hepatoP Cancer Research Results

hepatoP, L,hepatoprotective: Click to Expand ⟱
Source:
Type:
Hepatoprotective is the ability of a chemical substance to prevent damage to the liver.

Grapefruit:
-hepatoprotective potential has emerged from the study of naringenin and naringin.
Blueberries/cranberries:
-proanthocyanidins
Grape:
Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”:
Chamomile (Matricaria chamomilla or Chamomilla recutita):
Silymarin (Silybum marianum):
Blue green algae spirulina :
Propolis (bee glue):

POLYSACCHARIDES
β-glucans
Scientific Papers found: Click to Expand⟱
3837- Moringa,    Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑,
3842- Moringa,    Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *hepatoP↑, *lipid-P↓, *ALAT↓, *AST↓, *ALP↓, *creat↓, *RenoP↑, NF-kB↓, ChemoSen↑, *memory?,
3844- Moringa,    Review of the Safety and Efficacy of Moringa oleifera
- Review, NA, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *radioP↑, *eff↑, *toxicity↓, *ROS↓, *lipid-P↓, *DNAdam↓, *Catalase↑, *SOD↑, *GPx↑, *GSR↑, *GSTs↑, *AST↓, *ALAT↓, *ALP↓, *Bil↓,
2933- NAD,    Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns
- Review, Nor, NA - NA, AD, NA - NA, Diabetic, NA - NA, Stroke, NA - NA, LiverDam, NA - NA, Park, NA
*mtDam↓, *BioAv↝, *BioAv↑, *OS↑, *eff↑, *eff↑, *cognitive↑, *DNAdam↓, *SIRT1↑, *cardioP↑, *ROS↓, *Dose↝, *BioAv↑, *hepatoP↑, *eff↑, *BG↓, *creat↓,
1798- NarG,    Naringenin: A potential flavonoid phytochemical for cancer therapy
- Review, NA, NA
*Inflam↓, *antiOx↓, neuroP↑, hepatoP↑, AntiCan↑, Apoptosis↑, TumCCA↑, angioG↓, ROS↝, SOD↑, TGF-β↓, Treg lymp↓, IL1β↓, *BioAv↝, ChemoSen↑, cardioP↑,
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,
6486- Nimb,    Nimbolide: promising agent for prevention and treatment of chronic diseases
- Review, Var, NA - Review, AD, NA
*other↝, *Inflam↓, AntiCan↑, *Bacteria↓, *AntiViral↑, *neuroP↑, *hepatoP↑, *ROS?, *NRF2↑, *HO-1↑, *TLR4↓, *NF-kB↓, *AChE↓, *Aβ↓, *GSK‐3β↓, *LDL↓, *DNAdam↓, *lipid-P↓, *antiOx↑, *SOD1↑, *GSH↑, *IL6↓, *IL1β↓, *STAT3↓, *GPx↑, *Catalase↑, *MDA↓, *AntiDiabetic↑, *HDL↓, *MCP1/CCL2↓, *VEGF↓, *MMP9↓, *GutMicro↑, TumCP↓, TumCCA↑, TumCMig↓, NF-kB↓, ROS↑, PI3K↓, Akt↓, mTOR↓, ERK↓, EMT↓, TumMeta↓, ChemoSen↑, eff↑, selectivity↑, CDK4↓, CDK6↓, Wnt↓, β-catenin/ZEB1↓, STAT3↓, MMP2↓, Sp1/3/4↓, AP-1↓, P21↑, *AntiArt↑, *IL23↓, *IL17↓, *IFN-γ↓, *HSP70/HSPA5↓,
7290- PacT,  Aidi,    Clinical efficacy and safety of Aidi injection plus paclitaxel-based chemotherapy for advanced non-small cell lung cancer: A meta-analysis of 31 randomized controlled trials following the PRISMA guidelines
Dose↝, QoL↑, hepatoP↑, GastroP↑, chemoP↑, Dose↝,
3251- PBG,    The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways
- Review, AD, NA - Review, Diabetic, NA - Review, Var, NA - in-vitro, Nor, H9c2
*antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *Catalase↑, *HO-1↑, *NO↓, *NOS2↓, *NF-kB↓, *NRF2↑, *hepatoP↑, *MDA↓, *mtDam↓, *GSH↑, *p65↓, *TNF-α↓, *IL1β↓, *NRF2↑, *NRF2↓, *ROS⇅, *BioAv↓, *BioAv↑,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
TumCP↓, Apoptosis↑, ROS↑, TumAuto↑, cl‑Casp3↑, cl‑PARP↑, BAX↑, BAD↑, Bcl-2↓, toxicity↓, hepatoP↑, GSH↓,
5209- PI,    Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells
- in-vitro, Pca, DU145
TumCP↓, TumCMig↓, Apoptosis↑, p‑Akt↓, MMP9↓, p‑mTOR↓, TumMeta↓, *antiOx↓, *Inflam↓, *hepatoP↑, *Imm↑, *AntiCan↑,
