toxicity Cancer Research Results

toxicity, toxicity: Click to Expand ⟱
Source:
Type:
Toxicity
Scientific Papers found: Click to Expand⟱
1875- DCA,    Dichloroacetate inhibits neuroblastoma growth by specifically acting against malignant undifferentiated cells
- in-vitro, neuroblastoma, NA - in-vivo, NA, NA
selectivity↑, AntiCan↑, TumVol↓, PDKs↓, mt-OXPHOS↑, MMP↓, Glycolysis↓, toxicity↓, Warburg↓, ROS↑, eff↑,
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
1879- DCA,    Long-term stabilization of metastatic melanoma with sodium dichloroacetate
- Case Report, Melanoma, NA
OS↑, toxicity↓, Dose∅, Dose∅, Dose∅, QoL∅,
1873- DCA,    Dual-targeting of aberrant glucose metabolism in glioblastoma
- in-vitro, GBM, U87MG - in-vitro, GBM, U251
PDKs↓, eff↑, selectivity↑, MMP↓, ROS↑, Apoptosis↑, Warburg↓, eff↑, Dose∅, toxicity∅,
1868- DCA,  MET,    Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy
- Case Report, NA, NA
eff↑, toxicity∅, MMP↓, Apoptosis↑, selectivity↑, pH↝, Dose↝, Dose↝, eff↑,
1889- DCA,    A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
- Review, Var, NA
PDKs↓, Glycolysis↓, mt-H2O2↑, Apoptosis↑, TumCP↓, TumCG↓, toxicity∅,
5194- DCA,    Metabolic modulation of glioblastoma with dichloroacetate
- vitro+vivo, GBM, NA
MMP↓, mt-ROS↑, Apoptosis↑, CSCs↓, Hif1a↓, P53↑, angioG↓, toxicity↓, PDKs↓,
4901- DCA,  Sal,    Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
- Review, NSCLC, NA
Glycolysis↓, OXPHOS↑, PDKs↓, ROS↑, Apoptosis↑, GlucoseCon↓, lactateProd↓, RadioS↑, TumAuto↑, mTOR↓, LC3s↓, p62↑, TumCG↓, OS↑, toxicity↝, ChemoSen↑, eff↑, eff↑, Ferritin↓, CSCs↓, EMT↓, ROS↑, Cyt‑c↑, Casp3↑, ER Stress↑, selectivity↑, eff↑, TumCG↓,
1442- Deg,    Deguelin, a novel anti-tumorigenic agent targeting apoptosis, cell cycle arrest and anti-angiogenesis for cancer chemoprevention
- Review, Var, NA
PI3K/Akt↓, IKKα↓, AMP↓, mTOR↓, survivin↓, NF-kB↓, Apoptosis↑, TumCCA↑, toxicity↓, HSP90↓, Casp↑, TumCG↓, p27↑, cycE/CCNE↓, angioG↓, Hif1a↓, VEGF↓, *toxicity↑,
1446- Deg,    Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells
- in-vitro, BC, 4T1
cMET↓, p‑ERK↓, p‑Akt↓, TumCMig↓, TumCG↓, Weight∅, *toxicity∅, Hif1a↓, TumMeta↓,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1852- dietFMD,  Chemo,    Starvation Based Differential Chemotherapy: 
A Novel Approach for Cancer Treatment
- Review, Var, NA
ChemoSideEff↓, *toxicity↓, mTOR↓, IGF-1↓, IGFBP1↑, BG↓, ROS↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1810- dietKeto,  Oxy,    The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer
- in-vivo, Var, NA
BG↓, TumCG↓, OS↑, eff↑, Dose∅, KeyT↑, eff↑, cachexia↓, ChemoSen↑, *ROS↓, ROS↑, lipid-P↑, selectivity↑, toxicity∅,
5193- dietMet,  Rad,    A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy
- Trial, Var, NA
toxicity↝, other↝,
4913- DSF,    Anticancer effects of disulfiram: a systematic review of in vitro, animal, and human studies
- Review, Var, NA
Apoptosis↑, tumCV↑, eff↑, toxicity↓, antiNeop↑, ChemoSen↑, RadioS↑, OS↑, ROS↑, SOD↓, MMP1↓, eff↑, Half-Life↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
4917- DSF,  Chemo,  Cu,    Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma
- Trial, GBM, NA
OS∅, toxicity↑,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
1618- EA,    A comprehensive review on Ellagic acid in breast cancer treatment: From cellular effects to molecular mechanisms of action
- Review, BC, NA
TumCCA↑, TumCMig↓, TumCI↓, TumMeta↓, Apoptosis↑, TGF-β↓, SMAD3↓, CDK6↓, PI3K↓, Akt↓, angioG↓, VEGFR2↓, MAPK↓, NEDD9↓, NF-kB↓, eff↑, eff↑, RadioS↑, ChemoSen↑, DNAdam↑, eff↑, *toxicity∅, *toxicity∅,
660- EGCG,  FA,    Epigallocatechin-3-gallate Delivered in Nanoparticles Increases Cytotoxicity in Three Breast Carcinoma Cell Lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10
Apoptosis↑, *toxicity↓, *eff↓,
3208- EGCG,    Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α
- in-vitro, Colon, HT29 - in-vitro, Nor, 3T3
TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,
1514- EGCG,    Preferential inhibition by (-)-epigallocatechin-3-gallate of the cell surface NADH oxidase and growth of transformed cells in culture
- in-vitro, Cerv, HeLa - in-vitro, Nor, MCF10
selectivity↑, *toxicity∅, TumCG↓, NADHdeh?, eff↑, ENOX2↓, Dose?,
1516- EGCG,    Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential
- Review, NA, NA
