MDA Cancer Research Results

MDA, Serum malondialdehyde: Click to Expand ⟱
Source:
Type:
MDA : malondialdehyde. The level of oxidative stress can be measured by assessing the MDA levels.
Since MDA is highly cytotoxic and carcinogenic agent it is frequently used as a biomarker of oxidative stress during major health problems such as cancer, etc.
Malondialdehyde (MDA) is the most widely used agent to estimate the extent of lipid peroxidation. Timely diagnosis of the condition followed by supplementation with antioxidants like beta-carotene, pro-vitamin A, vitamin A, vitamin C, vitamin E, lipoic acid, zinc, selenium, and spirulina can prevent potentially malignant disorders.
MDA is a lipid peroxidation marker
Scientific Papers found: Click to Expand⟱
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,
3246- EGCG,    Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway
- in-vitro, Nor, NA
*MDA↓, *SOD↑, *SIRT1↑, *FOXO1↑, *SREBP2↓,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, eff↑, NRF2↑, HO-1↑,
5228- EMD,    Evaluating anticancer activity of emodin by enhancing antioxidant activities and affecting PKC/ADAMTS4 pathway in thioacetamide-induced hepatocellular carcinoma in rats
- in-vivo, HCC, NA
OS↑, PKCδ↓, ERK5↓, MMP3↓, VEGF↓, NRF2↑, HO-1↑, MDA↓, AFP↓,
3782- FA,    Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
- in-vivo, AD, NA
*cognitive↑, *ERK↓, *p‑Akt↓, *AChE↓, *BACE↓, *neuroP↑, *ROS↓, *MDA↓, *GSH↑, *GSSG↓, *p‑tau↓, *lipid-P↓, *Aβ↓,
3778- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer’s Disease: A Narrative Review
- Review, AD, NA
*neuroP↑, *Aβ↓, *antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK?, *hepatoP↑, *TLR4↓, *PPARγ↑, *NRF2↑, *Fenton↓, *IronCh↑, *MDA↓, *HO-1↑, *Bil↑, *GCLC↑, *GCLM↑, *NQO1↑, *GutMicro↑, *SOD↑, *Ca+2↓, *lipid-P↓, *PGE2↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3723- Gb,    Can We Use Ginkgo biloba Extract to Treat Alzheimer’s Disease? Lessons from Preclinical and Clinical Studies
- Review, AD, NA
*memory↑, *antiOx↑, *Casp3↓, *APP↓, *AChE↓, *Aβ↓, *5HT↑, *SOD↓, *MDA↓, *NO↓, *GSH↑, *Bcl-2↑, *BAX↑, *TNF-α↓, *IL1β↑, *iNOS↓, *IL10↓, *p‑tau↓, *ROS↓, *MAOB↓, *cognitive↑, *neuroP↑, *Apoptosis↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
2525- H2,    Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
- in-vivo, NA, NA
OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3771- H2,    Molecular Hydrogen Neuroprotection in Post-Ischemic Neurodegeneration in the Form of Alzheimer’s Disease Proteinopathy: Underlying Mechanisms and Potential for Clinical Implementation—Fantasy or Reality?
- Review, AD, NA - Review, Stroke, NA
*cognitive↑, AntiCan↑, *Inflam↓, *antiOx↑, *ROS↓, *neuroP↑, *SOD↑, *GPx↑, *MDA↑, *BBB↑, *OS↑, *Ca+2↓, *APP↓, *p‑tau↓,
3764- H2,    Therapeutic Effects of Hydrogen Gas Inhalation on Trimethyltin-Induced Neurotoxicity and Cognitive Impairment in the C57BL/6 Mice Model
- in-vivo, AD, NA
*memory↑, *Aβ↓, *p‑tau↓, *BAX↓, *ROS↓, *NO↓, *Ca+2↓, *MDA↓, *Catalase↓, *GPx↓, *TNF-α↓, *Bcl-2↑, *VEGF↑, *Inflam↓, *cognitive↑,
3767- H2,    The role of hydrogen therapy in Alzheimer's disease management: Insights into mechanisms, administration routes, and future challenges
- Review, AD, NA
*Inflam↓, *neuroP↑, *toxicity↓, *antiOx↑, *ROS↓, *NLRP3↓, *IL1β↓, *mtDam↓, *ATP↑, *AMPK↑, *FOXO3↑, *SOD1↑, *Catalase↑, *NRF2↑, *NO↓, *MDA↓, *lipid-P↓, *memory↑, *ER(estro)↓, *BDNF↑, *cognitive↑, *APP↓, *BACE↓, *Aβ↓, *BP∅, *BBB↑,
1635- HCA,    Hydroxycitric acid prevents hyperoxaluric-induced nephrolithiasis and oxidative stress via activation of the Nrf2/Keap1 signaling pathway
