ER Stress Cancer Research Results

ER Stress, endoplasmic reticulum (ER) stress signaling pathway: Click to Expand ⟱
Source:
Type:
Protein expression of ATF, GRP78, and GADD153 which is a hall marker of ER stress.
The endoplasmic reticulum (ER) stress signaling pathway plays a crucial role in maintaining cellular homeostasis and responding to various stressors, including those encountered in cancer. When cells experience stress, such as the accumulation of misfolded proteins, they activate a series of signaling pathways collectively known as the unfolded protein response (UPR). The UPR aims to restore normal function by enhancing the protein-folding capacity of the ER, degrading misfolded proteins, and, if the stress is unresolved, triggering apoptosis.
The activation of ER stress pathways can contribute to resistance against chemotherapy and targeted therapies. Cancer cells may utilize the UPR to survive treatment-induced stress, making it challenging to achieve effective therapeutic outcomes.

-ER stress-associated proteins include: phosphorylation of PERK, eIF2α, ATF4, CHOP and cleaved-caspase 12
Scientific Papers found: Click to Expand⟱
2060- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA
TumCP↓, TumAuto↑, eff↑, ROS↑, ER Stress↑, JNK↑,
1958- GamB,    Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells
- in-vitro, Pca, NA - in-vivo, NA, NA
AntiCan↑, TumCP↓, TumAuto↑, eff↑, JNK↑, ROS↑, ER Stress↑, eff↓, TumCG↓,
1960- GamB,  Vem,    Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation
- in-vitro, Liver, HepG2 - in-vitro, AML, K562
Proteasome↓, eff↑, Casp↑, ER Stress↑, ROS↑, eff↑,
1968- GamB,    Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis
- in-vitro, Lung, A549
tumCV↓, ROS↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, Casp12↑, p‑PERK↑, ER Stress↑,
1971- GamB,    Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis
- in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, MDA-MB-468 - in-vivo, NA, NA
Paraptosis↑, ER Stress↑, MMP↓, eff↓, selectivity↑, p‑ERK↑, p‑JNK↑, eff↓,
7056- GamB,    Gambogic acid induces cell death via covalent binding with PRDX1 to regulate ER stress and autophagy
- in-vitro, RCC, 786-O
ER Stress↑, TumAuto↑, ROS↑, PrxI↓, Apoptosis↑, BID↑, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑,
7066- GamB,    Unravelling the Therapeutic Potential of Gambogic Acid: Deciphering Its Molecular Mechanism of Action and Emerging Role as an Anticancer Xanthone
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, *cardioP↑, *Inflam↓, *AntiViral↑, *antiOx↑, NF-kB↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, Apoptosis↑, TumAuto↑, TumCP↓, TumCI↓, BioAv↓, ROS↑, MMP↓, SIRT1↓, Akt↓, mTORC1↓, AMPK↑, LRIG1↑, ER Stress↑, Paraptosis↑, Ferroptosis↑, HSP90↓, GSH↓, lipid-P↑, GPx4↓, miR-21↓, PI3K↓, Akt↓, PTEN↑, ASAP2↓, CDK7↓,
7087- GAR,    Garcinol as an Epigenetic Modulator: Mechanisms of Anti-Cancer Activity and Therapeutic Potential
- Review, Var, NA
