COX2/PTGS2 Cancer Research Results

COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
1792- CUR,  LEC,    Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanism
- in-vitro, Arthritis, RAW264.7 - NA, NA, HCC-38
*Inflam↓, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *NO↓, *PGE2↓, *MMPs↑, *TIMP1↑, *BioEnh↑,
1809- CUR,  Oxy,    Long-term stabilisation of myeloma with curcumin
- Case Report, Melanoma, NA
*OS↑, QoL↑, Dose↑, Dose↑, IL6↓, STAT3↓, NF-kB↓, COX2/PTGS2↓,
1418- CUR,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
*COX2/PTGS2↓, *Inflam↓, *5LO↓, *NO↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↑, *IL6↓, *IL8↓, *IL12↓, *MCP1/CCL2↓, *PGE2↓, *MMP2↓, *MMP3↓, *MMP9↓, *NLRP3↓, *ROS↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2/PTGS2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
6205- CUR,    Clinical trials on curcumin in relation to its bioavailability and effect on malignant diseases: critical analysis
- Review, Var, NA
BioAv↓, Half-Life↓, COX2/PTGS2↓, ChemoSen↑, cachexia↓, NF-kB↓,
6211- CUR,    The effect of curcumin on hypoxia in the tumour microenvironment as a regulatory factor in cancer
- Review, Var, NA
HIF-1↓, VEGF↓, angioG↓, RadioS↑, ChemoSen↑, other↝, Apoptosis↑, TumCG↓, TumMeta↓, BioAv↓, COX2/PTGS2↓, CD31/PECAM-1↓, IL8↓, TGF-β↓, NF-kB↓, JAK2↓, STAT3↓,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, eff↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6215- CUR,    Curcumin: biochemistry, pharmacology, advanced drug delivery systems, and its epigenetic role in combating cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *BioAv↓, NF-kB↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, DNMTs↓, TumCI↓, TumMeta↓, *BioAv↑, *BioAv↑, angioG↓, VEGF↓, MMPs↓, *ROS↓, *SOD↑, *Catalase↑, *GSTs↑, *HO-1↑, *NRF2↑, mTOR↓, GSK‐3β↓, FOXO1↓, *radioP↑, *IL1↓, *IL6↓, *TNF-α↓, HATs↓, HDAC↓, ROS↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, COX1↓, COX2/PTGS2↓, PGE2↓, *cytoP450↓, ChemoSen↑, cardioP↑, eff↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6212- CUR,  Rad,    Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers
- Review, Var, NA
RadioS↑, *radioP↑, EGFR↓, TGF-β↓, ROS↑, P53↑, PI3K↓, NF-kB↓, COX2/PTGS2↓, EMT↓, Hif1a↓, HSP90↓, mTOR↓, *Catalase↑, *SOD↑, *MDA↑, *Wound Healing↑, *hepatoP↑, *NF-kB↓, *ROS↓,
6223- CUR,    Curcumin Rewires the Tumor Metabolic Landscape: Mechanisms and Clinical Prospects
- Review, Var, NA
Ferroptosis↑, GutMicro↑, Akt↓, mTOR↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, TumCP↓, TumCI↓, TumMeta↓, AMPK↑, P53↑, NRF2↑, TumCCA↑, Apoptosis↑, Casp↑, GPx4↓, DNMTs↓, HDAC↓, VEGF↓, Imm↑, NK cell↑, Warburg↓, Hif1a↓, HK2↓, PKM2↓, LDHA↓, GLUT1↓, MCT1↓, AMPK↑, FASN↓, SCD1↓, GLS↓, Apoptosis↑, ETC↓, MMP↓, ROS↑, lipid-P↑, ChemoSen↑, PDK1 / PDPK1↓, Beclin-1/ATG6↓, ATP↓, Glycolysis↓, GlucoseCon↓, lactateProd↑, MMPs↓, GSH↓, G6PD↓, OXPHOS↓, SREBP2↓, COX2/PTGS2↓, AP-1↓, NADH↓, NRF2↑, HO-1↑, Iron↑, MDA↑, *ROS↓, *Inflam↓,
6217- CUR,    Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/β-catenin pathway
- Review, Var, NA
Wnt↓, β-catenin/ZEB1↓, PPARγ↑, Akt↓, *ROS↓, *Inflam↓, Bcl-2↓, GSK‐3β↑, NF-kB↓, COX2/PTGS2↓,
