| Source: HalifaxProj(inhibit) |
| Type: |
| Interleukin-6 (IL-6) is a cytokine that plays a significant role in inflammation and the immune response. It is produced by various cell types, including T cells, B cells, macrophages, and fibroblasts. IL-6 can promote tumor cell proliferation and survival. Many cancer cells produce IL-6, which can create an autocrine loop that supports their growth. IL-6 is a high-value inflammatory biomarker in cancer, reporting cytokine burden, catabolic stress, and STAT3-linked survival signaling. While not tumor-specific, elevated and rising IL-6 strongly predicts poor prognosis and limited treatment tolerance, making it an important system-state indicator alongside CRP and ferritin. |
| 4511- | GLA, | Gamma-Linolenic Acid (GLA) Protects against Ionizing Radiation-Induced Damage: An In Vitro and In Vivo Study |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7321- | Gos, | The potential roles of gossypol as anticancer agent: advances and future directions |
| - | Review, | Var, | NA |
| 7481- | H2, | Rad, | Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy |
| - | Trial, | Var, | NA |
| 7482- | H2, | Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application |
| - | Review, | Var, | NA | - | Review, | IBD, | NA | - | Review, | Stroke, | NA | - | Review, | Sepsis, | NA | - | Review, | AD, | NA |
| 7483- | H2, | Cisplatin, | Molecular hydrogen attenuates cisplatin-induced nephrotoxicity by modulating β-hydroxybutyrate metabolism |
| - | in-vivo, | Nor, | HK-2 |
| 7489- | H2, | Molecular Hydrogen in the Treatment of Respiratory Diseases |
| - | Review, | Asthma, | NA |
| 7492- | H2, | Chemo, | Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation |
| - | Review, | Var, | NA |
| 7927- | H2, | Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients |
| - | Human, | Asthma, | NA |
| 4346- | H2, | Medical Application of Hydrogen in Hematological Diseases |
| - | Review, | NA, | NA |
| 4307- | H2, | Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models |
| - | in-vivo, | AD, | NA |
| 2521- | H2, | Oxyhydrogen Gas: A Promising Therapeutic Approach for Lung, Breast and Colorectal Cancer |
| - | Review, | CRC, | NA | - | Review, | Lung, | NA | - | Review, | BC, | NA |
| 2516- | H2, | Hydrogen Gas in Cancer Treatment |
| - | Review, | Var, | NA |
| 2514- | H2, | Hydrogen: A Novel Option in Human Disease Treatment |
| - | Review, | NA, | NA |
| 2503- | H2, | Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report |
| - | Case Report, | Lung, | NA |
| 2530- | H2, | Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases |
| - | Case Report, | PSA, | NA |
| 3768- | H2, | Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial |
| - | Trial, | AD, | NA |
| 3770- | H2, | Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases |
| - | Review, | AD, | NA | - | Review, | Park, | NA |
| 3772- | H2, | Therapeutic potential of hydrogen-rich water in zebrafish model of Alzheimer’s disease: targeting oxidative stress, inflammation, and the gut-brain axis |
| - | in-vivo, | AD, | NA |
| 3773- | H2, | Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases |
| - | Review, | Park, | NA |
| 3787- | H2, | Hydrogen, a Novel Therapeutic Molecule, Regulates Oxidative Stress, Inflammation, and Apoptosis |
| - | Review, | AD, | NA |
| 3766- | H2, | The role of hydrogen in Alzheimer′s disease |
| - | Review, | AD, | NA |
| 1637- | HCA, | OLST, | Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators |
| - | in-vivo, | Colon, | NA |
| 7468- | HNK, | Honokiol and Its Emerging Role in Breast Cancer Therapy |
| - | Review, | BC, | NA |
| 7455- | HNK, | Honokiol in cancer: Roles in enhancing combination therapy efficacy and preventing post-transplant malignancies |