HATs↓, p300↓, CBP↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, Inflam↓, angioG↓, TumCP↓, TumMeta↓, TumCCA↑, EMT↓, CSCs↓, P53↑, TrxR↓, ROS↑, JNK↑, DNAdam↑, mt-Apoptosis↑, ER Stress↑, CHOP/DDIT3↑, DDIT4↑, TRIB3↑, SESN2↑, miR-218↑, eff↑, ChemoSen↑, BioAv↓, Half-Life↓, BioAv↑,
4506- GLA,    A basal level of γ-linolenic acid depletes Ca2+ stores and induces endoplasmic reticulum and oxidative stresses to cause death of breast cancer BT-474 cells
- in-vitro, BC, BT474
Apoptosis↓, Ca+2↑, MMP↓, p‑eIF2α↑, CHOP/DDIT3↑, ER Stress↑, ROS↑,
839- Gra,    Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
- in-vitro, Liver, HepG2
tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP/DDIT3↑,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
2514- H2,    Hydrogen: A Novel Option in Human Disease Treatment
- Review, NA, NA
*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,
2507- H2,    Hydrogen protects against chronic intermittent hypoxia induced renal dysfunction by promoting autophagy and alleviating apoptosis
- in-vivo, NA, NA
*RenoP↑, *ROS↓, *Apoptosis↓, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *Beclin-1/ATG6↑, *p62↓, *mTOR↓,
3769- H2S,    Research progress of hydrogen sulfide in Alzheimer's disease from laboratory to hospital: a narrative review
- Review, AD, NA
*APP↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *BP↓, *NLRP3↓, *ROS↓, *Aβ↓, *ER Stress↓,
2877- HNK,    Targeting histone deacetylase-3 blocked epithelial-mesenchymal plasticity and metastatic dissemination in gastric cancer
- in-vitro, GC, AGS
HDAC3↓, NF-kB↓, CEBPB↓, ER Stress↑, EMT↓, Wnt↓, β-catenin/ZEB1↓,
2883- HNK,    Honokiol targets mitochondria to halt cancer progression and metastasis
- Review, Var, NA
ChemoSen↑, BBB↓, Ca+2↑, Cyt‑c↑, Casp3↑, chemoPv↑, OCR↓, mitResp↓, Apoptosis↑, RadioS↑, NF-kB↓, Akt↓, TNF-α↓, PGE2↓, VEGF↓, NO↝, COX2/PTGS2↓, RAS↓, EMT↓, Snail↓, N-cadherin↓, β-catenin/ZEB1↓, E-cadherin↑, ER Stress↑, p‑STAT3↓, EGFR↓, mTOR↓, mt-ROS↑, PI3K↓, Wnt↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2863- HNK,    Honokiol induces paraptosis-like cell death through mitochondrial ROS-dependent endoplasmic reticulum stress in hepatocellular carcinoma Hep3B cells
- in-vitro, Liver, Hep3B
ER Stress↑, Ca+2↑, mtDam↑, PTEN↑, PARK2↑, Alix/AIP‑1↓, ROS↑, mt-ROS↑,
2073- HNK,    Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo
- in-vitro, OS, U2OS - in-vivo, NA, NA
TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,
5052- HPT,    Hyperthermia Induces Apoptosis through Endoplasmic Reticulum and Reactive Oxygen Species in Human Osteosarcoma Cells
- in-vitro, OS, U2OS
Apoptosis↑, ROS↑, Casp3↑, mtDam↑, Cyt‑c↑, Bcl-2↓, Bcl-xL↓, Bak↑, BAX↓, ER Stress↑, Ca+2↝, cal2↑,
601- HT,    Dihydroxyphenylethanol induces apoptosis by activating serine/threonine protein phosphatase PP2A and promotes the endoplasmic reticulum stress response in human colon carcinoma cells
- in-vivo, NA, HT-29
TumCG↓, Apoptosis↑, ER Stress↑, UPR↑, CHOP/DDIT3↑, JNK↑, TNF-α↓, PPP2R1A↑,
