COX2 Cancer Research Results

COX2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
5957- CEL,    Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line
- in-vitro, Colon, HT29
COX2↓, PDK1↓, Apoptosis↓,
5956- CEL,    Direct non-cyclooxygenase-2 targets of celecoxib and their potential relevance for cancer therapy
- Review, Var, NA
COX2↓, Pain↓, CA↓, PDK1↓, Apoptosis↑,
5955- CEL,    COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib
- in-vitro, Colon, NA
Risk↓, COX2↓, TumCCA↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
1105- CEL,    Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis
- in-vitro, BC, NA
COX2↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, miR-145↑, TGF-β↓, SMAD3↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
6018- CGA,    Chlorogenic acid: a review on its mechanisms of anti-inflammation, disease treatment, and related delivery systems
- Review, Var, NA - Review, RCC, NA
*BioAv↓, *Inflam↓, *TNF-α↓, *NO↓, *COX2↓, *PGE2↓, *NF-kB↓, *IL6↓, *IL1β↓, *TLR2↓, *MAPK↓, *NRF2↓, *HO-1↑, *NQO1↑, *cardioP↑, *neuroP↑, *SOD↑, *GSH↑, *ROS↓, *LDH↓, *MDA↓, *cognitive↑, *eff↑,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6002- CGA,    Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials
- Review, Var, NA - Review, Diabetic, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2↓, TNF-α↓, IL1β↓, IL6↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
1083- CGA,    COX2_Interaction">In Silico Insight the Prediction of Chlorogenic Acid in Coffee through Cyclooxygenase-2 (COX2) Interaction
- Analysis, NA, NA
COX2↓,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2↓, *Obesity↓, *cognitive↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2↓, iNOS↓, NF-kB↓, chemoP↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2↓, *NF-kB↓, *ROS↓,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2↓, NF-kB↓, PDK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
2789- CHr,    Anticancer Activity of Ether Derivatives of Chrysin
- Review, Var, NA
eff↑, COX2↓, PGE2↓, eff↑,
2794- CHr,    An updated review on the versatile role of chrysin in neurological diseases: Chemistry, pharmacology, and drug delivery approaches
- Review, Park, NA - Review, Stroke, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *IL1β↓, *TNF-α↓, *COX2↓, *iNOS↓, *NF-kB↓, *JNK↓, *HDAC↓, *GSK‐3β↓, *IFN-γ↓, *IL17↓, *GSH↑, *NRF2↑, *HO-1↑, *SOD↑, *MDA↓, *NO↓, *GPx↑, *TBARS↓, *AChE↓, *GR↑, *Catalase↑, *VitC↑, *memory↑, *lipid-P↓, *ROS↓,
3892- Cin,    Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *cardioP↑, angioG↓, VEGF↓, *LDL↓, COX2↓, Hif1a↓, *Aβ↓, *tau↓, *toxicity↓,
1792- CUR,  LEC,    Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanism
- in-vitro, Arthritis, RAW264.7 - NA, NA, HCC-38
*Inflam↓, *NF-kB↓, *iNOS↓, *COX2↓, *NO↓, *PGE2↓, *MMPs↑, *TIMP1↑, *BioEnh↑,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2↓,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
3753- CUR,  Gala,    A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
- Study, AD, NA
*BChE↓, *AChE↓, *Ach↑, *cognitive↑, *memory↑, *ROS↓, *Inflam↓, *NF-kB↓, *COX2?,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2↓, *MMPs↓, *eff↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BID↑, PARP↑, NF-kB↓, CDK1↓, COX2↓, RTK-RAS↓, PI3K/Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, ChemoSen↑,
158- CUR,    Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
MMP9↓, Matr↓, Inflam↓, antiOx↓, NF-kB↓, COX2↓, iNOS↓, TumCMig↓, TumCI↓,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
160- CUR,    Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2
- in-vitro, Pca, NA
CXCc↓, IκB↓, NF-kB↓, COX2↓, SPARC↓, EFEMP↓, IKKα↓,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2↓, GM-CSF↓, angioG↓, VEGF↓, CD31↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
p38↓, MKP5↑, TNF-α↓, COX2↓, NF-kB↓,
2466- CUR,    Regulatory Effects of Curcumin on Platelets: An Update and Future Directions
- Review, Nor, NA
*AntiAg↑, *antiOx↑, *Inflam↓, *12LOX↑, COX1↓, COX2↓, MMP9↓, NF-kB↓,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2↑, *NF-kB↓, *ICAM-1↓, *MCP1↓, *HO-1↑, CXCc↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2↓, CRP↓,
1085- DHA,  EPA,    DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells
- in-vitro, Nor, HUVECs
*COX2↓, *NF-kB↓, *PGE2↓, *IL6↓, *NF-kB↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2↓, Hif1a↓, VEGF↓, VEGFR2↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,