465- CUR,    Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues
- vitro+vivo, Liver, HepG2 - vitro+vivo, Liver, HUH7 - vitro+vivo, Liver, MHCC-97H
TumCG↓, MDSCs↓, TLR4↓, NF-kB↓, IL6↓, IL1↓, PGE2↓, COX2/PTGS2↓, GM-CSF↓, angioG↓, VEGF↓, CD31/PECAM-1↓, GM-CSF↓, α-SMA↓, p‑IKKα↓, MyD88↓,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BID↑, PARP↑, NF-kB↓, CDK1↓, COX2/PTGS2↓, RTK-RAS↓, PI3K/Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, ChemoSen↑,
158- CUR,    Curcumin-targeting pericellular serine protease matriptase role in suppression of prostate cancer cell invasion, tumor growth, and metastasis
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, PC3
MMP9↓, Matr↓, Inflam↓, antiOx↓, NF-kB↓, COX2/PTGS2↓, iNOS↓, TumCMig↓, TumCI↓,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
- Review, Pca, NA
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2/PTGS2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2/PTGS2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
160- CUR,    Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2
- in-vitro, Pca, NA
CXCc↓, IκB↓, NF-kB↓, COX2/PTGS2↓, SPARC↓, EFEMP↓, IKKα↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
p38↓, MKP5↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓,
3753- CUR,  Gala,    A Novel Galantamine–Curcumin Hybrid Inhibits Butyrylcholinesterase: A Molecular Dynamics Study
- Study, AD, NA
*BChE↓, *AChE↓, *Ach↑, *cognitive↑, *memory↑, *ROS↓, *Inflam↓, *NF-kB↓, *COX2/PTGS2?,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2/PTGS2↓, *MCP1/CCL2↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE/β-secretase↓, *AChE↓, *LDL↓,
3583- CUR,    Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
- Review, Arthritis, NA
*TNF-α↓, *IL1β↓, *NF-kB↓, *PGE2↓, *COX2/PTGS2↓, *MMPs↓, *eff↑,
3588- CUR,    The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
- Review, AD, NA
*cognitive↝, *BioAv↑, *Inflam↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *TNF-α↓, *IL1↓, *IL2↓, *IL6↓, *IL8↓, *IL12↓, *ROS↓, *RNS↓, *antiOx↑, *BBB↑, *BioAv↓, *cognitive↑, *memory↑, *tau↓, *eff↑,
3574- CUR,    The effect of curcumin (turmeric) on Alzheimer's disease: An overview
- Review, AD, NA
*antiOx↑, *Inflam↓, *lipid-P↓, *cognitive↑, *memory↑, *Aβ↓, *COX2/PTGS2↓, *ROS↓, *AP-1↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *SOD↑, *GSH↑, *HO-1↑, *IronCh↑, *BioAv↓, *Half-Life↝, *Dose↝, *BBB↑, *BioAv↑, *toxicity∅, *eff↑,
2466- CUR,    Regulatory Effects of Curcumin on Platelets: An Update and Future Directions
- Review, Nor, NA
*AntiAg↑, *antiOx↑, *Inflam↓, *12LOX↑, COX1↓, COX2/PTGS2↓, MMP9↓, NF-kB↓,
2819- CUR,  Chemo,    Curcumin as a hepatoprotective agent against chemotherapy-induced liver injury
- Review, Var, NA
*hepatoP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *ROS↓, *ALAT↓, *AST↓, *MDA↓, *NRF2↑, *COX2/PTGS2↑, *NF-kB↓, *ICAM-1↓, *MCP1/CCL2↓, *HO-1↑, CXCc↓,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
2814- CUR,    Curcumin in Cancer and Inflammation: An In-Depth Exploration of Molecular Interactions, Therapeutic Potentials, and the Role in Disease Management
- Review, Var, NA
