IL6 Cancer Research Results

IL6, Interleukin-6: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts.
IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth.
IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin.



Scientific Papers found: Click to Expand⟱
4511- GLA,    Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study
- vitro+vivo, Nor, RAW264.7
*radioP↑, *ROS↓, *DNAdam↓, *IL6↓, *TNF-α↓, *IL10↓, *NF-kB↓, *SOD↑, *Catalase↑, *GSH↑,
7321- Gos,    The potential roles of gossypol as anticancer agent: advances and future directions
- Review, Var, NA
other↝, BioAv↑, Bcl-2↓, Casp3↑, Casp9↑, MOMP↑, ROS↑, ATP↓, mtDam↑, Apoptosis↑, hTERT/TERT↓, Akt↓, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, NRF2↓, ARE↓, ICAM-1↓, CX43/GJA1↓, NF-kB↓, TLR4↓, IL6↓, Inflam↓, CUL5↝, CUL1↝, NOXA↑, TumCI↓, TumCMig↓, TumCA↓, FAK↓, MDM2↓, VEGF↓, angioG↓, HLA-I/II↑, Imm↑, Dose↝, Glycolysis↓, OXPHOS↓,
7481- H2,  Rad,    Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy
- Trial, Var, NA
Dose↝, CRP↓, NLR↓, IL6↓, AntiTum∅, *toxicity↓, Inflam↓, radioP↑, *IBI↑, *ROS↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, eff↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑,
7483- H2,  Cisplatin,    Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism
- in-vivo, Nor, HK-2
RenoP↑, BHB↑, HMGCS2↑, chemoP↑, *IL2↓, *IL6↓, *MCP1/CCL2↓, *TNF-α↓, *KeyT↝, *Inflam↓, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *PGC-1α↑, *BUN↓, *creat↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
7927- H2,    Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
- Human, Asthma, NA
*IL8↓, *IL4↓, *IL6↓, *Inflam↓, *Sepsis↓, *Stroke↓, *antiOx↑, *toxicity↓,
4346- H2,    Medical Application of Hydrogen in Hematological Diseases
- Review, NA, NA
*AntiAg↑, *TNF-α↓, *IL6↓, *IFN-γ↓, *NF-kB↓,
4307- H2,    Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models
- in-vivo, AD, NA
*cognitive↑, *Inflam↓, *ROS↓, *neuroP↑, *memory↑, *BBB↑, *BDNF↑, *TNF-α↓, *Catalase↑, *IL6↓, *Aβ↓, *GABA↓, *Dose↝,
2521- H2,    Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer
- Review, CRC, NA - Review, Lung, NA - Review, BC, NA
Inflam↑, ROS↓, ChemoSen↑, p‑PI3K↓, p‑Akt↓, QoL↑, GutMicro↑, chemoP↑, radioP↑, *NRF2↑, *Catalase↑, *GPx↑, *HO-1↑, *SOD↑, *TNF-α↓, *IL4↓, *IL6↓, ChemoSen↑, Appetite↑, cognitive↑, Pain↓, Sleep↑, other?,
2516- H2,    Hydrogen Gas in Cancer Treatment
- Review, Var, NA
*Half-Life↓, *ROS↓, *selectivity↑, *SOD↑, *HO-1↑, *NRF2↑, *chemoP↑, *radioP↑, ROS↑, *Inflam↓, eff↑, *TNF-α↓, *IL6↓, *cl‑Casp8↑, *Bax:Bcl2↓, *Apoptosis↓, *cardioP↑, *hepatoP↑, *RenoP↑, *chemoP↑, eff↝, chemoP↑, radioP↑, eff↑, TumCG↓, Ki-67↓, VEGF↓, selectivity↑,
2514- H2,    Hydrogen: A Novel Option in Human Disease Treatment
- Review, NA, NA
*Inflam↓, *IL1β↓, *IL6↓, *IL8↓, *IL10↓, *TNF-α↓, *ROS↓, *HO-1↓, *NRF2↑, *ER Stress↓, H2O2↑,
2503- H2,    Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
- Case Report, Lung, NA
TumVol↓, OS↑, Dose↝, Dose↝, CEA↓, CA125↓, CYFRA21-1↓, SIRT1↓, COX2/PTGS2↓, IL1β↓, IL6↓, TNF-α↓, HMGB1↓, NF-kB↓, EP2↓,
2530- H2,    Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases
- Case Report, PSA, NA
eff↑, Dose↝, eff↑, IL6↓, eff↑,
3768- H2,    Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial
- Trial, AD, NA
*ROS↓, *NO↓, *BACE/β-secretase↓, *BDNF↑, *VEGF↑, *p‑tau↓, *MCP1/CCL2↓, *IL6↓, *cognitive↑, *toxicity∅,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3772- H2,    Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *Inflam↓, *ROS↓, *GutMicro↑, *TNF-α↓, *IL6↓, *IL1β↓, *IL10↓, *Catalase↑, *GSH↑,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