5213- PI,    Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation
- in-vitro, Cerv, HeLa
Apoptosis↑, TumCG↓, ROS↑, MMP↓, DNAdam↑, Casp3↑, TumCCA↑, *Inflam↓, *antiOx↓, *hepatoP↑, ChemoSen↑, CSCs↓,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
3587- PI,    Piperine: A review of its biological effects
- Review, Park, NA - Review, AD, NA
*hepatoP↑, *Inflam↓, *neuroP↑, *antiOx↑, *angioG↑, *cardioP↑, *BioAv↑, *P450↓, *eff↑, *BioAv↑, E-cadherin↓, ER(estro)↓, MMP2↓, MMP9↓, VEGF↓, cMyc↓, BAX↑, P53↑, TumCG↓, OS↑, *cognitive↑, *GSK‐3β↓, *GSH↑, *Casp3↓, *Casp9↓, *Cyt‑c↓, *lipid-P↓, *motorD↑, *AChE↓, *memory↑, *cardioP↑, *ROS↓, *PPARγ↑, *ALAT↓, *AST↓, *ALP↓, *AMPK↑, *5HT↑, *SIRT1↑, *eff↑,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
2948- PL,    The promising potential of piperlongumine as an emerging therapeutics for cancer
- Review, Var, NA
tumCV↓, TumCP↓, TumCI↓, angioG↓, EMT↓, TumMeta↓, *hepatoP↑, *lipid-P↓, *GSH↑, cardioP↑, CycB/CCNB1↓, cycD1/CCND1↓, CDK2↓, CDK1↓, CDK4↓, CDK6↓, PCNA↓, Akt↓, mTOR↓, Glycolysis↓, NF-kB↓, IKKα↓, JAK1↓, JAK2↓, STAT3↓, ERK↓, cFos↓, Slug↓, E-cadherin↑, TOP2↓, P53↑, P21↑, Bcl-2↓, BAX↑, Casp3↑, Casp7↑, Casp8↑, p‑HER2/EBBR2↓, HO-1↑, NRF2↑, BIM↑, p‑FOXO3↓, Sp1/3/4↓, cMyc↓, EGFR↓, survivin↓, cMET↓, NQO1↑, SOD2↑, TrxR↓, MDM2↓, p‑eIF2α↑, ATF4↑, CHOP/DDIT3↑, MDA↑, Ki-67↓, MMP9↓, Twist↓, SOX2↓, Nanog↓, OCT4↓, N-cadherin↓, Vim↓, Snail↓, TumW↓, TumCG↓, HK2↓, RB1↓, IL6↓, IL8↓, SOD1↑, RadioS↑, ChemoSen↑, toxicity↓, Sp1/3/4↓, GSH↓, SOD↑,
7431- Poly,    Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression
- vitro+vivo, BC, 4T1
other↝, AntiTum↑, Dose↝, TumCG↓, ALAT↓, AST↓, hepatoP↑, COX2/PTGS2↓, MMP2↓, MMP9↓,
3929- PTS,    New Insights into Dietary Pterostilbene: Sources, Metabolism, and Health Promotion Effects
- Review, Var, NA - Review, Arthritis, NA
*NRF2↑, *BioAv↑, *ROS↓, *Inflam↓, *HO-1↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *hepatoP↑, *neuroP↑, *iNOS↓, *COX2/PTGS2↓, TumMeta↓, SOD2↓, ROS↑, TumCI↓, TumCG↓, HDAC1↓, PTEN↑, BP↓, *GutMicro↑,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3341- QC,    Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *BioAv↑, *GSH↑, *AChE↓, *BChE↓, *H2O2↓, *lipid-P↓, *SOD↑, *SOD2↑, *Catalase↑, *GPx↑, *neuroP↑, *HO-1↑, *cardioP↑, *MDA↓, *NF-kB↓, *IKKα↓, *ROS↓, *PI3K↑, *Akt↑, *hepatoP↑, P53↑, BAX↑, IGF-1R↓, Akt↓, AR↓, TumCP↓, GSH↑, SOD↑, Catalase↑, lipid-P↓, *TNF-α↓, *Ca+2↓,
2303- QC,  doxoR,    Quercetin greatly improved therapeutic index of doxorubicin against 4T1 breast cancer by its opposing effects on HIF-1α in tumor and normal cells
- in-vitro, BC, 4T1 - in-vivo, NA, NA
cardioP↑, hepatoP↑, TumCG↓, OS↑, ChemoSen↑, chemoP↑, Hif1a↓, *Hif1a↑, selectivity↑, TumVol↓, OS↑,
2344- QC,    Quercetin: A natural solution with the potential to combat liver fibrosis
- Review, Nor, NA
*HK2↓, *PFKP↓, *PKM2↓, *hepatoP↑, *ALAT↓, *AST↓, *Glycolysis↓, *lactateProd↓, *GlucoseCon↓, *CXCL1↓, *Inflam↓,
5857- RES,  CAP,  Rad,    Resveratrol and capsaicin as safer radiosensitizers for colorectal cancer compared to 5-fluorouracil
- in-vivo, Var, NA
RadioS↑, hepatoP↝, toxicity↓,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
2443- RES,    Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review
- Review, Var, NA