*Dose∅, Half-Life∅, BioAv∅, BBB↑, toxicity∅, eff↓, Apoptosis↑, Casp3↑, Cyt‑c↑, cl‑PARP↑, DNMTs↓, Telomerase↓, angioG↓, Hif1a↓, NF-kB↓, MMPs↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, P53↑, PTEN↑, IGF-1↓, H3↓, HDAC1↓, *LDH↓, *ROS↓,
1324- EMD,    Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin
- Review, Var, NA
*toxicity↑, *BioAv↓, Akt↓, ERK↓, ROS↑, MMP↓, Bcl-2↓, BAX↑, TumCCA↑,
1155- F,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, NA, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
3714- FA,    Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review
- Review, AD, NA
*antiOx↑, *Inflam↓, *neuroP↑, *NF-kB↓, *NLRP3↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL1β↓, *VCAM-1↓, *ICAM-1↓, *p‑MAPK↓, *p38↓, *JNK↓, *IL6↓, *IL8↓, *hepatoP↑, *RenoP↑, *Catalase↑, *PPARγ↑, *ROS↓, *Fenton↓, *IronCh↑, *SOD↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *ARE↑, *Bil↑, *radioP↑, *GCLC↑, *GCLM↑, *NQO1↑, *Half-Life↝, *GutMicro↑, *Aβ↓, *BDNF↑, *Ca+2↓, *lipid-P↓, *PGE2↓, *cognitive↑, *ChAT↑, *memory↑, *Dose↝, *toxicity↓,
3717- FA,    Neuroprotective Properties of Ferulic Acid in Preclinical Models of Alzheimer's Disease: A Systematic Literature Review
- Review, AD, NA
*toxicity↓, *BBB↑, *Aβ↓, *antiOx↑, *Inflam↓, *neuroP↑,
2499- Fenb,  VitE,    Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells
- in-vitro, Pca, PC3
TumCP∅, TumCP↓, toxicity↓, eff↑,
2494- Fenb,    Oral Fenbendazole for Cancer Therapy in Humans and Animals
- Review, Var, NA
Glycolysis↓, GlucoseCon↓, ROS↑, Apoptosis↑, BioAv↓, eff↑, toxicity↓, BioAv↑, BioAv↑, hepatoP↓, eff↑,
1915- Fer,    Vascular Imaging With Ferumoxytol as a Contrast Agent
- Analysis, Var, NA
eff↑, toxicity↓, other?,
2861- FIS,    The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress
- Review, Nor, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
4024- FulvicA,    ANTI-CARCINOGENIC ACTIVITY OF SHILAJIT REGARDING TO APOPTOSIS ASSAY IN CANCER CELLS: A SYSTEMATIC REVIEW OF IN-VITRO STUDIES
- Review, Var, NA
*Inflam↓, *antiOx↑, TumCG↓, tumCV↓, ROS↑, ChemoSen↑, toxicity↝,
4016- FulvicA,    Shilajit: A Natural Phytocomplex with Potential Procognitive Activity
- Review, AD, NA
*tau↓, *AntiAge↑, *Strength↑, *Dose↝, *BioAv↑, *antiOx↑, *memory↑, *Inflam↓, *cognitive↑, *neuroP↑, *toxicity↝, *toxicity↑,
997- GA,    The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H292 - in-vitro, Nor, HUVECs
PD-L1↓, p‑EGFR↓, p‑PI3K↓, p‑Akt↓, P53↑, miR-34a↑, *toxicity↓,
947- GA,    Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells
- in-vitro, Ovarian, OVCAR-3 - in-vitro, Melanoma, A2780S - in-vitro, Nor, IOSE364 - Human, NA, NA
TumCG↓, VEGF↓, angioG↓, p‑Akt↓, Hif1a↓, PTEN↑, BioAv↑, *toxicity↓,
1957- GamB,    Nanoscale Features of Gambogic Acid Induced ROS-Dependent Apoptosis in Esophageal Cancer Cells Imaged by Atomic Force Microscopy
- in-vitro, ESCC, EC9706
AntiCan↑, toxicity↓, TumCP↓, Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, RadioS↑,
794- GAR,    Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression
- in-vitro, RCC, NA - in-vitro, Lung, A549 - in-vitro, Nor, NA
DR5↑, cFLIP↓, *toxicity↓,
1186- Gb,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
842- Gra,    Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola)
- in-vitro, NA, NA - in-vitro, Nor, NA
other↓, *toxicity↓,
841- Gra,    The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach
- in-vitro, CRC, HT-29 - in-vitro, Nor, CCD841
PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,
837- Gra,    Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona muricata Linn. in normal and immortalized human cell lines
- in-vitro, BC, MDA-MB-435 - in-vitro, Nor, WRL68 - in-vitro, Nor, HaCaT
*toxicity↓,
851- Gra,    Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, CV1
Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,
849- Gra,    Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
- in-vitro, Pca, PC3 - in-vitro, Nor, PNT1A - in-vitro, NA, HeLa
Casp9↑, CXCL1↓, *toxicity↓,
2519- H2,    Hydrogen: an advanced and safest gas option for cancer treatment
- Review, Var, NA
antiOx↑, neuroP↓, BBB↑, toxicity∅, TumCP↓, Apoptosis↓, ROS↑, Hif1a↓, NF-kB↓, P53?, OS↑, chemoP↑,
2504- H2,    Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer
- Trial, Lung, NA
CD8+↑, OS↑, eff↝, CoQ10↑, PDT+↓, PGC-1α↑, Dose↝, *toxicity∅,

