Inflam Cancer Research Results

Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
3868- Bos,    Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome(®)) of Boswellia extract
*Inflam↓, *BioAv↓, *BioAv↑, *eff↑,
2777- Bos,    Inflammatory_Damage">Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage
- in-vitro, IBD, NA
*p‑NF-kB↓, *ROS↓, Inflam↓,
2775- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
ROS↑, ER Stress↑, TumCG↓, Apoptosis↑, Inflam↓, ChemoSen↑, Casp↑, ERK↓, cl‑PARP↑, AR↓, cycD1/CCND1↓, VEGFR2↓, CXCR4↓, radioP↑, NF-kB↓, VEGF↓, P21↑, Wnt↓, β-catenin/ZEB1↓, Cyt‑c↑, MMP2↓, MMP1↓, MMP9↓, PI3K↓, MAPK↓, JNK↑, *5LO↓, *NRF2↑, *HO-1↑, *MDA↓, *SOD↑, *hepatoP↑, *ALAT↓, *AST↓, *LDH↑, *CRP↓, *COX2↓, *GSH↑, *ROS↓, *Imm↑, *Dose↝, *eff↑, *neuroP↑, *cognitive↑, *IL6↓, *TNF-α↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
2772- Bos,    Mechanistic role of boswellic acids in Alzheimer’s disease: Emphasis on anti-inflammatory properties
- Review, AD, NA
*neuroP↑, *Inflam↓, *AChE↓, *Choline↑, *NRF2↑, *NF-kB↑, *BBB↑, *BioAv↑, *Half-Life↓, *Dose↝, *PGE2↓, *ROS↓, *cognitive↑, *antiOx↑, 5LO↓, *TNF-α↓, *IL6↓, *HO-1↑,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2↓, Ki-67↓, CD31↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
5704- BRU,    Brusatol ameliorates psoriatic dyslipidemia by targeting IL-1β to restore AMPK-mediated lipid homeostasis
- in-vivo, PSA, HaCaT
*Inflam↓, *IL17↓, *TNF-α↓, *IL22↓, *STAT3↓, *other↝, *eff↑, *Dose?,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5744- Buty,  PacT,    Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction
- in-vivo, Var, NA
chemoP↑, neuroP↑, Inflam↓, GutMicro↑, *ROS↓, Dose↝,
5743- Buty,    Regulation of Intestinal Butyrate Transporters by Oxidative and Inflammatory Status
- Review, Var, NA
*GutMicro↑, *other↑, *Inflam↓, *ROS↓, AntiCan↑, HCAR2↑, HDAC↓,
5742- Buty,    Butyrate: A Double-Edged Sword for Health?
- Review, Var, NA
HCAR2↑, Inflam↓, HDAC↓, *IFN-γ↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↑, *TNF-β↑, *NF-kB↓, *ROS↓, PPARγ↓, Weight↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2↓, eff↝, eff↑, other↝,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,
5735- Buty,    Butyrate and the Intestinal Epithelium: Modulation of Proliferation and Inflammation in Homeostasis and Disease
- Study, Nor, NA
*Inflam↓, GutMicro↑, Imm↑,
5733- Buty,  VitB3,    Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
- in-vivo, CRC, NA
GutMicro↑, HCAR2↑, AntiCan↑, Inflam↓, IL18↑,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
1650- CA,    Adjuvant Properties of Caffeic Acid in Cancer Treatment
- Review, Var, NA
ROS↑, antiOx↑, Inflam↓, AntiCan↑, NF-kB↓, STAT3↓, ERK↓, ChemoSen↑, RadioS↑, AMPK↑, eff↑, selectivity↑, COX2↓, Dose∅, PHDs↓, MMP9↓, MMP2↓, Dose∅, Dose∅, Ca+2↑, Dose?, MMP↓, RadioS↑,
5756- CA,    Experimental Evidence of Caffeic Acid’s Neuroprotective Activity in Alzheimer’s Disease: In Vitro, In Vivo, and Delivery-Based Insights
- vitro+vivo, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AChE↓, *BChE↓, *cognitive↑, *ROS↓, *Aβ↓, *tau↓, eff↑,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *eff↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5872- CA,    Nrf2/ARE-Mediated Antioxidant Actions of Pro-Electrophilic Drugs
- Review, Nor, NA
*NRF2↑, *GSH↑, *neuroP↑, *Inflam↓, *cardioP↑, *Obesity↓, *angioG↓, chemoP↑, *NF-kB↓,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
5832- CAP,    Capsaicin induces cell cycle arrest and apoptosis in human KB cancer cells
- in-vitro, Oral, KB
TumCP↓, tumCV↓, TumCCA↑, Apoptosis↑, MMP↓, Casp9↑, Casp3↑, PARP↑, Inflam↓, Pain↓,
5830- CAP,    Inhibition of pyroptosis and apoptosis by capsaicin protects against LPS-induced acute kidney injury through TRPV1/UCP2 axis in vitro
- in-vitro, Nor, HK-2
*IL1β↓, *IL18↓, *TRPV1↑, *ROS↓, *MMP↑, *Apoptosis↓, *RenoP↑, *Inflam↓, *UCPs↑,
5825- CAP,    Bioavailability of capsaicin and its implications for drug delivery
- Review, Var, NA - Review, Arthritis, NA - Review, Obesity, NA