*antiOx↑, *ROS↓, *PTEN↑, *Akt↓, *Catalase↑, *SOD↑, *ERK↓, *GSH↑, *AMPK↑, *FOXO1↝, *RNS↓, *Catalase↑, *cardioP↑, *PI3K↑, *eNOS↑, hepatoP↑,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2/PTGS2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
3057- RES,    The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*NRF2↑, *Keap1↓, *ROS↓, *Apoptosis↓, *Inflam↓, *antiOx↑, *hepatoP↑, *neuroP↑, *cardioP↑, *RenoP↑, *AntiCan↑, *memory↑, *SOD↑, *GPx↑, *Catalase↑, *MDA↓, *NRF2↑, *HO-1↑, *ROS↓, *Aβ↓, *iNOS↓, *COX2/PTGS2↓, *GSH↑, *HO-1⇅, *SIRT1↑,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑,
3006- RosA,    Rosmarinic acid attenuates glioblastoma cells and spheroids’ growth and EMT/stem-like state by PTEN/PI3K/AKT downregulation and ERK-induced apoptosis
- in-vitro, GBM, U87MG - in-vitro, GBM, LN229
TumCG↓, EMT↓, SIRT1↓, FOXO1↓, NF-kB↓, angioG↓, ROS↓, PTEN↓, PI3K↓, Akt↓, *Inflam↓, *cardioP↑, *hepatoP↑, *neuroP↑, Warburg↓,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,
3618- RosA,    Antioxidant and Antimicrobial Properties of Rosemary (Rosmarinus officinalis, L.): A Review
- Review, AD, NA
*hepatoP↑, *antiOx↑, *angioG↓, *other↓, *Inflam↓, *ROS↓, *IronCh↑, *lipid-P↓, *antiOx↑,
1749- RosA,    Rosmarinic Acid and Related Dietary Supplements: Potential Applications in the Prevention and Treatment of Cancer
- Review, Var, NA
antiOx↑, eff↑, *toxicity↝, *BioAv↑, *ROS↓, SOD↑, Catalase↑, GPx↑, lipid-P↓, P450↓, chemoP↑, hepatoP↑, ChemoSen↑,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
3933- RT,    The Pharmacological Potential of Rutin
- Review, AD, NA - Review, Stroke, NA - Review, Arthritis, NA
*antiOx↑, *neuroP↑, *cardioP↑, *Inflam↓, *TNF-α↓, *IL1β↓, *IL8↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *cognitive↑, *Cartilage↑, *AntiAg↑, *ROS↓, *lipid-P↓, *hepatoP↑, *ALAT↓, *AST↓, *RenoP↑,
6441- SAO,    Sandalwood Album Oil as a Botanical Therapeutic in Dermatology
- Review, PSA, NA
*Inflam↓, *eff↑, *5LO↓, *DPPH↓, *hepatoP↑, *ROS↓, *PGE2↓, *IL1β↓, *IL17↓, *PDE4↓, *tyrosinase↓, *AntiFungal↑, angioG↓, TumCG↓, DNAdam↑, *Snail↑, *Twist↑, *Vim↑, *EMT↓, *toxicity↓,
4729- Se,    Selenium regulates Nrf2 signaling to prevent hepatotoxicity induced by hexavalent chromium in broilers
*ROS↓, *NRF2↑, *GPx1↑, *NQO1↑, *mTOR↑, *Beclin-1/ATG6↓, *ATG5↓, *LC3s↓, *hepatoP↑,
4601- SeNPs,  AgNPs,    Antioxidant and hepatoprotective role of selenium against silver nanoparticles
- in-vivo, Nor, NA
*TAC↑, *CRP↓, *AST↓, *ALAT↓, *toxicity↓, *GSH↑, *SOD↑, *Catalase↑, *hepatoP↑,
4440- SeNPs,  AgNPs,    Selenium, silver, and gold nanoparticles: Emerging strategies for hepatic oxidative stress and inflammation reduction
- Review, NA, NA
*hepatoP↑, *antiOx↑, *Inflam↓, *ROS↓, *SOD↑, *GPx↑, *lipid-P↓,
4441- SeNPs,    The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures
- Review, Nor, NA
*ROS↓, *hepatoP↑, *selenoP↑, *ALAT↓, *AST↓, *GSH↑, *GPx↑, *TNF-α↓, *IL6↓, *NF-kB↓, *p65↓, *Dose⇅,
4443- SeNPs,    Bioogenic selenium and its hepatoprotective activity
- in-vivo, LiverDam, NA
*hepatoP↑, *AST↓, *ALAT↓, *LDH↓, *lipid-P?,
4444- SeNPs,    Antioxidant and Hepatoprotective Efficiency of Selenium Nanoparticles Against Acetaminophen-Induced Hepatic Damage
- in-vivo, LiverDam, NA
*hepatoP↑, *ROS↓, *Catalase↑, *SOD↑, *GSH↑, *DNAdam↓,
4445- SeNPs,  DFE,    A comparative study on the hepatoprotective effect of selenium-nanoparticles and dates flesh extract on carbon tetrachloride induced liver damage in albino rats