- vitro+vivo, Nor, NA
*other↓, *ROS↓, *SOD↑, *Catalase↑, *MDA↓, *NRF2↑,
1633- HCA,    Hydroxycitric Acid Alleviated Lung Ischemia-Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis through the Hif-1α Pathway
- in-vivo, NA, NA - in-vitro, Nor, HUVECs
*other↓, *Inflam↓, *MDA↓, *ROS↓, *Iron↓, *SOD↓, *Hif1a↓, *HO-1↓,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,
1924- JG,    Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway
- in-vitro, Lung, A549
TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,
1921- JG,    Juglone induces ferroptotic effect on hepatocellular carcinoma and pan-cancer via the FOSL1-HMOX1 axis
- in-vitro, PC, NA - vitro+vivo, PC, NA
TumCG↓, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, FOSL1↑, HO-1↑,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP↓, *Inflam↓, *antiOx↑, *GutMicro↑,
4231- Lut,    Luteolin and its antidepressant properties: From mechanism of action to potential therapeutic application
- Review, AD, NA
*PSD95↑, *BDNF↑, *SOD↑, *GSTA1↑, *MDA↑, *Casp3↓, *Mood↑, *antiOx↑, *Apoptosis↓, *Inflam↓, *ER Stress↓,
3828- Lyco,    Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer's disease
- in-vitro, AD, M146L
*ROS↓, *PI3K↑, *Akt↑, *NRF2↓, *antiOx↑, *BACE↓, *MDA↓,
3268- Lyco,    Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders
- Review, AD, NA
*BioAv↓, *AntiCan↑, *ROCK1↓, *Ki-67↓, *ICAM-1↓, *cardioP↑, *antiOx↑, *NQO1↑, *HO-1↑, *TNF-α↓, *IL22↓, *NRF2↑, *NF-kB↓, *MDA↓, *Catalase↑, *SOD↑, *GSH↑, *cognitive↑, *tau↓, *hepatoP↑, *MMP2↑, *AST↓, *ALAT↓, *P450↑, *DNAdam↓, *ROS↓, *neuroP↑, *memory↑, *Ca+2↓, *Dose↝, *Dose↑, *Dose↝, *toxicity∅, PGE2↓, CDK2↓, CDK4↓, STAT3↓, NOX↓, NOX4↓, ROS↓, *SREBP1↓, *FASN↓, *ACC↓,
3264- Lyco,    Pharmacological potentials of lycopene against aging and aging‐related disorders: A review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSH↑, *GSTs↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *iNOS↓, *NO↓, *TAC↑, *NOX4↓, *Inflam↓, *IL1↓, *IL6↓, *IL8↓, *IL1β↓, *TNF-α↓, *TLR2↓, *TLR4↓, *VCAM-1↓, *ICAM-1↓, *STAT3↓, *NF-kB↓, *ERK↓, *BP↓, ROS↓, PGE2↓, cardioP↑, *neuroP↑, *creat↓, *RenoP↑, *CRM↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
4228- Lyco,    A review for the pharmacological effect of lycopene in central nervous system disorders
- Review, AD, NA - Review, Park, NA
*cognitive↑, *memory↑, *Inflam↓, *Apoptosis↓, *ROS↓, *neuroP↑, *NF-kB↓, *JNK↓, *NRF2↑, *BDNF↑, *MDA↓, *GPx↑,
4803- Lyco,    Enhanced cytotoxic and apoptosis inducing activity of lycopene oxidation products in different cancer cell lines
- in-vitro, Pca, PC3 - in-vitro, BC, MCF-7 - in-vitro, Melanoma, A431 - in-vitro, Liver, HepG2 - in-vitro, Cerv, HeLa - in-vitro, Lung, A549
tumCV↓, GSH↓, MDA↑, ROS↑, Apoptosis↑,
4529- MAG,    Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities—A Review
- Review, Diabetic, NA
*AntiDiabetic↑, *glucose↓, *SOD↑, *Catalase↑, *ROS↓, *MDA↓, *GPx↑, *CYP2E1↓, *AGEs↓, *IL10↑, *neuroP↑, *GutMicro↑,
1204- MET,    Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT↓, NRF2↓, HO-1↓,
4103- MF,    Comparing the Effects of Long-term Exposure to Extremely Low-frequency Electromagnetic Fields With Different Values on Learning, Memory, Anxiety, and β-amyloid Deposition in Adult Rats
- in-vivo, NA, NA
*Dose↝, *memory↑, *ROS↑, *MDA↑,
3463- MF,    Pulsed Electromagnetic Fields Alleviates Hepatic Oxidative Stress and Lipids Accumulation in db/db mice
- in-vivo, NA, NA
*hepatoP↑, *MDA↓, *GSSG↓, *GSH↑, *GPx↑, *antiOx↑, *SREBP1↓,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