*AntiCan↑, *TRPV1↑, *cardioP↑, AntiCan↓, Apoptosis↑, ChemoSen↑, *Inflam↓, *Pain↓, *AntiAg↑, *Weight↓, *BioAv↑, BioAv↑, Half-Life↝, Half-Life↓,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5859- CAP,    Are We Ready to Recommend Capsaicin for Disorders Other Than Neuropathic Pain?
- Review, Var, NA
*TRPV1↑, *Ca+2↑, *Na+↑, *UCPs↑, *SIRT1↑, *PPARγ↑, *Inflam↓, *lipid-P↑, *IL6↓, *TNF-α↓, *NF-kB↓, *p‑Akt↑, *NRF2↑, *HO-1↑, *ROS↑, *GutMicro↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5854- CAP,    Pharmacological activity of capsaicin: Mechanisms and controversies (Review)
- Review, Var, NA - Review, AD, NA
Obesity↓, Half-Life↓, antiOx↑, TRPV1↑, STAT3↓, Ca+2↑, ROS↑, MMP↓, *neuroP↑, *tau↓, *Inflam↓, *ROS?,
5202- CAP,    Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways
- vitro+vivo, Bladder, 5637 - in-vitro, Bladder, T24/HTB-9
antiOx↑, Inflam↓, AntiCan↓, TRPV1↑, TumCP↓, TumCCA↑, ROS↑, FOXO3↑, TumCMig↓,
3854- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *APP↓, *MMP-10↝, *p‑tau↓, *Inflam↓, *neuroP↑, *Risk↓, *TNF-α↓, *IFN-γ↓, *IL6↓, *PPARα↑,
3855- CAP,    Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice
- in-vivo, AD, NA
*Risk↓, *Aβ↓, *p‑tau↓, *Inflam↓, *neuroP↑, *cognitive↑, *ADAM10↑, *PPARα↑,
2394- CAP,    Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction
- in-vitro, Nor, GES-1
*mtDam↓, *NRF2↑, *HO-1↑, *Trx↑, *GSS↑, *NQO1↑, *Keap1↓, *ROS↓, *PKM2↓, *LDHA↓, *Inflam↓,
2347- CAP,    Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis
- in-vivo, Nor, NA - in-vitro, Nor, RAW264.7
*PKM2↓, *LDHA↓, *Warburg↓, *COX2↓, *Sepsis↓, *Inflam↓, *ECAR↓, *OCR↑,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5770- CAPE,    Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B
- in-vitro, Nor, NA
*NF-kB↓, *Imm↑, *Inflam↓,
5766- CAPE,    A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model
- in-vivo, Nor, NA
*MDA↓, *NF-kB↓, *p65↓, *TNF-α↓, *cl‑Casp3↓, *GSR↑, *GSH↑, *NRF2↑, *HO-1↑, *Bax:Bcl2↓, *antiOx↑, *Inflam↓,
5758- CAPE,  PBG,    Caffeic acid phenethyl ester and therapeutic potentials
- Review, Var, NA
*antiOx↑, *Inflam↓, ChemoSen↑, chemoP↑, COX1↓, COX2↓, selectivity↑, NF-kB↓, RadioS↑, *ROS↓, *lipid-P↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5885- CAR,    Inhibition of TRPM7 by carvacrol suppresses glioblastoma cell proliferation, migration and invasion
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
TRPM7↓, tumCV↓, TumCMig↓, TumCI↓, MMP2↓, toxicity↓, *Inflam↓, AntiDiabetic↑, cardioP↑, neuroP↑, selectivity↑, Apoptosis↑, p‑Cofilin↑, F-actin↓, PI3K↓, Akt↓, MEK↓, MAPK↓,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2↓, *Dose↝,
5907- CAR,    Anti-proliferative and pro-apoptotic effect of carvacrol on human hepatocellular carcinoma cell line HepG-2
- in-vitro, Liver, HepG2
TumCG↓, Apoptosis↓, Casp3↓, cl‑PARP↑, Bcl-2↓, p‑ERK↓, p‑p38↑, *Bacteria↓, *AntiAg↑, *Inflam↓, *antiOx↑, *AChE↓, AntiTum↑, MMP↓, Cyt‑c↑, Bax:Bcl2↑, Casp↑, DNAdam↑, selectivity↑,
5896- CAR,  TV,    Carvacrol and Thymol Hybrids: Potential Anticancer and Antibacterial Therapeutics
- Review, Var, NA
BioAv↑, AntiCan↑, *antiOx↑, *Inflam↑, *Bacteria↓, ROS↑, DNAdam↑,
5900- CAR,  TV,    Lights and Shadows of Essential Oil-Derived Compounds: Antimicrobial and Anti-Inflammatory Properties of Eugenol, Thymol, Cinnamaldehyde, and Carvacrol
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *cardioP↑, *neuroP↑, *NADPH↓, *NRF2↑, *HO-1↑, *IL1β↓, *TNF-α↓,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5893- CAR,  TV,    Thymol and Carvacrol: Molecular Mechanisms, Therapeutic Potential, and Synergy With Conventional Therapies in Cancer Management
- Review, Var, NA
*Inflam↓, AntiCan↑, PI3K↓, Akt↓, mTOR↓, NOTCH↓, PIK3CA↓, EGFR↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, eff↝, *cardioP↑, *neuroP↑, *hepatoP↑, Apoptosis↑, MMP↓, Casp3↑, ROS↑, DNAdam↑, eff↑, BAX↑, BAD↑, FasL↑, Cyt‑c↑, Casp9↑, Casp8↑, TumCCA↑, P21↑, Smo↓, Gli1↓, JNK↑, ERK↓, MAPK↓, TRPM7↓, Wnt/(β-catenin)↓, BioAv↝, BioAv↑,

