Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
3416- TQ,    Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, 253J - in-vitro, Nor, SV-HUC-1
TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑,
6454- TUR,    Selective induction of apoptosis by ar-turmerone isolated from turmeric (Curcuma longa L) in two human leukemia cell lines, but not in human stomach cancer cell line
- in-vitro, AML, HL-60 - in-vitro, GC, NA
Apoptosis↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
5911- TV,    Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway
- vitro+vivo, CRC, NA
TumCP↓, Apoptosis↑, TumVol↓, Bax:Bcl2↑, EMT↓, TumCI↓, TumMeta↓, Wnt/(β-catenin)↓,
1020- UA,    Root Bark of Morus alba L. and Its Bioactive Ingredient, Ursolic Acid, Suppress the Proliferation of Multiple Myeloma Cells by Inhibiting Wnt/β-Catenin Pathway
- in-vitro, Melanoma, RPMI-8226
β-catenin/ZEB1↓, TCF↓, cMyc↓, cycD1/CCND1↓, TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, cl‑PARP↑, Casp7↑,
2350- UA,    Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Akt↓, Glycolysis↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, AMPK↑, TumAuto↑, Apoptosis↑, ERK↓, MMP↓, NO↑, ROS↑, DNAdam↑,
5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,
5019- UA,    Ursolic acid in colorectal cancer: mechanisms, current status, challenges, and future research directions
- Review, Var, NA
TumCP↓, Diff↑, Apoptosis↑, TumCI↓, angioG↓,
5020- UA,    Anticancer activity of ursolic acid on human ovarian cancer cells via ROS and MMP mediated apoptosis, cell cycle arrest and downregulation of PI3K/AKT pathway
- in-vitro, Ovarian, NA
tumCV↓, selectivity↑, BAX↑, Bcl-2↓, Apoptosis↑, ROS↑, TumCCA↑, Akt↓, PI3K↓,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,
5022- UA,    Ursolic Acid’s Alluring Journey: One Triterpenoid vs. Cancer Hallmarks
- Review, Var, NA
TumCP↓, Apoptosis↑, angioG↑, TumMeta↓, BioAv↓, Hif1a↓, Glycolysis↓, mitResp↓, Akt↓, MAPK↓, ERK↓, mTOR↓, P53↑, P21↑, E2Fs↑, STAT3↓, MMP↓, NLRP3↓, iNOS↓, CHK1↓, Chk2↓, BRCA1↓, E-cadherin↑, N-cadherin↓, Casp↑, p62↓, LC3II↑, Vim↓, ROS↑, CSCs↓, DNAdam↑, GutMicro↑, VEGF↓,
4869- Uro,    Urolithin A in Central Nervous System Disorders: Therapeutic Applications and Challenges
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,
4870- Uro,    Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
- in-vivo, AD, NA
*cognitive↑, *Apoptosis↓, *neuroP↑, *Aβ↓, *AMPK↑, *NF-kB↓, *MAPK↓, *BACE/β-secretase↑, *neuroG↑, *Inflam↓, *memory↑,
4871- Uro,  DHA,  LT,    A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease
- in-vitro, AD, NA
*ATP↑, *Apoptosis↓,
4878- Uro,    Activation of the Gut–Brain Interaction by Urolithin A and Its Molecular Basis
- Review, AD, NA
*memory↑, *SIRT1↑, *cognitive↑, *BDNF↑, *Apoptosis↓, *neuroG↑,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4835- Uro,    Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway
- in-vitro, SCC, NA
TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
4839- Uro,    Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, LNCaP