*BioAv↓, *Inflam↓, *antiOx↑, AntiCan↑, CK2↓, GSK‐3β↓, EGFR↓, TOP1↓, TOP2↓, NF-kB↓, COX2/PTGS2↓, CRP↓,
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2/PTGS2↓, ALDH↓, TumAuto↑, P-gp/ABCB1↓, eff↑,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- NA, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2/PTGS2↓, CA↓, ALDH↓, P-gp/ABCB1↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
6683- DCA,    Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts
- Review, Var, NA
PDK1 / PDPK1↓, lactateProd↓, Apoptosis↑, TumCP↓, selectivity↑, other↝, Dose↝, BioAv↑, Half-Life↓, Glycolysis↓, OXPHOS↑, Casp↑, i-pH↓, COX2/PTGS2↑, Hif1a↓, angioG↓, HMG-CoA↓, GSTZ1↓, OCR↑, lipoGen↓, fatigue↓, survivin↓, miR-375↑, eff↓, CSCs↓, TumAuto↑, mTOR↓, TumCI↓, TumVol↓, TumW↓, ATP↓, Warburg↓, eff↑, e-pH↑, eff↑, eff↑, other↝, RadioS↑, toxicity↓, Dose↝, eff↑, eff↑, eff↑, toxicity↝, eff↓,
6701- DFC,    Intracellular pH and calcium signaling as molecular targets of diclofenac-induced apoptosis against colon cancer
- in-vivo, Colon, NA
COX2/PTGS2↓, Inflam↓, chemoPv↑, Apoptosis↑, pH↓, ROS↑, Ca+2↑, MMP↓, APAF1↑,
6702- DFC,    Diclofenac
- Review, Nor, NA
*Inflam↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *TXA2↓, *BioAv↑, *Dose↝, *cardioP↓,
6703- DFC,    Molecular docking of anti-inflammatory drug diclofenac with metabolic targets: Potential applications in cancer therapeutics.
- Analysis, Var, NA
*Inflam?, *COX1↓, *COX2/PTGS2↓, GLUT1↓, MCT4↓, LDHA↓, ABCG2↓, MDM2↓, MRP1/ABCC1↓, SOD2↓, Myc↓, β-catenin/ZEB1↓, VEGF↓, IKKα↓, cJun↓, E2Fs↓,
6705- DFC,    Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases
- Review, Var, NA
*Inflam↓, *Pain↓, *COX1↓, *COX2/PTGS2↓, *toxicity↝, *BioAv↑, *AntiAg↑, *neuroP↑, ROS↑, p73↑, Myc↓, lactateProd↓, TumCCA↑, PI3K↓, Akt↓, NF-kB↓, SOD2↓, *neuroP↑,
6709- DFC,    Diclofenac induced apoptosis via altering PI3K/Akt/MAPK signaling axis in HCT 116 more efficiently compared to SW480 colon cancer cells
- in-vitro, CRC, HCT116 - in-vitro, Colon, SW480
COX2/PTGS2↓, Inflam↓, PI3K↓, Akt↓, eff↓,
6688- DFC,    New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- in-vivo, lymphoma, U937
AntiCan↑, COX2/PTGS2↓, Myc↓, GLUT1↓, LDHA↓, MCT1↓, GlucoseCon↓, lactateProd↓, TumCP↓, other∅, toxicity↝,
6694- DFC,    Repurposing Drugs in Oncology (ReDO)—diclofenac as an anti-cancer agent
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, angioG↓, ChemoSen↑, RadioS↑, Dose↝, toxicity↝, toxicity↝, BioAv↑, Half-Life↝, lactateProd↓, eff↑, *AntiAg↑,
6692- DFC,    Diclofenac Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer by Modulation of VEGF Levels and Arginase Activity
- in-vivo, PC, Panc02
TumW↓, Apoptosis↑, VEGF↓, COX2/PTGS2↓, ARG1/2↑, TumCG↓, angioG↓, ARG↓, NO↓,
6663- DFE,    Nutraceuticals of Phoenix dactylifera L.: Physicochemistry, Nutritional Value and Therapeutic Potential
- Review, Nor, NA - Review, AD, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiDiabetic↑, *AntiCan↑, *AntiArt↑, *neuroP↑, *hepatoP↑, *GastroP↑, *other↝, *cardioP↑, *cognitive↑, *ROS↓, *memory↑, *other↝, *SOD↑, *Catalase↑, *GSH↑, *GA↑, *Catechins↑, *FA↑, *QC↑, Api↑, *CA↑, *Imm↑, *Phen↑, *IL1β↓, *TGF-β↓, *COX1↓, *COX2/PTGS2↓, TumCP↓, Casp3↑, TumMeta↓, *GutMicro↑,