- in-vivo, LiverDam, NA
*hepatoP↑, *antiOx↑, *AntiCan↑, *BioAv↑, *toxicity↓, *ROS↓, *MDA↓, *ALAT↓, *Albumin↑, *GSH↑, *SOD↑, *RenoP↑,
4446- SeNPs,    Antioxidant and Hepatoprotective Effects of Moringa oleifera-mediated Selenium Nanoparticles in Diabetic Rats.
- in-vivo, Diabetic, NA
*glucose↓, *antiOx↑, *GPx↑, *Catalase↑, *SOD↑, *ROS↓, *cardioP↑, *HDL↑, *LDL↓, *hepatoP↑, *TNF-α↓, *IL6↓, *IL1β↓, *lipid-P↓, *Inflam↓, *ALAT↓, *AST↓, *ALP↓, *Dose↝, *Dose↝,
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
3300- SIL,    Toward the definition of the mechanism of action of silymarin: activities related to cellular protection from toxic damage induced by chemotherapy
- Review, Var, NA
*ROS↓, *SOD↑, *hepatoP↑, *AST↓, *ALAT↓, *lipid-P↓, *GSH↑, *Catalase↑, *GSTs↑, *GSR↑, *TNF-α↓, *IFN-γ↓, *IL4↓, *IL2↓, *NF-kB↓, *IL10↑, *Inflam↓, COX2/PTGS2↓, Apoptosis↑, ChemoSen↑, PGE2↓, VEGF↓,
3305- SIL,    Silymarin inhibits proliferation of human breast cancer cells via regulation of the MAPK signaling pathway and induction of apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vivo, NA, NA
TumCP↓, tumCV↓, BAX↑, cl‑PARP↑, Casp9↑, p‑JNK↑, Bcl-2↓, p‑p38↓, p‑ERK↓, *toxicity∅, Dose↝, *hepatoP↑, Inflam↓, AntiCan↑,
3307- SIL,    Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
- Review, Var, NA
*NRF2↑, *antiOx↑, *chemoP↑, *Inflam↓, *BioAv↑, eff↑, *NQO1↑, TNF-α↓, IL6↓, *GSH↑, *ROS↓, *MDA↓, eff↑, *hepatoP↑, *GPx↑, *SOD↑, *Catalase↑, *HO-1↑, *neuroP↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, NA, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2/PTGS2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,

Showing Research Papers: 201 to 250 of 295
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 295

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

MYCN↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 2,   GPx↑, 2,   GSH↓, 3,   GSH↑, 2,   HO-1↑, 2,   lipid-P↓, 3,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS↓, 2,   ROS↑, 6,   ROS↝, 2,   mt-ROS↑, 1,   SOD↑, 4,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   MMP↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↑, 1,   cMyc↓, 4,   CREB↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 2,   HK2↓, 2,   lactateProd↓, 2,   SIRT1↓, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 7,   p‑Akt↓, 1,   Apoptosis↑, 6,   ATF2↓, 1,   BAD↑, 1,   BAX↓, 1,   BAX↑, 6,   Bcl-2↓, 4,   Bcl-xL↓, 1,   BIM↑, 1,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 2,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   iNOS↓, 1,   p‑JNK↑, 1,   MAPK↓, 1,   MDM2↓, 1,   p‑p38↓, 1,   survivin↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   p‑eIF2α↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   DNMT1↓, 1,   P53↑, 4,   PARP↑, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 1,   CDK4↓, 2,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 1,   P21↑, 3,   RB1↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 2,   cMET↓, 2,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 3,   p‑ERK↓, 1,   FOXO1↓, 1,   p‑FOXO3↓, 1,   GSK‐3β↑, 1,   HDAC1↓, 1,   HDAC2↓, 1,   IGF-1R↓, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 5,   PTEN↓, 1,   PTEN↑, 3,   SOX2↓, 1,   STAT3↓, 4,   TOP2↓, 1,   TumCG↓, 8,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