4633- HT,    Unlocking the effective alliance of β-lapachone and hydroxytyrosol against triple-negative breast cancer cells
- in-vitro, BC, NA
AntiCan↑, CSCs↓, antiOx↑, NQO1↑, TumCCA↑, ER Stress↑, Apoptosis↑, UPR↑,
7592- I3C,    Indole-3-carbinol as a chemopreventive and anti-cancer agent
- Review, Var, NA
JNK↑, STAT3↓, TumCCA↑, P21↑, p27/CDKN1B↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, AhR↑, ER-α36↓, ChemoSen↑, ER Stress↑, UPR↑, BRCA1↑, BRCA2↑, TumCMig↓, TumCI↓, VEGF↓, IL8↓, MMP2↓, MMP9↓, RadioS↑, Akt↓, NF-kB↓, DR4↑, DR5↑,
7768- IBC,    Isobavachalcone Induces ROS-Mediated Apoptosis via Targeting Thioredoxin Reductase 1 in Human Prostate Cancer PC-3 Cells
- in-vitro, NA, PC3
NA↑, TrxR1↓, ER Stress↑, TumCP↓, Apoptosis↑, GRP78/BiP↑, ATF4↑, XBP-1↑, CHOP/DDIT3↑, p‑eIF2α↑, eff↓, cl‑Casp3↑,
7771- IBC,    Isobavachalcone induces concurrent apoptosis and pyroptosis in anaplastic thyroid cancer cells by modulating the caspase-mediated cleavage of PARP and GSDME
- vitro+vivo, Thyroid, CAL-62
TumCG↓, TumCCA↑, Apoptosis↑, Pyro↑, Casp↑, cl‑PARP↑, cl‑GSDME↑, TrxR1↓, ROS↑, ER Stress↑, Dose↝,
7758- ISL,    Targeting the JAK/STAT pathway with isoliquiritigenin in ovarian cancer: molecular mechanisms and therapeutic implications
- Review, Ovarian, NA
JAK↓, STAT↓, toxicity↓, *antiOx↑, *ROS↓, *NRF2↑, *ARE↑, *HO-1↑, *NQO1↑, *Inflam↓, *NF-kB↓, *MAPK↓, *SOD↑, *Catalase↑, *GPx↑, *AntiViral↑, *NADPH↑, ROS↓, p38↓, mTOR↓, STAT3↓, cycD1/CCND1↓, survivin↓, p38↑, MAPK↑, mtDam↑, ER Stress↑, ROS↑, Apoptosis↑, GLUT4↓, ATP↓, Glycolysis↓, eff↑,
7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Bcl-2↓, BAX↑, cl‑Casp3↑, Casp12↑, MMP↓, CRT↑, e-ATP↑, HMGB1↑, HSP70/HSPA5↑, HSP90↑, ER Stress↑,
8036- IVM,    Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway
- in-vitro, ESCC, KYSE-30
*AntiP↑, AntiTum↑, ER Stress↑, TumAuto↑, ATF4↑, CHOP/DDIT3↝, TumCG↓, PERK↑, ROS↑, *toxicity↓, Ca+2↑,
7896- IVT,  VT,    Molecular targets of vitexin and isovitexin in cancer therapy: a critical review
- Review, Var, NA
chemoPv↑, Dose↝, ACE/ACE1↓, Ca+2↓, *iNOS↓, *COX2/PTGS2↓, *ROS↓, *Stroke↓, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, TumAuto↑, HSP90↑, ER Stress↑, Hif1a↓, TumMeta↓, angioG↓, Tf↓, MAPK↓, PI3K↓, Akt↓, β-catenin/ZEB1↓, TumCCA↑, FOXO3↓, mTOR↓,
7893- IVT,    Isovitexin (IV) induces apoptosis and autophagy in liver cancer cells through endoplasmic reticulum stress
- vitro+vivo, Liver, NA
TumCG↓, Apoptosis↑, BAX↑, cl‑Casp3↑, cl‑PARP↑, Cyt‑c↑, TumAuto↑, LC3II↑, ATG3↑, ATG5↑, Beclin-1/ATG6↑, ER Stress↑, IRE1↑, XBP-1↑, CHOP/DDIT3↑, GRP78/BiP↑, *chemoPv↑,
8090- KAE,    A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound
- Review, Nor, NA
*cardioP↑, *AntiCan↑, *Inflam↓, *neuroP↑, *BioAv↓, selectivity?, p‑Akt↓, p‑cycD1/CCND1↓, p‑CDK4↓, p‑BID↓, p‑Mcl-1↓, p‑BRCA1↑, ATM↑, P53↑, P21↑, p38↑, BAX↑, BID↑, MMP↓, Casp3↑, Casp7↑, Casp9↑, AIF↑, ER Stress↑, TumMeta↓, ERK↓, AP-1↓, JNK↓, p38↓, GLUT1↓, GlucoseCon↓, MMP9↓, CYP1A1↓, ChemoSen↑, OCT4↓, Nanog↓, P-gp/ABCB1↓, ALDH1A1↓, TumCCA↑, DNAdam↑, γH2AX↑, COX2/PTGS2↓, i-ROS↓, Ca+2↓, eff↑, DR5↑, ChemoSen↑, Akt↓, PI3K↓, ROS↑, EMT↓, survivin↓,