6752- DHA,    A Randomized Multicenter Phase II Study of Docosahexaenoic Acid in Patients with a History of Breast Cancer, Premalignant Lesions, or Benign Breast Disease
- Trial, BC, NA
TNF-α∅, IL1β∅, COX2/PTGS2∅,
1085- DHA,  EPA,    DHA and EPA Down-regulate COX-2 Expression through Suppression of NF-kappaB Activity in LPS-treated Human Umbilical Vein Endothelial Cells
- in-vitro, Nor, HUVECs
*COX2/PTGS2↓, *NF-kB↓, *PGE2↓, *IL6↓, *NF-kB↑,
6289- DL,    D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis
- in-vivo, Var, NA
COX2/PTGS2↓, *GSH↑, *GPx↑, *Catalase↑, Bcl-2↓, BAX↑, *chemoPv↑, *Inflam↓, *ROS↓, *RAS↓,
6282- DL,    Limonene Exerts Anti-Inflammatory Effect on LPS-Induced Jejunal Injury in Mice by Inhibiting NF-κB/AP-1 Pathway
- in-vivo, IBD, NA
*RenoP↑, *creat↓, *Inflam↓, *TNF-α↓, *IL1β↓, *COX2/PTGS2↓, *ROS↓, *NRF2↑, *GastroP↑, *TLR4↓, *NF-kB↓, *AP-1↓, *Sepsis↓,
6281- DL,    Applications of Limonene in Neoplasms and Non-Neoplastic Diseases
- Review, Var, NA - Review, AD, NA - Review, Diabetic, NA
*antiOx↑, AntiTum↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *ROS↓, *toxicity↓, *BioAv↑, ChemoSen↑, BAX↑, P53↓, Bcl-2↓, iNOS↓, COX2/PTGS2↓, eff↑, ROS↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, TumCMig↓, *lipid-P↓, *GSH↑, *SOD↑, *GPx↑, *hepatoP↑, *glucose↓, *AGEs↓, *Obesity↓, *Aβ↓, *AChE↓,
6317- DRE,    The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells
- in-vitro, Melanoma, A375
Apoptosis↑, selectivity↑, Casp8↑, mt-ROS↑, eff↑, *toxicity↓, Diff↑, TumCP↓, chemoPv↑, *ROS↓, *NO↓, *COX2/PTGS2↓, *RNS↓, TumCI↓, MMP2↓, MMP9↓, p‑Src↓, p‑FAK↓,
6318- DRE,    Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
- vitro+vivo, CRC, HCT116 - NA, Nor, NCM460
TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,
6363- DRE,    Therapeutic Potential of Dandelion (Taraxacum officinale) Root Extract in Colon Cancer: A Comprehensive Review
- in-vitro, CRC, NA
Apoptosis↑, *Inflam↓, TLR4↓, NF-kB↓, *GutMicro↑, mtDam↑, *ROS↓, Casp1↑, TNF-α↑, Bcl-2↓, PARP↓, MMP↓, Cyt‑c↓, Casp3↑, TumVol↓, COX2/PTGS2↓, iNOS↓, ROS↑, selectivity↑, TumCMig↓, TumCI↓, ER Stress↑, PERK↑, eIF2α↑, ATF4↑, CHOP/DDIT3↑, TumCCA↑, cycD1/CCND1↓, P21↓, P53↑, BioAv↝, Half-Life↝,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,

Showing Research Papers: 151 to 200 of 491
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 491

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ARG↓, 1,   miR-375↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 1,   Copper↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 2,   GSTZ1↓, 1,   HO-1↓, 1,   HO-1↑, 1,   HO-2↓, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   NADH↓, 1,   NRF2↑, 3,   NRF2↝, 1,   OXPHOS↓, 2,   OXPHOS↑, 1,   ROS↓, 1,   ROS↑, 13,   ROS↝, 1,   mt-ROS↑, 2,   SOD2↓, 2,   TrxR↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   ETC↓, 2,   MKP5↑, 1,   MMP↓, 6,   mtDam↑, 1,   OCR↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   cMyc↓, 3,   ECAR↝, 1,   FASN↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 3,   HK2↓, 1,   HMG-CoA↓, 1,   IR↓, 1,   lactateProd↓, 5,   lactateProd↑, 1,   LDHA↓, 