3498- MF,    Effect of Static Magnetic Field on Oxidant/Antioxidant Parameters in Cancerous and Noncancerous Human Gastric Tissues
- in-vitro, GC, NA
*SOD↑, *MDA↓, SOD↓, GPx↓, MDA↑, Catalase↑,
209- MFrot,  MF,    The effect of a rotating magnetic field on the antioxidant system in healthy volunteers - preliminary study
- Human, NA, NA
*SOD↑, *Catalase↑, *ROMO1↑, *MDA↓, *TAC↑, *ROS↓,
4226- Moringa,    The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model
- in-vivo, NA, NA
*neuroP↑, *Mood↑, *BDNF↑, *AChE↓, *MDA↓,
3838- Moringa,    Characterization, Large-Scale HSCCC Separation and Neuroprotective Effects of Polyphenols from Moringa oleifera Leaves
- in-vitro, AD, PC12 - Review, Stroke, NA
*Inflam↓, *neuroP↑, *antiOx↑, *ROS↓, *memory↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *eff↑,
3834- Moringa,    Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer's Disease-Like Pathology and Cognitive Impairments
- in-vivo, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *Aβ↓, *BACE↓, *cal2↓, *p‑tau↓, *ROS↓, *SOD↑, *MDA↓, *cognitive↑, *memory↑,
3840- Moringa,    Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
- in-vivo, AD, NA
*antiOx↑, *memory↑, *neuroP↑, *MDA↓, *AChE↓, *SOD↑, *Catalase↑, *cognitive↑, *ROS↓, *Ach↑,
3841- Moringa,    Cerebroprotective effect of Moringa oleifera against focal ischemic stroke induced by middle cerebral artery occlusion
- in-vivo, Stroke, NA
*MDA↓, *SOD↑, *neuroP↑, *ROS↓, *Inflam↓, *eff↝,
3848- MSM,    Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway
- in-vitro, AD, NA
*ROS↓, *Inflam↓, *neuroP↑, *ER(estro)↑, *NRF2↑, *HO-1↑, *Trx1↑, *TXNIP↓, *MDA↓, *NOX↓, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *BDNF↑, *AChE↓, *p‑tau↓, *Aβ↓,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, NA, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
1273- Myr,    Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4
- vitro+vivo, GC, NA
Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,
4643- OLE,  HT,    Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine
- Review, Var, NA
TumCCA↑, Apoptosis↑, ER Stress↑, UPR↑, CHOP↑, ROS↑, Bcl-2↓, NOX4↑, Hif1a↓, MMP2↓, MMP↓, VEGF↓, Akt↓, NF-kB↓, p65↓, SIRT3↓, mTOR↓, Catalase↓, SOD2↓, FASN↓, STAT3↓, HDAC2↓, HDAC3↓, BAD↑, BAX↑, Bak↑, Casp3↑, Casp9↑, PARP↑, P53↑, P21↑, p27↑, Half-Life↝, BioAv↓, BioAv↓, selectivity↑, RadioS↑, *ROS↓, *GSH↑, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *chemoP↑, *Inflam↓, PPARγ↑,
1670- PBG,    Lung response to propolis treatment during experimentally induced lung adenocarcinoma
- in-vivo, Lung, NA
GSH↑, SOD↑, MDA↓, selectivity↑, Inflam↓, TumW↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3250- PBG,    Allergic Inflammation: Effect of Propolis and Its Flavonoids
- Review, NA, NA
*SOD↑, *GPx↑, *Catalase↑, *Prx↑, *HO-1↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL4↑, *IL10↑, *TLR4↓, *LOX1↓, *COX1↓, *COX2↓, *NF-kB↓, *AP-1↓, *ROS↓, *GSH↑, *TGF-β↓, *IL8↓, *MMP9↓, *α-SMA↓, *MDA↓,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3257- PBG,    The Potential Use of Propolis as a Primary or an Adjunctive Therapy in Respiratory Tract-Related Diseases and Disorders: A Systematic Scoping Review
- Review, Var, NA
CDK4↓, CDK6↓, pRB↓, ROS↓, TumCCA↑, P21↑, PI3K↓, Akt↓, EMT↓, E-cadherin↑, Vim↓, *COX2↓, *MPO↓, *MDA↓, *TNF-α↓, *IL6↓, *Catalase↑, *SOD↑, *AST↓, *ALAT↓, *IL1β↓, *IL10↓, *GPx↓, *TLR4↓, *Sepsis↓, *IFN-γ↑, *GSH↑, *NRF2↑, *α-SMA↓, *TGF-β↓, *IL5↓, *IL6↓, *IL8↓, *PGE2↓, *NF-kB↓, *MMP9↓,