3787- H2,    Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis
- Review, AD, NA
*Inflam↓, *antiOx↑, *ROS↓, *other↝, *NF-kB↓, *IL2↓, *IL6↓, *TNF-α↓, *HO-1↑, Apoptosis↑, TumAuto↑, *Sepsis↓, *NLRP3↓, Pyro↑,
3766- H2,    The role of hydrogen in Alzheimer′s disease
- Review, AD, NA
*antiOx↑, *Inflam↓, *AMPK↑, *SIRT1↑, *FOXO↑, *mtDam↓, *neuroP↑, *ROS↓, *p38↓, *cognitive↑, *BDNF↑, *memory↑, *lipid-P↓, *IL6↓, *TNF-α↓, *JNK↓, *NF-kB↓, *NLRP3↓,
1637- HCA,  OLST,    Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators
- in-vivo, Colon, NA
TumVol↓, OS↑, *IL6↓, *NF-kB↓, *eff↑, *Casp3↓, *TNF-α↓, *Catalase↑, *NO↓, *ROS↓, *Inflam↓, *Apoptosis↓,
7468- HNK,    Honokiol and Its Emerging Role in Breast Cancer Therapy
- Review, BC, NA
*ROS↓, *Inflam↓, CSCs↓, ChemoSen↑, BioAv↑, ROS↑, MMP↓, mtDam↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓, BAX↑, p‑STAT3↓, AMPK↑, miR-34a↑, EMT↓, HH↓, Shh↓, Gli1↓, PTCH1↓, NF-kB↓, TNF-α↓, IL6↓, Glycolysis↓, GlucoseCon↓, BioAv↓, BioAv↓, Half-Life↝,
7455- HNK,    Honokiol in cancer: Roles in enhancing combination therapy efficacy and preventing post-transplant malignancies
- Review, Var, NA
ChemoSen↑, Imm↝, *hepatoP↑, *cardioP↑, *neuroP↑, *AntiCan↑, *Inflam↓, *antiOx↑, eff↑, *TNF-α↓, *IL1?, *IL6?,
2871- HNK,    Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling
- in-vivo, Nor, NA
*TNF-α↓, *IL1β↓, *IL6↓, *VEGF↓, *NRF2↑, *SOD2↑, *HO-1↑, *Inflam↓, *Pain↓, *NO↓, toxicity↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp/ABCB1↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP/DDIT3↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2/PTGS2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2885- HNK,    Honokiol: a novel natural agent for cancer prevention and therapy
NF-kB↓, STAT3↓, EGFR↓, mTOR↓, BioAv↝, Inflam↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, cSrc↓, JAK1↓, JAK2↓, ERK↓, Akt↓, PTEN↑, ChemoSen↑, chemoP↑, COX2/PTGS2↓, PGE2↓, TNF-α↓, IL1β↓, IL6↓, Casp3↑, Casp8↑, Casp9↑, cl‑PARP↑, DNAdam↑, Cyt‑c↑, RadioS↑, RAS↓, BBB↑, BioAv↓, Half-Life↝, Half-Life↝, toxicity↓,
7471- Hops,    Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages
- in-vitro, Nor, RAW264.7
*IL6↓, *COX2/PTGS2↓, *iNOS↓, *NO↓, *NF-kB↓, *Inflam↓,
7569- HYP,    Inhibitory effects of hyperoside on lung cancer by inducing apoptosis and suppressing inflammatory response via caspase-3 and NF-κB signaling pathway
- vitro+vivo, Lung, A549
TumCP↓, TumCMig↓, TumCI↓, Casp3↑, Apoptosis↑, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL18↓, TumVol↓, TumW↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7565- HYP,    Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review
- Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *lipid-P↓, *ROS↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *MDA↓, *BAX↓, *Casp3↓, *Catalase↑, *SOD↑, *GSH↑, *BDNF↑, *TrkB↑, *NGF↑, *BDNF↑, *NF-kB↓, *AChE↓, *H2S↑, Casp3↑, Apoptosis↑, NF-kB↓, AMPK↑, HO-1↑, MAPK↑, cl‑Casp3↑, cl‑Casp9↑, BAX↑, SOD?, Catalase↓, NRF2↓, NQO1↓, HO-1↓, Bcl-2↓, TumCCA↑, FOXO1↑, TumAuto↑, Akt↓, mTOR↓, P70S6K↓, BMP7/OP1↓, *cardioP↑, *hepatoP↑, *antiCG↑, *AntiThr↑, *Diar↓, *AntiFungal↑, *CYP2D6↓, *PDGFR-BB↓, *PDGFRB↓, *toxicity↓, *Half-Life↑,
7563- HYP,    Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury
- vitro+vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NOX4↓, *NOX2↓, *NOX1↓, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *neuroP↑,
7560- HYP,    Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
- Review, Nor, NA - Review, AD, NA
*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,
