MDA Cancer Research Results

MDA, Serum malondialdehyde: Click to Expand ⟱
Source:
Type:
MDA : malondialdehyde. The level of oxidative stress can be measured by assessing the MDA levels.
Since MDA is highly cytotoxic and carcinogenic agent it is frequently used as a biomarker of oxidative stress during major health problems such as cancer, etc.
Malondialdehyde (MDA) is the most widely used agent to estimate the extent of lipid peroxidation. Timely diagnosis of the condition followed by supplementation with antioxidants like beta-carotene, pro-vitamin A, vitamin A, vitamin C, vitamin E, lipoic acid, zinc, selenium, and spirulina can prevent potentially malignant disorders.
MDA is a lipid peroxidation marker


Scientific Papers found: Click to Expand⟱
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
2214- SK,    Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway
- in-vitro, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *antiOx↑, *neuroP↑, *ROS↓, *MDA↓, *SOD↑, GSH↑,
1284- SK,    Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy
- in-vitro, Melanoma, RPMI-8226 - in-vitro, Melanoma, U266
Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,
4723- SSE,    Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4
- in-vitro, CRC, HCT116
TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,
4731- SSE,    Dietary selenium mitigates cadmium-induced apoptosis and inflammation in chicken testicles by inhibiting oxidative stress through the activation of the Nrf2/HO-1 signaling pathway
- in-vivo, Nor, NA
*ROS↓, *MDA↓, *H2O2↓, *Catalase↑, *GSH↑, *NRF2↑, *HO-1↑, *Bcl-2↑, *other↝,
4498- SSE,    Selenium in Human Health and Gut Microflora: Bioavailability of Selenocompounds and Relationship With Diseases
- Review, Var, NA - Review, AD, NA - Review, IBD, NA
*Imm↑, *GutMicro↑, *BioAv↑, *Risk↓, *Dose↝, Risk↓, *CRP↓, *GPx↓, *Inflam↓, *selenoP↑, *Dose↝, *ROS↓, *MDA↓, *SOD↑, *GPx↑, *IL1↓, *MCP1↓, *IL6↓, *TNF-α↓, Risk↓, *neuroP↑, *memory↑,
4215- SY,    Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway
- in-vivo, NA, NA
*memory↑, *AChE↓, *ChAT↑, *SOD↓, *MDA↓, *GPx↑, *BDNF↑, *TrkB↑, *CREB↑, *ROS↓,
3960- Taur,    Versatile Triad Alliance: Bile Acid, Taurine and Microbiota
- Review, AD, NA - Review, Stroke, NA
*ROS↓, *Inflam↓, *GABA↑, *memory↑, *cognitive↑, *iNOS↓, *CRP↓, *HO-1↑, *Prx↑, *Trx↑, *NRF2↑, *GSH↑, *SOD↑, *Catalase↑, *lipid-P↓, *MDA↓, *eff↝, *GutMicro↑, other↑,
2124- TQ,    Thymoquinone: an emerging natural drug with a wide range of medical applications
- Review, Var, NA
hepatoP↑, Bax:Bcl2↑, cycD1/CCND1↓, P21↑, TRAIL↑, P53↑, TumCCA↑, hepatoP↑, *ALAT↓, *AST↓, *MDA↓, *GSSG↓, *COX2↓, *lipid-P↓, PPARγ↑, p38↑, ROS↑, ChemoSen↑, selectivity↑, selectivity↑, *MDA↓, *SOD↑,
2115- TQ,    Protective effects of Nigella sativa on gamma radiation-induced jejunal mucosal damage in rats
- in-vivo, Nor, NA
*radioP↑, *MDA↓, *GSH↑,
2134- TQ,    Modulation of Nrf2/HO1 Pathway by Thymoquinone to Exert Protection Against Diazinon-induced Myocardial Infarction in Rats
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *ROS↓, *GSSG↓, *GSH↑, *VitE↑, *VitC↑, *NRF2↑, *HO-1↑, *NQO1↑, *SOD↑, *cardioP↑, *GSH/GSSG↑, *GPx↑,
2092- TQ,    Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer's Disease
- Review, AD, NA
*iNOS↓, *ROS↓, *GSH↑, *neuroP↑, *MMPs↓, *MMP↑, *TXNIP↓, *Prx↑, *memory↑, *MDA↓, *SOD↑, *Catalase↑, *BioAv↑,
1928- TQ,    Thymoquinone Crosstalks with DR5 to Sensitize TRAIL Resistance and Stimulate ROS-Mediated Cancer Apoptosis
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
TumCP↓, DR4↑, DR5↑, Casp8↑, FADD↑, Bcl-2↓, ROS↑, NO↑, MDA↑,
3409- TQ,    Thymoquinone therapy remediates elevated brain tissue inflammatory mediators induced by chronic administration of food preservatives
- in-vivo, Nor, NA