8098- KAE,    Kaempferol induces hepatocellular carcinoma cell death via endoplasmic reticulum stress-CHOP-autophagy signaling pathway
- in-vitro, HCC, HepG2 - in-vitro, HCC, HUH7
TumAuto↑, ER Stress↑, CHOP/DDIT3↓, chemoPv↑, RadioS↑, Akt↓, PI3K↓, ERK↓, ATG5↑, ATG7↑, Beclin-1/ATG6↑,
8107- KAE,    Kaempferol Induces Cell Death in A2780 Ovarian Cancer Cells and Increases Their Sensitivity to Cisplatin by Activation of Cytotoxic Endoplasmic Reticulum-Mediated Autophagy and Inhibition of Protein Kinase B
- in-vitro, Ovarian, A2780S
Apoptosis↑, tumCV↓, TumCP↓, TumAuto↑, GRP78/BiP↑, PERK↑, ATF6↑, IRE1↑, LC3II↑, Beclin-1/ATG6↑, Ca+2↑, ChemoSen↑, ER Stress↑,
8079- KAE,    Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Kaempferol in Colorectal Cancer Cells
- in-vitro, CRC, DLD1 - in-vitro, Lung, A549 - in-vitro, Liver, HUH7 - in-vitro, Cerv, HeLa
*antiOx↑, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, Dose↝, TumCP↓, ER Stress↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Casp12↝, NF-kB↓, P53↑,
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, eff↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8235- LCA,    Anticancer effects of licochalcones: A review of the mechanisms
- Review, Var, NA
mt-Apoptosis↑, TumAuto↑, TumCMig↓, LC3‑Ⅱ/LC3‑Ⅰ↑, ATG5↑, ATG7↑, p62↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, ATG3↑, Beclin-1/ATG6↑, ATG16L1↑, PERK↑, ATF4↑, ATP↓, Hif1a↓, GLUT1↓, PDK1 / PDPK1↓, Bcl-xL↓, Bcl-2↓, BAD↑, BAX↑, Casp3↑, survivin↓, EGFR↓, ERK↓, Akt↓, mtDam↑, MMP↓, Cyt‑c↑, Casp↑, MDM2↓, CycB/CCNB1↓, CDC2↓, CDC25↓, TumCCA↑, TumCP↓, Wnt↓, β-catenin/ZEB1↓, Sp1/3/4↓, MMP-10↓, MMP3↓, TumCI↓, Imm↑, PD-L1↓, ROS↑, 4E-BP1↓, eIF2α↓, PI3K↓, mTOR↓, p‑cMET↑, Ca+2↑, RUBCN↓, ATG13↑, TSC1↑, TSC2↑, PRAS40↑, PP2A↑, ULK1/ATG1↑, THEM4/CTMP↑, DR5↑, Fas↑, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, PKCδ↓, P70S6K↓, VEGF↓, angioG↓, HK2↓, Glycolysis↓, TrxR1↓, APAF1↑, cl‑PARP↑, Bax:Bcl2↑, ABCG2↓, BioEnh↑,
8261- LCA,    Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels
- in-vitro, CRC, T24/HTB-9
TumCP↓, ROS↑, Apoptosis↑, ER Stress↑, i-Ca+2↑, MMP↓, APAF1↑, Casp9↑, Casp3↑, cal2↑, CASP4↑,
8237- LCA,    Role of Licochalcone A in Potential Pharmacological Therapy: A Review
- Review, Var, NA
*other↝, *Inflam↓, *Bacteria↓, *antiOx↑, *AntiP↑, *neuroP↑, *glucose↝, *lipid-P↓, PKCδ↓, P70S6K↓, Akt↓, ER Stress↑, Apoptosis↑, Ca+2↑, PI3K↓, mTOR↓, Casp3↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑PARP↑, cycD1/CCND1↑, ROS↑, CHOP/DDIT3↑, ERK↑, p38↑, JNK↓, IAP1↓, XIAP↓, survivin↓, cFLIP↓, RIP1↓, EGFR↓, MET↓, HER2/EBBR2↓, p‑4E-BP1↓, PERK↑, eIF2α↑, PD-L1↓, HK2↓, Glycolysis↓, Sp1/3/4↓, FasL↑, MMP↓, ATP↓, TumAuto↑, WEE1↑, P21↑, CDK1↓, TumCCA↑, TumCMig↓, TumCI↓, ABCG2↓, HSP90↓, T-Cell↑, CD4+↑, CD25+↑, FOXP3↑, Imm↝, *Inflam↓, *NF-kB↓, *NRF2↑, *AntiArt↑,