7615- Ins,    A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia
*Dose↝, *IL6↓, *PI3K↓,
7629- Ins,    Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol
- in-vivo, Lung, NA
AntiCan↑, TumVol↓, PI3K↓, IL6↓, p‑STAT3↓, chemoPv↑,
7702- IP6,  Ins,  capec,    Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model
- in-vivo, CRC, NA
Dose↝, AntiTum↑, OS↑, TumW↓, TumMeta↓, E-cadherin↑, N-cadherin↓, Vim↓, TNF-α↓, IL6↓, IL8↓, ChemoSen↑,
7760- ISL,    Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability
- Review, Nor, NA
*BioAv↓, GlucoseCon↓, LDH↓, PDK1 / PDPK1↓, Glycolysis↓, mt-OXPHOS↓, Bax:Bcl2↓, cl‑Casp3↑, cl‑Casp9↑, Apoptosis↑, Hif1a↓, ROS↑, *AntiDiabetic↑, *cardioP↑, *RenoP↑, *ROS↓, *NF-kB↓, *NLRP3↓, *Pyro↓, *antiPs↑, *IL6↓, *IL8↓, BioAv↑, BioAv↑, BioAv↑,
7781- ISL,    Perspectives on the Role of Isoliquiritigenin in Cancer
- Review, Var, NA
*BioAv↝, *BBB↓, *BioAv↑, selectivity↑, *neuroP↑, *Inflam↓, NF-kB↓, TNF-α↓, IL6↓, IL1β↓, IL10↓, ICAM-1↓, COX2/PTGS2↓, PPARγ↑, MMP2↓, cFos↓, VEGF↓, CHOP/DDIT3↓, CTSK↓, CycB/CCNB1↑, cycD1/CCND1↑, TOP2↑, PI3K↓, Akt↓, mTOR↓, MMP9↓, TIMP1↓, ChemoSen↑, CSCs↓,
7784- ISL,    Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
- in-vivo, AD, NA
*Learn↑, *PSD95↑, *BDNF↑, *SOD↑, *GPx↑, *Bcl-2↑, *SYP↑, *Bax:Bcl2↓, *TNF-α↓, *IL1β↓, *IL6↓, *MIP‑1α/CCL3↓, *p‑GSK‐3β↑, *NRF2↑, *HO-1↑, *NQO1↑, *cognitive↑, *Inflam↓,
7780- ISL,    Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response
- in-vivo, Nor, NA
*hepatoP↑, *ROS↓, *PGC-1α↝, *NRF2↑, *HO-1↑, *NQO1↝, *Keap1↝, *GCLC↝, *GCLM↝, *NLRP3↓, *IL1β↓, *IL6↓, *TNF-α↓, *MIP2↓, *Bax:Bcl2↓, *cl‑Casp3↓, *Inflam↓, *Apoptosis↓,
7779- ISL,    Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury
- in-vivo, Alcohol, NA
*hepatoP↑, *FAM↑, *PGC-1α↑, *PPARα↑, *CPT1A↑, *ACADS/SCAD↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *miR-23a-3p↓,
7864- isoO,    Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, AD, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓, *Apoptosis↓, *Bcl-2↑, *BAX↓, *cl‑Casp9↓, *cl‑Casp3↓, *cl‑PARP↓, *NeuroI↓,
7861- isoO,    Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *GSK‐3β↓, *TNF-α↓, *IL6↓, *IL1β↓, *p‑GSK‐3β↑, *eff↑, *COX2/PTGS2↓, *ERK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *OCLN↑, *ZO-1↑, *BBB↝,
7886- isoO,    Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo
- vitro+vivo, Nor, NA
*TNF-α↓, *IL6↓, *NF-kB↓, *ERK↓,
7884- isoO,    Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome
- in-vitro, Nor, RAW264.7
*TNF-α↓, *IL6↓, *IL1β↓, *IL18↓, *PGE2↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *NF-kB↓, *NLRP3↓,
7883- isoO,    Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa
- vitro+vivo, Nor, RAW264.7
*Inflam↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *5LO↓, *IL1β↓, *Catalase↑, *GSTs↑,
7875- isoO,    Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway
- in-vitro, Nor, BV2
*iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↓, *ROS↓, *NF-kB↓,
7874- isoO,    Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways
- in-vivo, Nor, NA
*ROS↓, *IL6↓, *NRF2↑, *HO-1↑, *Keap1↓, *NOD1↓, *NLRP3↓, *Casp1↓, *ASC↓, *IL1β↓, *Apoptosis↓,
7837- ISQ,    Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation
- in-vivo, Nor, NA
*Dose↝, *autophagy↓, *ATG7↓, *BNIP3↓, *LC3B↓, *PINK1↓, *ROS↓, *SOD1↑, *SOD2↑, *NRF2↑, *NQO1↑, *HO-1↑, *NOX2↓, *NOX4↓, *DUOX1↓, *IL1β↓, *IL6↓, *TNF-α↓, *JAK↓, *STAT3↓, *Inflam↓,
8034- IVM,  doxoR,    Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation
- in-vitro, Oral, NA
tumCV↓, selectivity↑, TumCCA↑, Apoptosis↓, BAX↑, Casp3↑, P53↑, Bcl-2↓, Ki-67↓, IL6↓, ROS↑, mtDam↑,

