EGFR Cancer Research Results

EGFR, Epidermal Growth Factor Receptor: Click to Expand ⟱
Source: HalifaxProj(inhibit) CGL-Driver
Type: Oncogene
EGFR (Epidermal growth factor receptor), which belongs to the tyrosine kinase receptor family (RTKs)
Epidermal Growth Factor Receptor (EGFR) is a cell surface protein that plays a crucial role in the regulation of cell growth, survival, proliferation, and differentiation. It is part of the ErbB family of receptors and is activated by binding to its ligands, such as epidermal growth factor (EGF) and transforming growth factor-alpha (TGF-α).

-plays a crucial role in regulating cell growth and division.

Many cancers exhibit overexpression of EGFR, which can lead to enhanced signaling and contribute to tumor growth and survival. This overexpression is often associated with aggressive tumor behavior and poor prognosis.
Scientific Papers found: Click to Expand⟱
3413- TQ,    Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase
- in-vitro, CRC, HCT116
tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, EGFR↓, ROS↑,
2411- UA,    Ursolic acid in health and disease
- Review, Var, NA
Inflam↓, antiOx↑, NF-kB↓, Bcl-xL↓, Bcl-2↓, cycD1/CCND1↓, Ki-67↓, CD31/PECAM-1↓, STAT3↓, EGFR↓, P53↑, P21↓, HK2↓, PKM2↓, ATP↓, lactateProd↓, p‑ERK↓, MMP↓, NO↑, ATM↑, Casp3↑, AMPK↑, JNK↑, FAO↑, FASN↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, neuroP↑,
2414- β‐Ele,    Beta‐elemene inhibits breast cancer metastasis through blocking pyruvate kinase M2 dimerization and nuclear translocation
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCMig↓, TumCI↓, TumMeta↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, EGFR↓, GLUT1↓, LDHA↓, ECAR↓, OCR↓,

Showing Research Papers: 151 to 153 of 153
Prev Page 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 153

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   ECAR↓, 1,   FAO↑, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 2,   LDHA↓, 1,   PKM2↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 2,   Casp7↑, 1,   Casp9↑, 1,   JNK↑, 1,   p27/CDKN1B↑, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 2,   P21↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑ERK↓, 1,   STAT3↓, 2,  

Migration(tgid=13) ⓘ

CD31/PECAM-1↓, 1,   Ki-67↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 3,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 3,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 48

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GPx↑, 1,   GSH↑, 1,   GSTs↑, 1,   SOD↑, 1,  
Total Targets: 5

Scientific Paper Hit Count for: EGFR, Epidermal Growth Factor Receptor
14 Fisetin
11 Curcumin
10 EGCG (Epigallocatechin Gallate)
10 Quercetin
9 Honokiol
6 Shikonin
5 Silymarin (Milk Thistle) silibinin
4 almonertinib
4 Berberine
4 Resveratrol
3 Artemisinin
3 Bufalin/Huachansu
3 brusatol
3 Gallic acid
3 Luteolin
3 Sulforaphane (mainly Broccoli)
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Betulinic acid
2 Brucea javanica
2 cetuximab
2 chaetocin
2 Docetaxel
2 Ursolic acid
2 gefitinib, erlotinib
2 Formononetin
2 Graviola
2 Licochalcone A
2 Magnetic Fields
2 Nimbolide
2 Piperlongumine
1 Astragalus
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 Ashwagandha(Withaferin A)
1 Astaxanthin
1 Aloe anthraquinones
1 Biochanin A
1 Chemotherapy
1 Boron
1 α-Bisabolol / Chamomile oil
1 Capsaicin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Thymol-Thymus vulgaris
1 Chlorogenic acid
1 Chrysin
1 Crocetin
1 Radiotherapy/Radiation
1 Photodynamic Therapy
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Dandelion Root
1 Ellagic acid
1 Piperine
1 Evodiamine
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione
1 HydroxyTyrosol
1 Hyperoside
1 itraconazole
1 Kaempferol
1 Lapatinib
1 Licorice
1 Lycopene
1 Myricetin
1 Naringin
1 Niclosamide (Niclocide)
1 Phenethyl isothiocyanate
1 Gold NanoParticles
1 Rosmarinic acid
1 Gemcitabine (Gemzar)
1 statins
1 Citric Acid
1 Thymoquinone
1 β‐Elemene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:94  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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