Showing Research Papers: 151 to 200 of 762
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 762

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   GSH↓, 2,   lipid-P?, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   NADH↓, 1,   ROS↑, 14,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

MEK↓, 1,   MMP↓, 9,   MPT↑, 1,   mtDam↑, 2,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   PIK3CA↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   SIRT1↓, 2,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Apoptosis↓, 1,   Apoptosis↑, 13,   BAD↑, 1,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp↑, 6,   Casp3↓, 1,   Casp3↑, 7,   Casp7↑, 1,   Casp8↑, 4,   Casp9↑, 4,   Cyt‑c↑, 10,   DR4↑, 1,   DR5↑, 1,   FADD↑, 2,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 1,   IAP1↓, 1,   iNOS↓, 2,   JNK↑, 3,   p‑JNK↑, 1,   MAPK↓, 4,   p38↑, 2,   p‑p38↑, 1,   survivin↓, 1,   TRPV1↑, 4,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 4,  

Transcription & Epigenetics ⓘ

ac‑H3↓, 1,   ac‑H4↓, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   P53↑, 6,   PARP↑, 1,   cl‑PARP↑, 5,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 3,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 2,   P21↓, 1,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 4,   p‑ERK↓, 2,   FOXO3↑, 1,   Gli1↓, 1,   HDAC↓, 4,   Let-7↑, 1,   mTOR↓, 3,   NOTCH↓, 1,   PI3K↓, 5,   SHP1↓, 1,   Smo↓, 1,   STAT3↓, 3,   STAT3↑, 1,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,   TRPM7↓, 3,   TumCG↓, 3,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

