cMyc Cancer Research Results

cMyc, cellular-MYC oncogene: Click to Expand ⟱
Source:
Type: oncogene
The MYC proto-oncogenes are among the most commonly activated proteins in human cancer. The oncogene c-myc, which is frequently over-expressed in cancer cells, is involved in the transactivation of most of the glycolytic enzymes including lactate dehydrogenase A (LDHA) and the glucose transporter GLUT1 [51,52]. Thus, c-myc activation is a likely candidate to promote the enhanced glucose uptake and lactate release in the proliferating cancer cell. The c-Myc oncogene is a ‘master regulator’ of both cellular growth and metabolism in transformed cells.
-C-myc is a common oncogene that enhances aerobic glycolysis in the cancer cells by transcriptionally activating GLUT1, HK2, PKM2 and LDH-A

Inhibitors (downregulate):
Curcumin
Resveratrol: downregulate c-Myc expression.
Epigallocatechin Gallate (EGCG)
Quercetin
Berberine: decrease c-Myc expression and repress its transcriptional activity.
Scientific Papers found: Click to Expand⟱
942- UA,    Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling
- vitro+vivo, BC, MCF7 - in-vitro, BC, MDA-MB-231
Cav1↑, Glycolysis↓, cMyc↓, LDHA↓, Nrf1↓, PGC-1α↓, Sp1/3/4↑, TumCG↓,
4833- Uro,    Unveiling the potential of Urolithin A in Cancer Therapy: Mechanistic Insights to Future Perspectives of Nanomedicine
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
BioAv↝, TumAuto↝, TumCG↓, TumMeta↓, ChemoSen↑, Imm↑, RadioS↑, BioAv↑, other↝, eff↓, *antiOx↓, *Inflam↓, AntiCan↓, AntiAge↑, chemoP↑, *neuroP↑, *ROS↓, *cognitive↑, *lipid-P↓, *cardioP↑, *TNF-α↓, *IL6↓, GutMicro↑, TumCCA↑, Apoptosis↑, angioG↓, NF-kB↓, PI3K↓, Akt↓, Casp↑, survivin↓, TumCP↓, cycD1/CCND1↓, cMyc↑, BAX↑, Bcl-2↓, COX2/PTGS2↓, P53↑, p38↑, *ROS↓, *SOD↑, *GPx↑, SIRT1↑, FOXO1↑, eff↑, ChemoSen↑,
4837- Uro,    Urolithins: The Gut Based Polyphenol Metabolites of Ellagitannins in Cancer Prevention, a Review
- Review, Var, NA
AntiCan↑, TumCCA↑, Apoptosis↑, TumAuto↑, *BioAv↝, *BioAv↑, RAS↓, ERK↓, AR↓, TumCP↓, PI3K↓, Akt↓, NF-kB↓, COX2/PTGS2↓, IL6↓, IL1β↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, P53↑, Casp3↑, PARP↑, ROS↓, toxicity↓,
3136- VitC,    Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
- in-vitro, Colon, SW48 - in-vitro, Colon, LoVo
ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,
1817- VitK2,    Research progress on the anticancer effects of vitamin K2
- Review, Var, NA
TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 151 to 157 of 157
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 157

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Nrf1↓, 1,   ROS↓, 2,   ROS↑, 1,   i-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   Cav1↑, 1,   cMyc↓, 6,   cMyc↑, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 2,   Glycolysis↑, 1,   HK2↓, 1,   HK2↑, 1,   lactateProd↓, 1,   lactateProd↑, 1,   LDHA↓, 2,   LDHA↑, 1,   PDH↓, 1,   PFK↓, 1,   PKM2↓, 1,   p‑PKM2↓, 1,   SIRT1↑, 1,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↑, 3,   BAX↑, 2,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 2,   Casp8↑, 1,   Casp9↑, 1,   MAPK↓, 1,   p27/CDKN1B↑, 1,   p38↑, 2,   survivin↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   other↑, 1,   other↝, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 3,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 2,   p‑P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   p‑ERK↓, 1,   FOXO1↑, 1,   p‑mTOR↓, 1,   mTORC1↓, 1,   PI3K↓, 2,   PI3K↑, 1,   RAS↓, 2,   TumCG↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,   TumCI↓, 1,   TumCP↓, 2,   TumMeta↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   Hif1a↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IKKα↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 1,   NF-kB↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↓, 1,   ChemoSen↑, 2,   eff↓, 6,   eff↑, 6,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 99

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 2,   SOD↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   cognitive↑, 1,   neuroP↑, 1,  
Total Targets: 14

Scientific Paper Hit Count for: cMyc, cellular-MYC oncogene
12 Curcumin
10 Quercetin
9 Thymoquinone
8 Resveratrol
6 Baicalein
4 Artemisinin
4 Berbamine
4 Berberine
4 Luteolin
4 Piperlongumine
4 Silymarin (Milk Thistle) silibinin
3 Ashwagandha(Withaferin A)
3 EGCG (Epigallocatechin Gallate)
3 lambertianic acid
3 Lycopene
2 Apigenin (mainly Parsley)
2 Aspirin
2 Betulinic acid
2 Boswellia (frankincense)
2 brusatol
2 Chrysin
2 Ellagic acid
2 Sulforaphane (mainly Broccoli)
2 Emodin
2 Ferulic acid
2 Fisetin
2 Gambogic Acid
2 Niclosamide (Niclocide)
2 Nimbolide
2 Phenethyl isothiocyanate
2 Piperine
2 Pterostilbene
2 Ursolic acid
2 Urolithin
2 Vitamin K2
1 3-bromopyruvate
1 Silver-NanoParticles
1 Alpha-Lipoic-Acid
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Biochanin A
1 Beta-Caryophyllene
1 Bufalin/Huachansu
1 Boron
1 Chemotherapy
1 Caffeic acid
1 Metformin
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Propolis -bee glue
1 Crocetin
1 Cucurbitacin
1 Gemcitabine (Gemzar)
1 Cynaropicrin
1 Deguelin
1 Diclofenac
1 Docosahexaenoic Acid
1 Genistein (soy isoflavone)
1 Estrogen
1 Evodiamine
1 flavonoids
1 Galloflavin
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Honokiol
1 Indole-3-carbinol
1 Isobavachalcone
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Inositol
1 Ivermectin
1 Kaempferol
1 Methyl salicylate / Sweet Birch oil
1 Magnetic Fields
1 Mushroom Chaga
1 Neem
1 Phenylbutyrate
1 Cisplatin
1 salinomycin
1 Shikonin
1 Aflavin-3,3′-digallate
1 triptolide
1 Vitamin C (Ascorbic Acid)
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:35  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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