tau Cancer Research Results

tau, tau: Click to Expand ⟱
Source:
Type:
In healthy neurons, tau binds to and stabilizes microtubules, which are essential for maintaining cell structure and facilitating axonal transport.

In AD, tau becomes abnormally hyperphosphorylated. This excessive phosphorylation reduces its affinity for microtubules, leading to destabilization of the cytoskeletal structure.
-Abnormal phosphorylated tau (p-tau) can be detected in cerebrospinal fluid (CSF) and blood plasma.
-Imaging techniques like tau PET scans can visualize tau deposits in the brain.
Natural Products targeting tau
-Curcumin                via GSK-3β inhibition
-Resveratrol             Activates SIRT1
-EGCG                    inhibits Tau, but BBB penetration is questionable
Scientific Papers found: Click to Expand⟱
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE/β-secretase↓, *ATP↑, *neuroP↑,
4316- VitB3,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*NAD↑, *Aβ↓, *p‑tau↓,
4317- VitB5,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Ach↑, *ROS↓, *Inflam↓, *p‑tau↓, *Aβ↓, *Acetyl-CoA↑, *ATP↑, *ChAT↑, *memory↑,
3921- VitD3,  RES,    Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE/β-secretase↓, *p‑tau↓, *p‑CREB↑, *p‑NF-kB↓, *neuroP↑,
4090- VitK2,  ProBio,    Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment
- Review, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *memory↑, *NF-kB↓, *ROS↓, *GSH↑, *ATP↑, *p‑tau↓, *cardioP↑, *other↝, *cognitive↑,
4309- VitK2,    Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases
- Review, NA, NA
*Apoptosis↓, *ROS↓, *antiOx↑, *cognitive↑, *memory↑, *Risk↓, *p‑tau↓,

Showing Research Papers: 151 to 156 of 156
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 156

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GSH↑, 2,   ROS↓, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Acetyl-CoA↑, 1,   p‑CREB↑, 1,   NAD↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↑, 3,   other↝, 1,  

Migration(tgid=13) ⓘ

APP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 3,   NF-kB↓, 1,   p‑NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ChAT↑, 1,   p‑tau↓, 6,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 3,   memory↑, 4,   neuroP↑, 2,   Risk↓, 1,  
Total Targets: 27

Scientific Paper Hit Count for: tau, tau
9 Curcumin
9 Resveratrol
9 Urolithin
7 EGCG (Epigallocatechin Gallate)
6 Cinnamon
6 Emodin
5 Berberine
5 Mung Bean Sprouts
5 Selenium NanoParticles
5 Shilajit/Fulvic Acid
5 Ginseng
5 Luteolin
5 Quercetin
4 Caffeic acid
4 Capsaicin
4 Hydrogen Gas
4 isoorientin
4 Vitamin B1/Thiamine
3 Folic Acid, Vit B9
3 Ferulic acid
3 Rosmarinic acid
3 Thymoquinone
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Bacopa monnieri
2 Chlorogenic acid
2 Crocetin
2 Lactoferrin/Talactoferrin
2 Magnetic Fields
2 Mushroom Lion’s Mane
2 Vitamin B3,Niacin
2 Sulforaphane (mainly Broccoli)
2 Vitamin K2
1 1,8-Cineole
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Aromatherapy
1 Beta-Caryophyllene
1 xanthohumol
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Calorie Restriction Mimetics
1 Phosphatidylserine
1 Fisetin
1 Flickering Light Stimulation
1 Formononetin
1 Ginkgo biloba
1 hydrogen sulfide
1 Hydroxycinnamic-acid
1 Honokiol
1 Hyperoside
1 Isobavachalcone
1 isoquercitrin
1 Potassium
1 Kaempferol
1 Licochalcone A
1 Lycopene
1 Methylene blue
1 Isovitexin
1 Vitexin
1 Moringa oleifera
1 Methylsulfonylmethane
1 nicotinamide adenine dinucleotide
1 Phenylbutyrate
1 Protocatechuic acid
1 Piperine
1 Pterostilbene
1 chitosan
1 Rutin
1 S-adenosyl-L-methionine
1 Carvacrol
1 Shankhpushpi
1 Silymarin (Milk Thistle) silibinin
1 Ursolic acid
1 Vitamin A, Retinoic Acid
1 Vitamin B12
1 Vitamin B5,Pantothenic Acid
1 Vitamin D3
1 probiotics
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1231  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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