Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3878- Carno,    Safety and Efficacy Evaluation of Carnosine, An Endogenous Neuroprotective Agent for Ischemic Stroke
- in-vivo, Stroke, NA
*toxicity∅, *antiOx↑, *neuroP↑, *IronCh↑, *ROS↓,
3879- Carno,    Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults
- Human, AD, NA
*memory↑, *cognitive↑,
3873- Carno,    Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice
- in-vivo, AD, NA
*ROS↓, *IronCh↑, *Aβ↓, *AntiAge↑, *lipid-P↓, *cognitive↑, *memory∅,
3871- Carno,    Unveiling the Hidden Therapeutic Potential of Carnosine, a Molecule with a Multimodal Mechanism of Action: A Position Paper
- Review, NA, NA
*ROS↓, *NO↓, *Inflam↓,
3870- Carno,    Could carnosine or related structures suppress Alzheimer's disease?
- Review, AD, NA
*IronCh↑, *Aβ↓, *ROS↓, *Vim↓,
3880- Carno,    EFFECT OF ANSERINE/CARNOSINE SUPPLEMENTATION ON THE PREVENTION OF ALZHEIMER'S DISEASE IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT
- Trial, AD, NA
*cognitive↑, *other↑,
3881- Carno,    The Therapeutic Potential of Carnosine/Anserine Supplementation against Cognitive Decline: A Systematic Review with Meta-Analysis
- Review, AD, NA
*cognitive↑,
3872- Carno,    Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
- in-vitro, AD, NA
*antiOx↑, *Inflam↓, *Aβ↓, *neuroP↑, *ROS↓, *NO↓,
3869- Carno,    Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *IronCh↑, *AntiAge↑, *antiOx↑, *Inflam↓, *neuroP↑, *lipid-P↓, *toxicity↓, *NOX4↓, *SOD↑, *HNE↓, *IL6↓, *TNF-α↓, *IL1β↓, *Sepsis↓, *eff↑, *GABA↝, *Aβ↓, Glycolysis↓, AntiTum↑, p‑Akt↓, TumCCA↑, angioG↓, VEGFR2/KDR/Flk1↓, NF-kB↓,
5928- Catechins,    Bioavailability of Tea Catechins and Its Improvement
- Review, Nor, NA
*BioAv↝, *BioAv↓, *ROS⇅, *NRF2↑, *BioAv↑, *Half-Life↓, *BioAv↑, *BioAv↑, BioAv↑,
5929- Catechins,    Phase I trial of oral green tea extract in adult patients with solid tumors
- Trial, Var, NA
Dose↑, toxicity↝,
5930- Catechins,    Randomized, Placebo-Controlled Trial of Green Tea Catechins for Prostate Cancer Prevention
- Trial, Pca, NA
PSA↓, other↑, Risk↝,
603- Catechins,    Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
- in-vitro, NA, HL-60
ROS↑, DNAdam↑, H2O2↑,
939- Catechins,  5-FU,    Targeting Lactate Dehydrogenase A with Catechin Resensitizes SNU620/5FU Gastric Cancer Cells to 5-Fluorouracil
- vitro+vivo, GC, SNU620
lactateProd↓, ROS↑, tumCV↓, LDHA↓, mt-ROS↑, proApCas↑,
5916- Cats,  Chemo,    Uncaria tomentosa—Adjuvant Treatment for Breast Cancer: Clinical Trial
- Trial, BC, NA
*DNAdam↓, Neut↓, eff↑, Imm↑, Dose↝,
5922- Cats,    Uncaria tomentosa acts as a potent TNF-α inhibitor through NF-κB
- in-vitro, AML, THP1
NF-kB↓, AP-1↓, TNF-α↓,
5921- Cats,    Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells
- in-vitro, Colon, HT29
ChemoSen↑, Casp↑, DNAdam↑, ROS↑,
5917- Cats,    Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial
- Trial, CRC, NA
Dose↝, *DNArepair↑, toxicity↝, BioAv↝, eff∅,
5920- Cats,    Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours
- in-vivo, Melanoma, B16-BL6
eff↑, Ki-67↓, TumCP↓, Apoptosis↑, TumCG↓,
5919- Cats,  Cisplatin,    Uncaria tomentosa Leaves Decoction Modulates Differently ROS Production in Cancer and Normal Cells, and Effects Cisplatin Cytotoxicity
- in-vitro, Liver, HepG2
ROS↑, GSH↓, Apoptosis↑, Casp3↑, Casp7↑, NF-kB↓, selectivity↑, ChemoSen↑, chemoP↑,
5915- Cats,    Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells
- in-vitro, AML, NA
Apoptosis↑,
5914- Cats,    Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells
- in-vitro, AML, HL-60
*Inflam↓, eff↑, DNAdam↑, Cyt‑c↑, Casp3↑, PARP↑, Fas↑, proCasp8↑, cl‑BID↑, BAX↑, Bcl-xL↑, cl‑Mcl-1↑,
5913- Cats,    Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection
- Review, Nor, NA
*Inflam↓, *NF-kB↓, *DPPH↓, *TNF-α↓, *Imm↑,
5918- Cats,    Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors
- Trial, Var, NA
Dose↝, QoL↑, fatigue↓,
5811- CBC,    The Potential of Cannabichromene (CBC) as a Therapeutic Agent
- Review, Var, NA
*eff?, *Half-Life↝, *Inflam↓,
17- CBC/D,    CBC-1 as a Cynanbungeigenin C derivative inhibits the growth of colorectal cancer through targeting Hedgehog pathway component GLI 1
- in-vivo, CRC, NA
HH↓, Gli1↓, BioAv↓, TumCP↓,
18- CBC/D,    Cynanbungeigenin C and D, a pair of novel epimers from Cynanchum bungei, suppress hedgehog pathway-dependent medulloblastoma by blocking signaling at the level of Gli
- vitro+vivo, MB, NA
HH↓, Gli1↓,
6253- CBC/D,    The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma
- Review, MB, NA
Gli1↓, Dose↝, HH↓, BBB↑,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
5820- CBD,    Cannabidiol effects in stem cells: A systematic review
- Review, Var, NA
*other↑, CSCs↓, SOX2↓, other↝,
5812- CBD,    Cannabidiol oil or placebo in advanced cancer-disease progression and survival: a secondary analysis
- Trial, Var, NA
other∅, OS∅, other∅,
5813- CBD,    Pharmacokinetics of Cannabidiol: A Systematic Review and Meta-Regression Analysis
- Review, Var, NA
Dose↝, BioAv↑, BioAv↓, BioAv↑,
5814- CBD,    Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline
- Review, Var, NA
eff↓,
5815- CBD,    Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
- in-vitro, GBM, NA
TRPV2↑, selectivity↑, ChemoSen↑,
5816- CBD,    Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4
- in-vitro, GBM, NA
TRPV2↑, Ca+2↑, MitoP↑, eff↑,
5817- CBD,    COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
- vitro+vivo, Lung, A549
AntiTum⇅, tumCV↓, Apoptosis↑, eff↓, COX2/PTGS2↑, PPARγ↑,
5818- CBD,    Cannabidiol's cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress
- in-vivo, PC, PANC1
GRP78/BiP↑, ATF4↑, CHOP/DDIT3↑, UPR↑, TumCG↓, ER Stress↑, eff↓,
5819- CBD,    The potential role of cannabidiol (CBD) in lung cancer therapy: a systematic review of preclinical and clinical evidence
- Review, Lung, NA
Apoptosis↑, PPARγ↓, mtDam↑, ROS↑, EMT↓, CD8+↑, NK cell↑, ChemoSen↑, ATP↓, glucose↓, Ca+2↑, TRPV2↑,
1199- CBD,    Cannabidiol improves muscular lipid profile by affecting the expression of fatty acid transporters and inhibiting de novo lipogenesis
- in-vivo, Obesity, NA
lipoGen↓,
1081- CBDA,    Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
- in-vitro, BC, MDA-MB-231
COX2/PTGS2↓, Id1↓, SHARP↑,
5979- CDT,  AgNPs,    Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions
- Review, Var, NA
Fenton↑, eff↑,
5973- CDT,    Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances
- Review, Var, NA
Fenton↑, selectivity↑, eff↑,
5974- CDT,    Chemodynamic nanomaterials for cancer theranostics
- Review, Var, NA
Fenton↑, ROS↑, RadioS↑, other↑, GSH↓, GPx4↓, ChemoSen↑, sonoS↑,
5963- CEL,    Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis
- in-vitro, Liver, Hep3B - in-vitro, Liver, HepG2
Akt↓,
5966- CEL,    Determine whether administering celecoxib during radiotherapy can reduce the risk of recurrence of triple-negative breast cancer. Pilot study
- Trial, BC, NA
Risk↓, eff↑,
5965- CEL,  Cisplatin,    Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
- in-vitro, OS, MG63
COX2/PTGS2↓, ChemoSen↑, MDR1↓, MRP1/ABCC1↓, E-cadherin↓, β-catenin/ZEB1↓, Apoptosis↑, TumCCA↑, TumCG↓, P-gp/ABCB1↓, PI3K↓, Akt↓,
5964- CEL,    Celecoxib pathways: pharmacokinetics and pharmacodynamics
- Review, Var, NA
COX2/PTGS2↓, *Pain↓, *Inflam↓, Apoptosis↑, TumCCA↑, angioG↓, ER Stress↑, VEGF↓, MMP9↓, PDK1 / PDPK1↓, Akt↓, CA↓, CardioT↑,
5962- CEL,    The cyclooxygenase-2 inhibitor celecoxib is a potent inhibitor of human carbonic anhydrase II
- Study, Var, NA
CA↓,
5961- CEL,    Dual Cyclooxygenase and Carbonic Anhydrase Inhibition by Nonsteroidal Anti-Inflammatory Drugs for the Treatment of Cancer
- Review, Var, NA
COX2/PTGS2↓, CA↓,