Showing Research Papers: 201 to 250 of 452
Prev Page 5 of 10 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 452

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   CoQ10↑, 1,   ENOX2↓, 1,   GSTs↑, 1,   mt-H2O2↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   NADHdeh?, 1,   NRF2↑, 1,   OXPHOS↑, 1,   mt-OXPHOS↑, 1,   ROS↑, 16,   mt-ROS↑, 1,   SOD↓, 2,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   Insulin↓, 1,   MMP↓, 7,   OCR↓, 1,   OCR↑, 1,   PGC-1α↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ALAT↓, 1,   AMP↓, 1,   AMPK↑, 1,   p‑AMPK↑, 1,   cMyc↓, 1,   CREB↓, 1,   ECAR↓, 1,   FASN↓, 1,   GlucoseCon↓, 3,   Glycolysis↓, 4,   KeyT↑, 1,   lactateProd↓, 3,   LDH↓, 2,   lipoGen↓, 1,   p‑PDH↑, 1,   PDK1↓, 1,   PDKs↓, 6,   PI3K/Akt↓, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 4,   p‑Akt↓, 3,   Apoptosis↓, 1,   Apoptosis↑, 16,   ATF2↓, 1,   Bak↑, 3,   BAX↑, 5,   Bcl-2↓, 6,   Bcl-xL↓, 2,   BID↑, 1,   Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp7↑, 3,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 4,   cFLIP↓, 1,   Cyt‑c↑, 3,   DR5↑, 1,   Fas↑, 1,   MAPK↓, 2,   Mcl-1↓, 1,   p27↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TumCD↓, 1,  