Showing Research Papers: 201 to 250 of 413
Prev Page 5 of 9 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 413

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0)

BHB↑, 1,   BMP7/OP1↓, 2,   CD47↓, 1,   CTSK↓, 1,   CUL1↝, 1,   CUL5↝, 1,   CX43/GJA1↓, 1,   HLA-I/II↑, 1,   HMGCS2↑, 1,   miR-124-3p↓, 1,   MTA1↓, 1,   NLR↓, 1,   PFS↑, 1,  

Redox & Oxidative Stress(tgid=1)

ARE↓, 1,   Catalase↓, 3,   GSH↓, 2,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 1,   MDA↑, 1,   NQO1↓, 1,   NRF2↓, 2,   OXPHOS↓, 1,   mt-OXPHOS↓, 1,   ROS↓, 2,   ROS↑, 6,   SOD?, 1,   SOD↓, 2,   TAC↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

ATP↓, 1,   MMP↓, 2,   mtDam↑, 3,   PGC-1α↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4)

AMPK↑, 2,   GlucoseCon↓, 2,   Glycolysis↓, 3,   LDH↓, 1,   PDK1 / PDPK1↓, 1,   PPARγ↑, 1,   SCD1↓, 1,   SIRT1↓, 1,  

Cell Death(tgid=5)

Akt↓, 8,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 7,   BAD↑, 1,   Bak↑, 1,   BAX↑, 5,   Bax:Bcl2↓, 1,   Bcl-2↓, 7,   Bcl-xL↓, 2,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp8↑, 3,   Casp9↑, 3,   cl‑Casp9↑, 3,   cFLIP↓, 1,   Cyt‑c↑, 2,   Fas↑, 1,   hTERT/TERT↓, 1,   IAP2/BIRC3↓, 1,   MAPK↑, 1,   MDM2↓, 1,   MOMP↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 1,   Pyro↑, 1,  

Kinase & Signal Transduction(tgid=6)

cSrc↓, 1,  

Transcription & Epigenetics(tgid=7)

EZH2↓, 1,   other?, 1,   other↝, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8)

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

Autophagy & Lysosomes(tgid=9)

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   TumAuto↑, 4,  

DNA Damage & Repair(tgid=10)

DNAdam↑, 1,   P53↑, 2,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11)

