aβ↓, *TNF-α↓, *SOD↑, *SIRT1↑, *Catalase↑, *GSH↑, *MDA↓, *GSTs↑, *IL4↑, *GPx↑, *COX2/PTGS2↓, *PGE2↓, *NO↓, CDK2↑, COX2/PTGS2↑, MMP9↑, ICAM-1↓, *BDNF↑, *PPARγ↑, *AChE↓, *Inflam↓, *HO-1↑, *NF-kB↓, *ROS↓,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
1453- SFN,    Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, TumCP↓, TumCCA↑, H3↑, H4↑, HDAC↓, CDK1↑, CDK2↑, p19↑, *BioAv↑,
3323- SIL,    Anticancer therapeutic potential of silibinin: current trends, scope and relevance
- Review, Var, NA
Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2/PTGS2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,
3044- SK,    Shikonin Inhibits Non-Small-Cell Lung Cancer H1299 Cell Growth through Survivin Signaling Pathway
- in-vitro, Lung, H1299 - in-vitro, Lung, H460
TumCP↓, survivin↓, TumCCA↓, CDK2↓, CDK4↓, XIAP↓, Casp3↑, Casp9↑, cycD1/CCND1↓, cycE/CCNE↓,
6436- T4O,    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression
- in-vitro, Melanoma, A431
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, EMT↓, AntiTum↑, cal2↑, cl‑β-catenin/ZEB1↑, cl‑Casp12↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, BAX↑, TumCCA↑, selectivity↑, N-cadherin↓, E-cadherin↑, Ki-67↓, PCNA↑,
5331- TFdiG,    Anti-Cancer Properties of Theaflavins
- Review, Var, NA
AntiCan↑, TumCP↓, TumCMig↓, Apoptosis↑, cl‑PARP↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, BAX↑, Bcl-2↓, p‑Akt↓, p‑mTOR↓, PI3K↓, cMyc↓, P53↑, ROS↑, NF-kB↓, MMP9↓, MMP2↓, TumVol↓, PSA↓, TumCCA↑, VEGF↓, Hif1a↓, CDK2↓, CDK4↓, GSH↓, Dose↑, BioAv↓, BioAv↓, BioAv↑,
3408- TQ,    Thymoquinone: A small molecule from nature with high therapeutic potential
- Review, AD, NA - Review, Park, NA
*neuroP↑, *hepatoP↑, *cardioP↑, *Inflam↓, *antiOx↑, ChemoSen↑, eff↑, eff↑, TumCP↓, TumCCA↑, angioG↓, cycA1/CCNA1↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,
3133- VitC,    Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells
- in-vitro, Ovarian, NA
*SVCT-2↑, *GLUT1↓, SVCT-2↓, GLUT1↑, TumCP↓, CDK2↓, PARP↓, selectivity↑,

Showing Research Papers: 101 to 116 of 116
Prev Page 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 116