Transcription & Epigenetics ⓘ

H3↓, 1,   other?, 1,   other↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 2,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   HSP90↓, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

LC3s↓, 1,   p62↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNA-PK↑, 1,   DNAdam↑, 2,   DNMTs↓, 1,   P53?, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↑, 3,   PCNA↓, 2,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   cycE1↓, 1,   P21↑, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CDK8↓, 1,   cMET↓, 1,   CSCs↓, 3,   EMT↓, 4,   ERK↓, 2,   p‑ERK↓, 1,   Gli1↓, 1,   HDAC1↓, 1,   HH↓, 1,   IGF-1↓, 3,   IGF-1↑, 1,   IGFBP1↑, 1,   miR-34a↑, 1,   mTOR↓, 4,   NOTCH↓, 1,   P90RSK↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   PTEN↑, 2,   Shh↓, 2,   Smo↓, 1,   STAT3↓, 1,   Sufu↑, 1,   TumCG↓, 16,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

EM↑, 1,   GLI2↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMPs↓, 1,   NEDD9↓, 1,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TGF-β↓, 2,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 5,   TumCP∅, 1,   TumMeta↓, 4,   Twist↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 10,   ATF4↑, 1,   p‑EGFR↓, 1,   Hif1a↓, 8,   VEGF↓, 5,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,   GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   CXCL1↓, 1,   IKKα↓, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↑, 1,   M2 MC↓, 1,   NF-kB↓, 8,   PD-L1↓, 1,   PDT+↓, 1,  

Cellular Microenvironment ⓘ

IM↓, 1,   pH↝, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 2,   BioAv∅, 1,   ChemoSen↑, 9,   Dose?, 1,   Dose↑, 1,   Dose↝, 5,   Dose∅, 6,   eff↓, 2,   eff↑, 27,   eff↝, 2,   Half-Life↓, 1,   Half-Life∅, 1,   RadioS↑, 8,   selectivity↑, 10,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   BG↓, 4,   p‑EGFR↓, 1,   Ferritin↓, 1,   IL6↓, 1,   LDH↓, 2,   PD-L1↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   antiNeop↑, 1,   AntiTum↑, 1,   cachexia↓, 1,   chemoP↑, 1,   ChemoSideEff↓, 2,   cognitive↑, 1,   hepatoP↓, 1,   neuroP↓, 1,   OS↑, 6,   OS∅, 1,   QoL↑, 1,   QoL∅, 2,   Remission↑, 1,   toxicity↓, 10,   toxicity↑, 1,   toxicity↝, 6,   toxicity∅, 7,   TumVol↓, 1,   Weight∅, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 219

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 5,   ARE↑, 1,   Bil↑, 1,   Catalase↑, 2,   Fenton↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GSH↑, 2,   HO-1↑, 1,   lipid-P↓, 3,   MDA↓, 2,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 1,   OXPHOS↑, 1,   ROS↓, 5,   SOD↑, 2,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Core Metabolism/Glycolysis ⓘ

12LOX↓, 1,   LDH↓, 1,   PPARγ↑, 1,  

Cell Death ⓘ

iNOS↓, 1,   JNK↓, 1,   p‑MAPK↓, 1,   p38↓, 1,  

Migration ⓘ

Ca+2↓, 1,   VCAM-1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↑, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   ICAM-1↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL6↑, 1,   IL8↓, 1,   Inflam↓, 7,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 2,   ChAT↑, 1,   tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 3,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   Dose↝, 2,   Dose∅, 1,   eff↓, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

Bil↑, 1,   GutMicro↑, 1,   IL6↓, 1,   IL6↑, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 1,   cognitive↑, 2,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 5,   radioP↑, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↓, 15,   toxicity↑, 4,   toxicity↝, 1,   toxicity∅, 11,  
Total Targets: 69