8248- LCA,    Licochalcone A Inhibits the Proliferation of Human Lung Cancer Cell Lines A549 and H460 by Inducing G2/M Cell Cycle Arrest and ER Stress
- in-vitro, NSCLC, A549 - in-vitro, Lung, H460
tumCV↓, TumCG↓, TumCCA↑, MDM2↓, CycB/CCNB1↓, cDC2↓, CDC25↓, Casp3↑, PARP↑, ER Stress↑, p‑eIF2α↑, ATF4↑, TumCP↓, selectivity↑, Bcl-xL↓, Bcl-2↓,
8249- LCA,    Induction of C/EBP homologous protein-mediated apoptosis and autophagy by licochalcone A in non-small cell lung cancer cells
tumCV↓, LDH↑, Apoptosis↑, selectivity↑, LC3II↑, TumAuto↑, ER Stress↑, CHOP/DDIT3↑, chemoP↑, RenoP↑, cl‑PARP↑, cl‑Casp7↑, cl‑Casp3↑,
8210- LCA,    Licochalcone A-Induced Human Bladder Cancer T24 Cells Apoptosis Triggered by Mitochondria Dysfunction and Endoplasmic Reticulum Stress
- in-vitro, Bladder, T24/HTB-9
chemoPv↑, TumCP↓, ROS↑, Apoptosis↑, mtDam↑, Casp3↑, cl‑PARP↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, Casp12↑, mt-ROS↑, tumCV↓, GSH/GSSG↓, NA↓,
8211- LCA,    Licochalcone A induces endoplasmic reticulum stress-mediated apoptosis of endometrial cancer cells via upregulation of GRP78 expression
- in-vitro, EC, NA
AntiCan↑, tumCV↓, Apoptosis↑, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑,
8219- LCA,    Licochalcone A Ameliorates Cognitive Dysfunction in an Alzheimer's Disease Model by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis
- in-vivo, AD, NA
*Dose↝, *cognitive↑, *Aβ↓, *ER Stress↓, *BioAv↑, *toxicity↓, *PERK↓, *eIF2α↓, *ATF4↓, *CHOP/DDIT3↓, *NRF2↑,
8187- LGE,    Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation
- in-vitro, BC, 4T1 - in-vitro, Ovarian, OVCAR-3 - in-vitro, Ovarian, SKOV3
TumCP↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Bcl-2↓, ER Stress↑, CHOP/DDIT3↑, GADD45A↑, EDEM↑, ATF4↑, HSP90↑, ATG5↑, eIF2α↑, ROS↑, P53↑, eff↓,
1100- LT,    Luteolin, a flavonoid, as an anticancer agent: A review
- Review, NA, NA
TumCP↓, TumCCA↑, Apoptosis↑, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, ROS↑, ER Stress↑, mtDam↑, p‑eIF2α↝, p‑PERK↝, p‑CHOP/DDIT3↝, p‑ATF4↝, cl‑Casp12↝,
2923- LT,    Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells
- in-vitro, NA, NA
Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1/ATG6↓, Hif1a↓, LC3II↑, Beclin-1/ATG6↑,

Showing Research Papers: 151 to 200 of 303
Prev Page 4 of 7 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 303

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   p‑AMT/GCST/T-protein↑, 1,   ASAP2↓, 1,   ATG13↑, 1,   ATG16L1↑, 1,   CASP4↑, 1,   CD47↓, 1,   CDK7↓, 1,   DDIT4↑, 1,   EDEM↑, 1,   LRIG1↑, 1,   miR-124-3p↓, 1,   NA↓, 1,   NA↑, 1,   PFS↑, 1,   RUBCN↓, 1,   THEM4/CTMP↑, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 1,   ULK1/ATG1↑, 1,   WEE1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   CYP1A1↓, 1,   Ferroptosis↑, 2,   GPx4↓, 1,   GSH↓, 1,   GSH/GSSG↓, 1,   H2O2↑, 1,   lipid-P↑, 1,   NQO1↑, 1,   NRF2↑, 3,   PARK2↑, 1,   PrxI↓, 1,   ROS↓, 1,   ROS↑, 25,   i-ROS↓, 1,   