AP-1↓, 2,   E-cadherin↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 3,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   Treg lymp↓, 1,   TumCI↓, 3,   TumCMig↓, 4,   TumCP↓, 10,   TumMeta↓, 5,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 6,   ATF4↑, 1,   EGFR↓, 2,   HIF-1↑, 1,   Hif1a↓, 2,   VEGF↓, 4,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   GLUT1↓, 1,   P-gp/ABCB1↓, 1,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 5,   IKKα↓, 1,   IL1β↓, 2,   IL6↓, 3,   IL8↓, 1,   Inflam↓, 3,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 9,   PGE2↓, 1,   TNF-α↓, 4,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   CDK6↓, 2,   ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↑, 1,   BioEnh?, 1,   ChemoSen↑, 11,   Dose↝, 5,   eff↑, 5,   MRP1/ABCC1↓, 1,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AR↓, 1,   AST↓, 2,   BP↓, 1,   EGFR↓, 2,   p‑HER2/EBBR2↓, 1,   IL6↓, 3,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   cardioP↑, 4,   chemoP↑, 3,   chemoPv↑, 1,   hepatoP↑, 8,   hepatoP↝, 1,   neuroP↑, 2,   OS↑, 3,   QoL↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 3,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 185

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   AntiArt↑, 1,   AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 22,   Bil↓, 1,   Catalase↑, 16,   DPPH↓, 1,   Fenton↓, 1,   GPx↑, 12,   GPx1↑, 1,   GSH↑, 18,   GSR↑, 2,   GSTs↑, 3,   H2O2↓, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↑, 8,   HO-1⇅, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 14,   MDA↓, 8,   NQO1↑, 3,   NRF2↓, 1,   NRF2↑, 11,   RNS↓, 1,   ROS?, 1,   ROS↓, 32,   ROS↑, 2,   ROS⇅, 1,   selenoP↑, 1,   SOD↑, 17,   SOD1↑, 1,   SOD2↑, 1,   TAC↑, 2,   Thiols↑, 1,   Trx↑, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 3,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   MMP↑, 1,   mtDam↓, 4,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 14,   AMPK↑, 4,   BUN↓, 1,   CRM↑, 2,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 2,   LDL↓, 2,   NADPH↓, 1,   NADPH↑, 1,   PFKP↓, 1,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↑, 4,   SIRT2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 1,   Casp3↓, 2,   Casp9↓, 2,   Cyt‑c↓, 1,   iNOS↓, 4,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   p38↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↓, 1,   HSPs↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   Beclin-1/ATG6↓, 1,   LC3s↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   ERK↓, 1,   FOXO1↝, 1,   GSK‐3β↓, 2,   IGF-1↓, 1,   mTOR↑, 1,   PI3K↑, 2,   PTEN↑, 1,   STAT3↓, 1,   tyrosinase↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   5LO↝, 1,   AntiAg↑, 3,   Ca+2↓, 1,   Cartilage↑, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   Fibronectin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   Smad7↑, 1,   Snail↑, 1,   TGF-β↓, 1,   Twist↑, 1,   Vim↓, 1,   Vim↑, 1,   α-SMA↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   eNOS↑, 1,   Hif1a↑, 1,   NO↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 6,   CRP↓, 1,   CXCL1↓, 1,   IFN-γ↓, 2,   IKKα↓, 1,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 6,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL6↓, 5,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 21,   