5LO↓, 1,   AXL↓, 1,   Ca+2↑, 4,   i-Ca+2?, 1,   CD31↓, 1,   p‑Cofilin↑, 1,   E-cadherin↑, 1,   F-actin↓, 2,   Ki-67↓, 2,   miR-200b↑, 1,   MMP1↓, 2,   MMP2↓, 6,   MMP9↓, 7,   MMPs↓, 1,   N-cadherin↓, 1,   PDGF↓, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 3,   TumCMig↓, 5,   TumCP↓, 5,   TumMeta↓, 6,   ZEB2↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 4,   EGFR↓, 1,   Hif1a↓, 1,   p‑PDGFR-BB↓, 1,   PHDs↓, 1,   VEGF↓, 8,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 9,   CXCR4↓, 3,   HCAR2↑, 4,   IKKα↓, 1,   IL1↓, 1,   IL10↓, 1,   IL18↑, 1,   IL1α↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   Imm↑, 2,   Inflam↓, 10,   MCP1↓, 1,   MIP2↓, 1,   NF-kB↓, 6,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 6,   BioAv↝, 2,   ChemoSen↑, 10,   Dose?, 1,   Dose↑, 1,   Dose↝, 3,   Dose∅, 3,   eff↓, 1,   eff↑, 17,   eff↝, 2,   Half-Life↓, 3,   Half-Life↝, 1,   RadioS↑, 5,   selectivity↑, 8,  

Clinical Biomarkers ⓘ

AFP↓, 2,   AR↓, 2,   ascitic↓, 1,   AST↓, 1,   creat↓, 1,   EGFR↓, 1,   GutMicro↑, 4,   IL6↓, 3,   Ki-67↓, 2,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiCan↓, 2,   AntiCan↑, 7,   AntiDiabetic↑, 1,   AntiTum↑, 1,   cardioP↑, 1,   chemoP↑, 4,   chemoPv↑, 5,   hepatoP↑, 2,   neuroP↑, 2,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 2,   Weight↓, 1,   Weight↑, 1,  
Total Targets: 190

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 14,   Catalase↑, 5,   GPx↑, 4,   GSH↑, 7,   GSR↑, 4,   GSS↑, 1,   GSTA1↑, 1,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 7,   lipid-P↑, 1,   MDA↓, 6,   NQO1↑, 1,   NRF2↑, 10,   ROS?, 1,   ROS↓, 20,   ROS↑, 1,   ROS↝, 1,   SOD↑, 7,   TAC↑, 1,   Trx↑, 1,   UCPs↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   mitResp↑, 1,   MMP↑, 1,   MMP∅, 1,   mtDam↓, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 5,   AMPK↑, 2,   ECAR↓, 1,   FAO↑, 1,   FASN↓, 1,   LDH↓, 2,   LDH↑, 1,   LDHA↓, 2,   NADPH↓, 2,   PGM1?, 1,   PKM2↓, 3,   PPARα↑, 2,   PPARγ↑, 1,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↑, 1,   Apoptosis↓, 1,   Bax:Bcl2↓, 1,   Casp3↓, 1,   Casp3∅, 1,   cl‑Casp3↓, 1,   Cyt‑c∅, 1,   MAPK↓, 1,   MAPK↑, 1,   TRPV1↑, 5,  

Kinase & Signal Transduction ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 2,   other↝, 2,  

Proliferation, Differentiation & Cell State ⓘ

Choline↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   PI3K↑, 1,   STAT3↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

5LO↓, 2,   AntiAg↑, 3,   APP↓, 1,   Ca+2↑, 2,   Ca+2↝, 1,   CLDN1↑, 1,   MMP-10↝, 1,   Na+↑, 1,   PKA↑, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   eNOS↑, 1,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 1,   Na+↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CRP↓, 1,   HCAR2↑, 1,   IFN-γ↓, 2,   IL10↑, 2,   IL17↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL22↓, 1,   IL6↓, 6,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 37,   Inflam↑, 3,   NF-kB↓, 9,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p65↓, 1,   PGE2↓, 1,   TNF-α↓, 10,   TNF-β↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 5,   ADAM10↑, 1,   BChE↓, 2,   BDNF↓, 1,   tau↓, 3,   p‑tau↓, 3,  

Protein Aggregation ⓘ

Aβ↓, 4,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   Dose?, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 6,   Half-Life↓, 2,  

Clinical Biomarkers ⓘ

ALAT↓, 5,   ALP↓, 2,   AST↓, 4,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 6,   LDH↓, 2,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   AntiDiabetic↑, 1,   cardioP↑, 6,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↓, 1,   cognitive↑, 6,   hepatoP↑, 3,   memory↑, 3,   neuroP↑, 13,   Obesity↓, 3,   OS↑, 1,   Pain↓, 2,   RenoP↑, 2,   Risk↓, 2,   toxicity↓, 1,   Weight↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 5,   Sepsis↓, 2,  
Total Targets: 142