mt-ROS↑, 3,   SIRT3↑, 1,   SOD↓, 1,   TrxR↓, 1,   TrxR1↓, 3,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 3,   e-ATP↑, 1,   BOK↑, 1,   CDC2↓, 1,   CDC25↓, 2,   mitResp↓, 1,   MMP↓, 15,   MPT↑, 1,   mtDam↑, 8,   OCR↓, 1,   PGC-1α↑, 1,   c-Raf↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 3,   ATG7↑, 3,   cMyc↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 2,   LDH↑, 1,   PDK1 / PDPK1↓, 1,   PKM2↑, 1,   SCD1↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 14,   Akt↑, 1,   p‑Akt↓, 1,   APAF1↑, 2,   Apoptosis↓, 1,   Apoptosis↑, 26,   mt-Apoptosis↑, 2,   BAD↑, 2,   Bak↑, 1,   BAX↓, 1,   BAX↑, 11,   Bax:Bcl2↑, 2,   Bcl-2↓, 13,   Bcl-xL↓, 4,   BID↑, 3,   p‑BID↓, 1,   Casp↑, 3,   Casp12↑, 4,   Casp12↝, 1,   cl‑Casp12↑, 1,   cl‑Casp12↝, 1,   Casp3↑, 15,   cl‑Casp3↑, 5,   Casp7↑, 1,   cl‑Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 9,   cl‑Casp9↑, 1,   CBP↓, 1,   cFLIP↓, 2,   Cyt‑c↑, 8,   DR4↑, 2,   DR5↑, 6,   FADD↑, 1,   Fas↑, 4,   FasL↑, 1,   Ferroptosis↑, 2,   cl‑GSDME↑, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   JNK↓, 3,   JNK↑, 7,   p‑JNK↑, 1,   MAPK↓, 4,   MAPK↑, 1,   Mcl-1↓, 1,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 2,   NAIP↓, 1,   p27/CDKN1B↑, 1,   p38↓, 2,   p38↑, 4,   Paraptosis↑, 2,   PPP2R1A↑, 1,   Proteasome↓, 1,   Pyro↑, 2,   RIP1↓, 1,   survivin↓, 6,   Telomerase↓, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,   HER2/EBBR2↓, 1,   Sp1/3/4↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   EZH2↓, 1,   H3↑, 1,   H4↑, 1,   HATs↓, 1,   HATs↑, 1,   miR-21↓, 1,   miR-218↑, 1,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3,   cl‑ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 18,   CHOP/DDIT3↝, 1,   p‑CHOP/DDIT3↝, 1,   cl‑CHOP/DDIT3↑, 1,   CRT↑, 1,   eIF2α↓, 1,   eIF2α↑, 4,   p‑eIF2α↑, 6,   p‑eIF2α↝, 1,   ER Stress↑, 45,   GRP78/BiP↑, 12,   GRP94↑, 2,   HSP70/HSPA5↑, 2,   HSP90↓, 2,   HSP90↑, 3,   IRE1↑, 2,   PERK↑, 5,   p‑PERK↑, 3,   p‑PERK↝, 1,   UPR↑, 5,   XBP-1↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 2,   ATG5↑, 6,   Beclin-1/ATG6↑, 6,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B-II↑, 1,   LC3II↑, 5,   p62↑, 1,   SESN2↑, 1,   TumAuto↑, 14,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   DNAdam↓, 1,   DNAdam↑, 2,   GADD45A↑, 1,   P53↑, 5,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 9,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 3,   CDK4↓, 4,   p‑CDK4↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 3,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21?, 1,   P21↑, 3,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 15,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   p‑4E-BP1↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CD44↓, 1,   cDC2↓, 1,   CEBPB↓, 1,   p‑cMET↑, 2,   CSCs↓, 4,   EMT↓, 8,   ERK↓, 4,   ERK↑, 3,   p‑ERK↑, 2,   FOXO3↓, 1,   HDAC↓, 2,   HDAC3↓, 1,   mTOR↓, 7,   mTORC1↓, 2,   Nanog↓, 3,   Nestin↓, 2,   NOTCH1↓, 1,   NOTCH3↓, 1,   OCT4↓, 3,   p300↓, 1,   P70S6K↓, 2,   PI3K↓, 12,   PTEN↑, 2,   RAS↓, 1,   RAS↑, 1,   Shh↓, 1,   SOX2↓, 1,   STAT↓, 1,   STAT3↓, 6,   p‑STAT3↓, 2,   TumCG↓, 6,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