tumCV↓, Apoptosis↓, P53↑, P21↑, PUMA↑, NOXA↑, MDM2↓, XIAP↓,
4840- Uro,    Urolithin A: A promising selective estrogen receptor modulator and 27-hydroxycholesterol attenuator in breast cancer
- vitro+vivo, BC, NA
MMP↓, TumCP↓, Apoptosis↑, tumCV↓, ER-α36↝, *toxicity↓,
4841- Uro,    Urolithin A induces cell cycle arrest and apoptosis by inhibiting Bcl-2, increasing p53-p21 proteins and reactive oxygen species production in colorectal cancer cells
- in-vitro, CRC, HT29 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
TumCP↓, TumCCA↑, Apoptosis↑, P53↑, P21↑, Bcl-2↓, Cyt‑c↑, Casp↑, ROS↑, *ROS↓,
4846- Uro,    Urolithin A exerts anti-tumor effects on gastric cancer via activating autophagy-Hippo axis and modulating the gut microbiota
- in-vivo, GC, NA
TumCG↓, Hippo↑, Warburg↓, Apoptosis↑, GutMicro↑,
4847- Uro,    Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620 colorectal cancer cells
- in-vitro, CRC, SW-620
TumCP↓, TumCMig↓, MMP9↓, TumAuto↑, Apoptosis↑, TumCCA↓, TumMeta↓, ChemoSen↓,
4849- Uro,    Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway
- vitro+vivo, GC, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, TumAuto↑, TumCG↓, chemoP↑, ChemoSen↑,
4852- Uro,    Dietary Urolithin B Suppresses Lung Tumorigenesis Correlating with Autophagy Induction and Gut Microbiota Remodeling
- vitro+vivo, Lung, NA
TumCG↓, *GutMicro↑, *Inflam↓, *antiOx↑, AntiTum↑, TumCCA↑, Apoptosis↑,
4853- Uro,    Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer
- vitro+vivo, PC, MIA PaCa-2 - in-vitro, NA, PANC1
p‑Akt↓, p‑p70S6↓, TumCG↓, OS↑, PI3K↓, mTOR↓, TumCP↓, TumCMig↓, Apoptosis↑, TAMS↓, Treg lymp↓, Wnt↓, IGF-1↓, *toxicity↓, *BioAv↑, Half-Life↝,
4854- Uro,    Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC)
- Review, Pca, NA
AR↓, ROS↓, Apoptosis↑, selectivity↑, Dose↑, MDA↓, SOD↑, GPx↑, ROS↑, Casp3↑, Casp9↑,
4033- VitB3,    Can nicotinamide riboside protect against cognitive impairment?
- in-vivo, AD, NA
*memory↑, *DNAdam↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *BACE/β-secretase↓, *Aβ↓, *BBB↑, *GutMicro↑, *eff↑,
1836- VitC,  VitK3,  Chemo,    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib
- in-vitro, AML, NA
tumCV↓, selectivity↑, Apoptosis↑, eff↑, ChemoSen↑,
610- VitC,    Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
- in-vitro, lymphoma, JPL119 - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, HS587T - in-vitro, Nor, NA
Apoptosis↑, necrosis↑, H2O2↑, *toxicity↓,
599- VitC,    Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
- Review, NA, NA
H2O2↑, DNAdam↑, ROS↑, Fenton↑, Apoptosis↑, necrosis↑,
633- VitC,    Diverse antitumor effects of ascorbic acid on cancer cells and the tumor microenvironment
- Analysis, NA, NA
Fenton↑, ROS↑, EMT↓, DNAdam↑, PARP↑, NAD↓, ATP↓, Apoptosis↑,
631- VitC,    Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
- vitro+vivo, Liver, NA
SVCT-2∅, ROS↑, DNAdam↑, ATP↓, TumCCA↑, Apoptosis↑, OS↑, CD133↓, EpCAM↓, OV6↓, γH2AX↑,
3139- VitC,    Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress
- in-vitro, Nor, H9c2