Showing Research Papers: 2051 to 2100 of 8269
Prev Page 42 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Fenton↑, 3,   GPx4↓, 1,   GSH↓, 2,   H2O2↑, 1,   MDA↓, 1,   ROS↑, 6,   mt-ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   lipoGen↓, 1,   PDK1 / PDPK1↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SHARP↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis↑, 8,   BAX↑, 1,   Bcl-xL↑, 1,   cl‑BID↑, 1,   Casp↑, 1,   Casp3↑, 2,   Casp7↑, 1,   proCasp8↑, 1,   Cyt‑c↑, 1,   Fas↑, 1,   cl‑Mcl-1↑, 1,   proApCas↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

TRPV2↑, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 1,   other∅, 2,   sonoS↑, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

MitoP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

AXIN1↑, 1,   CSCs↓, 2,   EMT↓, 2,   Gli↓, 1,   Gli1↓, 3,   GSK‐3β↓, 1,   HH↓, 4,   Id1↓, 1,   PI3K↓, 1,   SOX2↓, 1,   TumCG↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   CA↓, 3,   Ca+2↑, 2,   E-cadherin↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↑, 1,   MMP9↓, 2,   N-cadherin↓, 1,   Snail↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   ATF4↑, 1,   Hif1a↓, 1,   VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   COX2/PTGS2↑, 1,   Imm↑, 1,   Neut↓, 1,   NF-kB?, 1,   NF-kB↓, 3,   NK cell↑, 1,   PSA↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 4,   BioAv↝, 1,   ChemoSen↑, 6,   Dose↑, 1,   Dose↝, 5,   eff↓, 3,   eff↑, 7,   eff∅, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 1,   selectivity↑, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   Ki-67↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   AntiTum⇅, 1,   CardioT↑, 1,   chemoP↑, 1,   fatigue↓, 1,   hepatoP↑, 1,   OS∅, 1,   QoL↑, 1,   Risk↓, 1,   Risk↝, 1,   toxicity↝, 2,   TumVol↓, 1,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 121

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   DPPH↓, 1,   HNE↓, 1,   HO-1↑, 1,   lipid-P↓, 2,   NOX4↓, 1,   NRF2↑, 2,   ROS↓, 6,   ROS⇅, 1,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 4,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   DNArepair↑, 1,  

Migration(tgid=13) ⓘ

Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 8,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

GABA↝, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   eff?, 1,   eff↑, 1,   Half-Life↓, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   cognitive↑, 4,   memory↑, 1,   memory∅, 1,   neuroP↑, 4,   Pain↓, 1,   toxicity↓, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 41

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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