Akt2↓, 1,   Alix/AIP‑1↓, 1,   AP-1↓, 1,   Ca+2↓, 2,   Ca+2↑, 11,   Ca+2↝, 1,   i-Ca+2↑, 1,   cal2↑, 2,   E-cadherin↑, 3,   ER-α36↓, 1,   MALAT1↓, 1,   MET↓, 1,   MMP-10↓, 1,   MMP2↓, 2,   MMP3↓, 2,   MMP9↓, 4,   MMPs↓, 2,   N-cadherin↓, 3,   PKCδ↓, 2,   Snail↓, 2,   SOX4↓, 2,   TIMP2↓, 1,   TRIB3↑, 1,   TSC1↑, 1,   TumCI↓, 7,   TumCMig↓, 6,   TumCP↓, 15,   TumCP↑, 1,   TumMeta↓, 5,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 6,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 7,   p‑ATF4↝, 1,   EGFR↓, 4,   Hif1a↓, 6,   NO↝, 1,   VEGF↓, 6,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   GLUT1↓, 2,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↓, 4,   CXCR4↓, 1,   FOXP3↑, 1,   HMGB1↑, 1,   IKKα↓, 1,   IL8↓, 1,   Imm↑, 1,   Imm↝, 2,   Inflam↓, 1,   JAK↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 10,   NK cell↑, 1,   p65↓, 1,   PD-L1↓, 2,   PGE2↓, 2,   T-Cell↑, 1,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 4,   BioAv↑, 2,   BioEnh↑, 1,   ChemoSen↑, 12,   Dose↝, 6,   eff↓, 6,   eff↑, 11,   Half-Life↓, 2,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 3,   selectivity?, 1,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

BMPs↑, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   EGFR↓, 4,   EZH2↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   LDH↑, 1,   PD-L1↓, 2,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   antiNeop↑, 1,   AntiTum↑, 1,   chemoP↑, 4,   chemoPv↑, 4,   NP/CIPN↓, 1,   OS↑, 1,   PRAS40↑, 1,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 2,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 350

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,   AntiP↑, 2,   compII↑, 1,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 10,   ARE↑, 1,   Catalase↑, 3,   Ferroptosis↓, 1,   GPx↑, 2,   GPx4↑, 1,   GSH↑, 3,   HO-1↓, 1,   HO-1↑, 4,   i-Iron↓, 1,   lipid-P↓, 1,   MDA↓, 3,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 8,   ROS↓, 13,   SOD↑, 4,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   compIII↑, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 1,   glucose↝, 1,   LDHA↑, 1,   LDL↓, 1,   NADPH↓, 1,   NADPH↑, 1,   PPARα↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 2,   Casp1↓, 1,   Casp12↓, 2,   Casp3↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 2,   p‑JNK↓, 1,   MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 4,   eIF2α↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 6,   GRP78/BiP↓, 2,   PERK↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 2,   p62↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 2,   PI3K↑, 1,  

Migration(tgid=13) ⓘ