*Apoptosis∅, *LDH∅, *MDA∅, *SOD↓, eff↝,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1 / PDPK1↓, BNIP3↓,
3109- VitC,    Vitamin C Inhibited Pulmonary Metastasis through Activating Nrf2/HO-1 Pathway
- in-vitro, Lung, H1299
TumMeta↓, NRF2↑, HO-1↑, cl‑Casp3↑, cl‑Casp9↑, DNAdam↑, Apoptosis↑, other↑, selectivity↑,
2366- VitD3,    Vitamin D3 decreases glycolysis and invasiveness, and increases cellular stiffness in breast cancer cells
- in-vitro, BC, MCF7
Glycolysis↓, tumCV↓, Apoptosis↑, mTOR↓, AMPK↑, EMT↓, E-cadherin↑, F-actin↑, Vim↓,
4618- VitD3,    Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1
- in-vivo, Cerv, NA
Risk↓, RadioS↑, Apoptosis↑, EMT↝,
2274- VitK2,    Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop
- in-vitro, Nor, SH-SY5Y
*Bcl-2↓, *BAX↑, *MMP↑, *ROS↓, *p62↓, *LC3A↑, *Dose↝, *Apoptosis↓, *PINK1↑, *PARK2↑,
4309- VitK2,    Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases
- Review, NA, NA
*Apoptosis↓, *ROS↓, *antiOx↑, *cognitive↑, *memory↑, *Risk↓, *p‑tau↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1824- VitK2,    Vitamin K and its analogs: Potential avenues for prostate cancer management
- Review, Pca, NA
AntiCan↑, toxicity∅, Risk↓, Apoptosis↑, ROS↑, TumCCA↑, eff↑, DNAdam↑, MMP↓, Cyt‑c↑, pro‑Casp3↑, FasL↑, Fas↑, TumAuto↑, ChemoSen↑, RadioS↑,
1816- VitK2,    Role of Vitamin K in Selected Malignant Neoplasms in Women
- Review, Var, NA
TumCP↓, TumMeta↓, TumAuto↑, Apoptosis↑, Apoptosis↑, Casp3↑, Casp7↑, ROS↑, AR↓, EMT↓, Wnt↓, MMP↓, Cyt‑c↑, NF-kB↓, cycD1/CCND1↓, TumCCA↓,
1822- VitK2,    Vitamin K: A novel cancer chemosensitizer
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumCCA↑, P-gp/ABCB1↓,
1840- VitK2,    The mechanisms of vitamin K2-induced apoptosis of myeloma cells
- in-vitro, Melanoma, NA
TumCG↓, Apoptosis↑, Casp3↑, ROS↑, p‑MAPK↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,
1839- VitK3,    Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, Apoptosis↑, TumCCA↑, ROS↑, eff↓, AR↓, Trx↓, Bcl-2↓,
7919- VT,    Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway
- in-vitro, AML, U937
TumCD↑, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, chemoPv↑,

Showing Research Papers: 1751 to 1800 of 1809
Prev Page 36 of 37 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1809

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 2,   GPx↑, 1,   H2O2↑, 3,   HO-1↑, 1,   lipid-P↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 17,   i-ROS↑, 2,   SOD↑, 1,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 4,   mitResp↓, 1,   MMP↓, 10,   mtDam↓, 1,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   cMyc↓, 3,   cMyc↑, 1,   Glycolysis↓, 4,   HK2↓, 3,   lactateProd↓, 2,   NAD↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↓, 1,   Apoptosis↑, 41,   BAX↑, 8,   Bax:Bcl2↑, 1,   Bcl-2↓, 9,   Bcl-xL↑, 1,   Casp↑, 4,   Casp3↑, 8,   cl‑Casp3↑, 5,   pro‑Casp3↑, 1,   Casp7↑, 2,   cl‑Casp7↑, 1,   Casp8↑, 3,   cl‑Casp8↑, 1,   Casp9↑, 5,   cl‑Casp9↑, 2,   Chk2↓, 1,   Cyt‑c↑, 7,   Fas↑, 1,   FasL↑, 1,   Hippo↑, 1,   iNOS↓, 1,   MAPK↓, 2,   p‑MAPK↑, 1,   MDM2↓, 1,   necrosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↑, 1,   p38↑, 2,   PUMA↑, 1,   survivin↓, 2,   TRAIL↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑p70S6↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↑, 2,   other↝, 1,   OV6↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,   LC3II↑, 1,   p62↓, 1,   TumAuto↑, 8,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   CHK1↓, 1,   DNAdam↑, 9,   P53↑, 7,   p‑P53↑, 1,   PARP↑, 3,   cl‑PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 4,   E2Fs↑, 1,   P21↑, 4,   TumCCA↓, 2,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↓, 1,   CSCs↓, 1,   CTNNB1↓, 1,   Diff↑, 1,   EMT↓, 5,   EMT↝, 1,   EpCAM↓, 1,   ERK↓, 5,   p‑ERK↓, 1,   FOXO1↑, 1,   IGF-1↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   PI3K↓, 4,   RAS↓, 2,   STAT3↓, 1,   TCF↓, 1,   TumCG↓, 9,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 2,   E-cadherin↑, 3,   ER-α36↝, 1,   F-actin↑, 1,   MMP2↓, 2,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 2,   PKA↓, 1,   PKCδ↓, 1,   Snail↓, 1,   Treg lymp↓, 1,   TumCI↓, 5,   TumCMig↓, 8,   TumCP↓, 17,   TumMeta↓, 6,   Twist↓, 1,   Vim↓, 3,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   angioG↑, 1,   ATF4↑, 1,   Hif1a↓, 1,   NO↑, 1,   TAMS↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,   SVCT-2∅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   IKKα↓, 1,   IL17↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 6,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   ChemoSen↓, 2,   ChemoSen↑, 7,   Dose↑, 1,   eff↓, 4,   eff↑, 8,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 3,   selectivity↑, 4,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AR↓, 4,   AST↓, 1,   BRCA1↓, 1,   GutMicro↑, 3,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 3,   AntiTum↑, 2,   chemoP↑, 3,   chemoPv↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,   OS↑, 2,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 1,   toxicity∅, 2,   TumVol↓, 1,  
Total Targets: 194

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 4,   Catalase↑, 2,   Ferroptosis↓, 1,   GPx↑, 3,   GSH↑, 1,   GSTs↑, 1,   H2O2↓, 1,   HDL↑, 1,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 1,   MDA∅, 1,   NADH↓, 1,   NRF2↑, 1,   PARK2↑, 3,   RNS↓, 1,   ROS↓, 7,   SOD↓, 1,   SOD↑, 4,   VDAC1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   MMP↑, 2,   PINK1↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 3,   LDH∅, 1,   LDL↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 1,   Apoptosis↓, 8,   Apoptosis∅, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↑, 1,   Ferroptosis↓, 1,   MAPK↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3A↑, 1,   MitoP↑, 1,   p62↓, 3,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   neuroG↑, 2,   PI3K↓, 1,   p‑PI3K↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Cartilage↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 1,   CRP↓, 1,   IL1β↓, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 6,   