*MDA↓, *TGF-β↓, *CRP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *Casp3↓, *GSH↑, *NRF2↑, *IL10↑, *neuroP↑, *ROS↓, *Apoptosis↓, *Inflam↓,
3406- TQ,  SeNPs,    A study to determine the effect of nano-selenium and thymoquinone on the Nrf2 gene expression in Alzheimer’s disease
- in-vivo, AD, NA
*NRF2↑, *GSH↑, *MDA↓, *TNF-α↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1↓, *IP-10/CXCL-10↓, *PGE2↓,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,
3422- TQ,    Thymoquinone, as a Novel Therapeutic Candidate of Cancers
- Review, Var, NA
selectivity↑, P53↑, PTEN↑, NF-kB↓, PPARγ↓, cMyc↓, Casp↑, *BioAv↓, BioAv↝, eff↑, survivin↓, Bcl-xL↓, Bcl-2↓, Akt↓, BAX↑, cl‑PARP↑, CXCR4↓, MMP9↓, VEGFR2↓, Ki-67↓, COX2↓, JAK2↓, cSrc↓, Apoptosis↑, p‑STAT3↓, cycD1/CCND1↓, Casp3↑, Casp7↑, Casp9↑, N-cadherin↓, Vim↓, Twist↓, E-cadherin↑, ChemoSen↑, eff↑, EMT↓, ROS↑, DNMT1↓, eff↑, EZH2↓, hepatoP↑, Zeb1↓, RadioS↑, HDAC↓, HDAC1↓, HDAC2↓, HDAC3↓, *NAD↑, *SIRT1↑, SIRT1↓, *Inflam↓, *CRP↓, *TNF-α↓, *IL6↓, *IL1β↓, *eff↑, *MDA↓, *NO↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, PI3K↓, mTOR↓,
3558- TQ,    Behavioral and histological study on the neuroprotective effect of thymoquinone on the cerebellum in AlCl3-induced neurotoxicity in rats through modulation of oxidative stress, apoptosis, and autophagy
- in-vivo, AD, NA
*MDA↓, *NO↓, *GSH↑, *neuroP↑, *cognitive↑,
3559- TQ,    Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer’s disease
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AChE↓, AntiCan↑, *cardioP↑, *RenoP↑, *neuroP↑, *hepatoP↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↑, TumCCA↑, angioG↓, *NF-kB↓, *TLR2↓, *TLR4↓, *MyD88↓, *TRIF↓, *IRF3↓, *IL1β↓, *IL6↓, *IL12↓, *NRF2↑, *COX2↓, *VEGF↓, *MMP9↓, *cMyc↓, *cycD1/CCND1↓, *TumCP↓, *TumCI↓, *MDA↓, *TGF-β↓, *CRP↓, *Casp3↓, *GSH↑, *IL10↑, *iNOS↑, *lipid-P↓, *SOD↑, *H2O2↓, *ROS↓, *LDH↓, *Catalase↑, *GPx↑, *AChE↓, *cognitive↑, *MAPK↑, *JNK↑, *BAX↓, *memory↑, *Aβ↓, *MMP↑,
3560- TQ,    Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes
- in-vivo, AD, NA
*cognitive↑, *SOD↑, *TAC↑, *AChE↓, *MDA↓, *NO↓, *TNF-α↓, *Bcl-2↑, *Ach↑, *neuroP↑,
5904- TV,    Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Obesity, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *Inflam↓, *Bacteria↓, AntiTum↑, IronCh↑, *HDL↑, *LDL↓, *BioAv↝, *Half-Life↝, *BioAv↑, *SOD↑, *GPx↑, *GSTs↑, *eff↑, radioP↑, *MDA↓, *other↑, *COX1↓, *COX2↓, *AntiAg↑, *RNS↓, *NO↓, *H2O2↓, *NOS2↓, *NADH↓, *Imm↑, Apoptosis↑, TumCP↓, angioG↓, TumCMig↓, Ca+2↑, TumCCA↑, DNAdam↑, BAX↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, AIF↑, i-ROS↑, MMP↓, Cyt‑c↑, APAF1↑, Ca+2↑, MMP9↓, MMP2↓, PKCδ↓, ERK↓, H2O2↑, BAX↑, Bcl-2↓, DNAdam↑, lipid-P↑, ChemoSen↑, chemoP↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *BP↓, *AntiDiabetic↑, *Obesity↓, RenoP↑, *GastroP↑, hepatoP↑, *AChE↓, *cognitive↑, *BChE↓, *other↓, *BioAv↑,
4854- Uro,    Urolithins: Emerging natural compound targeting castration-resistant prostate cancer (CRPC)
- Review, Pca, NA
AR↓, ROS↓, Apoptosis↑, selectivity↑, Dose↑, MDA↓, SOD↑, GPx↑, ROS↑, Casp3↑, Casp9↑,
580- VitC,  MF,    Extremely low frequency magnetic field induces oxidative stress in mouse cerebellum
- in-vivo, Nor, NA
*other↓, *MDA↓, *GPx∅, *SOD↑, *GSH∅,
3139- VitC,    Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress
- in-vitro, Nor, H9c2
*Apoptosis∅, *LDH∅, *MDA∅, *SOD↓, eff↝,
1216- VitC,    Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer
- in-vitro, Laryn, FaDu - in-vitro, SCC, SCC-154
Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,
4187- VitD3,    Protective effects of vitamin D on neurophysiologic alterations in brain aging: role of brain-derived neurotrophic factor (BDNF)
- in-vivo, NA, NA
*BDNF↑, *MDA↓, *Casp3↓,

