PI3K Cancer Research Results

PI3K, Phosphatidylinositide-3-Kinases: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-CS
Type:
Phosphatidylinositol 3-kinase (PtdIns3K or PI3K) is a family of enzymes that play a crucial role in cell signaling pathways, particularly in the regulation of cell growth, survival, and metabolism. The PI3K pathway is one of the most frequently altered pathways in human cancer. Inhibition of the PI3K pathway has been explored as a therapeutic strategy for cancer treatment. Several PI3K inhibitors have been developed and are currently being tested in clinical trials. These inhibitors can target specific components of the pathway, such as PI3K, AKT, or mTOR.

Class I phosphoinositide 3-kinase (PI3K)
Class III PtdIns3K
In contrast to the class III PtdIns3K as a positive regulator of autophagy, class I PI3K-AKT signaling has an opposing effect on the initiation of autophagy.

PI3K inhibitors include:
-Idelalisib , Copanlisib, Alpelisib
-LY294002?
-Wortmannin: potent PI3K inhibitor, has some associated toxicity.
-Quercetin:
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
Scientific Papers found: Click to Expand⟱
3576- CUR,    Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease
- Review, AD, NA
*Inflam↓, *antiOx↑, *memory↑, *Aβ↓, *BBB↑, *cognitive↑, *tau↓, *LDL↓, *AChE↓, *IL1β↓, *IronCh↑, *neuroP↑, *BioAv↝, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *Ferritin↑, *HO-2↓, *ROS↓, *Ach↑, *GSH↑, *Bcl-2↑, *ChAT↑,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- NA, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2/PTGS2↓, CA↓, ALDH↓, P-gp/ABCB1↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
1871- DAP,    Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
- in-vitro, AML, U937 - in-vivo, AML, NA
TumCP↓, Apoptosis↑, TumCG↓, PDK1 / PDPK1↓, cl‑PARP↑, Bcl-xL↓, Bcl-2↓, Beclin-1/ATG6↓, ATG3↓, PI3K↓, Akt↓, eff↑,
6675- Deg,    Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway
- in-vitro, BC, MCF7 - in-vitro, BC, BT474 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, TNF-α↓, PI3K↓, Akt↓,
6677- Deg,    Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
- in-vitro, NSCLC, NA
Glycolysis↓, TumCG↓, Akt↓, Apoptosis↑, TumCP↓, HK2↓, PI3K↓, cMyc↓,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6709- DFC,    Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480
COX2/PTGS2↓, Inflam↓, PI3K↓, Akt↓, eff↓,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
Risk↓, AMPK↑, Akt↓, mTOR↓, SIRT1↑, Hif1a↓, NRF2↓, SOD↑, ROS↑, IGF-1↓, p‑Akt↓, PI3K↑, GutMicro↑, OS↑, eff↝, ROS↑, TumCCA↑, *DNArepair↑, DNAdam↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
6269- DL,    Induction of apoptosis by D-limonene is mediated by inactivation of Akt in LS174T human colon cancer cells
- in-vitro, CRC, LS174T
tumCV↓, Apoptosis↑, Casp3↑, Casp9↑, cl‑PARP↑, BAX↑, Cyt‑c↑, Bcl-2↓, PI3K↓, Akt↓,
