HK2 Cancer Research Results

HK2, Hexokinase 2: Click to Expand ⟱
Source:
Type: enzyme
HK2 (Hexokinase 2) is an enzyme that plays a crucial role in glycolysis, the process by which cells convert glucose into energy. HK2 is a key regulatory enzyme in the glycolytic pathway, and it is primarily expressed in various tissues, including muscle, brain, and cancer cells.
HK2 has been shown to be overexpressed in many types of tumors, including breast, lung, and colon cancer. This overexpression may contribute to the development and progression of cancer by promoting glycolysis and energy production in cancer cells.
HK2 is a key regulatory enzyme in the glycolytic pathway.
HK2 plays a role in the regulation of glucose metabolism in diabetes.
HK2 is involved in the regulation of cell proliferation, apoptosis, and autophagy.

HK2 Inhibitors:
-2DG
-Curcumin
-Resveratrol
-EGCG
-Berberine
-Methyl Jasmonate (MJ)
-Honokiol
Scientific Papers found: Click to Expand⟱
2369- VitD3,    Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation
- in-vitro, CRC, DLD1 - in-vitro, CRC, RKO
MEG3↑, Glycolysis↓, lactateProd↓, LDHA↓, PKM2↓, HK2↓,
2365- VitD3,    Vitamin D Affects the Warburg Effect and Stemness Maintenance of Non- Small-Cell Lung Cancer Cells by Regulating the PI3K/AKT/mTOR Signaling Pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1975 - in-vivo, NA, NA
Glycolysis↓, Warburg↓, GLUT1↓, LDHA↓, HK2↓, PKM2↓, OCT4↓, SOX2↓, Nanog↓, PI3K↓, Akt↓, mTOR↓,
1214- VitK2,    Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells
- in-vitro, Bladder, T24/HTB-9 - in-vitro, Bladder, J82
Glycolysis↑, GlucoseCon↑, lactateProd↑, TCA↓, PI3K↑, Akt↑, AMPK↑, mTORC1↓, TumAuto↑, GLUT1↑, HK2↑, LDHA↑, ACC↓, PDH↓, eff↓, cMyc↓, Hif1a↑, p‑Akt↑, eff↓, eff↓, eff↓, eff↓, ROS↑,
2301- Wog,    Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
- Review, Var, NA
HK2↓, PDK1 / PDPK1↓, LDHA↓, Hif1a↓, PI3K↓, Akt↓, Glycolysis↓, P53↑, GLUT1↓,
2397- Wor,    Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action
- Review, Var, NA
lactateProd↓, GlucoseCon↓, GLUT3↓, HK2↓, PKM2↓, LDHA↓,
2425- γ-Toc,    Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis
- in-vitro, NA, MCF7 - in-vivo, NA, NA
TumCG↓, GlucoseCon↓, ATP↓, lactateProd↓, Glycolysis↓, HK2↓, PFK↓, PKM2↓, LDHA↓, Akt↓, p‑mTOR↓, cMyc↓,

Showing Research Papers: 151 to 156 of 156
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 156

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   cMyc↓, 2,   GlucoseCon↓, 2,   GlucoseCon↑, 1,   Glycolysis↓, 4,   Glycolysis↑, 1,   HK2↓, 5,   HK2↑, 1,   lactateProd↓, 3,   lactateProd↑, 1,   LDHA↓, 5,   LDHA↑, 1,   PDH↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 1,   PKM2↓, 4,   TCA↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↑, 1,   MEG3↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,   p‑mTOR↓, 1,   mTORC1↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 2,   PI3K↑, 1,   SOX2↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   Hif1a↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   GLUT1↑, 1,   GLUT3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 5,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HK2, Hexokinase 2
14 3-bromopyruvate
8 Quercetin
8 Propolis -bee glue
8 Sulforaphane (mainly Broccoli)
7 2-DeoxyGlucose
7 Baicalein
7 EGCG (Epigallocatechin Gallate)
7 Resveratrol
6 Metformin
6 Chrysin
5 Shikonin
4 Curcumin
4 Graviola
3 Berberine
3 Capsaicin
3 Citric Acid
3 Fenbendazole
3 Ursolic acid
2 Apigenin (mainly Parsley)
2 Baicalin
2 Cinnamon
2 Chemotherapy
2 Emodin
2 Kaempferol
2 Licochalcone A
2 Magnetic Fields
2 Pachymic acid
2 Piperlongumine
2 Silymarin (Milk Thistle) silibinin
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
1 Sorafenib (brand name Nexavar)
1 Radiotherapy/Radiation
1 cetuximab
1 Alpha-Lipoic-Acid
1 doxorubicin
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 5-fluorouracil
1 Betulinic acid
1 Caffeic acid
1 Chlorogenic acid
1 chaetocin
1 Deguelin
1 Diclofenac
1 diet FMD Fasting Mimicking Diet
1 diet Methionine-Restricted Diet
1 Piperine
1 Taurine
1 flavonoids
1 Ginkgolide B
1 Hydrogen Gas
1 Honokiol
1 Ivermectin
1 Laetrile B17 Amygdalin
1 lambertianic acid
1 Licorice
1 Luteolin
1 Matrine
1 Oroxylin-A
1 Proanthocyanidins
1 Phenylbutyrate
1 Rosmarinic acid
1 Thymoquinone
1 triptolide
1 Vitamin K2
1 Wogonin
1 Worenine
1 γ-Tocotrienol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:773  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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