APP↓, 2,   p‑Rac1↓, 1,   TGF-β↑, 1,   TXNIP↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 3,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 2,   IFN-γ↓, 2,   IKKα↑, 1,   IL10↓, 2,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL4↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 12,   LPS↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 3,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 3,   BACE/β-secretase↓, 1,   NLRP3↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   Dose↝, 3,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 3,   BP↓, 1,   creat↓, 1,   GutMicro↑, 3,   IL6↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 4,   chemoPv↑, 1,   cognitive↑, 2,   hepatoP↑, 4,   neuroP↓, 1,   neuroP↑, 7,   Obesity↓, 1,   RenoP↑, 3,   toxicity↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 1,   Sepsis↓, 1,  
Total Targets: 122

Scientific Paper Hit Count for: ER Stress, endoplasmic reticulum (ER) stress signaling pathway
13 Silver-NanoParticles
13 Phenylbutyrate
12 Quercetin
11 Curcumin
11 Berberine
9 EGCG (Epigallocatechin Gallate)
9 Fisetin
8 Ashwagandha(Withaferin A)
8 Licochalcone A
7 Artemisinin
7 Chrysin
7 salinomycin
7 Gambogic Acid
7 Piperlongumine
6 Apigenin (mainly Parsley)
6 Magnetic Fields
6 Honokiol
6 Kaempferol
6 Luteolin
5 Allicin (mainly Garlic)
5 Resveratrol
5 Rosmarinic acid
5 Sulforaphane (mainly Broccoli)
5 Vitamin C (Ascorbic Acid)
4 Baicalein
4 Betulinic acid
4 Capsaicin
4 Celastrol
4 Propolis -bee glue
4 Emodin
4 Electrical Pulses
4 Shikonin
4 Selenite (Sodium)
3 Photodynamic Therapy
3 Boron
3 Crocetin
3 Copper and Cu NanoParticles
3 Hydrogen Gas
3 HydroxyTyrosol
3 Nimbolide
3 Selenium NanoParticles
2 3-bromopyruvate
2 Andrographis
2 Cisplatin
2 Boswellia (frankincense)
2 Celecoxib
2 Isobavachalcone
2 Isovitexin
2 Plumbagin
2 Pterostilbene
2 Thymoquinone
1 5-Aminolevulinic acid
1 Auranofin
1 Astragalus
1 Radiotherapy/Radiation
1 Alpha-Lipoic-Acid
1 Melatonin
1 immunotherapy
1 Sorafenib (brand name Nexavar)
1 Aloe anthraquinones
1 Berbamine
1 Chemotherapy
1 Bacopa monnieri
1 α-Bisabolol / Chamomile oil
1 doxorubicin
1 Bortezomib
1 Bullatacin
1 Carnosic acid
1 Carvacrol
1 carboplatin
1 Cannabidiol
1 chitosan
1 Choline
1 Cinnamon
1 Coenzyme Q10
1 Cynaropicrin
1 Dichloroacetate
1 Dipyridamole
1 Aspirin
1 Dandelion Root
1 Disulfiram
1 Ellagic acid
1 Ferulic acid
1 Fenbendazole
1 verapamil
1 Garcinol
1 γ-linolenic acid (Borage Oil)
1 Graviola
1 hydrogen sulfide
1 Hyperthermia
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoquercitrin
1 Ivermectin
1 Vitexin
1 Lemongrass Extract/Citral
1 Lutein
1 Lycopene
1 Magnolol
1 Magnetic Field Rotating
1 Magnesium
1 Naringin
1 nelfinavir/Viracept
1 Docetaxel
1 Oroxylin-A
1 Oleuropein
1 temozolomide
1 Phenethyl isothiocyanate
1 Parthenolide
1 Paclitaxel/Taxol
1 Scoulerine
1 SonoDynamic Therapy UltraSound
1 Osimertinib
1 Adagrasib
1 Taurine
1 Urolithin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:103  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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