6287- DL,    D-Limonene Is a Potential Monoterpene to Inhibit PI3K/Akt/IKK-α/NF-κB p65 Signaling Pathway in Coronavirus Disease 2019 Pulmonary Fibrosis
- in-vivo, Covid, NA
*PI3K↓, *Akt↓, *NF-kB↓,
6342- DRE,    Mechanistic Study on the Inhibitory Effect of Dandelion Extract on Breast Cancer Cell Proliferation and Its Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
eff↑, selectivity↑, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, JAK1↓, STAT↓, PPARγ↑, TumCP↓, SIRT6↓, SCD1↓, STAT3↓, Casp8↓, STAT6↓, PAK1↓, FABP4↓,
6343- DRE,    Dandelion root extract affects ESCC progression via regulating multiple signal pathways
- vitro+vivo, ESCC, NA
*Inflam↓, TumCG↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↓, TumCG↓, PI3K↓, p‑Akt↓, RAS↓, Raf↓, p‑ERK↓, Bcl-2↓, BAX↑,
6348- DRE,    New prospects in oncotherapy: bioactive compounds from Taraxacum officinale
- Review, Var, NA
Dose↝, TumCP↓, toxicity↓, *AntiDiabetic↑, *antiOx↑, *hepatoP↑, *diuretic↑, *Inflam↓, *neuroP↑, *Imm↑, eff↑, Apoptosis↑, tumCV↓, selectivity↑, TumCMig↓, EMT↓, MMP2↓, MMP9↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, JNK↓, ERK↓,
6354- DRE,    Taraxacum officinale L. in leukemia and lymphoma: current knowledge and prospects for horticulture
- Review, AML, NA
ROS↑, mt-Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, STAT3↓, Dose↝, *hepatoP↑, Casp8↑, mtDam↑, TumCD↑, selectivity↑, DNAdam↑, BAX↑, P53↑, Bcl-2↓, CSCs↓, *toxicity↓, tumCV↓, Imm↑, FAK↓, mTOR↓, ChemoSen↑, eff↝, eff↑,
6359- DRE,    Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends
- Review, Var, NA
*antiOx↑, *Inflam↓, Dose↝, PI3K↓, Akt↓, NF-kB↓,
6360- DRE,    Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma
- in-vitro, ESCC, KYSE450 - in-vitro, ESCC, Eca109
TumCG↓, TumCP↓, TumCMig↓, TumCI↓, angioG↓, Apoptosis↑, PI3K↓, Akt↓, p‑Akt↓, survivin↓, Bax:Bcl2↑, Casp3↑, Casp9↑, MMP2↓, MMP9↓, VEGF↓, EMT↓, eff↑, DNAdam↑, p‑STAT3↑, ChemoSen↑,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
1606- EA,    Ellagic acid inhibits proliferation and induced apoptosis via the Akt signaling pathway in HCT-15 colon adenocarcinoma cells
- in-vitro, Colon, HCT15
TumCP↓, cycD1/CCND1↓, Apoptosis↑, PI3K↓, Akt↓, ROS↑, Casp3↑, Cyt‑c↑, Bcl-2↓, TumCCA↑, Dose∅, ALP↓, LDH↓, PCNA↓, P53↑, Bax:Bcl2↑,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2/KDR/Flk1↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
3233- EGCG,    Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways
- in-vitro, Cerv, HeLa
DNMTs↓, DNMT1↓, DNMT3A↓, HDAC2↓, HDAC3↓, HDAC4↓, EZH2↓, PI3K↓, Wnt↓, MAPK↓, hTERT/TERT↓, MMP2↓, MMP7↓, IL6↓, MDM2↓, MMP-10↓, TP53↑, PTEN↑,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
1322- EMD,    The versatile emodin: A natural easily acquired anthraquinone possesses promising anticancer properties against a variety of cancers
- Review, Var, NA