Showing Research Papers: 201 to 227 of 227
Prev Page 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 227

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress

Ferroptosis↑, 3,   GPx↑, 1,   GPx4↓, 3,   GSH↓, 2,   GSH↑, 1,   H2O2↑, 1,   Iron↑, 2,   Iron↝, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 4,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 8,   i-ROS↑, 1,   SOD↓, 1,   SOD↑, 1,  

Metal & Cofactor Biology

IronCh↑, 1,  

Mitochondria & Bioenergetics

AIF↑, 1,   ATP↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis

cMyc↓, 1,   LDH↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,  

Cell Death

Akt↓, 1,   Akt↑, 1,   APAF1↑, 1,   Apoptosis↑, 4,   BAX↑, 3,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 3,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 1,   DR4↑, 1,   DR5↑, 1,   FADD↑, 1,   Ferroptosis↑, 3,   p38↑, 1,   survivin↓, 1,   TRAIL↑, 1,  

Kinase & Signal Transduction

cSrc↓, 1,  

Transcription & Epigenetics

EZH2↓, 1,   other↑, 1,   tumCV↓, 1,  

DNA Damage & Repair

DNAdam↑, 2,   DNMT1↓, 1,   P53↑, 2,   cl‑PARP↑, 2,  

Cell Cycle & Senescence

cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State

EMT↓, 1,   ERK↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   mTOR↓, 1,   PI3K↓, 2,   PTEN↑, 1,   STAT3↓, 1,   p‑STAT3↓, 2,   TumCG↓, 1,  

Migration

Ca+2↑, 2,   E-cadherin↑, 1,   Ki-67↓, 2,   MMP2↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   PKCδ↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   Twist↓, 1,   Vim↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature

angioG↓, 2,   NO↑, 1,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling

COX2↓, 1,   CXCR4↓, 1,   HMGB1↓, 1,   JAK2↓, 1,   NF-kB↓, 1,  

Hormonal & Nuclear Receptors

AR↓, 1,  

Drug Metabolism & Resistance

BioAv↝, 1,   ChemoSen↑, 3,   Dose↑, 1,   eff↑, 3,   eff↝, 1,   RadioS↑, 1,   selectivity↑, 4,  

Clinical Biomarkers

AR↓, 1,   EZH2↓, 1,   Ki-67↓, 2,   LDH↓, 1,  

Functional Outcomes

AntiCan↑, 2,   AntiTum↑, 1,   chemoP↑, 1,   hepatoP↑, 4,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,  
Total Targets: 109

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress

antiOx↑, 3,   Catalase↑, 8,   GPx↓, 1,   GPx↑, 8,   GPx∅, 1,   GSH↑, 13,   GSH∅, 1,   GSH/GSSG↑, 1,   GSR↑, 1,   GSSG↓, 2,   GSTs↑, 1,   H2O2↓, 3,   HDL↑, 1,   HO-1↑, 6,   lipid-P↓, 4,   MDA↓, 22,   MDA∅, 1,   NADH↓, 1,   NQO1↑, 2,   NRF2↑, 10,   Prx↑, 2,   RNS↓, 1,   ROS↓, 13,   selenoP↑, 1,   SOD↓, 2,   SOD↑, 14,   TAC↑, 3,   Trx↑, 1,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics

MMP↑, 3,  

Core Metabolism/Glycolysis

ALAT↓, 2,   BUN↓, 1,   cMyc↓, 1,   CREB↑, 1,   LDH↓, 2,   LDH∅, 1,   LDL↓, 1,   NAD↑, 1,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death