CDK4↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12)

CD133↓, 1,   cFos↓, 1,   p‑cMET↑, 1,   CSCs↓, 2,   EMT↓, 1,   EP2↓, 1,   ERK↓, 2,   FOXO1↑, 1,   Gli1↓, 1,   HDAC↓, 1,   HH↓, 1,   miR-34a↑, 1,   mTOR↓, 5,   Nestin↓, 1,   P70S6K↓, 2,   PI3K↓, 4,   p‑PI3K↓, 1,   PTCH1↓, 1,   PTEN↑, 1,   RAS↓, 1,   RAS↑, 1,   Shh↓, 2,   STAT3↓, 1,   p‑STAT3↓, 3,   TOP2↑, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration(tgid=13)

CEA↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   Ki-67↓, 2,   LRP1↓, 1,   MALAT1↓, 1,   MMP2↓, 2,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   TIMP1↓, 1,   TIMP2↓, 1,   TumCA↓, 1,   TumCI↓, 6,   TumCMig↓, 5,   TumCP↓, 4,   TumMeta↓, 2,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14)

angioG↓, 2,   EGFR↓, 2,   Hif1a↓, 2,   VEGF↓, 7,  

Barriers & Transport(tgid=15)

BBB↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

COX2/PTGS2↓, 3,   CRP↓, 1,   CXCR4↓, 1,   HMGB1↓, 1,   ICAM-1↓, 2,   IL10↓, 1,   IL18↓, 1,   IL1β↓, 5,   IL6↓, 12,   IL8↓, 2,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 3,   Inflam↑, 1,   JAK1↓, 1,   JAK2↓, 1,   NF-kB↓, 9,   NK cell↑, 1,   PD-L1↓, 1,   PGE2↓, 1,   TLR4↓, 2,   TNF-α↓, 7,  

Protein Aggregation(tgid=19)

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20)

CDK6↑, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 3,   BioAv↑, 5,   BioAv↝, 1,   ChemoSen↑, 10,   Dose↝, 8,   eff↑, 8,   eff↝, 1,   eff∅, 1,   Half-Life↝, 3,   RadioS↑, 1,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22)

BMPs↑, 1,   CA125↓, 1,   CEA↓, 1,   CRP↓, 1,   CYFRA21-1↓, 1,   EGFR↓, 2,   EZH2↓, 1,   GutMicro↑, 1,   hTERT/TERT↓, 1,   IL6↓, 12,   Ki-67↓, 2,   LDH↓, 1,   PD-L1↓, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 2,   AntiTum↑, 1,   AntiTum∅, 1,   Appetite↑, 1,   chemoP↑, 8,   chemoPv↑, 1,   cognitive↑, 1,   NP/CIPN↓, 1,   OS↑, 3,   Pain↓, 1,   QoL↑, 3,   radioP↑, 6,   RenoP↑, 1,   Sleep↑, 1,   toxicity↓, 2,   TumVol↓, 6,   TumW↓, 3,  

Infection & Microbiome(tgid=24)

CD8+↑, 2,  
Total Targets: 208

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0)

ACADS/SCAD↑, 1,   AntiArt↑, 1,   antiCG↑, 1,   antiD↓, 1,   autophagy↓, 1,   compII↑, 1,   CYP2D6↓, 1,   DUOX1↓, 1,   FAM↑, 1,   Learn↑, 1,   miR-23a-3p↓, 1,   NeuroI↓, 1,   NOD1↓, 1,   NOX1↓, 1,   NOX2↓, 2,   SpO2↑, 1,   Stroke↓, 4,   SYP↑, 1,  

Redox & Oxidative Stress(tgid=1)

antiOx↑, 12,   Catalase↑, 13,   Fenton↓, 1,   GCLC↝, 1,   GCLM↝, 1,   GPx↑, 4,   GPx1↑, 1,   GSH↑, 5,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 15,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 3,   MDA↓, 7,   MFN2↑, 1,   MPO↓, 2,   NOX4↓, 3,   NQO1↑, 2,   NQO1↝, 1,   NRF2↑, 16,   RNS↓, 1,   ROS↓, 28,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 9,   SOD1↑, 1,   SOD2↑, 2,   TBARS↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3)

ATP↑, 2,   compIII↑, 1,   MMP↑, 2,   mtDam↓, 1,   PGC-1α↑, 2,   PGC-1α↝, 1,   PINK1↓, 1,  