Apoptosis↑, TumCP↓, ROS↑, TumAuto↑, EMT↓, TGF-β↓, DNAdam↑, ER Stress↑, TumCCA↑, ATP↓, NF-kB↓, CYP1A1↑, STAC2↓, JAK↓, PI3K↓, Akt↓, MAPK↓, FASN↓, HER2/EBBR2↓, ChemoSen↑, eff↑, ChemoSen↑, angioG↓, VEGF↓, MMP2↓, eNOS↓, FOXD3↑, MMP9↓, TIMP1↑,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, eff↑, MMP2↓, MMP9↓, eff↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, eff↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?,
6823- EMD,    Role of emodin to prevent gastrointestinal cancers: recent trends and future prospective
- Review, Var, NA
AntiCan↑, *antiOx↑, *chemoP↑, *Inflam↓, TumCP↓, TumMeta↓, TumCCA↑, MAPK↑, BAX↑, Casp↑, ROS↑, *BioAv↓, other↝, TumCI↓, EMT↓, TumCG↑, Apoptosis↑, TumCP↑, MMP2↓, Casp3↑, ChemoSen↑, PI3K↓, Akt↓, Cyt‑c↑, cl‑PARP↑, MMP↓, Warburg↓, HK2↓, PKM2↓, LDHA↓, mtDam↑, Apoptosis↑, N-cadherin↓, Vim↓, E-cadherin↑, eff↑, eff↑, eff↑, toxicity↝, toxicity↑,
988- EMD,    Emodin Induced Necroptosis and Inhibited Glycolysis in the Renal Cancer Cells by Enhancing ROS
- in-vitro, RCC, NA
Necroptosis↑, p‑RIP1↑, MLKL↑, ROS↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2/PTGS2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6391- Eug,  BCP,  5-FU,    Exploring Mechanism of Actions for Eugenol and Beta-Caryophyllene to Combat Colorectal Cancer Chemotherapy Using Network Pharmacology
- in-vitro, CRC, HCT116
eff↑, ChemoSen↑, HSP90↓, Dose↝, TumAuto↑, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, JNK↓, p38↓, EMT↓,
6381- Eug,    Biological Properties and Prospects for the Application of Eugenol—A Review
- Review, Var, NA
*eff↑, *BioAv↝, *BioAv↝, *BioAv↑, *antiOx↑, *AntiAg↑, *Inflam↓, *AntiBio↑, *MAOA↓, *neuroP↑, *ROS↓, *RNS↓, *eff↑, NF-kB↓, PGE2↓, COX2/PTGS2↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, tumCV↓, PI3K↓, Akt↓, MMPs↓, ChemoSen↑, ALDH↓, *Pain↓, *VGSC↓, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *5LO↓, *chemoPv↑,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
6388- Eug,    Eugenol’s anti-cancer properties, its modulation of signalling pathways, and cascades across various cancers: A review
- Review, Var, NA
Dose↝, AntiCan↑, *Inflam↓, *cardioP↑, *neuroP↑, angioG↓, TumMeta↓, *BioAv↑, *eff↑, *toxicity↝, antiNeop↑, TumCCA↑, Apoptosis↑, *antiOx↑, *lipid-P↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *AntiArt↑, *Bacteria↓, TumAuto↑, PI3K↓, Akt↓, FOXO3↝, BAX↑, mTOR↓, NF-kB↓, P53↑, TumCG↓, CSCs↓, CD44↓, EpCAM↓, NOTCH1↓, OCT4↓, Bcl-2↓, PDK1 / PDPK1↓, HER2/EBBR2↓, BAD↓, cycD1/CCND1↓, ROS↑, Casp3↑, selectivity↑, MMP2↓, MMP9↓, TIMP1↑, VEGF↓, VEGFR1↓, RECK↑, TIMP2↑, DNAdam↑, MMP↓, Thiols↓, PARP↑, *Pain↓, E2Fs↓, survivin↓,
6338- Eug,    Tumor suppressive roles of eugenol in human lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCMig↓, TumCI↓, Akt↓, MMP2↓, *lipid-P↓, *COX2/PTGS2↓, *ROS↓, PI3K↓,
6325- Eug,    Anticancer Properties of Eugenol: A Review
- Review, Var, NA
*antiOx↑, *AntiCan↑, *Inflam↓, TumCD↑, TumCCA↑, TumCMig↓, TumMeta↓, angioG↓, ChemoSen↑, chemoP↑, *BioAv↝, *BioAv↑, *BioAv↑, *BioAv↑, *Bacteria↓, *ROS↓, *IL6↓, *COX2/PTGS2↓, *TNF-α↓, *lipid-P↓, *SOD1↑, *Catalase↑, *GPx1↑, *GSTs↑, ROS↑, MMP↓, Apoptosis↑, COX2/PTGS2↓, TumCCA↑, E2Fs↓, PI3K↓, Akt↓, MMPs↓, CSCs↓, OCT4↓, CD44↓, EpCAM↓, NOTCH1↓, TumVol↓, Casp3↑, P53↑, cl‑PARP↑, MMP2↓, MMP9↓, TIMP1↑, ALDH↓, NF-kB↓, *toxicity↓,