Apoptosis↓, 1,   Apoptosis∅, 1,   BAX↓, 1,   Bcl-2↑, 2,   Casp3↓, 3,   iNOS↓, 4,   iNOS↑, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↓, 1,  

Transcription & Epigenetics

Ach↑, 1,   other↓, 2,   other↑, 1,   other↝, 1,  

Cell Cycle & Senescence

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State

PI3K↑, 1,  

Migration

AntiAg↑, 1,   MMP9↓, 1,   MMPs↓, 1,   TGF-β↓, 2,   TumCI↓, 1,   TumCP↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature

NO↓, 5,   VEGF↓, 1,  

Barriers & Transport

GastroP↑, 1,   NHE3↑, 1,  

Immune & Inflammatory Signaling

COX1↓, 1,   COX2↓, 3,   CRP↓, 5,   IL1↓, 1,   IL10↑, 2,   IL12↓, 2,   IL1β↓, 5,   IL6↓, 4,   Imm↑, 2,   Inflam↓, 7,   IP-10/CXCL-10↓, 1,   MCP1↓, 2,   MyD88↓, 1,   NF-kB↓, 4,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 6,   TRIF↓, 1,  

Synaptic & Neurotransmission

AChE↓, 5,   BChE↓, 1,   BDNF↑, 2,   ChAT↑, 1,   GABA↑, 1,   TrkB↑, 1,  

Protein Aggregation

Aβ↓, 1,  

Drug Metabolism & Resistance

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 1,   Dose↝, 2,   eff↑, 2,   eff↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers

ALAT↓, 2,   AST↓, 2,   BP↓, 1,   CRP↓, 5,   GutMicro↑, 2,   IL6↓, 4,   LDH↓, 2,   LDH∅, 1,   NOS2↓, 1,  

Functional Outcomes

AntiDiabetic↑, 1,   cardioP↑, 3,   cognitive↑, 5,   hepatoP↑, 1,   memory↑, 5,   neuroP↑, 8,   Obesity↓, 1,   radioP↑, 1,   RenoP↑, 3,   Risk↓, 1,  

Infection & Microbiome

Bacteria↓, 1,   IRF3↓, 1,  
Total Targets: 123

Scientific Paper Hit Count for: MDA, Serum malondialdehyde
14 Thymoquinone
11 Silver-NanoParticles
11 Boron
11 Quercetin
10 Curcumin
10 Silymarin (Milk Thistle) silibinin
7 Magnetic Fields
7 Propolis -bee glue
6 Betulinic acid
6 Carvacrol
6 Hydrogen Gas
6 Lycopene
5 Baicalein
5 Chlorogenic acid
5 Moringa oleifera
5 Shikonin
4 Resveratrol
4 Alpha-Lipoic-Acid
4 Astaxanthin
4 Berberine
4 Vitamin C (Ascorbic Acid)
4 Rosmarinic acid
4 Sulforaphane (mainly Broccoli)
3 Allicin (mainly Garlic)
3 Apigenin (mainly Parsley)
3 Luteolin
3 Crocetin
3 Ferulic acid
3 Rutin
3 Selenium NanoParticles
3 Selenite (Sodium)
2 doxorubicin
2 Andrographis
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 borneol
2 Selenium
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Thymol-Thymus vulgaris
2 Chrysin
2 Chemotherapy
2 EGCG (Epigallocatechin Gallate)
2 HydroxyCitric Acid
2 Juglone
2 Piperlongumine
2 Pterostilbene
1 3-bromopyruvate
1 cetuximab
1 5-Hydroxytryptophan
1 Anthocyanins
1 Paclitaxel
1 Melatonin
1 Cisplatin
1 Baicalin
1 Radiotherapy/Radiation
1 Biochanin A
1 Bromelain
1 Boswellia (frankincense)
1 Caffeic acid
1 Carnosic acid
1 Celastrol
1 chitosan
1 Chlorophyllin
1 Chocolate
1 Citric Acid
1 Coenzyme Q10
1 Galantamine
1 diet Methionine-Restricted Diet
1 Emodin
1 Ginkgo biloba
1 Graviola
1 Huperzine A/Huperzia serrata
1 Lutein
1 Magnolol
1 Metformin
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Mushroom Lion’s Mane
1 Myricetin
1 Oleuropein
1 HydroxyTyrosol
1 Phenethyl isothiocyanate
1 Orlistat
1 salinomycin
1 Sulfasalazine
1 Anti-oxidants
1 Date Fruit Extract
1 Sesame seeds and Oil
1 Shankhpushpi
1 Silicic Acid
1 Safflower yellow
1 Taurine
1 5-fluorouracil
1 Urolithin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:570  State#:%  Dir#:%
wNotes=0 sortOrder:rid,rpid

 

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