MCP1/CCL2↓, 1,   NF-kB↓, 8,   p65↓, 2,   PGE2↓, 1,   TLR4↓, 1,   TNF-α↓, 8,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 3,   BChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 11,   BioAv↝, 9,   Dose⇅, 1,   Dose↝, 8,   eff↑, 7,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 14,   Albumin↑, 1,   ALP↓, 5,   AST↓, 12,   BG↓, 2,   Bil↓, 1,   BP↓, 1,   creat↓, 3,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 5,   LDH↓, 2,   NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   AntiCan↑, 3,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 12,   chemoP↑, 2,   cognitive↑, 3,   hepatoP↑, 41,   memory?, 1,   memory↑, 3,   motorD↓, 1,   motorD↑, 2,   neuroP↑, 13,   OS↑, 1,   PDE4↓, 1,   radioP↑, 2,   RenoP↑, 6,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 2,   Bacteria↑, 1,  
Total Targets: 189

Scientific Paper Hit Count for: hepatoP, L,hepatoprotective
23 Silymarin (Milk Thistle) silibinin
20 Thymoquinone
11 Silver-NanoParticles
10 Baicalein
9 Carvacrol
8 Emodin
7 Resveratrol
7 Ferulic acid
7 Hydrogen Gas
7 Selenium NanoParticles
6 Chlorogenic acid
6 Chrysin
6 Dandelion Root
5 Allicin (mainly Garlic)
5 Curcumin
5 Ashwagandha(Withaferin A)
5 Kaempferol
5 Licochalcone A
5 Piperine
5 Rosmarinic acid
4 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
4 Centella asiatica / Gotu kola → asiaticoside
4 Crocetin
4 EGCG (Epigallocatechin Gallate)
4 Isoliquiritigenin
4 Quercetin
3 Berberine
3 Boron
3 buckwheat sprouts
3 Rutin
3 Chemotherapy
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Radiotherapy/Radiation
3 Hibiscus sabdariffa
3 Honokiol
3 Hyperoside
3 Isobavachalcone
3 Isovitexin
3 Moringa oleifera
3 Shikonin
2 Alpha-Lipoic-Acid
2 isoquercitrin
2 Apigenin (mainly Parsley)
2 Baicalin
2 doxorubicin
2 Betulinic acid
2 Selenium
2 Thymol-Thymus vulgaris
2 Sorafenib (brand name Nexavar)
2 Vitamin C (Ascorbic Acid)
2 Propolis -bee glue
2 methotrexate
2 Hydroxycinnamic-acid
2 Polyphenols
2 Cucurbitacin
2 Date Fruit Extract
2 Fucoidan
2 Graviola
2 Lycopene
2 Vitexin
2 Metformin
2 Magnetic Fields
2 Nimbolide
2 Ursolic acid
1 1,8-Cineole
1 Astragalus
1 Gold NanoParticles
1 Acer okamotoanum
1 Artemisinin
1 Ascorbyl Palmitate
1 Melatonin
1 Astaxanthin
1 Biochanin A
1 Bacopa monnieri
1 Boswellia (frankincense)
1 α-Bisabolol / Chamomile oil
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 Chlorophyllin
1 Choline
1 Chyawanprash
1 Cichoric acid / Chicoric acid
1 Cinnamon
1 Coenzyme Q10
1 Calorie Restriction Mimetics
1 Carvone
1 Diclofenac
1 diet Fermented Foods
1 D-limonene
1 Ellagic acid
1 Ginkgo biloba-EGb 761
1 Eugenol
1 Sesame seeds and Oil
1 Fenbendazole
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Formononetin
1 Gallic acid
1 Ginkgo biloba
1 Ginger/6-Shogaol/Gingerol
1 Grapeseed extract
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Inositol
1 L-ornithine
1 Lactoferrin/Talactoferrin
1 Linalool
1 Luteolin
1 Mung Bean Sprouts
1 Magnetic Field Rotating
1 nicotinamide adenine dinucleotide
1 Naringin
1 Neem
1 Paclitaxel/Taxol
1 Aidi injection
1 Propyl gallate
1 Piperlongumine
1 Pterostilbene
1 Capsaicin
1 α-Santalol/Sandalwood oil
1 Sulforaphane (mainly Broccoli)
1 Cisplatin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1179  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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