Core Metabolism/Glycolysis(tgid=4)

ALAT↓, 5,   AMPK↑, 2,   ATG7↓, 1,   BUN↓, 3,   CPT1A↑, 1,   H2S↑, 1,   KeyT↝, 1,   LDL↓, 2,   NADPH↓, 4,   PPARα↑, 1,   SIRT1↑, 4,  

Cell Death(tgid=5)

Akt↓, 1,   Akt↑, 3,   p‑Akt↑, 1,   Apoptosis↓, 7,   BAX↓, 3,   Bax:Bcl2↓, 3,   Bcl-2↑, 4,   Bcl-xL↑, 1,   Casp1↓, 2,   Casp12↓, 1,   Casp3↓, 6,   cl‑Casp3↓, 2,   cl‑Casp8↑, 1,   Casp9↓, 2,   cl‑Casp9↓, 1,   GranB/GZMB↓, 1,   iNOS↓, 5,   JNK↓, 1,   p‑JNK↓, 1,   p38↓, 2,   Pyro↓, 1,   TUNEL↓, 1,  

Transcription & Epigenetics(tgid=7)

AntiThr↑, 2,   other↓, 1,   other↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8)

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9)

BNIP3↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↓, 1,  

DNA Damage & Repair(tgid=10)

DNAdam↓, 2,   cl‑PARP↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12)

EMT↓, 1,   ERK↓, 2,   FOXO↑, 1,   FOXO3↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 2,   mTOR↓, 2,   p‑mTOR↓, 2,   PDGFRB↓, 1,   PI3K↓, 1,   PI3K↑, 3,   PTEN↓, 1,   STAT3↓, 1,   STAT3↑, 1,  

Migration(tgid=13)

5LO↓, 1,   AntiAg↑, 2,   APP↓, 1,   BACH1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   PAI-1/SERPINE1↓, 1,   p‑Rac1↓, 1,   TGF-β↑, 1,   Treg lymp↝, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   VCAM-1↓, 1,   Vim↓, 1,   ZO-1↑, 2,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14)

ATF4↓, 1,   NO↓, 6,   PDGFR-BB↓, 1,   VEGF↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15)

BBB↓, 1,   BBB↑, 2,   BBB↝, 2,   IBI↑, 2,   OCLN↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16)

ASC↓, 2,   CD25+↑, 1,   CD4+↑, 2,   COX2/PTGS2↓, 9,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IKKα↑, 1,   IL1?, 1,   IL10↓, 4,   IL10↑, 2,   IL18↓, 1,   IL1β↓, 19,   IL2↓, 2,   IL4↓, 3,   IL4↑, 1,   IL6?, 1,   IL6↓, 37,   IL8↓, 5,   Imm↑, 1,   Inflam↓, 27,   JAK↓, 1,   JAK2↑, 1,   LPS↓, 2,   M2 MC↑, 1,   MCP1/CCL2↓, 3,   MIP‑1α/CCL3↓, 1,   MIP2↓, 1,   NF-kB↓, 17,   PGE2↓, 3,   TLR4↓, 3,   TNF-α↓, 32,  

Cellular Microenvironment(tgid=17)

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18)

AChE↓, 1,   BDNF↑, 7,   GABA↓, 1,   NGF↑, 2,   PSD95↑, 1,   p‑tau↓, 1,   TrkB↑, 2,  

Protein Aggregation(tgid=19)

Aβ↓, 3,   BACE/β-secretase↓, 2,   NLRP3↓, 11,  

Hormonal & Nuclear Receptors(tgid=20)

BNP↓, 1,  

Drug Metabolism & Resistance(tgid=21)

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 7,   eff↑, 5,   Half-Life↓, 1,   Half-Life↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22)

ALAT↓, 5,   ALP↓, 1,   AST↓, 6,   creat↓, 3,   GutMicro↑, 2,   IL6?, 1,   IL6↓, 37,   Urea↓, 1,  

Functional Outcomes(tgid=23)

AntiCan↑, 2,   AntiDiabetic↑, 1,   antiPs↑, 2,   cardioP↑, 10,   chemoP↑, 3,   cognitive↑, 7,   hepatoP↑, 11,   memory↑, 3,   neuroP?, 1,   neuroP↑, 12,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 6,   toxicity↓, 4,   toxicity∅, 1,   Weight↑, 1,  

