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| Type: |
| Brain-Derived Neurotrophic Factor (BDNF) is a key neurotrophin (a type of growth factor) involved in brain health, and its role in Alzheimer’s Disease (AD) has been extensively studied. -AD patients often have lower BDNF levels in key brain regions, such as the hippocampus and cortex. -This reduction correlates with cognitive decline and brain atrophy. -BDNF normally protects neurons from Aβ toxicity -Exercise and cognitive training have been shown to boost BDNF levels and may slow cognitive decline. - natural compounds (like curcumin or flavonoids) may also upregulate BDNF. |
| 4168- | Mg, | Antidepressant-like activity of magnesium in the olfactory bulbectomy model is associated with the AMPA/BDNF pathway |
| - | in-vivo, | NA, | NA |
| 4226- | Moringa, | The Oil Formulation Derived from Moringa Oleifera Seeds Ameliorates Behavioral Abnormalities in Water-immersion Restraint Stress Mouse Model |
| - | in-vivo, | NA, | NA |
| 3848- | MSM, | Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway |
| - | in-vitro, | AD, | NA |
| 3814- | mushLions, | Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model |
| - | in-vitro, | AD, | NA |
| 4160- | NAD, | The biochemical pathways of central nervous system neural degeneration in niacin deficiency |
| - | Review, | NA, | NA |
| 4223- | NarG, | Effect of 2-Week Naringin Supplementation on Neurogenesis and BDNF Levels in Ischemia–Reperfusion Model of Rats |
| - | in-vivo, | Stroke, | NA |
| 4224- | NarG, | The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model |
| - | in-vivo, | Obesity, | NA | - | NA, | AD, | NA |
| 4225- | NarG, | Naringin treatment improves functional recovery by increasing BDNF and VEGF expression, inhibiting neuronal apoptosis after spinal cord injury |
| - | in-vivo, | NA, | NA |
| 4156- | PB, | The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain |
| - | in-vivo, | AD, | NA |
| 4218- | PBG, | The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells |
| - | in-vitro, | Nor, | SH-SY5Y | - | in-vitro, | AD, | NA |
| 4219- | PBG, | Propolis Increases Brain Derived Neurotrophic Factor Expression in the Prefrontal Cortex of Rat Stress Model |
| - | in-vivo, | AD, | NA |
| 7831- | PCA, | MBS, | Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review |
| - | Review, | AD, | NA |
| 4220- | PI, | Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination |
| - | in-vivo, | AD, | NA | - | in-vivo, | MS, | NA |
| 4221- | PI, | Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells |
| - | in-vitro, | NA, | NA |
| 4222- | PI, | Potential of piperine for neuroprotection in sepsis-associated encephalopathy |
| - | in-vivo, | Sepsis, | NA |
| 7517- | Poly, | Modulation of neurotrophic signaling pathways by polyphenols |
| - | Review, | Nor, | NA |
| 4170- | ProBio, | PB, | Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-d-aspartate receptor subunits and d-serine |
| - | in-vivo, | NA, | NA |
| 3922- | PTS, | Pterostilbene attenuates amyloid-β induced neurotoxicity with regulating PDE4A-CREB-BDNF pathway |
| - | in-vivo, | AD, | NA |
| 4296- | QC, | A Flavonoid on the Brain: Quercetin as a Potential Therapeutic Agent in Central Nervous System Disorders |
| - | Review, | AD, | NA |
| 4162- | QC, | Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF-TrkB-PI3K/Akt signaling pathway |
| - | in-vivo, | Stroke, | NA |
| 4153- | RES, | Effect of oral resveratrol on the BDNF gene expression in the hippocampus of the rat brain |
| - | in-vivo, | AD, | NA |
| 4154- | RES, | Resveratrol improves postnatal hippocampal neurogenesis and brain derived neurotrophic factor in prenatally stressed rats |
| - | in-vivo, | AD, | NA |
| 3798- | RES, | Resveratrol reverses hippocampal synaptic markers injury and SIRT1 inhibition against developmental Pb exposure |
| - | in-vivo, | NA, | NA |