| - | Review, | Var, | NA |
| 2871- | HNK, | Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling |
| - | in-vivo, | Nor, | NA |
| 2868- | HNK, | Honokiol: A review of its pharmacological potential and therapeutic insights |
| - | Review, | Var, | NA | - | Review, | Sepsis, | NA |
| 2885- | HNK, | Honokiol: a novel natural agent for cancer prevention and therapy |
| 7471- | Hops, | Spent hops (Humulus Lupulus L.) extract as modulator of the inflammatory response in lipopolysaccharide stimulated RAW 264.7 macrophages |
| - | in-vitro, | Nor, | RAW264.7 |
| 7569- | HYP, | Inhibitory effects of hyperoside on lung cancer by inducing apoptosis and suppressing inflammatory response via caspase-3 and NF-κB signaling pathway |
| - | vitro+vivo, | Lung, | A549 |
| 7567- | HYP, | Hyperoside: A review on its sources, biological activities, and molecular mechanisms |
| - | Review, | Var, | NA |
| 7565- | HYP, | Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review |
| - | Review, | AD, | NA |
| 7563- | HYP, | Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury |
| - | vitro+vivo, | Nor, | NA |
| 7560- | HYP, | Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity |
| - | Review, | Nor, | NA | - | Review, | AD, | NA |
| 7615- | Ins, | A Randomized Phase IIb Trial of myo-Inositol in Smokers with Bronchial Dysplasia |
| 7629- | Ins, | Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol |
| - | in-vivo, | Lung, | NA |
| 7702- | IP6, | Ins, | capec, | Inositol Hexakisphosphate and Inositol Enhance the Inhibition of Colorectal Cancer Growth and Liver Metastasis by Capecitabine in a Mouse Model |
| - | in-vivo, | CRC, | NA |
| 7760- | ISL, | Pharmacological Potentials and Delivery Strategies of Isoliquiritigenin: Challenges and Advances in Enhancing Bioavailability |
| - | Review, | Nor, | NA |
| 7781- | ISL, | Perspectives on the Role of Isoliquiritigenin in Cancer |
| - | Review, | Var, | NA |
| 7784- | ISL, | Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity |
| - | in-vivo, | AD, | NA |
| 7780- | ISL, | Isoliquiritigenin alleviates LPS/ D-GalN-induced acute liver failure by activating the PGC-1α/ Nrf2 pathway to reduce oxidative stress and inflammatory response |
| - | in-vivo, | Nor, | NA |
| 7779- | ISL, | Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury |
| - | in-vivo, | Alcohol, | NA |
| 7864- | isoO, | Isoorientin Inhibits Amyloid β25-35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | AD, | BV2 |
| 7861- | isoO, | Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3 β |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7886- | isoO, | Vascular barrier protective effects of orientin and isoorientin in LPS-induced inflammation in vitro and in vivo |
| - | vitro+vivo, | Nor, | NA |
| 7884- | isoO, | Orientin Ameliorates LPS-Induced Inflammatory Responses through the Inhibitory of the NF-κB Pathway and NLRP3 Inflammasome |
| - | in-vitro, | Nor, | RAW264.7 |
| 7883- | isoO, | Evaluation of Anti-Inflammatory Properties of Isoorientin Isolated from Tubers of Pueraria tuberosa |
| - | vitro+vivo, | Nor, | RAW264.7 |
| 7875- | isoO, | Isoorientin Inhibits Amyloid β25–35-Induced Neuronal Inflammation in BV2 Cells by Blocking the NF-κB Signaling Pathway |
| - | in-vitro, | Nor, | BV2 |
| 7874- | isoO, | Isoorientin protects lipopolysaccharide-induced acute lung injury in mice via modulating Keap1/Nrf2-HO-1 and NLRP3 inflammasome pathways |
| - | in-vivo, | Nor, | NA |
| 7837- | ISQ, | Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation |
| - | in-vivo, | Nor, | NA |
| 8034- | IVM, | doxoR, | Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation |
| - | in-vitro, | Oral, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:158 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid