Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
4267- Caff,    Caffeine‐mediated BDNF release regulates long‐term synaptic plasticity through activation of IRS2 signaling
- in-vivo, NA, NA
*cognitive↑, *memory↑, *Mood↑, *BDNF↑, *TrkB↑,
1206- Caff,    Caffeine inhibits TGFβ activation in epithelial cells, interrupts fibroblast responses to TGFβ, and reduces established fibrosis in ex vivo precision-cut lung slices
- in-vitro, NA, NA - ex-vivo, NA, NA
Fibrosis↓, TGF-β↓, α-SMA↓,
1205- Caff,  immuno,    Caffeine-enhanced anti-tumor activity of anti-PD1 monoclonal antibody
- in-vivo, Melanoma, B16-F10
OS↑, CD4+↑, CD8+↑, AntiTum↑, TNF-α↑, IFN-γ↑,
1653- Caff,    Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study
- Review, Melanoma, NA
AntiCan↑, eff↓,
4161- Caff,    Chronic caffeine prevents changes in inhibitory avoidance memory and hippocampal BDNF immunocontent in middle-aged rats
- in-vivo, AD, NA
*BDNF↑, *cognitive↑, *memory↑,
5778- Calc,  VitD3,    Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies
- Study, CRC, NA
Risk↓, eff↝, Risk↓,
5777- Calc,    Calcium intake and colorectal cancer risk: dose-response meta-analysis of prospective observational studies
- Study, CRC, NA
Risk↓,
5775- Calc,    Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study
- Study, CRC, NA
Risk↓, Dose↓, eff↝,
5776- Calc,    Calcium
- Review, Var, NA
Risk∅, Risk↓, Risk↓, Risk↓,
5779- Calc,    Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials
- Study, CRC, NA
chemoPv↑,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5841- CAP,    The red pepper’s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKβ
- in-vitro, HCC, HepG2
AMPK↑, CaMKII ↑, tumCV↓, Akt↓, mTOR↓, ROS↑,
5840- CAP,    Dietary compounds as potent inhibitors of the signal transducers and activators of transcription (STAT) 3 regulatory network
- Review, Var, NA
STAT3↓,
5839- CAP,    Capsaicin: beyond TRPV1
- Review, Var, NA
TRPV1↑, eff↑, DNMT1↓,
5838- CAP,    Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway
- in-vitro, NPC, NA
TumCG↓, TumCCA↑, TumAuto↑, Casp3↑, Ca+2↑, ROS↑, MMP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, p62↓, Fap1↓, PI3K↓, DNAdam↑,
5837- CAP,    Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression
- in-vitro, lymphoma, PEL
STAT3↓, Imm↑,
5836- CAP,    In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway
- vitro+vivo, PC, AsPC-1 - in-vitro, PC, Bxpc-3
tumCV↓, Apoptosis↑, ROS↑, MMP↓, eff↓, BAX↑, Bcl-2↓, survivin↓, Cyt‑c↑, AIF↑, selectivity↑, JNK↑, TumCG↓,
5835- CAP,    Capsaicin and dihydrocapsaicin induce apoptosis in human glioma cells via ROS and Ca2+-mediated mitochondrial pathway
- in-vitro, GBM, U251
tumCV↓, Apoptosis↑, selectivity↑, ROS↑, Ca+2↑, MMP↓, Cyt‑c↑, Casp↑, eff↑, MPT↑, ETC↓, Casp3↑, Casp9↑,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5832- CAP,    Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
- in-vitro, Oral, KB
TumCP↓, tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, Casp9↑, Casp3↑, PARP↑, Inflam↓, Pain↓,
5831- CAP,    Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin
TRPV1↑, Ca+2↑, AntiCan↑, TumCP↓, Pain↓, TumCG↓, ChemoSen↑, Apoptosis↑, ROS↑, MMP↓, Cyt‑c↑, Casp↑,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5829- CAP,    Anti-cancer activity of capsaicin and its analogs in gynecological cancers
- Review, Var, NA
Pain↓, BioAv↓, toxicity↝, toxicity↓,
5828- CAP,    Capsaicin: a novel radio-sensitizing agent for prostate cancer
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
RadioS↑, NF-kB↓, TumCCA↑, TumCG↓, TumCP↓, DNAdam↑, γH2AX↑, Ki-67↓,
5827- CAP,    The Effect of Topical Capsaicin 8% on Pain in Chemotherapy-induced Peripheral Neuropathy
- Trial, Var, NA
Pain↓, NP/CIPN↓, Dose↝, TRPV1↑, Ca+2↑,
5826- CAP,    Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload
- in-vitro, Thyroid, NA
TRPV1↑, tumCV↓, Ca+2↑, mtDam↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, Apoptosis↑,
5824- CAP,    Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level
- Study, Diabetic, NA
*glucose↓, *Insulin↑, *Dose↑, *AntiDiabetic↑,
5844- CAP,    Non-pungent long chain capsaicin-analogs arvanil and olvanil display better anti-invasive activity than capsaicin in human small cell lung cancers
- in-vitro, Lung, DMS114
eff↑, AMPK↑, toxicity↝, BioAv↑, TRPV1↑, TumCI↓,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5860- CAP,    Beneficial Effects of Capsaicin in Disorders of the Central Nervous System
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*neuroP↑, *memory↑, *Pain↓, *TRPV1↑, *Aβ↓, *tau↓, *cognitive↑, *Risk↓, *motorD↓, *ROS↓, *TNF-α↓, *IL1β↓, *eff↑, *Risk↓,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5856- CAP,    Potential of capsaicin as a combinatorial agent to overcome chemoresistance and to improve outcomes of cancer therapy
- Review, Var, NA
ChemoSen↑, Apoptosis↑, TumAuto↑, angioG↓, TumCG↓, TumMeta↓, P-gp/ABCB1↝, ERK↝, NF-kB↝, STAT3↝, eff↑,
5855- CAP,    Unravelling the Mystery of Capsaicin: A Tool to Understand and Treat Pain
- in-vivo, Nor, NA
NP/CIPN↓, BioAv↑, Half-Life↑, TRPV1↑, Pain↓, TRPV1↑,
5854- CAP,    Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
- Review, Var, NA - Review, AD, NA
Obesity↓, Half-Life↓, antiOx↑, TRPV1↑, STAT3↓, Ca+2↑, ROS↑, MMP↓, *neuroP↑, *tau↓, *Inflam↓, *ROS?,
5853- CAP,    Pharmacokinetic analysis of capsaicin after topical administration of a high-concentration capsaicin patch to patients with peripheral neuropathic pain
- Review, Var, NA
NP/CIPN↓,
5852- CAP,    Capsaicin Synergizes with Camptothecin to Induce Increased Apoptosis in Human Small Cell Lung Cancers via the Calpain Pathway
- vitro+vivo, NSCLC, NA
ChemoSen↑, Ca+2↑, cal2↑,
5851- CAP,    Capsaicin Potentiates Anticancer Drug Efficacy Through Autophagy-Mediated Ribophorin II Downregulation and Necroptosis in Oral Squamous Cell Carcinoma Cells
- in-vitro, Oral, NA
ChemoSen↑, TumAuto↑, ER Stress↑, P-gp/ABCB1↓,
5850- CAP,    Anticancer Activity of Natural and Synthetic Capsaicin Analogs
- Review, Var, NA
TRPV1↑, Ca+2↑, ROS↑, mitResp↓, ChemoSen↑, P-gp/ABCB1↓,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP/DDIT3↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
5848- CAP,  SRF,    Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
ChemoSen↑, Apoptosis↑, Casp9↑, PARP↑, Akt↓, AMPK↑, p‑ACC↑,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
5846- CAP,    Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell
- in-vitro, HCC, HepG2
Dose↝, miR-126↑, Ki-67↓, PI3K↓, mTOR↓, Akt↑, eff↑, Casp3↑,
5845- CAP,    Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
- in-vivo, RCC, A498 - in-vitro, RCC, T24/HTB-9 - NA, Bladder, 5637
TRPV1↑, TumCP↓, Casp↑, Apoptosis↑, SIRT1↓, MMP2↓, MMP9↓, TumCMig↓, TumCCA↑, ROS↑, DNAdam↑, PD-L1↑, eff↓,
5843- CAP,    The Effects of Capsaicin on Gastrointestinal Cancers
- Review, GC, NA
*BioAv↑, ROS↑, Apoptosis↑, Glycolysis↓, HK2↓, MMP9↓, AMPK↑, TumCP↓, Casp3↑, Bcl-2↓, P53↑, BAX↑,
5212- CAP,  PI,  Chemo,    Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin
- in-vitro, Colon, Caco-2
ChemoSen↑, P-gp/ABCB1↓, eff↑,
5204- CAP,    Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways
- in-vitro, Colon, SW480 - in-vitro, Colon, CT26
TumCP↓, TumCMig↑, TumCI↑, EMT↑, MMP2↓, MMP9↑, STAT3↑, TumMeta↑, ROS↑,
5203- CAP,    Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNFα) and Nuclear Factor Kappa B (NFκB) Signaling Pathway in Oral Cancer Cells
- in-vitro, OS, KB
tumCV↓, TNF-α↓, NF-kB↓, selectivity↑, Apoptosis↑, TumCMig↓,