Showing Research Papers: 101 to 150 of 227
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 227

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 2,   Catalase↑, 2,   Ferroptosis↑, 4,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 5,   GSH↓, 6,   GSH↑, 2,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 4,   Iron↑, 5,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 3,   MDA↑, 8,   NOX4↓, 1,   NOX4↑, 2,   NRF2↓, 2,   NRF2↑, 3,   ROS↓, 3,   ROS↑, 7,   SIRT3↓, 1,   SOD↓, 3,   SOD↑, 2,   SOD2↓, 1,   T-SOD↓, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL4↑, 1,   ALAT↓, 1,   FASN↓, 1,   LDH↓, 1,   PPARγ↑, 2,  

Cell Death ⓘ

Akt↓, 3,   Apoptosis↑, 3,   BAD↑, 1,   Bak↑, 1,   BAX↑, 4,   Bcl-2↓, 3,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   Fas↑, 1,   Ferroptosis↑, 4,   p27↑, 2,  

Transcription & Epigenetics ⓘ

pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   PARP↑, 1,   PCNA↓, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 2,   CDK4↓, 3,   P21↑, 3,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK5↓, 1,   FOSL1↑, 1,   FOXO3↓, 1,   GDF15↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   mTOR↓, 1,   PI3K↓, 2,   STAT↓, 1,   STAT3↓, 4,   TumCG↓, 3,  

Migration ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP7↓, 1,   MMP9↓, 1,   PKCδ↓, 1,   SOX4↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 2,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   Hif1a↓, 3,   VEGF↓, 4,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL10↑, 1,   IL4↑, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 3,   p65↓, 1,   PGE2↓, 3,   PSA∅, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 1,   GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   ChemoSen↑, 1,   eff↓, 1,   eff↑, 2,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers ⓘ

AFP↓, 1,   ALAT↓, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 1,   PSA∅, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   OS↓, 1,   OS↑, 2,   QoL↑, 1,   RenoP↑, 1,   TumW↓, 1,  
Total Targets: 127

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 16,   ARE↑, 1,   Bil↑, 2,   Catalase↓, 1,   Catalase↑, 16,   CYP2E1↓, 1,   Fenton↓, 2,   GCLC↑, 2,   GCLM↑, 2,   GPx↓, 2,   GPx↑, 9,   GPx1↑, 1,   GSH↑, 15,   GSR↓, 1,   GSR↑, 1,   GSSG↓, 2,   GSTA1↑, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 10,   Iron↓, 2,   Keap1↓, 1,   lipid-P↓, 6,   MDA↓, 37,   MDA↑, 3,   MPO↓, 1,   NOX4↓, 1,   NQO1↑, 5,   NRF2↓, 2,   NRF2↑, 16,   Prx↑, 1,   ROMO1↑, 1,   ROS↓, 31,   ROS↑, 1,   ROS⇅, 1,   mt-ROS↓, 2,   SIRT3↑, 1,   SOD↓, 2,   SOD↑, 26,   SOD1↑, 2,   SOD2↑, 1,   TAC↑, 2,   Trx1↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↓, 1,   IronCh↑, 2,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   mtDam↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ALAT↓, 3,   AMPK↑, 2,   CREB↑, 1,   CRM↑, 1,   FASN↓, 1,   FGF21↑, 1,   glucose↓, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↑, 1,   LDL↓, 1,   NADPH↓, 1,   PFK↑, 1,   PKM2↑, 1,   PPARα↑, 2,   PPARγ↑, 2,   SIRT1↑, 3,   SREBP1↓, 3,   SREBP2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↓, 3,   BAX↓, 1,   BAX↑, 1,   Bcl-2↑, 2,   Casp1↓, 1,   Casp3↓, 2,   iNOS↓, 6,   JNK↓, 3,   MAPK↓, 1,   p‑MAPK?, 1,   p‑MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   ER Stress↓, 2,   HSP70/HSPA5↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 2,   ERK↑, 1,   FOXO1↑, 1,   FOXO3↑, 2,   IGF-1↓, 1,   mTOR↓, 2,   PI3K↑, 1,   PTEN↓, 1,   STAT3↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   APP↓, 3,   Ca+2↓, 5,   cal2↓, 1,   Ki-67↓, 1,   MMP2↓, 1,   MMP2↑, 1,   MMP9↓, 3,   PKA↑, 1,   ROCK1↓, 1,   TGF-β↓, 2,   TXNIP↓, 2,   VCAM-1↓, 4,   ZO-1↑, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature ⓘ