Scientific Paper Hit Count for: Inflam, inflammation
33 Curcumin
30 Silymarin (Milk Thistle) silibinin
30 Quercetin
28 Thymoquinone
27 Hydrogen Gas
27 Magnetic Fields
22 Resveratrol
18 Alpha-Lipoic-Acid
18 Berberine
18 Selenium NanoParticles
17 Lycopene
17 Rosmarinic acid
16 Ashwagandha(Withaferin A)
15 Capsaicin
15 Carvacrol
15 Sulforaphane (mainly Broccoli)
15 Urolithin
14 Propolis -bee glue
13 Silver-NanoParticles
12 Apigenin (mainly Parsley)
12 Baicalein
12 Chlorogenic acid
11 Ferulic acid
11 Fisetin
11 Honokiol
10 Radiotherapy/Radiation
10 Pterostilbene
9 Selenite (Sodium)
9 Boron
9 Chrysin
8 Astaxanthin
8 Boswellia (frankincense)
8 Chemotherapy
8 Piperlongumine
8 Vitamin C (Ascorbic Acid)
8 Shikonin
7 Betulinic acid
7 Vitamin B3,Niacin
7 Butyrate
6 Allicin (mainly Garlic)
6 Artemisinin
6 Thymol-Thymus vulgaris
6 EGCG (Epigallocatechin Gallate)
6 Magnolol
6 Piperine
6 Rutin
5 Aspirin -acetylsalicylic acid
5 Caffeic acid
5 Celastrol
5 chitosan
5 Chocolate
5 Cinnamon
5 Coenzyme Q10
5 Shilajit/Fulvic Acid
5 Luteolin
5 Magnetic Field Rotating
5 Ursolic acid
4 Bacopa monnieri
4 Caffeic Acid Phenethyl Ester (CAPE)
4 Ginger/6-Shogaol/Gingerol
4 Moringa oleifera
4 nicotinamide adenine dinucleotide
4 Taurine
4 Vitamin B5,Pantothenic Acid
4 Vitamin D3
4 Vitamin K2
3 Baicalin
3 Biochanin A
3 Folic Acid, Vit B9
3 Bromelain
3 Cisplatin
3 Carnosine
3 Spermidine
3 Crocetin
3 Ellagic acid
3 HydroxyCitric Acid
3 HydroxyTyrosol
3 Methylsulfonylmethane
3 Sulfasalazine
3 Vitamin B1/Thiamine
2 Anthocyanins
2 alpha Linolenic acid
2 Melatonin
2 Vitamin B12
2 brusatol
2 borneol
2 Cat’s Claw
2 Celecoxib
2 Chlorophyllin
2 Choline
2 Selenium
2 Hydroxycinnamic-acid
2 Vitamin E
2 Lecithin
2 Galantamine
2 Huperzine A/Huperzia serrata
2 diet Short Term Fasting
2 Exercise
2 Ginkgo biloba
2 Ginseng
2 Orlistat
2 doxorubicin
2 Potassium
2 Lutein
2 Mushroom Lion’s Mane
2 Naringin
2 Oleocanthal
2 Phenylbutyrate
2 Phenethyl isothiocyanate
2 Phosphatidylserine
2 Salvia officinalis
2 Shankhpushpi
2 Salvia miltiorrhiza
2 Aflavin-3,3′-digallate
1 2-DeoxyGlucose
1 5-Hydroxytryptophan
1 Astragalus
1 Acetyl-l-carnitine
1 Aloe anthraquinones
1 beta-glucans
1 beta-carotene(VitA)
1 Vitamin B6,pyridoxine
1 Bifidobacterium
1 Brucea javanica
1 Bruteridin(bergamot juice)
1 Paclitaxel
1 Carnosic acid
1 Cannabichromene
1 Prebiotic
1 Calorie Restriction Mimetics
1 Rivastigmine
1 Disulfiram
1 immunotherapy
1 Electrical Pulses
1 Ascorbyl Palmitate
1 Flickering Light Stimulation
1 Iron
1 Gallic acid
1 γ-linolenic acid (Borage Oil)
1 hydrogen sulfide
1 Juglone
1 Licorice
1 Zeaxanthin
1 5-fluorouracil
1 MCToil
1 Metformin
1 Nimbolide
1 Oleuropein
1 Peppermint
1 Propyl gallate
1 Psoralidin
1 Parthenolide
1 EMF
1 Radio Frequency
1 Aromatherapy
1 Gold NanoParticles
1 Sesame seeds and Oil
1 Silicic Acid
1 Vitamin A, Retinoic Acid
1 Vitamin B2,Riboflavin
1 probiotics
1 Zinc
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:953  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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