Showing Research Papers: 101 to 150 of 354
Prev Page 3 of 8 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 354

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

NA↓, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 2,   antiOx↑, 2,   CYP1A1↓, 1,   GSH↓, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↓, 2,   HO-1↑, 2,   HO-2↓, 1,   lipid-P↑, 2,   NRF2↓, 2,   NRF2↑, 3,   NRF2↝, 1,   ROS↓, 3,   ROS↑, 12,   ROS↝, 1,   TBARS↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   mt-ATP↓, 1,   ETC↓, 1,   mitResp↓, 1,   mitResp↑, 1,   MKP5↑, 1,   MMP↓, 5,   MMP↑, 1,   MPT↑, 1,   mtDam↑, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   AMPK↑, 1,   cMyc↓, 4,   ECAR↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 2,   IR↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 1,   PDK1?, 2,   PDK1↓, 4,   PDK3↑, 1,   PI3K/Akt↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 6,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 4,   Apoptosis↓, 1,   Apoptosis↑, 11,   Apoptosis↝, 1,   Bak↑, 2,   BAX↑, 6,   BAX↝, 1,   Bax:Bcl2↑, 3,   Bcl-2↓, 4,   Bcl-2↝, 1,   Bcl-xL↓, 4,   Bcl-xL↝, 1,   BID↑, 1,   Casp↑, 2,   Casp3↑, 7,   Casp3↝, 1,   Casp8↑, 1,   Casp9↑, 3,   CK2↓, 1,   Cyt‑c↑, 4,   Cyt‑c↝, 1,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 2,   FasL↑, 1,   HEY1↓, 1,   hTERT/TERT↓, 3,   iNOS↓, 4,   JNK↑, 3,   JNK↝, 1,   MAPK↓, 1,   MAPK↑, 2,   MAPK↝, 1,   Mcl-1↓, 3,   MDM2↓, 1,   Myc↓, 1,   NOXA↑, 1,   p38↓, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 1,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   PAK↓, 1,   RTK-RAS↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   Matr↓, 1,   miR-145↑, 1,   other↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

p‑eIF2α↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP90↓, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↝, 1,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,   DNAdam↑, 3,   P53↑, 6,   P53↝, 1,   p‑P53↑, 1,   PARP↑, 3,   cl‑PARP↑, 2,   PCNA↓, 6,   SIRT6↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 6,   CDK4↓, 2,   Cyc↝, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 4,   P21↝, 1,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

AR-V7?, 1,   CD44↓, 1,   CDK8↓, 2,   CSCs↓, 2,   EMT↓, 6,   EMT↝, 1,   ERK↓, 2,   p‑ERK↓, 1,   FGF↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   HDAC↓, 2,   HDAC8↓, 1,   HH↓, 1,   mTOR↓, 4,   mTOR↝, 1,   Nanog↓, 1,   NOTCH↓, 2,   NOTCH1↓, 2,   NOTCH1↑, 2,   NOTCH3↓, 1,   OCT4↓, 1,   P90RSK↓, 1,   PI3K↓, 4,   PI3K↑, 1,   PI3K↝, 2,   PTEN↑, 1,   PTEN↝, 1,   SCF↓, 1,   Shh↓, 2,   SOX2↓, 1,   STAT1↓, 1,   STAT3↓, 6,   STAT3↑, 1,   p‑STAT3↓, 2,   p‑STAT3↑, 1,   STAT4↓, 1,   STAT5↓, 1,   TOP1↓, 3,   TOP2↓, 1,   TumCG↓, 4,   Wnt↓, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 3,  

