Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
5989- Chit,    Chitosan: A review of molecular structure, bioactivities and interactions with the human body and micro-organisms
- Review, Var, NA
Wound Healing↑, Imm↑, AntiTum↑,
5991- Chit,    Chitosan-Based Nanoencapsulated Essential Oils: Potential Leads against Breast Cancer Cells in Preclinical Studies
- Review, BC, NA
*other↝, *BioAv↓, eff↑, toxicity↓, eff↑, TumCD↑, Half-Life↑, selectivity↑, EPR↑, ROS↑, Apoptosis↑, eff↑,
5999- Chit,    How chitosan can help against breast cancer
- Review, BC, NA
eff↑, DDS↑, Half-Life↑, eff↑, eff↑,
5998- Chit,    Trial: Chitosan can help reduce AGE levels in patients with prostate cancer.
- Trial, Pca, NA
AGEs↓, Wound Healing↑, Obesity↓,
5997- Chit,    Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU
- in-vivo, Lung, NA
Imm↑, TumMeta↓, eff↑,
5996- Chit,    NEW CHITOSAN-BASED CHEMO PHARMACEUTICAL DELIVERY SYSTEMS FOR TUMOR CANCER TREATMENT: SHORT-REVIEW
- Review, Var, NA
BioAv↑, Wound Healing↑, DDS↑, toxicity↓, eff↑,
5995- Chit,  CUR,    Enhancement of anticancer activity and drug delivery of chitosan-curcumin nanoparticle via molecular docking and simulation analysis
- vitro+vivo, Var, NA
eff↑, EPR↑, DNAdam↑, TumCCA↑, ROS↑, toxicity↓,
5994- Chit,    Anticancer Activity of Chitosan, Chitosan Derivatives, and Their Mechanism of Action
- Review, Var, NA
angioG↓, *Imm↑, *antiOx↑, selectivity↑, other↝, toxicity↓, BioAv↑, eff↝, Half-Life↑, MPT↑, MMP9↓, lipid-P↑, EPR↑, NK cell↑, Casp3↑, Casp8↑, TumCCA↑, ROS↑, DDS↑, VEGF↓, TIMP1↑, ChemoSen↑, eff↑,
5993- Chit,    In vivo stepwise immunomodulation using chitosan nanoparticles as a platform nanotechnology for cancer immunotherapy
- in-vitro, Var, NA
Imm↑,
5992- Chit,    Preparation of chitosan nanoparticles for simultaneous drug delivery of dacarbazine and enoxaparin in melanoma
- in-vitro, Melanoma, B16-F10
eff↑, DDS↑,
5990- Chit,    Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies
- Review, Var, NA
DDS↑, eff↓, *Bacteria↓, *antiOx↑, *Wound Healing↑, *Imm↑, TumCP↓, TumMeta↓, angioG↓, Apoptosis↑, ROS↑, ER Stress↑, BioAv↑, Half-Life↑, eff↑, EPR↑, ChemoSen↑, eff↑,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
4477- Chit,    Recent Advances in Chitosan and its Derivatives in Cancer Treatment
- Review, NA, NA
*BioAv↑, AntiTum↑, eff↑, TumCG↓, angioG↓, TumMeta↓, eff↑, *toxicity↓, other↝,
4476- Chit,    Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial
- Trial, NA, NA
*LDL↓,
4475- Chit,    Cholesterol-lowering properties and safety of chitosan
- Review, Nor, NA
*Weight↝, *LDL↓,
4479- Chit,    Chitosan nanoparticles triggered the induction of ROS-mediated cytoprotective autophagy in cancer cells
- in-vitro, Cerv, HeLa - in-vitro, HCC, SMMC-7721 cell
TumAuto↑, ROS↑, eff↓,
4493- Chit,  Selenate,  Se,    A novel synthetic chitosan selenate (CS) induces apoptosis in A549 lung cancer cells via the Fas/FasL pathway
- in-vitro, Lung, A549
tumCV↓, Apoptosis↑, TumCCA↑, Fas↑, FasL↑, FADD↑, Casp↑,
4481- Chit,    Antioxidant Properties and Redox-Modulating Activity of Chitosan and Its Derivatives: Biomaterials with Application in Cancer Therapy
- Review, Var, NA
*BioAv↑, *toxicity↓, *antiOx↑, AntiCan↑, *Inflam↓, *ROS↓, *lipid-P↓, MDA↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, MDA↑, GSH↓, ChemoSen↑,
4490- Chit,  FA,    Chitosan Nanoparticle-Based Drug Delivery Systems: Advances, Challenges, and Future Perspectives
- Review, NA, NA
EPR↑, *BioAv↑, *eff↑, *other↝, *Insulin↑, *Bacteria↓, eff↑, ChemoSen↑,
4489- Chit,  SeNPs,    Inhibiting Metastasis and Improving Chemosensitivity via Chitosan-Coated Selenium Nanoparticles for Brain Cancer Therapy
- in-vitro, GBM, U87MG
TumCG↓, TumCMig↓, TumCI↓, ChemoSen↑, *BBB↑, eff↑, eff↑, eff↑, selectivity↑, MMP2↓, MMP9↓, EPR↑,
4487- Chit,  PreB,    Unravelling the Role of Chitin and Chitosan in Prebiotic Activity and Correlation With Cancer: A Narrative Review
- Review, NA, NA
*GutMicro↑, Apoptosis↑, BAX↑, Bcl-2↓, *Inflam↓, AntiTum↑,
4482- Chit,    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44
- in-vitro, Lung, A549 - in-vitro, Liver, HepG2
EPR↑, mtDam↑, ROS↑, Apoptosis↑,
428- Chit,  docx,  CUR,    Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer
- vitro+vivo, Lung, H460 - vitro+vivo, Lung, H1299 - vitro+vivo, Lung, A549 - vitro+vivo, Lung, PC9
MDSCs↓, TregCell↓, IL10↓, NK cell↑,
