chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
2189- SK,    PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells
- in-vitro, Melanoma, NA
PKM2↓, chemoPv↑, eff↝, lactateProd↓, ROS↑, *ROS?, *PKM2↓,
5105- SSE,    Sodium selenite induces apoptosis by generation of superoxide via the mitochondrial-dependent pathway in human prostate cancer cells
- in-vitro, Pca, LNCaP
TumCD↑, Apoptosis↑, ROS↑, eff↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, necrosis↑, chemoPv↑,
112- SuD,    Inhibition of Gli/hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP
HH↓, Gli1↓, PTCH1↓, TumCG↓, chemoPv↑, eff↑,
5221- TQ,    Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
- in-vitro, AML, HL-60
chemoPv↑, Apoptosis↑, MMP↓, Casp8↑, Casp9↑, Bax:Bcl2↑, Cyt‑c↑,
2122- TQ,    Review on Molecular and Therapeutic Potential of Thymoquinone in Cancer
- Review, Var, NA
ChemoSen↓, *ROS↓, *GSH↑, RenoP↑, hepatoP↑, COX2/PTGS2↓, NF-kB↓, chemoPv↑, neuroP↑, TumCCA↑, P21↑, p27/CDKN1B↑, ROS↑, DNAdam↑, MUC4↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2/BIRC3↑, XIAP↓, TNF-α↓, COX2/PTGS2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
4538- TQ,    Thymoquinone Anticancer Effects Through the Upregulation of NRF2 and the Downregulation of PD‐L1 in MDA‐MB‐231 Triple‐Negative Breast Cancer Cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468
antiOx↑, H2O2↓, Catalase↑, SOD↑, GSH↑, PRNP↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, chemoPv↑, ROS↓,
5018- UA,    Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies
- Review, Var, NA
Inflam↓, TumCCA↑, chemoPv↑, TumMeta↓, antiOx↑, AntiViral↑, AntiDiabetic↑,
3148- VitC,    Antioxidants in brain tumors: current therapeutic significance and future prospects
- Review, Var, NA
*antiOx↑, *ROS↓, chemoPv↑, ChemoSen↑, TET2↑, eff↑, OS↑, QoL↑, eff↑,
7919- VT,    Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway
- in-vitro, AML, U937
TumCD↑, Apoptosis↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, chemoPv↑,

Showing Research Papers: 151 to 160 of 160
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 160

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GCLM↑, 1,   GSH↑, 1,   H2O2↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 5,   ROS⇅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 3,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

lactateProd↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 3,   Cyt‑c↑, 2,   IAP1↓, 1,   IAP2/BIRC3↑, 1,   Mcl-1↓, 1,   necrosis↑, 1,   p27/CDKN1B↑, 1,   survivin↓, 1,   TumCD↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   Gli1↓, 1,   HH↓, 1,   miR-34a↑, 1,   mTOR↓, 1,   NOTCH↓, 1,   PI3K↓, 1,   PTCH1↓, 1,   PTEN↑, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

MUC4↓, 2,   PRNP↑, 1,   Rac1↓, 1,   TumMeta↓, 1,   Twist↓, 1,   α-tubulin↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   Inflam↓, 2,   IκB↓, 1,   NF-kB↓, 2,   p‑p65↓, 1,   PD-L1↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 2,   eff↓, 1,   eff↑, 3,   eff↝, 1,   RadioS↑, 1,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   chemoPv↑, 10,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 85

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS?, 1,   ROS↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

PKM2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
8 Curcumin
7 Phenethyl isothiocyanate
6 Chemotherapy
6 Capsaicin
6 Chrysin
6 Resveratrol
6 Quercetin
5 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 D-limonene
4 Fisetin
4 Nimbolide
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chlorophyllin
3 Chocolate
3 Indole-3-carbinol
3 α-Santalol/Sandalwood oil
2 Astaxanthin
2 Arctigenin
2 Biochanin A
2 Carvacrol
2 Celecoxib
2 Cucurbitacin
2 Genistein (soy isoflavone)
2 Eugenol
2 Formononetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 Inositol
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Isovitexin
2 Vitexin
2 Licochalcone A
1 Annona atemoya Seed Extract
1 Silver-NanoParticles
1 probiotics
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Luteolin
1 Ashwagandha(Withaferin A)
1 Berberine
1 Beta-Caryophyllene
1 Boron
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Caffeic acid
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Chlorogenic acid
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Crocetin
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 methylseleninic acid
1 Deguelin
1 Diclofenac
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 Garcinol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Honokiol
1 Hops (Humulus lupulus)
1 Hyperoside
1 Inulin Prebiotic
1 Isoliquiritigenin
1 isoflavones
1 Juglone
1 Kaempferol
1 Lasiodin
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Oleuropein
1 Psoralidin
1 Rutin
1 buckwheat sprouts
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1417  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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