Scientific Paper Hit Count for: toxicity, toxicity
31 Silver-NanoParticles
21 Selenium NanoParticles
16 chitosan
15 Magnetic Fields
12 Selenite (Sodium)
12 Sulforaphane (mainly Broccoli)
11 5-Hydroxytryptophan
10 Dichloroacetate
9 3-bromopyruvate
9 Phenylbutyrate
8 Chemotherapy
8 Curcumin
8 Honokiol
7 Ashwagandha(Withaferin A)
7 Baicalein
7 Berberine
7 Carvacrol
6 Apigenin (mainly Parsley)
6 borneol
6 Boron
6 Copper and Cu NanoParticles
6 Metformin
6 EGCG (Epigallocatechin Gallate)
6 Graviola
6 Resveratrol
6 Magnetic Field Rotating
6 Piperlongumine
6 Pterostilbene
6 Selenium
5 Auranofin
5 Allicin (mainly Garlic)
5 HydroxyCitric Acid
5 Cisplatin
5 Artemisinin
5 Radiotherapy/Radiation
5 Capsaicin
5 Shikonin
5 Urolithin
5 Vitamin K2
4 Alpha-Lipoic-Acid
4 beta-glucans
4 Betulinic acid
4 Celastrol
4 Chlorogenic acid
4 salinomycin
4 Disulfiram
4 Hydrogen Gas
4 Propolis -bee glue
4 Phenethyl isothiocyanate
4 Silymarin (Milk Thistle) silibinin
4 Thymoquinone
3 Vitamin C (Ascorbic Acid)
3 SonoDynamic Therapy UltraSound
3 Anti-oxidants
3 Atorvastatin
3 Baicalin
3 Carnosine
3 Chlorophyllin
3 Chrysin
3 diet FMD Fasting Mimicking Diet
3 Oxygen, Hyperbaric
3 Ellagic acid
3 Magnolol
3 Melatonin
3 Bicarbonate(Sodium)
3 Niclosamide (Niclocide)
3 Quercetin
3 Rosmarinic acid
3 Sulfasalazine
2 Astragalus
2 Gold NanoParticles
2 Zinc
2 doxorubicin
2 Ascorbyl Palmitate
2 Arsenic trioxide
2 Aloe anthraquinones
2 Berbamine
2 brusatol
2 Bacopa monnieri
2 Boswellia (frankincense)
2 Thymol-Thymus vulgaris
2 Cinnamon
2 Coenzyme Q10
2 Vitamin E
2 Deguelin
2 immunotherapy
2 Ferulic acid
2 Fenbendazole
2 Shilajit/Fulvic Acid
2 Gallic acid
2 Luteolin
2 Lycopene
2 metronomic chemo
2 Propyl gallate
2 Piperine
2 Psoralidin
2 Ramucirumab (CYRAMZA)
2 Whole Body Vibration
1 Resiquimod
1 Andrographis
1 5-Aminolevulinic acid
1 Aspirin -acetylsalicylic acid
1 Paclitaxel
1 Astaxanthin
1 Dipyridamole
1 Biochanin A
1 Bufalin/Huachansu
1 Brucea javanica
1 Bromelain
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 carboplatin
1 Catechins
1 Cat’s Claw
1 Celecoxib
1 Chocolate
1 Citric Acid
1 Camptothecin
1 irinotecan
1 Black phosphorus
1 chemodynamic therapy
1 Docosahexaenoic Acid
1 diet Ketogenic
1 diet Methionine-Restricted Diet
1 Folic Acid, Vit B9
1 Emodin
1 Fucoidan
1 ferumoxytol
1 Fisetin
1 Gambogic Acid
1 Garcinol
1 Ginkgo biloba
1 Hydroxycinnamic-acid
1 hydroxychloroquine
1 HydroxyTyrosol
1 itraconazole
1 Juglone
1 Laetrile B17 Amygdalin
1 MCToil
1 Methyl Jasmonate
1 magnetic nanoparticles
1 Moringa oleifera
1 Mushroom Lion’s Mane
1 nicotinamide adenine dinucleotide
1 Naringin
1 Oleuropein
1 Peppermint
1 5-fluorouracil
1 sericin
1 Sanguinarine
1 Plumbagin
1 probiotics
1 Bifidobacterium
1 benzo(a)pyrene
1 EMF
1 Date Fruit Extract
1 Docetaxel
1 Taurine
1 Aflavin-3,3′-digallate
1 Vitamin B1/Thiamine
1 Wogonin
1 Xylitol
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1025  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page