ATF4↓, 1,   ATF4↑, 1,   Hif1a↓, 1,   LOX1↓, 1,   NO↓, 8,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 3,   GLUT4↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 5,   ICAM-1↓, 4,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↓, 1,   IL10↓, 2,   IL10↑, 2,   IL18↓, 1,   IL1β↓, 10,   IL1β↑, 1,   IL2↓, 1,   IL22↓, 1,   IL4↑, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 4,   Inflam↓, 21,   MCP1↓, 1,   NF-kB↓, 10,   p65↓, 1,   PGE2↓, 3,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 11,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 8,   BDNF↑, 7,   ChAT↑, 1,   PSD95↑, 2,   tau↓, 1,   p‑tau↓, 6,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 8,   BACE↓, 4,   MAOB↓, 1,   NLRP3↓, 5,  

Hormonal & Nuclear Receptors ⓘ

ER(estro)↓, 1,   ER(estro)↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   Dose↑, 1,   Dose↝, 4,   eff↑, 1,   eff↝, 1,   Half-Life↝, 1,   P450↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 3,   AST↓, 4,   Bil↑, 2,   BP↓, 1,   BP∅, 1,   creat↓, 1,   GutMicro↑, 5,   IL6↓, 7,   Ki-67↓, 1,   NOS2↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 13,   hepatoP↑, 7,   memory↑, 12,   Mood↑, 2,   motorD↑, 1,   neuroP↑, 20,   OS↑, 2,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   toxicity↓, 3,   toxicity∅, 3,  

Infection & Microbiome ⓘ

Sepsis↓, 2,  
Total Targets: 198

Scientific Paper Hit Count for: MDA, Serum malondialdehyde
14 Thymoquinone
11 Silver-NanoParticles
11 Boron
11 Quercetin
10 Curcumin
10 Silymarin (Milk Thistle) silibinin
7 Magnetic Fields
7 Propolis -bee glue
6 Betulinic acid
6 Carvacrol
6 Hydrogen Gas
6 Lycopene
5 Baicalein
5 Chlorogenic acid
5 Moringa oleifera
5 Shikonin
4 Resveratrol
4 Alpha-Lipoic-Acid
4 Astaxanthin
4 Berberine
4 Vitamin C (Ascorbic Acid)
4 Rosmarinic acid
4 Sulforaphane (mainly Broccoli)
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Luteolin
3 Crocetin
3 Ferulic acid
3 Rutin
3 Selenium NanoParticles
3 Selenite (Sodium)
2 doxorubicin
2 Andrographis
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 borneol
2 Selenium
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chrysin
2 Chemotherapy
2 EGCG (Epigallocatechin Gallate)
2 HydroxyCitric Acid
2 Juglone
2 Piperlongumine
2 Pterostilbene
1 3-bromopyruvate
1 cetuximab
1 5-Hydroxytryptophan
1 Anthocyanins
1 Paclitaxel
1 Melatonin
1 Cisplatin
1 Baicalin
1 Radiotherapy/Radiation
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Caffeic acid
1 Carnosic acid
1 Celastrol
1 chitosan
1 Chlorophyllin
1 Chocolate
1 Citric Acid
1 Coenzyme Q10
1 Galantamine
1 diet Methionine-Restricted Diet
1 Emodin
1 Ginkgo biloba
1 Graviola
1 Huperzine A/Huperzia serrata
1 Lutein
1 Magnolol
1 Metformin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane
1 Myricetin
1 Oleuropein
1 HydroxyTyrosol
1 Phenethyl isothiocyanate
1 Orlistat
1 salinomycin
1 Sulfasalazine
1 Anti-oxidants
1 Date Fruit Extract
1 Sesame seeds and Oil
1 Shankhpushpi
1 Silicic Acid
1 Safflower yellow
1 Taurine
1 5-fluorouracil
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:570  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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