Migration ⓘ

AP-1↝, 1,   ATPase↓, 1,   CA↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   CD31↓, 1,   CDKN1C↑, 1,   CLDN1↓, 2,   E-cadherin↑, 4,   EFEMP↓, 1,   FAK↓, 1,   p‑FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 1,   Ki-67↓, 2,   MMP-10↓, 1,   MMP2↓, 6,   MMP2↝, 1,   MMP9↓, 8,   MMP9↑, 1,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 2,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 1,   Slug↓, 1,   SMAD3↓, 2,   Snail↓, 4,   SPARC↓, 1,   TET1↑, 1,   TGF-β↓, 4,   TumCI↓, 5,   TumCMig↓, 6,   TumCP↓, 8,   TumMeta↓, 1,   Twist↓, 4,   uPA↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 10,   EGFR↓, 5,   EGFR↝, 1,   Endoglin↑, 1,   Hif1a↓, 8,   VEGF↓, 10,   VEGF↝, 1,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   GLUT1↓, 1,   NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 3,   COX1↑, 1,   COX2↓, 31,   COX2↑, 1,   COX2↝, 1,   CRP↓, 1,   CXCc↓, 2,   GM-CSF↓, 2,   IKKα↓, 1,   p‑IKKα↓, 1,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL2↑, 1,   IL5↓, 1,   IL6↓, 9,   IL6↝, 1,   IL8↓, 3,   Inflam↓, 5,   IκB↓, 1,   JAK↓, 2,   MDSCs↓, 1,   MyD88↓, 1,   NF-kB↓, 18,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↓, 2,   PD-L1↓, 3,   PGE2↓, 5,   PSA↝, 1,   TLR4↓, 2,   TNF-α↓, 6,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   AR↝, 1,   CDK6↓, 4,   CYP19?, 1,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 9,   Dose↑, 2,   Dose↝, 3,   Dose∅, 1,   eff↑, 11,   Half-Life↓, 1,   RadioS↑, 7,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 2,   AR↓, 1,   AR↝, 1,   AST↓, 1,   CRP↓, 1,   EGFR↓, 5,   EGFR↝, 1,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 3,   IL6↓, 9,   IL6↝, 1,   Ki-67↓, 2,   LDH↓, 1,   Myc↓, 1,   PD-L1↓, 3,   PSA↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 3,   chemoPv↑, 2,   neuroP↑, 2,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   radioP↑, 2,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity↝, 1,   TumVol↓, 1,  
Total Targets: 317

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 12,   Catalase↓, 1,   Catalase↑, 8,   GPx↓, 1,   GPx↑, 8,   GSH↑, 10,   GSR↓, 1,   GSTs↑, 3,   H2O2↓, 1,   HDL↑, 2,   HO-1↓, 2,   HO-1↑, 7,   Keap1↓, 1,   lipid-P↓, 8,   MDA↓, 8,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 2,   NRF2↑, 8,   RNS↓, 1,   ROS↓, 20,   SOD↑, 13,   SOD1↑, 1,   TAC↑, 1,   TBARS↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↑, 1,   ALAT↓, 1,   AMPK↑, 2,   glucose↓, 1,   glucose↝, 1,   GLUT2↑, 1,   HMG-CoA↓, 1,   LDH↓, 3,   LDL↓, 2,   lipidLev↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PPARα↑, 1,   PPARα↝, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↓, 2,   Casp↓, 1,   Casp3↓, 4,   Casp9↓, 3,   Cyt‑c↓, 1,   Fas↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 6,   JNK↓, 2,   MAPK↓, 4,  

Transcription & Epigenetics ⓘ

Ach↑, 1,   other↓, 1,   other↑, 2,   other↝, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,   HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   GSK‐3β↓, 3,   HDAC↓, 1,   mTOR↓, 1,   p300↓, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT↓, 1,   STAT3↓, 1,  