3,   lipoGen↓, 1,   MCT4↓, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PI3K/Akt↓, 1,   PKM2↓, 1,   PPARγ↑, 2,   SCD1↓, 1,   SIRT1↓, 1,   SREBP2↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 8,   Akt↑, 1,   Akt↝, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 12,   Apoptosis↝, 1,   BAX↑, 5,   BAX↝, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 8,   Bcl-2↝, 1,   Bcl-xL↓, 2,   Bcl-xL↝, 1,   BID↑, 2,   Casp↑, 3,   Casp1↑, 2,   Casp3↑, 4,   Casp3↝, 1,   Casp8↑, 3,   Casp9↓, 1,   Casp9↑, 2,   CK2↓, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   Cyt‑c↝, 1,   Diablo↑, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 5,   JNK↑, 1,   JNK↝, 1,   MAPK↓, 1,   Mcl-1↓, 2,   MCT1↓, 2,   MDM2↓, 2,   Myc↓, 4,   NOXA↑, 1,   p38↓, 1,   Proteasome↓, 1,   PUMA↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↓, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   PAK↓, 1,   RTK-RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   HATs↓, 1,   Matr↓, 1,   other↓, 2,   other↑, 1,   other↝, 3,   other∅, 1,   PhotoS↑, 2,   sonoS↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 3,   HSP90↓, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNAdam↑, 1,   DNMTs↓, 2,   P53↓, 1,   P53↑, 7,   P53↝, 1,   p73↑, 1,   PARP↓, 2,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 2,   CDK4↓, 1,   Cyc↝, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 4,   cycD1/CCND1↝, 1,   CycD3↓, 1,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↓, 1,   P21↑, 2,   P21↝, 1,   p‑RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 4,   CD133↑, 1,   CDK8↓, 2,   cFos↓, 1,   CSCs↓, 2,   Diff↑, 1,   EMT↓, 3,   p‑ERK↓, 1,   FGF↓, 1,   FOXO1↓, 1,   GSK‐3β↓, 2,   GSK‐3β↑, 1,   HDAC↓, 2,   HH↓, 1,   mTOR↓, 5,   mTOR↝, 1,   NOTCH↓, 2,   NOTCH1↓, 1,   P90RSK↓, 1,   PI3K↓, 7,   PI3K↝, 1,   PTEN↑, 1,   PTEN↝, 1,   Shh↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT1↓, 1,   STAT3↓, 7,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 5,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AP-1↓, 1,   AP-1↝, 1,   ARG1/2↑, 1,   ATPase↓, 1,   CA↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   CD31/PECAM-1↓, 2,   EFEMP↓, 1,   p‑FAK↓, 2,   MMP2↓, 5,   MMP2↝, 1,   MMP9↓, 7,   MMPs↓, 5,   PDGF↓, 1,   PKCδ↓, 2,   SMAD3↓, 1,   Snail↓, 2,   SPARC↓, 1,   TGF-β↓, 5,   TumCA↓, 1,   TumCI↓, 9,   TumCMig↓, 5,   TumCP↓, 7,   TumMeta↓, 5,   Twist↓, 2,   α-SMA↓, 1,   β-catenin/ZEB1↓, 4,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 8,   ATF4↑, 1,   EGFR↓, 6,   EGFR↝, 1,   Endoglin↑, 1,   HIF-1↓, 1,   Hif1a↓, 4,   NO↓, 1,   VEGF↓, 9,   VEGF↝, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 3,   NHE1↓, 1,   P-gp/ABCB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 5,   COX2/PTGS2↓, 28,   COX2/PTGS2↑, 2,   COX2/PTGS2↝, 1,   COX2/PTGS2∅, 1,   CRP↓, 1,   CXCc↓, 2,   GM-CSF↓, 2,   IKKα↓, 2,   p‑IKKα↓, 1,   IL1↓, 3,   IL12↓, 2,   IL18↓, 1,   IL1β∅, 1,   IL2↓, 3,   IL5↓, 1,   IL6↓, 5,   IL6↝, 1,   IL8↓, 3,   Imm↑, 2,   Inflam↓, 4,   IκB↓, 1,   JAK↓, 3,   JAK2↓, 1,   MCP1/CCL2↓, 1,   MDSCs↓, 1,   MyD88↓, 1,   NF-kB↓, 24,   NF-kB↑, 1,   NF-kB↝, 1,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 