6080- CHL,  VitC,    Protective Effects of Sodium Copper Chlorophyllin and/or Ascorbic Acid Against Barium Chloride-Induced Oxidative Stress in Mouse Brain and Liver
- in-vivo, Nor, NA
*neuroP↑, *MDA↓, *hepatoP↑, *IronCh↑, *ROS↓, *lipid-P↓,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6066- CHL,    The chlorophyllin-induced cell cycle arrest and apoptosis in human breast cancer MCF-7 cells is associated with ERK deactivation and Cyclin D1 depletion
- in-vitro, BC, MCF7
ERK↓, Bcl-2↓, Apoptosis↑,
6078- CHL,    Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
- Review, Nor, NA
*BioAv↑, chemoPv↑, *ROS↓, eff↑,
6074- CHL,    Study Protocol of a Prospective Phase 2 Study of Chlorophyllin for the Management of Brain Radionecrosis in Patients With Diffuse Glioma (CHROME)
- Study, GBM, NA
*Inflam↓,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
6071- CHL,    First-in-human clinical trial of high-dose sodium copper chlorophyllin: Pharmacology and efficacy as a dual immunomodulatory/antiviral agent
- Trial, Nor, NA
*Dose↑, *toxicity↓, *Imm↑,
6081- CHL,    Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review
- Review, Nor, NA
*antiOx↑, *toxicity↓, *BioAv↓, *BioAv↑, *neuroP↑, *Obesity↓, *AntiCan↑, *TumCP↓, *PhotoS↑, *neuroP↑,
6073- CHL,  GEM,    Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis
- in-vitro, PC, NA
ChemoSen↑, eff↑, AntiTum↑, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, GSH↓, ROS↑, HSP70/HSPA5↑,
6067- CHL,    Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
- in-vitro, BC, MCF7
TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CycB/CCNB1↑,
6065- CHL,    Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin
- Review, HCC, NA
*eff↑, *chemoPv↑, *other↝,
6075- CHL,  docx,    The effect of the combination therapy with chlorophyllin, a glutathione transferase P1-1 inhibitor, and docetaxel on triple-negative breast cancer invasion and metastasis in vivo/in vitro
- vitro+vivo, BC, 4T1
TumCMig↓, eff↑, TumMeta↓, TumCCA↑, Trx↓, ROS↓, TumCD↑, GSTP1/GSTπ↓,
6077- CHL,    Cancer chemoprevention by dietary chlorophylls: A 12,000-animal dose-dose matrix biomarker and tumor study
- in-vivo, Var, NA
eff↑, chemoP↑,
6079- CHL,    Chlorophyllin Modulates Gut Microbiota and Inhibits Intestinal Inflammation to Ameliorate Hepatic Fibrosis in Mice
- in-vivo, Nor, NA
*eff↑, *GutMicro↑, *NF-kB↓, *MMPs↑, *TIMP1↓, *Inflam↓, *Dysb↓,
6069- CHL,  PDT,    Anti-Cancer Effect of Chlorophyllin-Assisted Photodynamic Therapy to Induce Apoptosis through Oxidative Stress on Human Cervical Cancer
- in-vitro, Cerv, HeLa
eff↑, ROS↑, Casp8↓, Casp9↑, BAX↑, Cyt‑c↑, Bcl-2↓, AKT1↓,
6068- CHL,    Dietary chlorophyllin inhibits the canonical NF-κB signaling pathway and induces intrinsic apoptosis in a hamster model of oral oncogenesis
- in-vivo, Oral, NA
NF-kB↓, IKKα↓, Apoptosis↓, Bcl-2↑, survivin↓, Casp↑, cl‑PARP↑,
6076- CHL,    Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers
- Human, Nor, NA
eff↑,
6093- CHOC,    The relevance of theobromine for the beneficial effects of cocoa consumption
- Review, Nor, NA - NA, Asthma, NA
*toxicity↓, *eff↑, *Half-Life↑, *eff↑, *Inflam↓, *HDL↑, *Obesity↓,
6094- CHOC,    Impact of Cocoa Products Intake on Plasma and Urine Metabolites: A Review of Targeted and Non-Targeted Studies in Humans
- Human, Nor, NA
*GutMicro↑, *BP↓, *AntiAg↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2/PTGS2↓, iNOS↓, NF-kB↓, chemoP↑,
6084- CHOC,    Cocoa Polyphenols and Their Potential Benefits for Human Health
- Review, Nor, NA - Review, Stroke, NA - Review, IBD, NA
*lipid-P↓, *ROS↓, *Inflam↓, *BP↓, *cardioP↑, *chemoPv↑, *BioAv⇅, *antiOx↑, *Risk↓, *5LO↓, *AntiAg↑, *Imm↑, *NF-kB↓, *other↓, CYP1A1↓, COX2/PTGS2↓, *Obesity↓, *cognitive↑,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6086- CHOC,    Cocoa and Chocolate in Human Health and Disease
- Review, Var, NA
*antiOx↑, *AntiDiabetic↑, *cognitive↑, *AntiAg↑, *AntiAg↑, *LDL↓, *HDL↑, *BP↓, *eff↓, *ROS↓,
6087- CHOC,    Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
- Trial, Nor, NA
*cardioP↑, *Dose↝, *BP↓, *Inflam↓, *AntiAg↑, *Risk↓,
6088- CHOC,    Effect of chocolate on older patients with cancer in palliative care: a randomised controlled study
- Trial, Var, NA
eff↑, *ROS↓, *MDA↓, *GSH↑,
6089- CHOC,    Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
- Trial, Nor, NA
*Dose↝, *BP↓, *cognitive↑,