6846- EVO,    Evodiamine Inhibits Colorectal Cancer Growth via RTKs Mediated PI3K/AKT/p53 Signaling Pathway
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116
TumCP↓, TumCI↓, TumCCA↑, PI3K↓, AKT1↓, P53↑, Bcl-2↓, BAX↑, Apoptosis↑, p‑Casp9↑, E-cadherin↑, N-cadherin↓, MMP9↓, CSCs↓, EGFR↓, PDGFRA↓, Dose↝, TumCG↓,
6842- EVO,    Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma
- in-vitro, GBM, U251 - in-vitro, GBM, LN229
TumCP↓, ROS↑, MMP↓, PI3K↓, Akt↓, p‑MAPK↑, cl‑Casp3↑,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, eff↑, eff↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,
1654- FA,    Molecular mechanism of ferulic acid and its derivatives in tumor progression
- Review, Var, NA
AntiCan↑, Inflam↓, RadioS↑, ROS↑, Apoptosis↑, TumCCA↑, TumCMig↑, TumCI↓, angioG↓, ChemoSen↑, ChemoSideEff↓, P53↑, cycD1/CCND1↓, CDK4↓, CDK6↓, TumW↓, miR-34a↑, Bcl-2↓, Casp3↑, BAX↑, β-catenin/ZEB1↓, cMyc↓, Bax:Bcl2↑, SOD↓, GSH↓, LDH↓, ERK↑, eff↑, JAK2↓, STAT6↓, NF-kB↓, PYCR1↓, PI3K↓, Akt↓, mTOR↓, Ki-67↓, VEGF↓, FGFR1↓, EMT↓, CAIX/CA9↓, LC3II↑, p62↑, PKM2↓, Glycolysis↓, *BioAv↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
6909- FIS,    Modulation of PI3K/ AKT/ mTOR and apoptosis pathway in colon cancer cells by the plant flavonoid fisetin
- in-vitro, Colon, Caco-2
AntiCan↑, tumCV↓, Bcl-2↓, PI3K↓, mTOR↓, NF-kB↓, BAX↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *antiOx↑, *neuroP↑,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
6911- FIS,    New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells
- vitro+vivo, BC, NA
MMP↓, mt-ROS↑, Apoptosis↑, p‑AMPK↑, Akt↓, HSP90↓, PI3K↓, Akt↓, mTOR↓, TumCP↓, TumMeta↓, angioG↓, TumCD↑, selectivity↑, TumVol↓,
6914- FIS,    Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells
- in-vitro, Nor, RAW264.7
*p‑PI3K↓, *p‑Akt↓, *p‑mTOR↓,
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, eff↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
6922- FIS,    Inhibition of Akt/mTOR signaling by the dietary flavonoid fisetin
- Review, Var, NA
*memory↑, *Inflam↓, *5LO↓, *lipid-P↓, *NF-kB↓, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, *ROS↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumCMig↓, MMPs↓, PSA↓,

Showing Research Papers: 151 to 200 of 498
Prev Page 4 of 10 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 498

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Copper↓, 1,   CYP1A1↑, 1,   GPx↓, 1,   GSH↓, 1,   GSTs↑, 1,   HO-1↓, 1,   hyperG↓, 1,   lipid-P↑, 1,   MAD↓, 1,   NRF2↓, 1,   OXPHOS↝, 1,   PARK2↑, 1,   PYCR1↓, 1,   ROS↑, 25,   mt-ROS↑, 1,   SOD↓, 2,   SOD↑, 1,   SOD2↓, 1,   Thiols↓, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

KLF5↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 3,   CDC25↓, 1,   FGFR1↓, 3,   MMP↓, 9,   MPT↑, 1,   mtDam↑, 3,   OCR↓, 1,   OCR↑, 1,   PINK1↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   AKT1↓, 1,   ALAT↓, 3,   AminoA↓, 1,   AMPK↑, 4,   p‑AMPK↑, 1,   ATP:AMP↓, 1,   CAIX/CA9↓, 1,   cMyc↓, 4,   FABP4↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   GLUT2↓, 1,   glyC↓, 1,   Glycolysis↓, 6,   HK2↓, 3,   lactateProd↓, 2,   LDH↓, 3,   LDHA↓, 1,   NADPH↓, 1,   PDH↝, 1,   PDK1 / PDPK1↓, 2,   PFK1↓, 1,   PKM2↓, 2,   PPARγ↑, 1,   PPARγ↝, 1,   SCD1↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP2↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 36,   Akt↑, 3,   p‑Akt↓, 5,   APAF1↑, 1,   Apoptosis↓, 2,   Apoptosis↑, 25,   mt-Apoptosis↑, 1,   ASK1↑, 1,   BAD↓, 1,   BAD↑, 1,   BAX↓, 1,   BAX↑, 13,   Bax:Bcl2↑, 3,   Bcl-2↓, 16,   Bcl-xL↓, 2,   BIM↑, 1,   Casp↑, 3,   Casp3↑, 16,   cl‑Casp3↑, 1,   Casp6↑, 1,   Casp8↓, 1,   Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 5,   p‑Casp9↑, 1,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 5,   DR4↑, 1,   DR5↑, 1,   Fas↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   JNK↓, 3,   MAPK↓, 8,   MAPK↑, 1,   p‑MAPK↑, 1,   Mcl-1↓, 1,   MDM2↓, 1,   MLKL↑, 1,   Myc↓, 1,   Necroptosis↑, 2,   NOXA↑, 1,   p27/CDKN1B↑, 2,   p38↓, 1,   Proteasome↓, 1,   PUMA↑, 1,   p‑RIP1↑, 1,   survivin↓, 3,   TumCD↑, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

FOXD3↑, 1,   HER2/EBBR2↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   other↓, 2,   other↝, 1,   tumCV↓, 9,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   HSP90↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↓, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 2,   p62↑, 1,   TumAuto↑, 5,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 8,   DNMT1↓, 2,   DNMT3A↓, 2,   DNMTs↓, 1,   P53↑, 9,   p73↑, 1,   PARP↓, 1,   PARP↑, 4,   cl‑PARP↑, 7,   PCNA↓, 4,   SIRT6↓, 1,   TP53↑, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK2↑, 1,   CDK4↓, 5,   CDK4↑, 2,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 8,   CycD3↓, 2,   cycE/CCNE↓, 2,   E2Fs↓, 2,   P21↑, 3,   Securin↓, 1,   TumCCA↓, 1,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   CD44↓, 2,   CDK8↓, 1,   CIP2A↓, 1,   CSCs↓, 4,   Diff↓, 1,   EMT↓, 12,   EpCAM↓, 2,   ERK↓, 2,   ERK↑, 1,   p‑ERK↓, 1,   FGF↓, 1,   FGFR2↓, 1,   FOXO3↓, 1,   FOXO3↝, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HDAC4↓, 1,   HH↓, 1,   IGF-1↓, 2,   IGFBP1↑, 1,   miR-34a↑, 1,   mTOR↓, 12,   mTOR↑, 2,   mTORC2↓, 1,   Nanog↓, 1,   NOTCH↓, 3,   NOTCH1↓, 2,   OCT4↓, 3,   P90RSK↓, 1,   PDGFRA↓, 1,   PI3K↓, 41,   PI3K↑, 3,   p‑PI3K↓, 1,   PTEN↑, 4,   RAS↓, 1,   Shh↓, 1,   STAT↓, 2,   STAT3↓, 5,   p‑STAT3↓, 1,   p‑STAT3↑, 1,   STAT6↓, 3,   TCF↓, 1,   TumCG↓, 10,   TumCG↑, 1,   tyrosinase↓, 2,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg?, 1,   CA↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 7,   FAK↓, 1,   Fibronectin↓, 1,   