3,   PSA↝, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 3,   TNF-α↑, 1,   TNF-α↝, 1,   TNF-α∅, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,   e-pH↑, 1,   i-pH↓, 1,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↝, 1,   CDK6↓, 2,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 1,   ChemoSen↑, 9,   Dose↑, 2,   Dose↝, 5,   Dose∅, 1,   eff↓, 3,   eff↑, 16,   Half-Life↓, 2,   Half-Life↝, 2,   MRP1/ABCC1↓, 1,   RadioS↑, 9,   selectivity↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↝, 1,   AST↓, 1,   CRP↓, 1,   EGFR↓, 6,   EGFR↝, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 2,   IL6↓, 5,   IL6↝, 1,   Myc↓, 4,   PD-L1↓, 1,   PSA↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 2,   chemoPv↑, 2,   fatigue↓, 1,   hepatoP↑, 1,   QoL↑, 1,   radioP↑, 1,   toxicity↓, 3,   toxicity↝, 4,   TumVol↓, 2,   TumW↓, 2,  

Ingredients & Constituents(tgid=25) ⓘ

Api↑, 1,  
Total Targets: 323

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 1,   AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 9,   Catalase↑, 6,   GPx↑, 5,   GSH↑, 8,   GSR↓, 1,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 7,   lipid-P↓, 5,   MDA↓, 3,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 7,   RNS↓, 2,   ROS↓, 20,   SOD↑, 8,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↑, 1,   ALAT↓, 1,   AMPK↑, 2,   cytoP450↓, 1,   glucose↓, 2,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDH↓, 1,   LDL↓, 1,   NADPH↓, 1,   NADPH↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Casp1↓, 1,   Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 1,   other↝, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↓, 2,   mTOR↓, 1,   p300↓, 1,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 3,   AP-1↓, 2,   CDK5↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMPs↓, 1,   MMPs↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 4,   TXA2↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GastroP↑, 3,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 4,   COX2/PTGS2?, 1,   COX2/PTGS2↓, 16,   COX2/PTGS2↑, 1,   CRP↓, 1,   ICAM-1↓, 1,   IL1↓, 3,   IL10↑, 1,   IL12↓, 2,   IL17↓, 1,   IL1β↓, 6,   IL2↓, 2,   IL2↑, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 6,   IL8↓, 2,   Imm↑, 1,   INF-γ↓, 1,   Inflam?, 1,   Inflam↓, 21,   MCP1/CCL2↓, 3,   NF-kB↓, 12,   NF-kB↑, 1,   PGE2↓, 6,   TLR4↓, 1,   TNF-α↓, 9,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BChE↓, 1,   BDNF↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 3,   BACE/β-secretase↓, 1,   NLRP3↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 7,   BioEnh↑, 1,   Dose↝, 2,   eff↑, 4,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   creat↓, 1,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 6,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 2,   AntiTum↓, 1,   cardioP↓, 1,   cardioP↑, 3,   chemoPv↑, 1,   cognitive↑, 5,   cognitive↝, 1,   hepatoP↑, 5,   memory↑, 5,   neuroP↑, 8,   Obesity↓, 1,   OS↑, 2,   Pain↓, 1,   radioP↑, 3,   RenoP↑, 1,   toxicity↓, 2,   toxicity↝, 1,   toxicity∅, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