Migration ⓘ

5LO↓, 2,   AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   CDK5↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   MMPs↓, 1,   MMPs↑, 1,   TIMP1↑, 1,   TRPC1↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,   NO↓, 5,   VEGF↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2?, 1,   COX2↓, 17,   COX2↑, 1,   CRP↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL1↓, 2,   IL10↑, 1,   IL12↓, 2,   IL17↓, 3,   IL18↓, 1,   IL1β↓, 8,   IL2↓, 2,   IL2↑, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 1,   INF-γ↓, 1,   Inflam↓, 20,   MCP1↓, 3,   NF-kB↓, 18,   NF-kB↑, 1,   PGE2↓, 7,   TLR2↓, 1,   TLR4↓, 3,   TNF-α↓, 11,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BChE↓, 1,   BDNF↑, 1,   tau↓, 2,   p‑tau↓, 1,  

Protein Aggregation ⓘ

AGEs↓, 1,   Aβ↓, 5,   BACE↓, 1,   NLRP3↓, 2,  

Hormonal & Nuclear Receptors ⓘ

GR↓, 1,   GR↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 8,   BioAv↑, 4,   BioAv⇅, 1,   BioAv↝, 1,   BioEnh↑, 1,   Dose⇅, 1,   Dose↝, 2,   eff↑, 7,   eff↝, 1,   Half-Life↝, 1,   P450↓, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 2,   BP↓, 2,   CRP↓, 1,   IL6↓, 7,   LDH↓, 3,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 6,   cardioP⇅, 1,   chemoP↑, 1,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 6,   cognitive↝, 1,   hepatoP↑, 7,   memory↑, 7,   neuroP↑, 11,   Obesity↓, 1,   OS↑, 2,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 3,  
Total Targets: 169

Scientific Paper Hit Count for: COX2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
24 Thymoquinone
20 Curcumin
19 Quercetin
18 Resveratrol
12 Fisetin
12 Lycopene
11 Silymarin (Milk Thistle) silibinin
10 Propolis -bee glue
10 Celecoxib
10 Chrysin
9 Apigenin (mainly Parsley)
9 Boswellia (frankincense)
9 Carvacrol
9 Sulforaphane (mainly Broccoli)
8 Berberine
7 Artemisinin
7 Honokiol
7 Rosmarinic acid
6 Chlorogenic acid
6 EGCG (Epigallocatechin Gallate)
5 Baicalein
5 Ellagic acid
5 Ferulic acid
5 Piperine
4 Aspirin -acetylsalicylic acid
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Shikonin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Radiotherapy/Radiation
3 Betulinic acid
3 Bromelain
3 Butyrate
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cisplatin
3 Chemotherapy
3 Luteolin
3 Magnetic Fields
3 Phenethyl isothiocyanate
3 Pterostilbene
2 acetaminophen
2 Allicin (mainly Garlic)
2 alpha Linolenic acid
2 Andrographis
2 Baicalin
2 Boron
2 Carnosic acid
2 Caffeic acid
2 Thymol-Thymus vulgaris
2 Chocolate
2 Ursolic acid
2 Garcinol
2 Hydroxycinnamic-acid
2 Magnolol
2 Naringin
2 Oleuropein
2 Oleocanthal
2 Piperlongumine
2 Rutin
2 Vitamin C (Ascorbic Acid)
2 Vitamin K2
1 Auranofin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Bruteridin(bergamot juice)
1 Cannabidiol
1 cannabidiolic acid
1 Celastrol
1 Cinnamon
1 Lecithin
1 Oxygen, Hyperbaric
1 Galantamine
1 Docetaxel
1 Ginger/6-Shogaol/Gingerol
1 Docosahexaenoic Acid
1 eicosapentaenoic acid
1 Evodiamine
1 Exercise
1 Shilajit/Fulvic Acid
1 Gambogic Acid
1 Paclitaxel
1 γ-linolenic acid (Borage Oil)
1 Grapeseed extract
1 Proanthocyanidins
1 Hydrogen Gas
1 IP6 (Inosital 1,2,3,4,5,6-hexakisphosphate)
1 Laetrile B17 Amygdalin
1 Licorice
1 5-fluorouracil
1 Melatonin
1 Metformin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane
1 Myricetin
1 Kaempferol
1 Germacranolide
1 Perilla
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Aflavin-3,3′-digallate
1 doxorubicin
1 Vitamin B1/Thiamine
1 Whole Body Vibration
1 Wogonin
1 xanthohumol
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:66  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page