Ki-67↓, 4,   KLF2↓, 1,   MMP-10↓, 1,   MMP1↓, 1,   MMP2↓, 14,   MMP7↓, 2,   MMP9↓, 12,   MMPs↓, 7,   N-cadherin↓, 3,   NEDD9↓, 1,   PAK1↓, 1,   PDGF↓, 1,   PKA↓, 2,   PKCδ↓, 2,   RECK↑, 1,   Slug↓, 2,   SMAD3↓, 1,   Snail↓, 5,   STAC2↓, 1,   TGF-β↓, 4,   TGF-β↑, 1,   TIMP1↑, 4,   TIMP2↑, 1,   TumCI↓, 12,   TumCMig↓, 10,   TumCMig↑, 1,   TumCP↓, 18,   TumCP↑, 1,   TumMeta↓, 9,   Twist↓, 2,   uPA↓, 1,   VEGFR1↓, 1,   Vim↓, 5,   Zeb1↓, 2,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 11,   EGFR↓, 2,   eNOS↓, 1,   Hif1a↓, 2,   VEGF↓, 8,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 4,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 2,   COX2/PTGS2↓, 9,   IFN-γ↑, 1,   IL12↑, 1,   IL6↓, 2,   Imm↑, 1,   Inflam↓, 3,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 2,   NF-kB↓, 18,   PD-1↓, 1,   PGE2↓, 3,   PSA↓, 2,   TLR2↓, 1,   TNF-α↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 5,   CDK6↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 3,   ChemoSen↑, 17,   Dose↝, 6,   Dose∅, 1,   eff↓, 2,   eff↑, 26,   eff↝, 2,   eff∅, 1,   Half-Life↓, 1,   RadioS↑, 6,   selectivity↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 3,   AR↓, 1,   AST↓, 3,   BG↓, 2,   EGFR↓, 2,   EZH2↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 3,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 4,   LDH↓, 3,   Myc↓, 1,   PSA↓, 2,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   antiNeop↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 3,   OS↑, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 1,  
Total Targets: 317

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,   diuretic↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 10,   Catalase↑, 4,   GPx↑, 2,   GPx1↑, 1,   GSH↑, 6,   GSTs↑, 3,   HO-1↑, 3,   HO-2↓, 1,   lipid-P↓, 4,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 3,   RNS↓, 2,   ROS↓, 10,   SOD↓, 1,   SOD↑, 2,   SOD1↑, 1,   TAC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,   IronCh↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   p‑CREB↑, 1,   glucose↓, 1,   LDL↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 1,   Bcl-2↑, 1,   iNOS↓, 3,   MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   mTOR↓, 1,   p‑mTOR↓, 1,   PI3K↓, 4,   PI3K↑, 1,   p‑PI3K↓, 1,   RAS↓, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 2,   PKCδ↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   IL1β↓, 2,   IL6↓, 4,   Imm↑, 2,   Inflam↓, 17,   MyD88↓, 1,   NF-kB↓, 4,   TLR4↓, 1,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   ChAT↑, 1,   MAOA↓, 2,   tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 4,   Dose↝, 1,   eff↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   Ferritin↑, 1,   GutMicro↑, 1,   IL6↓, 4,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 3,   neuroP↑, 10,   Obesity↓, 1,   Pain↓, 3,   RenoP↑, 2,   toxicity↓, 3,   toxicity↝, 3,   toxicity∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 4,  
