Bax:Bcl2 Cancer Research Results

Bax:Bcl2, Bax:Bcl2 ratio: Click to Expand ⟱
Source:
Type:
Bax and Bcl-2 are the major members of Bcl-2 family that play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction.
Bax/Bcl-2 ratio is typically significantly lower in tumors.
Scientific Papers found: Click to Expand⟱
2108- TQ,    Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa
- Review, Var, NA
HDAC↓, TumCCA↑, cycD1/CCND1↓, p16↑, P53↑, Bax:Bcl2↑, Bcl-xL↓, NF-kB↓, IAP1↓, IAP2/BIRC3↓, XIAP↓, survivin↓, COX2/PTGS2↓, cMyc↓, ROS↑, Casp3↑, cl‑PARP↑, Cyt‑c↑, STAT3↓,
5911- TV,    Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway
- vitro+vivo, CRC, NA
TumCP↓, Apoptosis↑, TumVol↓, Bax:Bcl2↑, EMT↓, TumCI↓, TumMeta↓, Wnt/(β-catenin)↓,
1313- VitD3,  MEL,    The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line
- in-vitro, BC, MCF7
BAX↑, Bcl-2↓, Bax:Bcl2↑, eff↑,
7914- VT,    Vitexin induces apoptosis through mitochondrial pathway and PI3K/Akt/mTOR signaling in human non-small cell lung cancer A549 cells
- vitro+vivo, Lung, A549
tumCV↓, selectivity↑, Cyt‑c↑, MMP↓, p‑PI3K↓, p‑Akt↓, p‑mTOR↓, TumCG↓, mtDam↑, LDH↑, Bax:Bcl2↑, cl‑Casp3↑,

Showing Research Papers: 151 to 154 of 154
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 154

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   mtDam↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,   LDH↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 4,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Cyt‑c↑, 2,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   HDAC↓, 1,   p‑mTOR↓, 1,   p‑PI3K↓, 1,   STAT3↓, 1,   TumCG↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↑, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 40

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Bax:Bcl2, Bax:Bcl2 ratio
9 Thymoquinone
7 Apigenin (mainly Parsley)
6 Baicalein
6 Berberine
6 Emodin
6 Sulforaphane (mainly Broccoli)
5 Quercetin
4 Isoliquiritigenin
4 Lycopene
3 EGCG (Epigallocatechin Gallate)
3 Curcumin
3 Caffeic acid
3 Carvacrol
3 Crocetin
3 Ellagic acid
3 Formononetin
3 Garcinol
3 iodine
3 isoorientin
3 Ivermectin
2 Cisplatin
2 Silver-NanoParticles
2 Arctigenin
2 Docetaxel
2 Berbamine
2 Beta-Caryophyllene
2 Propolis -bee glue
2 Chlorogenic acid
2 Coenzyme Q10
2 D-limonene
2 Dandelion Root
2 Gambogic Acid
2 Graviola
2 HydroxyTyrosol
2 Licochalcone A
2 Luteolin
2 Myricetin
1 2-DeoxyGlucose
1 Astragalus
1 Allicin (mainly Garlic)
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Paclitaxel/Taxol
1 Betulinic acid
1 borneol
1 Boswellia (frankincense)
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Copper and Cu NanoParticles
1 Diclofenac
1 Radiotherapy/Radiation
1 Ginkgo biloba-EGb 761
1 Ferulic acid
1 Fenbendazole
1 Fisetin
1 Fucoidan
1 Gallic acid
1 Ginkgolic acids
1 Ginkgo biloba
1 Ginkgetin
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Huperzine A/Huperzia serrata
1 Hyperoside
1 Indole-3-carbinol
1 isoquercitrin
1 Juglone
1 Kaempferol
1 Magnolol
1 Naringin
1 Nimbolide
1 Plumbagin
1 Rosmarinic acid
1 salinomycin
1 Terpinen-4-ol / Tea Tree Oil
1 doxorubicin
1 Thymol-Thymus vulgaris
1 Vitamin D3
1 Melatonin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:352  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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