Infection & Microbiome(tgid=24)

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,   Diar↓, 1,   Sepsis↓, 6,  
Total Targets: 233

Scientific Paper Hit Count for: IL6, Interleukin-6
19 Hydrogen Gas
15 Curcumin
15 Quercetin
12 Lycopene
12 Sulforaphane (mainly Broccoli)
9 EGCG (Epigallocatechin Gallate)
9 Magnetic Fields
8 Propolis -bee glue
8 Resveratrol
8 Silymarin (Milk Thistle) silibinin
8 Shikonin
8 Thymoquinone
7 Baicalein
7 Beta-Caryophyllene
7 Celastrol
7 isoorientin
7 Urolithin
6 Artemisinin
6 Berberine
6 Boron
6 Rosmarinic acid
5 Alpha-Lipoic-Acid
5 Ashwagandha(Withaferin A)
5 Cisplatin
5 Crocetin
5 Eugenol
5 Honokiol
5 Hyperoside
5 Isoliquiritigenin
5 Luteolin
4 Silver-NanoParticles
4 Apigenin (mainly Parsley)
4 Isovitexin
4 Boswellia (frankincense)
4 α-Bisabolol / Chamomile oil
4 Chemotherapy
4 Chlorogenic acid
4 Piperine
4 Ellagic acid
4 Emodin
4 Folic Acid, Vit B9
4 Fisetin
4 lambertianic acid
4 Piperlongumine
4 Vitamin C (Ascorbic Acid)
3 Allicin (mainly Garlic)
3 Melatonin
3 Butyrate
3 Caffeic acid
3 Ferulic acid
3 Inositol
3 Kaempferol
3 Lactoferrin/Talactoferrin
3 Magnetic Field Rotating
3 Pterostilbene
3 Selenite (Sodium)
2 Auranofin
2 Astragalus
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Anethole/trans-Anethole
2 Ascorbyl Palmitate
2 Astaxanthin
2 Aloe anthraquinones
2 beta-glucans
2 Baicalin
2 Betulinic acid
2 borneol
2 Selenium
2 Capsaicin
2 Carvacrol
2 Chrysin
2 Coenzyme Q10
2 Ursolic acid
2 eicosapentaenoic acid
2 diet Fermented Foods
2 Dandelion Root
2 Radiotherapy/Radiation
2 Vitamin B12
2 Formononetin
2 Gallic acid
2 Paclitaxel/Taxol
2 Germanium Organic/Ge-132 / propagermanium (organogermanium)
2 Licochalcone A
2 Nimbolide
2 Rutin
2 Selenium NanoParticles
1 1,8-Cineole
1 2-DeoxyGlucose
1 Annona atemoya Seed Extract
1 alpha Linolenic acid
1 Andrographis
1 Fennel Oil/Foeniculum vulgare
1 Atorvastatin
1 immunotherapy
1 Berbamine
1 Biochanin A
1 xanthohumol
1 Bacopa monnieri
1 Bruteridin(bergamot juice)
1 buckwheat sprouts
1 Carnosine
1 Centella asiatica / Gotu kola → asiaticoside
1 Chyawanprash
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Oxygen, Hyperbaric
1 Cynaropicrin
1 Docosahexaenoic Acid
1 diet Short Term Fasting
1 D-limonene
1 Ginkgo biloba-EGb 761
1 Tetrahydroxystilbene glucoside
1 Electrical Pulses
1 Exercise
1 Sesame seeds and Oil
1 Gamma-aminobutyric acid
1 Galloflavin
1 Gambogic Acid
1 Garcinol
1 Ginkgo biloba
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Ginkgetin
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gossypol/AT-101
1 HydroxyCitric Acid
1 Orlistat
1 Hops (Humulus lupulus)
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 capecitabine
1 isoquercitrin
1 Ivermectin
1 doxorubicin
1 Juglone
1 Potassium
1 Licorice
1 Linalool
1 5-fluorouracil
1 Methylsulfonylmethane
1 Naringin
1 Niclosamide (Niclocide)
1 Oleuropein
1 probiotics
1 Bifidobacterium
1 Phosphatidylserine
1 Perilla
1 Rauwolfia serpentina/Indian Snakeroot
1 Docetaxel
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Turmerones
1 Vitamin B3,Niacin
1 Vitexin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:158  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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