TumCP Cancer Research Results

TumCP, Tumor Cell proliferation: Click to Expand ⟱
Source:
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Tumor cell proliferation is a key characteristic of cancer. It refers to the rapid and uncontrolled growth of cells that can lead to the formation of tumors.
Scientific Papers found: Click to Expand⟱
1264- CAP,    Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells
- in-vitro, HCC, NA
TumCP↓, TumCMig↓, TumCCA↑, MMP∅, MMP2↓, MMP9↓, α-SMA↓, COL1A1↓, COL3A1↓, TIMP1↓,
1262- CAP,    Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
- vitro+vivo, BC, NA
FBI-1↓, Ki-67↓, Bcl-2↓, survivin↓, BAX↑, Casp3↑, TumCP↓, Apoptosis↑,
1518- CAP,    Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo
- in-vitro, CRC, HCT116
ENOX2↑, TumCP↑, TumCMig↑, Dose?, eff↑,
2013- CAP,    Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vivo, NA, NA
TumCP↓, P53↑, P21↑, BAX↑, PSA↓, AR↓, NF-kB↓, Proteasome↓, TumVol↓, eff∅,
5767- CAPE,    Caffeic Acid Phenethyl Ester Is a Potential Therapeutic Agent for Oral Cancer
- Review, Oral, NA
TumCP↓, tumCV↓, TumMeta↓, Akt↓, NF-kB↓, MMPs↓, EGFR↓, COX2↓, TumCCA?,
5761- CAPE,    Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCCA↑, AMPK↓, NF-kB↓, β-catenin/ZEB1↓, CREB↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5910- CAR,    Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage
- in-vitro, Melanoma, B16-F10 - NA, NA, A375
ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,
5905- CAR,  HCQ,    Synergistic inhibition of metastatic melanoma by carvacrol and chloroquine: an in vitro and in silico investigation of apoptosis and molecular targets
- in-vitro, Melanoma, NA
eff↑, tumCV↑, IGF-1R↓, SIRT2↓, HSP90↓, TumCP↓, Akt↓,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
1287- CAR,    Carvacrol induces apoptosis in human breast cancer cells via Bcl-2/CytC signaling pathway
- in-vitro, BC, HCC1937
TumCP↓, TumCCA↑, Apoptosis↑, BAX↑, Cyt‑c↑, Casp3↑, Bcl-2↓,
5920- Cats,    Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours
- in-vivo, Melanoma, B16-BL6
eff↑, Ki-67↓, TumCP↓, Apoptosis↑, TumCG↓,
17- CBC/D,    CBC-1 as a Cynanbungeigenin C derivative inhibits the growth of colorectal cancer through targeting Hedgehog pathway component GLI 1
- in-vivo, CRC, NA
HH↓, Gli1↓, BioAv↓, TumCP↓,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
1105- CEL,    Celecoxib inhibits the epithelial-to-mesenchymal transition in bladder cancer via the miRNA-145/TGFBR2/Smad3 axis
- in-vitro, BC, NA
COX2↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, miR-145↑, TGF-β↓, SMAD3↓,
955- CEL,    Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells
- in-vitro, RPE, D407
TumCP↓, VEGF↓, Hif1a↓,
5953- Cela,  CUR,    The Combination of Celastrol and Curcumin Enhances the Antitumor Effect in Nasopharyngeal Carcinoma by Inducing Ferroptosis
- vitro+vivo, NPC, NA
eff↑, TumCP↓, GPx4↓, eff↑, TumAuto↑, Ferroptosis↑, Dose↝, ACSL4↑, toxicity↓,
5939- Cela,  Chemo,    Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells
- in-vitro, Melanoma, U266 - in-vitro, Melanoma, RPMI-8226
TumCP↓, ChemoSen↑, cycD1/CCND1↓, Bcl-2↓, survivin↓, XIAP↓, Mcl-1↓, NF-kB↓, IL6↓, STAT3↓, Apoptosis↑, TumCCA↑, Casp3↑, HSP90↓, HO-1↑, JAK2↓, Src↓, Akt↑,
5940- Cela,    Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway
- in-vivo, Pca, PC3
Dose↝, TumVol↓, TumW↓, angioG↓, VEGF↓, TumCMig↓, TumCP↓, TumCI↓, Akt↓, mTOR↓, P70S6K↓,
5942- Cela,    Celastrol elicits antitumor effects by inhibiting the STAT3 pathway through ROS accumulation in non-small cell lung cancer
- vitro+vivo, NSCLC, H460 - in-vitro, NSCLC, PC9
TumCG↓, TumCP↓, TumMeta↓, ROS↑, ER Stress↑, p‑STAT3↓, Apoptosis↑, eff↓, TumCG↓, IL6↓, other↝,
5944- Cela,    HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
- in-vitro, AML, U937
TumCP↓, TumCCA↑, TumCD↑, HSP90↓, HSP70/HSPA5↑, cycD1/CCND1↓, CDK4↓, CDK6↓, ATPase↓,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
6021- CGA,    Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action
- in-vitro, Var, NA
*hepatoP↑, *Bacteria↓, *Imm↑, *antiOx↑, *AntiDiabetic↓, *AntiCan↑, TumCCA↑, Apoptosis↑, TumCP↓,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6012- CGA,    Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma
- in-vitro, CCA, HCC9810
TumCP↓, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, TumCCA↑, AKR1B10↓, Akt↓, mtDam↑, BAX↑, Casp9↑, Casp3↑, Bcl-2↓,
6030- CGA,    Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, Nor, MCF10
NF-kB↓, AntiTum↑, tumCV↓, TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, EMT↓, TumCG↓, OS↑, TumMeta↓, CD4+↑, CD8+↑, Imm↑,
5983- Chit,    Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy
- Review, BC, NA
DDS↑, BioAv↑, EPR↑, TumCP↓, angioG↓, TumMeta↓, other↑,
5984- Chit,    Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system
- Review, Var, NA
DDS↑, BioAv↑, TumCP↓, angioG↓, TumMeta↓, Apoptosis↑, eff↑,
5985- Chit,  immuno,    Immunomodulatory potential of chitosan-based materials for cancer therapy: a systematic review of in vitro, in vivo and clinical studies.
- Review, Var, NA
TumCP↓, TumW↓, OS↑, eff↑,
5990- Chit,    Chitosan Nanoparticles for Targeted Cancer Therapy: A Review of Stimuli-Responsive, Passive, and Active Targeting Strategies
- Review, Var, NA
DDS↑, eff↓, *Bacteria↓, *antiOx↑, *Wound Healing↑, *Imm↑, TumCP↓, TumMeta↓, angioG↓, Apoptosis↑, ROS↑, ER Stress↑, BioAv↑, Half-Life↑, eff↑, EPR↑, ChemoSen↑, eff↑,
4478- Chit,    Chitosan promotes ROS-mediated apoptosis and S phase cell cycle arrest in triple-negative breast cancer cells: evidence for intercalative interaction with genomic DNA
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, BC, T47D
TumCP↓, selectivity↑, MMP↓, ROS↑, TumCCA↑, Apoptosis↑, Casp3↑,
6073- CHL,  GEM,    Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis
- in-vitro, PC, NA
ChemoSen↑, eff↑, AntiTum↑, TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, GSH↓, ROS↑, HSP70/HSPA5↑,
6070- CHL,    Preclinical evaluation of sodium copper chlorophyllin: safety, pharmacokinetics, and therapeutic potential in breast cancer chemotherapy and cyclophosphamide-induced bladder toxicity
- in-vitro, BC, 4T1
TumCP↓, DNAdam↑, Apoptosis↑, *ROS↓, *toxicity↓, ChemoSen↑,
6067- CHL,    Antiproliferative effect of chlorophyllin derived from a traditional Chinese medicine Bombyx mori excreta on human breast cancer MCF-7 cells