NF-kB↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,   BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE/β-secretase↓, 1,   BACE/β-secretase↑, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 4,   BioAv↝, 3,   Dose↝, 1,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   CRP↓, 1,   GutMicro↑, 2,   IL6↓, 2,   LDH∅, 1,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2,   cardioP↑, 2,   cognitive↑, 7,   hepatoP↑, 1,   memory↑, 4,   motorD↑, 1,   neuroP↑, 4,   Obesity↓, 1,   radioP↑, 1,   Risk↓, 2,   Strength↑, 1,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 96

Scientific Paper Hit Count for: Apoptosis, Apoptosis
69 Curcumin
67 Silver-NanoParticles
45 Magnetic Fields
44 Quercetin
36 Thymoquinone
34 Berberine
34 EGCG (Epigallocatechin Gallate)
32 Sulforaphane (mainly Broccoli)
29 Baicalein
25 Ashwagandha(Withaferin A)
25 Capsaicin
25 Kaempferol
25 Shikonin
23 Betulinic acid
23 Honokiol
23 Phenethyl isothiocyanate
22 Radiotherapy/Radiation
22 Resveratrol
22 Licochalcone A
20 Garcinol
19 Artemisinin
19 Apigenin (mainly Parsley)
19 Boron
19 Chrysin
19 Selenite (Sodium)
18 Cisplatin
18 Dandelion Root
18 Lycopene
18 Urolithin
17 Gambogic Acid
17 Hyperoside
16 Chemotherapy
16 Emodin
16 Eugenol
16 Fisetin
16 Formononetin
15 chitosan
15 Carvacrol
15 Luteolin
15 Nimbolide
14 Astaxanthin
14 Crocetin
14 Ivermectin
13 Beta-Caryophyllene
13 salinomycin
13 Graviola
13 Magnolol
13 Indole-3-carbinol
12 Allicin (mainly Garlic)
12 Metformin
12 chaetocin
12 HydroxyTyrosol
12 Isobavachalcone
12 Juglone
12 Selenium NanoParticles
11 Paclitaxel/Taxol
11 Propolis -bee glue
11 Chlorogenic acid
11 Silymarin (Milk Thistle) silibinin
11 Dichloroacetate
11 Isoliquiritigenin
11 Isovitexin
10 isoquercitrin
10 Copper and Cu NanoParticles
10 Vitamin C (Ascorbic Acid)
10 Alpha-Lipoic-Acid
10 doxorubicin
10 Fucoidan
10 Gallic acid
10 Ginkgetin
10 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
10 isoorientin
10 Phenylbutyrate
10 Piperlongumine
9 Photodynamic Therapy
9 5-fluorouracil
9 α-Bisabolol / Chamomile oil
9 Selenium
9 Cucurbitacin
9 Hydrogen Gas
9 Magnetic Field Rotating
9 Rosmarinic acid
8 Coenzyme Q10
8 Auranofin
8 Gemcitabine (Gemzar)
8 Bufalin/Huachansu
8 Caffeic acid
8 Citric Acid
8 Carvone
8 Cynara scolymus/Globe Artichoke/Artichoke Extract
8 Electrical Pulses
8 Ursolic acid
8 Cynaropicrin
8 Ginkgolide B
7 Atorvastatin
7 Biochanin A
7 borneol
7 Boswellia (frankincense)
7 Carnosic acid
7 Cinnamon
7 Deguelin
7 Lemongrass Extract/Citral
7 Genistein (soy isoflavone)
7 Evodiamine
7 Vitamin K2
6 Astragalus
6 Fenbendazole
6 Andrographis
6 Celecoxib
6 D-limonene
6 Disulfiram
6 Ellagic acid
6 Echinacea
6 Ferulic acid
6 Ginkgo biloba
6 Hibiscus sabdariffa
6 Piperine
6 Parthenolide
6 Terpinen-4-ol / Tea Tree Oil
5 3-bromopyruvate
5 Anethole/trans-Anethole
5 immunotherapy
5 Melatonin
5 Thymol-Thymus vulgaris
5 Celastrol
5 Chlorophyllin
5 Diclofenac
5 Aflavin-3,3′-digallate
5 iodine
5 Vitexin
5 Licorice
5 Lactoferrin/Talactoferrin
5 Plumbagin
5 Pterostilbene
4 1,8-Cineole
4 Rutin
4 Gold NanoParticles