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↓, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 2,   ROS⇅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   BCR↓, 1,   CDC16↓, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   FGFR1↓, 1,   MMP↓, 2,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 4,   LDH↑, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 3,   Bak↑, 1,   BAX↓, 1,   BAX↑, 4,   Bcl-2↓, 5,   BID↓, 1,   BID↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 4,   cl‑Casp9↑, 1,   CBP↑, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   DR5↑, 2,   Fas↑, 1,   FasL↑, 1,   IAP1↑, 1,   ICAD↑, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 3,   Mcl-1↓, 1,   MDM2↓, 1,   Myc↓, 1,   p27/CDKN1B↑, 2,   p38↑, 2,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CDC7↓, 1,   HER2/EBBR2↓, 2,   Sp1/3/4↓, 1,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↑, 1,   H4↑, 1,   miR-21↑, 1,   p‑pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATFs↑, 1,   CHOP/DDIT3↑, 2,   eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↑, 2,   HSP27↑, 1,   HSP70/HSPA5↓, 2,   HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 2,   LC3B-II↑, 1,   LC3II↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   CYP1B1↑, 1,   DNAdam↑, 1,   DNMT1↓, 1,   DNMTs↓, 1,   p16↑, 1,   P53↑, 5,   PARP↓, 2,   cl‑PARP↑, 2,   PCNA↓, 1,   PCNA↑, 1,   UHRF1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 13,   CDK2↑, 3,   CDK4↓, 7,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 8,   cycE/CCNE↓, 5,   cycF↓, 1,   E2Fs↓, 3,   p19↑, 1,   P21↑, 4,   RB1↑, 1,   TumCCA↓, 1,   TumCCA↑, 11,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cDC2↓, 1,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 2,   EP300↑, 1,   ERK↓, 2,   ERK↑, 1,   FGF↓, 1,   FOXO↑, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   IGFBP3↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   NF2↑, 1,   NOTCH↓, 2,   P70S6K↓, 1,   PI3K↓, 4,   PTEN↑, 1,   RAS↓, 2,   Shh↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TOP2↓, 1,   TumCG↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   Ca+2↑, 1,   cal2↑, 1,   CDK4/6↓, 1,   DLC1↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   ITGA5↓, 1,   Ki-67↓, 1,   KRAS↓, 1,   MMP2↓, 4,   MMP7↓, 1,   MMP9↓, 4,   MMP9↑, 1,   MMPs↓, 1,   MSH2↑, 1,   N-cadherin↓, 2,   PDGF↓, 1,   PKCδ↓, 1,   Slug↓, 2,   Smad1↑, 1,   Snail↓, 2,   TGF-β↓, 1,   TSC1↑, 1,   TSP-1↑, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 8,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim↓, 1,   Zeb1↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 1,   p‑EGFR↓, 1,   HIF-1↓, 1,   Hif1a↓, 1,   VEGF↓, 5,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↑, 1,   P-gp/ABCB1↓, 1,   SVCT-2↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   COX2/PTGS2↑, 1,   CRP↓, 1,   CXCL1↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IL1↓, 1,   IL10↓, 2,   IL12↓, 1,   IL1β↓, 1,   IL2↑, 1,   IL6↓, 3,   Inflam↓, 1,   JAK2↓, 2,   NF-kB↓, 5,   p65↓, 1,   PD-L1↓, 1,   PSA↓, 2,   TLR4↓, 1,   TNF-α↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↑, 3,   Dose↑, 1,   eff↑, 8,   Half-Life↝, 1,   selectivity↑, 5,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   BRCA1↑, 1,   CRP↓, 1,   EGFR↓, 1,   p‑EGFR↓, 1,   HER2/EBBR2↓, 2,   IL6↓, 3,   Ki-67↓, 1,   KRAS↓, 1,   LDH↑, 1,   Myc↓, 1,   PD-L1↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   chemoPv↑, 1,   TGFβR1↑, 1,   TumVol↓, 1,  
Total Targets: 239

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 2,   MDA↓, 1,   Nrf1↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDL↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Cyt‑c↓, 1,   IAP1↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   SVCT-2↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL4↑, 1,   Inflam↓, 4,   MCP1/CCL2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 2,   chemoPv↑, 1,   hepatoP↑, 1,   neuroP↑, 2,   Pain↓, 1,  
Total Targets: 46

Scientific Paper Hit Count for: CDK2, Cyclin-dependent kinase 2
16 Fisetin
5 Lycopene
5 Quercetin
4 Chrysin
4 Ellagic acid
4 Garcinol
4 Honokiol
4 Luteolin
3 Apigenin (mainly Parsley)
3 Artemisinin
3 Propolis -bee glue
3 Ferulic acid
3 Sulforaphane (mainly Broccoli)
2 Berberine
2 Boswellia (frankincense)
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 HydroxyTyrosol
2 Indole-3-carbinol
2 Juglone
2 Magnolol
2 Thymoquinone
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Cisplatin
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Biochanin A
1 Betulinic acid
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Chlorogenic acid
1 Cinnamon
1 Hydroxycinnamic-acid
1 Crocetin
1 Cucurbitacin
1 Emodin
1 Eugenol
1 Gallic acid
1 Ginseng
1 5-fluorouracil
1 Inulin Prebiotic
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Lactobacillus
1 Lapachol
1 Licochalcone A
1 Licorice
1 Metformin
1 Magnetic Fields
1 Chemotherapy
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Plumbagin
1 Pterostilbene
1 Resveratrol
1 Rosmarinic acid
1 Sesame seeds and Oil
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:467  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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