- in-vitro, BC, MCF-7
TumCP↓, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CycB/CCNB1↑,
6081- CHL,    Enhancing Health Benefits through Chlorophylls and Chlorophyll-Rich Agro-Food: A Comprehensive Review
- Review, Nor, NA
*antiOx↑, *toxicity↓, *BioAv↓, *BioAv↑, *neuroP↑, *Obesity↓, *AntiCan↑, *TumCP↓, *PhotoS↑, *neuroP↑,
6085- CHOC,    Epicatechin-rich cocoa polyphenol inhibits Kras-activated pancreatic ductal carcinoma cell growth in vitro and in a mouse model
- in-vivo, PC, NA
selectivity↑, TumCP↓, p‑Akt↓, NF-kB↓, TumCG↓, *BioAv↑, *chemoPv↑,
6083- CHOC,    Preventive Effects of Cocoa and Cocoa Antioxidants in Colon Cancer
- Review, Colon, NA
ROS↓, Inflam↓, TumCP↓, Apoptosis↑, *Dose↝, *BioAv↓, *BioAv↑, GSH↑, GSTs↑, PGE2↓, COX1↑, IL8↓, COX2↓, iNOS↓, NF-kB↓, chemoP↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2782- CHr,    Broad-Spectrum Preclinical Antitumor Activity of Chrysin: Current Trends and Future Perspectives
- Review, Var, NA - Review, Stroke, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *BioAv↓, *cardioP↑, *lipidLev↓, *RenoP↑, *TNF-α↓, *IL2↓, *PI3K↓, *Akt↓, *ROS↓, *cognitive↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, VEGF↓, p‑STAT3↓, TumMeta↓, TumCP↓, eff↑, eff↑, IL1β↓, IL6↓, NF-kB↓, ROS↑, MMP↓, Cyt‑c↑, Apoptosis↑, ER Stress↑, Ca+2↑, TET1↑, Let-7↑, Twist↓, EMT↓, TumCCA↑, Casp3↑, Casp9↑, BAX↑, HK2↓, GlucoseCon↓, lactateProd↓, Glycolysis↓, SHP1↑, N-cadherin↓, E-cadherin↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, RadioS↑, NOTCH1↑, NRF2↓, BioAv↑, eff↑,
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
2787- CHr,    Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics
- Analysis, Var, MCF-7
TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,
2791- CHr,    Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction
- in-vitro, Ovarian, OV90
TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,
1107- CHr,    Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
- in-vitro, BC, NA
TumCP↓, Apoptosis↑, MMP-10↓, E-cadherin↑, Vim↓, Snail↓, Slug↓, EMT↓,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,
1583- Citrate,    Extracellular citrate and metabolic adaptations of cancer cells
- Review, NA, NA
Warburg↓, OXPHOS↓, Dose∅, TumCP↓, ATP↓, eff↑, Apoptosis↑, TumCG↓, PFK1↓,
1580- Citrate,    Citrate activates autophagic death of prostate cancer cells via downregulation CaMKII/AKT/mTOR pathway
- in-vitro, Pca, PC3 - in-vivo, PC, NA - in-vitro, Pca, LNCaP - in-vitro, Pca, WPMY-1
Apoptosis↑, Ca+2↓, Akt↓, mTOR↓, selectivity↑, TumCP↓, cl‑Casp3↑, cl‑PARP↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, ATG5↑, ATG7↑, Beclin-1↑, TumAuto↑, CaMKII ↓,
1579- Citrate,    Effect of Food Additive Citric Acid on The Growth of Human Esophageal Carcinoma Cell Line EC109
- in-vitro, ESCC, Eca109
TumCP↓, e-LDH↑, MMP↓, Ca+2?, PFK↓, Glycolysis↓,
1578- Citrate,    Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update
- Review, Var, NA
TCA↑, FASN↑, Glycolysis↓, glucoNG↑, PFK1↓, PFK2↓, FBPase↑, TumCP↓, eff↑, ACLY↓, Dose↑, Casp3↑, Casp2↑, Casp8↑, Casp9↑, Bcl-xL↓, Mcl-1↓, IGF-1R↓, PI3K↓, Akt↓, mTOR↓, PTEN↑, ChemoSen↑, Dose?,

Showing Research Papers: 201 to 250 of 700
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 700

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

AKR1B10↓, 1,  

Redox & Oxidative Stress ⓘ

CYP1A1↑, 1,   ENOX2↑, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 3,   GSH↑, 1,   GSTs↑, 1,   HO-1↓, 1,   HO-1↑, 2,   MDA↓, 1,   MDA↑, 1,   NRF2↓, 2,   OXPHOS↓, 1,   Prx↓, 1,   PrxII↓, 1,   ROS↓, 1,   ROS↑, 12,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   mitResp↑, 1,   MMP↓, 6,   MMP∅, 1,   MPT↓, 1,   MPT↑, 1,   mtDam↑, 3,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   ACSL4↑, 1,   AKT1↓, 1,   AMPK↓, 1,   ATG7↑, 1,   CREB↓, 1,   FASN↑, 1,   FBI-1↓, 1,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 1,   Glycolysis↓, 5,   HK2↓, 1,   lactateProd↓, 1,   e-LDH↑, 1,   NADPH↓, 1,   PFK↓, 1,   PFK1↓, 2,   PFK2↓, 1,   SIRT2↓, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 10,   Akt↑, 1,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↑, 27,   BAX↑, 9,   Bcl-2↓, 9,   Bcl-xL↓, 2,   Casp↑, 2,   Casp2↑, 1,   Casp3↑, 12,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 5,   Cyt‑c↑, 6,   FADD↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 2,   iNOS↓, 1,   JNK↑, 2,   p‑JNK↑, 1,   MAPK↓, 1,   MAPK↑, 2,   Mcl-1↓, 2,   Necroptosis↑, 1,   p38↑, 3,   Proteasome↓, 1,   survivin↓, 3,   TumCD↑, 2,  

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,   p‑p70S6↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   miR-145↑, 1,   other↑, 1,   other↝, 1,   tumCV↓, 3,   tumCV↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   eIF2α↑, 1,   ER Stress↑, 5,   HSP70/HSPA5↑, 2,   HSP90↓, 4,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 4,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   P53↑, 3,   cl‑PARP↑, 4,   PCNA↓, 3,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 3,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 2,   P21↑, 3,   TumCCA?, 1,   TumCCA↑, 14,  

Proliferation, Differentiation & Cell State ⓘ

AR-V7?, 1,   AXIN1↑, 1,   CD44↓, 1,   CSCs↓, 2,   EMT↓, 7,   ERK↓, 2,   p‑ERK↑, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1R↓, 2,   Let-7↑, 1,   mTOR↓, 4,   Nanog↓, 1,   NOTCH1↑, 1,   OCT4↓, 1,   P70S6K↓, 1,   PI3K↓, 3,   PI3K↑, 1,   PTEN↑, 1,   SCF↓, 1,   SHP1↑, 1,   SOX2↓, 1,   Src↓, 1,   STAT3↓, 2,   p‑STAT3↓, 2,   TRPM7↓, 1,   TumCG↓, 7,   Wnt/(β-catenin)↓, 2,  

Migration ⓘ

AP-1↓, 1,   ATPase↓, 1,   AXL↓, 1,   Ca+2?, 1,   Ca+2↓, 1,   Ca+2↑, 3,   COL1A1↓, 1,   COL3A1↓, 1,   E-cadherin↑, 4,   F-actin↓, 1,   Ki-67↓, 3,   MMP-10↓, 1,   MMP2↓, 3,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 3,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↓, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TumCI↓, 12,   TumCMig↓, 12,   TumCMig↑, 1,   TumCP↓, 48,   TumCP↑, 1,   TumMeta↓, 14,   Twist↓, 1,   Vim↓, 2,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 8,   ATF4↑, 1,   EGFR↓, 1,   EPR↑, 2,   Hif1a↓, 2,   VEGF↓, 5,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   COX1↑, 1,   COX2↓, 6,   CXCR4↓, 1,   IL1β↓, 1,   IL6↓, 4,   IL8↓, 1,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 5,   JAK2↓, 1,   NF-kB↓, 10,   NF-kB↑, 1,   p‑NF-kB↓, 1,   PGE2↓, 3,   PSA↓, 1,   TNF-α↓, 3,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,   CYP19?, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 8,   ChemoSen↑, 7,   DDS↑, 3,   Dose?, 2,   Dose↑, 1,   Dose↝, 4,   Dose∅, 1,   eff↓, 2,   eff↑, 19,   eff∅, 1,   Half-Life↑, 1,   RadioS↑, 2,   selectivity↑, 6,  

Clinical Biomarkers ⓘ

AFP↓, 2,   AR↓, 1,   EGFR↓, 1,   hTERT/TERT↓, 2,   IL6↓, 4,   Ki-67↓, 3,   e-LDH↑, 1,   PSA↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↑, 3,   CardioT↑, 1,   chemoP↑, 2,   chemoPv↑, 2,   hepatoP↓, 1,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 3,   Risk↓, 1,   toxicity↓, 2,   toxicity↑, 1,   toxicity↝, 1,   TumVol↓, 3,   TumW↓, 3,   Weight↑, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 243

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Catalase↑, 3,   GPx↑, 3,   GSH↑, 2,   GSR↑, 2,   HDL↑, 1,   HO-1↓, 1,   Keap1↓, 1,   lipid-P↓, 2,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 4,   SOD↑, 3,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP∅, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 2,   glucose↝, 1,   GLUT2↑, 1,   HMG-CoA↓, 1,   LDH↓, 2,   lipidLev↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Fas↓, 1,   HGF/c-Met↑, 1,   iNOS↓, 1,   MAPK↓, 1,  

Transcription & Epigenetics ⓘ

PhotoS↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↑, 1,   PI3K↓, 1,  

Migration ⓘ

Ca+2↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL2↓, 1,   Imm↑, 2,   Inflam↓, 4,   NF-kB↓, 1,   TLR4↓, 2,   TNF-α↓, 2,  

Protein Aggregation ⓘ

AGEs↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   BioAv↑, 4,   BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 2,   AST↓, 2,   LDH↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↓, 1,   cardioP↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 1,   hepatoP↑, 3,   neuroP↑, 4,   Obesity↓, 1,   RenoP↑, 2,   toxicity↓, 2,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 2,  
Total Targets: 66

Scientific Paper Hit Count for: TumCP, Tumor Cell proliferation
41 Curcumin
24 Thymoquinone
23 Quercetin
23 Shikonin
19 Magnetic Fields
18 EGCG (Epigallocatechin Gallate)
18 Berberine
18 Sulforaphane (mainly Broccoli)
17 Resveratrol
16 Baicalein
14 Silver-NanoParticles
14 Capsaicin
14 Phenethyl isothiocyanate
13 Apigenin (mainly Parsley)
12 Artemisinin
12 Propolis -bee glue
11 Ashwagandha(Withaferin A)
11 Astaxanthin
11 Boron
11 Lycopene
10 Magnolol
10 Selenite (Sodium)
10 Silymarin (Milk Thistle) silibinin
10 Urolithin
9 Berbamine
9 Luteolin
8 Garcinol
8 Honokiol
7 Astragalus
7 Citric Acid
7 chitosan
7 Bufalin/Huachansu
7 Piperlongumine
6 Radiotherapy/Radiation
6 Boswellia (frankincense)
6 Carnosic acid
6 Rosmarinic acid
6 Celastrol
6 Chrysin
6 Ellagic acid
6 Phenylbutyrate
6 salinomycin
5 Betulinic acid
5 Chemotherapy
5 Carvacrol
5 Emodin
5 Fisetin
5 Juglone
5 Vitamin K2
4 Allicin (mainly Garlic)
4 Gemcitabine (Gemzar)
4 Melatonin
4 Atorvastatin
4 5-fluorouracil
4 brusatol
4 Chlorogenic acid
4 Chlorophyllin
4 Disulfiram
4 Copper and Cu NanoParticles
4 Gambogic Acid
4 HydroxyTyrosol
4 Metformin
4 Magnetic Field Rotating
4 Nimbolide
4 Cisplatin
4 Piperine
4 Ursolic acid
3 Alpha-Lipoic-Acid
3 Andrographis
3 Aspirin -acetylsalicylic acid
3 Paclitaxel
3 immunotherapy
3 Butyrate
3 Thymol-Thymus vulgaris
3 Celecoxib
3 Chocolate
3 Photodynamic Therapy
3 diet Methionine-Restricted Diet
3 Galloflavin
3 Hydrogen Gas
3 Methylene blue
3 Oleuropein
3 Propyl gallate
3 Plumbagin
3 Pterostilbene
3 Aflavin-3,3′-digallate
3 VitK3,menadione
3 Zerumbone
2 Auranofin
2 Ascorbyl Palmitate
2 Arctigenin
2 Docetaxel
2 Baicalin
2 Biochanin A
2 Brucea javanica
2 Bacopa monnieri
2 Caffeic acid
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Coenzyme Q10
2 Dichloroacetate
2 diet FMD Fasting Mimicking Diet
2 diet Short Term Fasting
2 Genistein (soy isoflavone)
2 Ferulic acid
2 Gallic acid
2 γ-linolenic acid (Borage Oil)
2 Graviola
2 Naringin
2 Niclosamide (Niclocide)
2 Psoralidin
2 Sulfasalazine
2 Selenium
2 Salvia miltiorrhiza
2 Vitamin C (Ascorbic Acid)
2 Vitamin D3
1 2-DeoxyGlucose
1 Sorafenib (brand name Nexavar)
1 3-bromopyruvate
1 Glucose
1 SonoDynamic Therapy UltraSound
1 Zinc
1 Ajoene (compound of Garlic)
1 alpha Linolenic acid
1 Aloe anthraquinones
1 beta-glucans
1 almonertinib
1 bempedoic acid
1 Bevacizumab (brand Avastin)
1 temozolomide
1 Bromelain
1 borneol
1 Bortezomib
1 Bruteridin(bergamot juice)
1 hydroxychloroquine
1 Cat’s Claw
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 Cinnamon
1 Camptothecin
1 irinotecan
1 Dichloroacetophenone(2,2-)
1 Deguelin
1 Date Fruit Extract
1 Evodiamine
1 Electrical Pulses
1 Exercise
1 Fucoidan
1 Fenbendazole
1 Vitamin E
1 Shilajit/Fulvic Acid
1 Ginkgo biloba
1 Germacranolide
1 Ginger/6-Shogaol/Gingerol
1 Siegesbeckia glabrescens
1 Hydroxycinnamic-acid
1 Hyperthermia
1 Inoscavin A
1 itraconazole
1 Ivermectin
1 Laetrile B17 Amygdalin
1 Licorice
1 Caffeine
1 doxorubicin
1 Mushroom Chaga
1 nicotinamide adenine dinucleotide
1 Bicarbonate(Sodium)
1 Oroxylin A
1 Oleocanthal
1 Proanthocyanidins
1 sericin
1 xanthohumol
1 Gold NanoParticles
1 Rutin
1 Oxaliplatin
1 Selenium NanoParticles
1 diet Plant based
1 Formononetin
1 Spermidine
1 Tumor Treating Fields
1 Arsenic trioxide
1 Wogonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:327  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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