Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

Scientific Papers found: Click to Expand⟱

3416-

TQ,

Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway

-

in-vitro,

Bladder,

T24/HTB-9

 TQ (20–100 μM) for 24 h

-

in-vitro,

Bladder,

253J

-

in-vitro,

Nor,

SV-HUC-1

TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑,

5904-

TV,

Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development

-

Review,

Var,

NA

-

Review,

Stroke,

NA

-

Review,

Diabetic,

NA

-

Review,

Obesity,

NA

-

Review,

AD,

NA

-

Review,

Arthritis,

NA

*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2/PTGS2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,

5021-

UA,

Anticancer effect of ursolic acid via mitochondria-dependent pathways

-

Review,

Var,

NA

Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,

3790-

UA,

Therapeutic applications of ursolic acid: a comprehensive review and utilization of predictive tools

*Inflam↓, *antiOx↑, AntiCan↑, *neuroP↑, *hepatoP↑, *cardioP↑, *MMP↑, *ROS↓, *PGC-1α↑, *BDNF↑, *cognitive↑, Bcl-2↓, Cyt‑c↑, DR5↑, Casp9↑, Casp8↑, Casp3↑, TumCCA↑, *BioAv↓, *Dose↝, *Half-Life↓, *Half-Life↓,

1817-

VitK2,

Research progress on the anticancer effects of vitamin K2

-

Review,

Var,

NA

TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumCG↓, ChemoSen↓, ChemoSideEff↓, toxicity∅, eff↑, cycD1/CCND1↓, CDK4↓, eff↑, IKKα↓, NF-kB↓, other↑, p27/CDKN1B↑, cMyc↓, i-ROS↑, Bcl-2↓, BAX↑, p38↑, MMP↓, Casp9↑, p‑ERK↓, RAS↓, MAPK↓, p‑P53↑, Casp8↑, Casp3↑, cJun↑, MMPs↓, eff↑, eff↑,

Showing Research Papers: 201 to 205 of 205
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 205

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

H2O2↑, 1, lipid-P↑, 1, ROS↑, 1, i-ROS↑, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1, ATP↓, 1, MMP↓, 3, mtDam↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1, cMyc↓, 1, Glycolysis↓, 1, HK2↓, 1, lactateProd↓, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 1, APAF1↑, 1, Apoptosis↑, 4, BAX↑, 3, Bcl-2↓, 3, Casp3↑, 4, cl‑Casp3↑, 1, cl‑Casp7↑, 1, Casp8↑, 4, cl‑Casp8↑, 1, Casp9↑, 4, Cyt‑c↑, 3, DR5↑, 1, MAPK↓, 1, p27/CDKN1B↑, 1, p38↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1, other↑, 1, tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1, CHOP/DDIT3↑, 1, p‑eIF2α↑, 1, ER Stress↑, 1, GRP78/BiP↑, 1, IRE1↑, 1, PERK↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2, P53↑, 1, p‑P53↑, 1, cl‑PARP↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1, cycD1/CCND1↓, 1, TumCCA↑, 4,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1, p‑ERK↓, 1, RAS↓, 1, TumCG↓, 1,

Migration(tgid=13) ⓘ

Ca+2↑, 2, MMP2↓, 1, MMP9↓, 1, MMPs↓, 1, PKA↓, 1, PKCδ↓, 1, TumCI↓, 1, TumCMig↓, 2, TumCP↓, 3,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, ATF4↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2, IKKα↓, 1, IL17↓, 1, IL6↓, 1, Inflam↓, 1, NF-kB↓, 2, TNF-α↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1, ChemoSen↑, 1, eff↑, 4,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 1, IL6↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1, AntiTum↑, 1, chemoP↑, 1, ChemoSideEff↓, 1, hepatoP↑, 1, radioP↑, 1, RenoP↑, 1, toxicity∅, 1,
Total Targets: 84

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2, Catalase↑, 1, GPx↑, 2, GSH↑, 1, GSTs↑, 1, H2O2↓, 1, HDL↑, 1, MDA↓, 1, NADH↓, 1, RNS↓, 1, ROS↓, 2, SOD↑, 2,

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1, PGC-1α↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1, other↑, 1,

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1, COX2/PTGS2↓, 1, Imm↑, 1, Inflam↓, 2,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1, BChE↓, 1, BDNF↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1, BioAv↑, 2, BioAv↝, 1, Dose↝, 1, eff↑, 1, Half-Life↓, 2, Half-Life↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1, NOS2↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 2, cardioP↑, 2, cognitive↑, 2, hepatoP↑, 2, neuroP↑, 1, Obesity↓, 1,

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,
Total Targets: 43

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase

11 Apigenin (mainly Parsley)
10 Fisetin
8 Quercetin
8 Sulforaphane (mainly Broccoli)
7 Allicin (mainly Garlic)
7 Thymoquinone
6 Baicalein
6 Boswellia (frankincense)
6 Dandelion Root
6 EGCG (Epigallocatechin Gallate)
4 Silver-NanoParticles
4 Curcumin
4 Emodin
4 Gambogic Acid
4 Luteolin
3 Artemisinin
3 Berberine
3 Betulinic acid
3 Photodynamic Therapy
3 Citric Acid
3 Ferulic acid
3 Gallic acid
3 Garcinol
3 Hibiscus sabdariffa
3 Hyperoside
3 Kaempferol
3 Magnolol
3 Phenethyl isothiocyanate
3 Propyl gallate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Brucea javanica
2 Bromelain
2 Boron
2 Carvacrol
2 Thymol-Thymus vulgaris
2 chaetocin
2 Chrysin
2 Fucoidan
2 Ginkgetin
2 Graviola
2 Propolis -bee glue
2 Honokiol
2 Rutin
2 isoquercitrin
2 Juglone
2 Licochalcone A
2 Magnetic Fields
2 Nimbolide
2 Shikonin
2 Aflavin-3,3′-digallate
2 Ursolic acid
1 Resiquimod
1 Cisplatin
1 Metformin
1 2-DeoxyGlucose
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Trastuzumab
1 Berbamine
1 α-Bisabolol / Chamomile oil
1 Cat’s Claw
1 Celecoxib
1 chitosan
1 Chlorophyllin
1 Crocetin
1 Carvone
1 Cynaropicrin
1 Diclofenac
1 Ellagic acid
1 eicosapentaenoic acid
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hydrogen Gas
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Isoliquiritigenin
1 Morin
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Radiotherapy/Radiation
1 Chemotherapy
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 buckwheat sprouts
1 α-Santalol/Sandalwood oil
1 Auranofin
1 Docetaxel
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:44  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

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