Bcl-xL Cancer Research Results

Bcl-xL, Bcl-xL: Click to Expand ⟱
Source:
Type: pro-survival proteins
The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL.
BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype.
Scientific Papers found: Click to Expand⟱
3429- TQ,    Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells
- in-vitro, AML, NA - in-vivo, NA, NA
DNMT1↓, Sp1/3/4↓, NF-kB↓, Apoptosis↑, Casp↑, Bcl-xL↓, COX2/PTGS2↓, iNOS↓, 5LO↓, TNF-α↓, cycD1/CCND1↓, BioAv↝, TumCG↓,
3423- TQ,    Epigenetic role of thymoquinone: impact on cellular mechanism and cancer therapeutics
- Review, Var, NA
AntiCan↑, Inflam↓, hepatoP↑, RenoP↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, ROS↑, P53↑, PTEN↑, P21↑, p27/CDKN1B↑, BRCA1↑, PI3K↓, Akt↓, MAPK↓, ERK↓, p‑ERK↓, MMPs↓, FAK↓, Twist↓, Zeb1↓, EMT↓, TumMeta↓, angioG↓, VEGF↓, HDAC↓, Maspin↑, SIRT1↑, DNMT1↓, DNMT3A↓, HDAC1↓, HDAC4↓,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
eff↑, ROS↑, tumCV↓, TumCG↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp9↑, Bcl-xL↑, Cyt‑c↑, Bcl-2↓,

Showing Research Papers: 151 to 154 of 154
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 154

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   FAO↑, 1,   FASN↓, 1,   HK2↓, 1,   lactateProd↓, 1,   PKM2↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 3,   Bcl-xL↑, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,   JNK↑, 1,   MAPK↓, 1,   p27/CDKN1B↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↑, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   P53↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 2,   HDAC↓, 1,   HDAC1↓, 1,   HDAC4↓, 1,   PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 1,   CD31/PECAM-1↓, 1,   FAK↓, 1,   Ki-67↓, 1,   MMPs↓, 1,   TumMeta↓, 1,   Twist↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   EGFR↓, 1,   NO↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 2,   NF-kB↓, 2,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↑, 1,   EGFR↓, 1,   Ki-67↓, 1,   Maspin↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   RenoP↑, 1,  
Total Targets: 73

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   SOD↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: Bcl-xL, Bcl-xL
14 Thymoquinone
9 Apigenin (mainly Parsley)
6 Curcumin
6 Gossypol/AT-101
5 Baicalein
5 Quercetin
4 Alpha-Lipoic-Acid
4 EGCG (Epigallocatechin Gallate)
3 Boswellia (frankincense)
3 Fisetin
3 Gambogic Acid
3 Ginkgetin
3 Indole-3-carbinol
3 lambertianic acid
3 Nimbolide
3 Sulforaphane (mainly Broccoli)
3 Resveratrol
3 Silymarin (Milk Thistle) silibinin
2 Paclitaxel/Taxol
2 Artemisinin
2 Cisplatin
2 Berbamine
2 Beta-Caryophyllene
2 Boron
2 Butyrate
2 Carnosic acid
2 Capsaicin
2 chaetocin
2 Cucurbitacin
2 Docetaxel
2 Ursolic acid
2 Ellagic acid
2 Garcinol
2 Honokiol
2 Licochalcone A
2 Lemongrass Extract/Citral
2 Luteolin
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Plumbagin
2 VitK3,menadione
1 Astragalus
1 Silver-NanoParticles
1 Camptothecin
1 Anethole/trans-Anethole
1 Berberine
1 Betulinic acid
1 brusatol
1 Carvacrol
1 Sorafenib (brand name Nexavar)
1 Cat’s Claw
1 Chrysin
1 Cinnamon
1 Citric Acid
1 Gemcitabine (Gemzar)
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 D-limonene
1 Emodin
1 Eurycomanone
1 Eugenol
1 Evodiamine
1 Formononetin
1 Isoliquiritigenin
1 Ginger/6-Shogaol/Gingerol
1 carboplatin
1 Chemotherapy
1 Hydrogen Gas
1 Hibiscus sabdariffa
1 Hyperthermia
1 Hyperoside
1 Isobavachalcone
1 Juglone
1 Kaempferol
1 Magnolol
1 Magnetic Fields
1 Niclosamide (Niclocide)
1 Neem
1 Radiotherapy/Radiation
1 Piperine
1 Piperlongumine
1 Rosmarinic acid
1 Shikonin
1 Taurine
1 Photodynamic Therapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:28  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page