Showing Research Papers: 1901 to 1950 of 8263
Prev Page 39 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8263

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   NADH↓, 2,   NRF2↑, 1,   RNS↑, 1,   ROS↑, 16,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 1,   ETC↓, 1,   mitResp↓, 1,   MMP↓, 11,   MPT↑, 3,   mtDam↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑ACC↑, 1,   AMPK↑, 5,   Glycolysis↓, 1,   HK2↓, 1,   SIRT1↓, 3,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Akt↑, 1,   Apoptosis↑, 16,   Bak↑, 1,   BAX↑, 4,   Bcl-2↓, 3,   Casp↑, 5,   Casp3↑, 7,   Casp9↑, 3,   Cyt‑c↑, 6,   Fap1↓, 1,   Fas↑, 1,   JNK↑, 2,   p38↑, 1,   survivin↓, 1,   TRPV1↑, 12,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNMT1↓, 1,   P53↑, 5,   PARP↑, 2,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 3,   cycE/CCNE↓, 2,   P21↑, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   ERK↝, 1,   mTOR↓, 2,   PI3K↓, 2,   PI3K↑, 1,   STAT3↓, 4,   STAT3↑, 1,   STAT3↝, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 6,  

Migration(tgid=13) ⓘ

Ca+2↑, 11,   cal2↑, 1,   E-cadherin↑, 1,   Fibrosis↓, 1,   Ki-67↓, 2,   MMP2↓, 3,   MMP9↓, 3,   MMP9↑, 1,   Snail↓, 1,   TGF-β↓, 1,   TRIB3↑, 1,   TumCI↓, 1,   TumCI↑, 1,   TumCMig↓, 4,   TumCMig↑, 1,   TumCP↓, 7,   TumCP↑, 1,   TumMeta↓, 2,   TumMeta↑, 1,   Twist↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 1,   miR-126↑, 1,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 4,   P-gp/ABCB1↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   IFN-γ↑, 1,   Imm↑, 1,   Inflam↓, 1,   NF-kB↓, 2,   NF-kB↝, 1,   PD-L1↑, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↑, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   ChemoSen↑, 9,   Dose↓, 1,   Dose↝, 2,   eff↓, 3,   eff↑, 6,   eff↝, 2,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 1,   RadioS↑, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

AR↑, 1,   Ki-67↓, 2,   PD-L1↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 2,   AntiTum↑, 1,   chemoPv↑, 4,   NP/CIPN↓, 3,   Obesity↓, 2,   OS↑, 1,   Pain↓, 5,   RenoP↑, 1,   Risk↓, 7,   Risk∅, 1,   toxicity↓, 1,   toxicity↝, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 135

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 1,   GPx↑, 1,   GSR↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NRF2↑, 1,   ROS?, 1,   ROS↓, 4,   ROS↑, 1,   SOD↑, 1,   UCPs↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 2,   NADPH↓, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   iNOS↓, 1,   MAPK↓, 1,   TRPV1↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,   Ca+2↑, 2,   Na+↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

eNOS↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL18↓, 1,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 7,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 2,   tau↓, 2,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   Dose↑, 1,   eff↑, 1,   Half-Life↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   GutMicro↑, 2,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 1,   cardioP↑, 2,   cognitive↑, 3,   memory↑, 3,   Mood↑, 1,   motorD↓, 1,   neuroP↑, 3,   Obesity↓, 1,   Pain↓, 3,   RenoP↑, 1,   Risk↓, 2,   Weight↓, 1,  
Total Targets: 66

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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