| 4286- | RES, | Neuroprotective Properties of Resveratrol and Its Derivatives—Influence on Potential Mechanisms Leading to the Development of Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 4217- | Sage, | RosA, | Aroma, | Neuroprotective Potential of Aromatic Herbs: Rosemary, Sage, and Lavender |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4214- | Se, | Selenium ameliorates cognitive impairment through activating BDNF/TrkB pathway |
| - | in-vivo, | NA, | NA |
| 4189- | Sesame, | Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways |
| - | in-vivo, | AD, | NA |
| 4190- | Sesame, | Sesame Seeds: A Nutrient-Rich Superfood |
| - | Review, | NA, | NA |
| 4200- | SFN, | Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription |
| - | in-vitro, | NA, | NA |
| 4202- | SFN, | Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity |
| - | Review, | Park, | NA |
| 4201- | SFN, | Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents |
| - | in-vivo, | NA, | NA |
| 4199- | SFN, | Sulforaphane and Brain Health: From Pathways of Action to Effects on Specific Disorders |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4198- | SFN, | Sulforaphane epigenetically enhances neuronal BDNF expression and TrkB signaling pathways |
| - | vitro+vivo, | AD, | NA |
| 4203- | SIL, | Unlocking the Neuroprotective Potential of Silymarin: A Promising Ally in Safeguarding the Brain from Alzheimer’s Disease and Other Neurological Disorders |
| - | Review, | NA, | NA |
| 4204- | SIL, | Silymarin administration after cerebral ischemia improves survival of obese mice by increasing cortical BDNF and IGF1 levels |
| - | NA, | Stroke, | NA |
| 3318- | SIL, | Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 4206- | SIL, | Silymarin ameliorates experimentally induced depressive like behavior in rats: Involvement of hippocampal BDNF signaling, inflammatory cytokines and oxidative stress response |
| - | in-vivo, | NA, | NA |
| 4205- | SIL, | The Therapeutic Effect of Silymarin and Silibinin on Depression and Anxiety Disorders and Possible Mechanism in the Brain: A Systematic Review |
| - | Review, | AD, | NA |
| 4207- | SIL, | Silymarin sex-dependently improves cognitive functions and alters TNF-α, BDNF, and glutamate in the hippocampus of mice with mild traumatic brain injury |
| 3049- | SK, | Shikonin Attenuates Chronic Cerebral Hypoperfusion-Induced Cognitive Impairment by Inhibiting Apoptosis via PTEN/Akt/CREB/BDNF Signaling |
| - | in-vivo, | Nor, | NA | - | NA, | Stroke, | NA |
| 4216- | SSE, | Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF/TrKB/PI3K/AKT and inhibiting NF-κB signaling pathways |
| - | in-vitro, | NA, | NA |
| 4215- | SY, | Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway |
| - | in-vivo, | NA, | NA |
| 4151- | Taur, | Gins, | Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage |
| - | in-vitro, | AD, | NA |
| 4157- | Taur, | Antidepressant dose of taurine increases mRNA expression of GABAA receptor α2 subunit and BDNF in the hippocampus of diabetic rats |
| - | in-vivo, | AD, | NA |
| 4172- | TQ, | Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway |
| - | in-vivo, | AD, | NA |
| 4173- | TQ, | Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons |
| - | in-vivo, | NA, | NA |
| 6453- | TUR, | Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil |
| - | Review, | Var, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3790- | UA, | Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools |
| 3789- | UA, | Ex, | Combined Ursolic Acid and Resistance/Endurance Training Improve Type 3 Diabetes Biomarkers-Related Memory Deficits in Hippocampus of Aged Male Wistar Rats |
| - | in-vivo, | AD, | NA |
| 4860- | Uro, | Urolithins–gut Microbial Metabolites with Potential Health Benefits |
| - | Review, | Nor, | NA | - | Review, | AD, | NA | - | Review, | Park, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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