Showing Research Papers: 2251 to 2300 of 8269
Prev Page 46 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1)

CYP1A1↓, 1,   CYP1A1↑, 1,   GSH↓, 2,   GSH↑, 1,   GSTP1/GSTπ↓, 1,   GSTs↑, 1,   lipid-P↑, 1,   MDA↓, 1,   MDA↑, 1,   ROS↓, 2,   ROS↑, 10,   Trx↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

MMP↓, 2,   MPT↑, 1,   mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4)

AKT1↓, 1,  

Cell Death(tgid=5)

p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 12,   BAX↑, 2,   Bcl-2↓, 3,   Bcl-2↑, 1,   Casp↑, 2,   Casp3↑, 2,   Casp8↓, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   FADD↑, 1,   Fas↑, 1,   FasL↑, 1,   iNOS↓, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7)

other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8)

ER Stress↑, 1,   HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9)

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11)

CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12)

ERK↓, 1,   TumCG↓, 3,  

Migration(tgid=13)

MMP2↓, 1,   MMP9↓, 2,   TIMP1↑, 1,   TregCell↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 8,   TumMeta↓, 5,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 4,   EPR↑, 7,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

COX1↑, 1,   COX2/PTGS2↓, 2,   IKKα↓, 1,   IL10↓, 1,   IL8↓, 1,   Imm↑, 3,   Inflam↓, 2,   MDSCs↓, 1,   NF-kB↓, 3,   NK cell↑, 2,   PGE2↓, 2,  

Protein Aggregation(tgid=19)

AGEs↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↑, 3,   ChemoSen↑, 7,   DDS↑, 5,   eff↓, 2,   eff↑, 26,   eff↝, 1,   Half-Life↑, 4,   selectivity↑, 6,  

Functional Outcomes(tgid=23)

AntiCan↑, 2,   AntiTum↑, 5,   chemoP↑, 2,   chemoPv↑, 3,   Obesity↓, 1,   toxicity↓, 4,   Wound Healing↑, 3,  
Total Targets: 85

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0)

Dysb↓, 1,  

Redox & Oxidative Stress(tgid=1)

antiOx↑, 6,   GSH↑, 1,   HDL↑, 2,   lipid-P↓, 3,   MDA↓, 2,   ROS↓, 8,  

Metal & Cofactor Biology(tgid=2)

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3)

Insulin↑, 1,   MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4)

LDL↓, 3,  

Transcription & Epigenetics(tgid=7)

other↓, 1,   other↝, 3,   PhotoS↑, 1,  

Migration(tgid=13)

5LO↓, 1,   AntiAg↑, 5,   Ca+2↓, 1,   MMPs↑, 1,   TIMP1↓, 1,   TumCP↓, 1,  

Barriers & Transport(tgid=15)

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16)

Imm↑, 4,   Inflam↓, 7,   NF-kB↓, 2,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 3,   BioAv↑, 7,   BioAv⇅, 1,   Dose↑, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 5,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22)

BP↓, 5,   GutMicro↑, 3,  

Functional Outcomes(tgid=23)

AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   chemoPv↑, 3,   cognitive↑, 3,   hepatoP↑, 1,   neuroP↑, 3,   Obesity↓, 3,   Risk↓, 2,   toxicity↓, 6,   Weight↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24)

Bacteria↓, 2,  
Total Targets: 47

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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