4 Ascorbyl Palmitate
4 Berbamine
4 Brucea javanica
4 Bacopa monnieri
4 Bromelain
4 Butyrate
4 Centella asiatica / Gotu kola → asiaticoside
4 Dichloroacetophenone(2,2-)
4 Ginkgo biloba-EGb 761
4 Eurycomanone
4 Galloflavin
4 Geraniol
4 Ginger/6-Shogaol/Gingerol
4 γ-linolenic acid (Borage Oil)
4 Gossypol/AT-101
4 itraconazole
4 Lasiodin
4 Linalool
4 Spermidine
3 2-DeoxyGlucose
3 Aspirin
3 Dipyridamole
3 tamoxifen
3 Baicalin
3 brusatol
3 Bruteridin(bergamot juice)
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cat’s Claw
3 Cannabidiol
3 Cichoric acid / Chicoric acid
3 Cyclopamine
3 Date Fruit Extract
3 diet FMD Fasting Mimicking Diet
3 Fennel Oil/Foeniculum vulgare
3 Ginkgolic acids
3 Grapeseed extract
3 HydroxyCitric Acid
3 Orlistat
3 Hyperthermia
3 Inositol
3 isoflavones
3 Lapachol
3 Methyl salicylate / Sweet Birch oil
3 Magnesium
3 Naringin
3 Niclosamide (Niclocide)
3 Sanguinarine
3 Psoralidin
3 α-Santalol/Sandalwood oil
3 Taurine
3 VitK3,menadione
3 Zerumbone
2 cetuximab
2 5-Aminolevulinic acid
2 Ajoene (compound of Garlic)
2 alpha Linolenic acid
2 DTS(dibenzyl trisulphide) from Anamu
2 Sorafenib (brand name Nexavar)
2 Aloe anthraquinones
2 beta-glucans
2 Docetaxel
2 Bortezomib
2 Bullatacin
2 Chocolate
2 Hydroxycinnamic-acid
2 irinotecan
2 Polyphenols
2 CUSP9
2 gefitinib, erlotinib
2 diet Short Term Fasting
2 Folic Acid, Vit B9
2 eicosapentaenoic acid
2 Shilajit/Fulvic Acid
2 hydrogen sulfide
2 Helleborus niger extracts – Christmas Rose
2 Methylglyoxal
2 Oleuropein
2 Oleocanthal
2 Oxygen, Hyperbaric
2 Propyl gallate
2 Sulfasalazine
2 polyethylene glycol
2 Vitamin D3
1 5-Hydroxytryptophan
1 Annona atemoya Leaf Extract
1 Glucose
1 entinostat
1 Trichostatin A
1 Radio Frequency
1 Acetyl-l-carnitine
1 Amodiaquine
1 temozolomide
1 Trastuzumab
1 almonertinib
1 epirubicin
1 Lapatinib
1 bempedoic acid
1 Bifidobacterium
1 Beta‐Lapachone
1 Selenate
1 Prebiotic
1 Choline
1 methotrexate
1 Vitamin E
1 Carica papaya leaf extract
1 Camptothecin
1 chemodynamic therapy
1 Dihydrocaffeic Acid
1 methylseleninic acid
1 diet Methionine-Restricted Diet
1 Dimethyl Sulfoxide
1 Mistletoe/Viscum album Extracts
1 Cannabichromene
1 Tetrahydroxystilbene glucoside
1 Exercise
1 ferumoxytol
1 Arsenic trioxide
1 Vitamin A, Retinoic Acid
1 carboplatin
1 olaparib/LYNPARZA
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Ginseng
1 Rapamycin
1 High-Ozonide Oil
1 Hops (Humulus lupulus)
1 Huperzine A/Huperzia serrata
1 Inoscavin A
1 Inulin Prebiotic
1 Butein
1 Scopoletin
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Mung Bean Sprouts
1 Lutein
1 Iron
1 magnetic nanoparticles
1 Methylsulfonylmethane
1 Mushroom Chaga
1 Mushroom Lion’s Mane
1 Myrrh
1 nicotinamide adenine dinucleotide
1 Proanthocyanidins
1 Phenolic Acids
1 Rhein
1 Rauwolfia serpentina/Indian Snakeroot
1 Vorinostat
1 Oxaliplatin
1 Scoulerine
1 acetazolamide
1 Osimertinib
1 Adagrasib
1 Glutathione
1 Tomatine
1 Turmerones
1 Docosahexaenoic Acid
1 Vitamin B3,Niacin
1 Whole Body Vibration
1 xanthohumol
1 Zinc Oxide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page