CA↑, 1,   Catechins↑, 1,   FA↑, 1,   GA↑, 1,   Phen↑, 1,   QC↑, 1,  
Total Targets: 146

Scientific Paper Hit Count for: COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
28 Curcumin
25 Thymoquinone
19 Quercetin
18 Resveratrol
15 Fisetin
12 Lycopene
11 Celecoxib
11 Chrysin
11 Silymarin (Milk Thistle) silibinin
10 Apigenin (mainly Parsley)
10 Propolis -bee glue
10 Eugenol
9 Boswellia (frankincense)
9 Carvacrol
9 isoorientin
9 Sulforaphane (mainly Broccoli)
8 Berberine
8 Beta-Caryophyllene
8 Diclofenac
7 Artemisinin
7 EGCG (Epigallocatechin Gallate)
7 Honokiol
7 Kaempferol
7 Rosmarinic acid
6 Chlorogenic acid
6 Ginger/6-Shogaol/Gingerol
5 Radiotherapy/Radiation
5 Baicalein
5 Echinacea
5 Ellagic acid
5 Ferulic acid
5 Garcinol
5 Piperine
4 Aspirin
4 Ashwagandha(Withaferin A)
4 Capsaicin
4 Cisplatin
4 lambertianic acid
4 Shikonin
4 Urolithin
3 Silver-NanoParticles
3 Alpha-Lipoic-Acid
3 Isovitexin
3 Betulinic acid
3 Bromelain
3 α-Bisabolol / Chamomile oil
3 Butyrate
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Cichoric acid / Chicoric acid
3 Chemotherapy
3 D-limonene
3 Dandelion Root
3 Formononetin
3 Gambogic Acid
3 Grapeseed extract
3 Isoliquiritigenin
3 Luteolin
3 Magnetic Fields
3 Phenethyl isothiocyanate
3 Pterostilbene
3 Rutin
2 acetaminophen
2 Allicin (mainly Garlic)
2 alpha Linolenic acid
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Andrographis
2 Baicalin
2 xanthohumol
2 Cannabidiol
2 Boron
2 buckwheat sprouts
2 Caffeic acid
2 Carnosic acid
2 Thymol-Thymus vulgaris
2 Chocolate
2 Crocetin
2 Ursolic acid
2 CUSP9
2 Docosahexaenoic Acid
2 Emodin
2 Genistein (soy isoflavone)
2 Geraniol
2 Hydroxycinnamic-acid
2 Hyperoside
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Vitexin
2 Licorice
2 Lemongrass Extract/Citral
2 Magnolol
2 Naringin
2 Nimbolide
2 Oleuropein
2 Oleocanthal
2 Piperlongumine
2 Vitamin C (Ascorbic Acid)
2 Vitamin K2
1 1,8-Cineole
1 Auranofin
1 Aloe anthraquinones
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 brusatol
1 Bruteridin(bergamot juice)
1 Cynanbungeigenin C (CBC) and D (CBD)
1 cannabidiolic acid
1 Celastrol
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Lecithin
1 Oxygen, Hyperbaric
1 Docetaxel
1 Galantamine
1 Dichloroacetate
1 Date Fruit Extract
1 eicosapentaenoic acid
1 Evodiamine
1 Exercise
1 flavonoids
1 Bortezomib
1 Shilajit/Fulvic Acid
1 Gamma-aminobutyric acid
1 Paclitaxel/Taxol
1 Ginkgo biloba
1 Ginkgetin
1 γ-linolenic acid (Borage Oil)
1 Proanthocyanidins
1 Siegesbeckia glabrescens
1 Hydrogen Gas
1 Hops (Humulus lupulus)
1 Inositol
1 iodine
1 Laetrile B17 Amygdalin
1 Lasiodin
1 Licochalcone A
1 5-fluorouracil
1 Melatonin
1 Metformin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane
1 Myricetin
1 Neem
1 Protocatechuic acid
1 Mung Bean Sprouts
1 Polyphenols
1 Perilla
1 Germacranolide sesquiterpene lactone
1 Salvia officinalis
1 Sanguinarine
1 Sesame seeds and Oil
1 Aflavin-3,3′-digallate
1 doxorubicin
1 Turmerones
1 Vitamin B1/Thiamine
1 Whole Body Vibration
1 Wogonin
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:66  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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