Total Targets: 100

Scientific Paper Hit Count for: PI3K, Phosphatidylinositide-3-Kinases
21 Fisetin
19 Quercetin
17 Thymoquinone
16 Kaempferol
13 Apigenin (mainly Parsley)
13 Curcumin
11 Inositol
11 Resveratrol
10 Berberine
10 Shikonin
9 Baicalein
8 5-fluorouracil
8 Carvacrol
8 Formononetin
8 Honokiol
8 Sulforaphane (mainly Broccoli)
7 Isovitexin
7 Chrysin
7 Cinnamon
7 Eugenol
7 Licochalcone A
6 Alpha-Lipoic-Acid
6 Dandelion Root
6 Emodin
6 Garcinol
6 Isoliquiritigenin
6 Vitexin
6 Luteolin
6 Magnolol
6 Nimbolide
6 Rosmarinic acid
6 Urolithin
5 Anethole/trans-Anethole
5 Cisplatin
5 Capsaicin
5 Chlorogenic acid
5 Fucoidan
5 Gambogic Acid
5 Ginseng
5 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
5 isoorientin
5 Lycopene
5 Silymarin (Milk Thistle) silibinin
4 Astragalus
4 Beta-Caryophyllene
4 Carnosic acid
4 Propolis -bee glue
4 diet FMD Fasting Mimicking Diet
4 Ellagic acid
4 Ferulic acid
4 Hyperoside
4 Magnetic Fields
4 Naringin
3 Silver-NanoParticles
3 Allicin (mainly Garlic)
3 Chemotherapy
3 Artemisinin
3 Astaxanthin
3 Bacopa monnieri
3 α-Bisabolol / Chamomile oil
3 Thymol-Thymus vulgaris
3 Centella asiatica / Gotu kola → asiaticoside
3 Radiotherapy/Radiation
3 Gallic acid
3 Ginkgolide B
3 Hydrogen Gas
3 HydroxyTyrosol
3 Indole-3-carbinol
3 isoquercitrin
3 itraconazole
3 Selenite (Sodium)
3 Vitamin K2
2 Coenzyme Q10
2 Auranofin
2 Ashwagandha(Withaferin A)
2 Trastuzumab
2 Baicalin
2 Biochanin A
2 Betulinic acid
2 Brucea javanica
2 brusatol
2 Boswellia (frankincense)
2 Celecoxib
2 chaetocin
2 Hydroxycinnamic-acid
2 Citric Acid
2 Ursolic acid
2 Deguelin
2 Diclofenac
2 D-limonene
2 EGCG (Epigallocatechin Gallate)
2 Evodiamine
2 Geraniol
2 Ginger/6-Shogaol/Gingerol
2 Hibiscus sabdariffa
2 Inulin Prebiotic
2 Ivermectin
2 Licorice
2 Myricetin
2 Piperine
2 Plumbagin
2 Parthenolide
2 Pterostilbene
2 Aflavin-3,3′-digallate
1 1,8-Cineole
1 HydroxyCitric Acid
1 Acetyl-l-carnitine
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Aspirin
1 Ascorbyl Palmitate
1 Aloe anthraquinones
1 almonertinib
1 Berbamine
1 Bufalin/Huachansu
1 borneol
1 Caffeic acid
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celastrol
1 Cucurbitacin
1 CUSP9
1 Dichloroacetophenone(2,2-)
1 Sorafenib (brand name Nexavar)
1 flavonoids
1 Bortezomib
1 chitosan
1 Ginkgo biloba
1 Genistein (soy isoflavone)
1 Ginkgetin
1 hydrogen sulfide
1 Isobavachalcone
1 Juglone
1 lambertianic acid
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Mung Bean Sprouts
1 Melatonin
1 Metformin
1 Magnetic Field Rotating
1 Neem
1 sericin
1 Phenethyl isothiocyanate
1 Phenolic Acids
1 doxorubicin
1 Piperlongumine
1 Psoralidin
1 Paclitaxel/Taxol
1 Rhein
1 Rutin
1 buckwheat sprouts
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 acetazolamide
1 Turmerones
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:252  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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