Cancer Database Query Results

Scientific Papers found: Click to Expand⟱
3624- Cro,    Crocus Sativus L. (Saffron) in Alzheimer's Disease Treatment: Bioactive Effects on Cognitive Impairment
- Review, AD, NA
*AChE↓, *memory↑, *cognitive↑, *MDA↑, *Thiols↑, *GPx↑, *antiOx↑, *ROS↓, *Casp3↓, *neuroP↑, *SOD↑, *Ach↑, *ChAT↑, *BBB↑, *Aβ↓, *tau↓, *cognitive↑, *Inflam↓,
3625- Cro,    Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and placebo-controlled trial
- Trial, AD, NA
*Aβ↓, *cognitive↑,
3626- Cro,    Comparing the efficacy and safety of Crocus sativus L. with memantine in patients with moderate to severe Alzheimer's disease: a double-blind randomized clinical trial
- Trial, AD, NA
*cognitive↓,
3627- Cro,    The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
- Review, AD, NA - Review, Stroke, NA
*other↑, *monoA↑, *Aβ↓, *AChE↓, *cognitive↑, *neuroP↑, *lipid-P↓, *SOD↑, *ROS↓, *GPx↑, *MDA↓, *memory↑, *antiOx↑, *Inflam↓, *other↓, *ER Stress↓,
3628- Cro,  VitE,  CUR,    Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *lipid-P↓, *Aβ↓, *AChE↓, *cognitive↑, *Inflam↓,
3629- Cro,    Studying saffron nanopowder (Crocus Sativus L.) on the temporal memory of rats suffering Parkinson's disease
- in-vivo, Park, NA
*memory↑,
3630- Cro,    Crocin Improves Cognitive Behavior in Rats with Alzheimer's Disease by Regulating Endoplasmic Reticulum Stress and Apoptosis
- in-vivo, AD, NA
*memory↑, *Bcl-2↑, *BAX↓, *Casp3↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Dose↝,
3631- Cro,    Investigation of the neuroprotective effects of crocin via antioxidant activities in HT22 cells and in mice with Alzheimer's disease
- in-vitro, AD, HT22 - in-vivo, AD, NA
*ROS↓, *Ca+2↓, *BAX↓, *BAD↓, *Casp3↓, *cognitive↑, *memory↑, *Aβ↓, *GPx↑, *SOD↑, *ChAT↑, *Ach↑, *AChE↓, *ROS↓, *p‑Akt↑, *p‑mTOR↑, *neuroP↑,
3634- Cro,    A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease
- Trial, AD, NA
*cognitive↑,
3635- Cro,    A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
- Review, NA, NA
*memory↑, *cognitive↑, *BioAv↑, *ROS↓, *IL1↓, *TNF-α↓, *NF-kB↓, *neuroP↑, *lipid-P↓, *Thiols↑, *antiOx↑, *AChE↓, *MAOA↝, *SIRT1↑, *PGC-1α↑, *Ach↑,
3637- Cro,    Investigation of the neuroprotective action of saffron (Crocus sativus L.) in aluminum-exposed adult mice through behavioral and neurobiochemical assessment
- NA, AD, NA
*cognitive∅, *MAOA↓, *MDA↓, *GSH↑, *AChE↓,
3832- Cro,    Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *memory↑, *Apoptosis↓, *cognitive↑, *ER Stress↓,
4158- Cro,    Antidepressant effects of crocin and its effects on transcript and protein levels of CREB, BDNF, and VGF in rat hippocampus
- in-vivo, AD, NA
*CREB↑, *BDNF↑, *Mood↑,
945- Cro,    Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer
- in-vitro, Lung, A549 - in-vitro, Cerv, HeLa
LDH↓,
6522- CRV,    l-carvone decreases breast cancer cells adhesion, migration, and invasion by suppressing FAK activation
- in-vivo, Var, NA
*Inflam↓, TumCG↓, VEGF↓, ChemoSen↑, FAK↓, ITGB1↓,
6521- CRV,    L-carvone induces p53, caspase 3 mediated apoptosis and inhibits the migration of breast cancer cell lines
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCP↓, TumCMig↓, Apoptosis↑, TumCCA↑, DNAdam↑, ROS↑, GSH↑, P53↑, BAD↑, cl‑Casp3↑, cl‑PARP↑, Apoptosis↑,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
6520- CRV,    Health Benefits and Pharmacological Properties of Carvone
- Review, Nor, NA
*Bacteria↓, *AntiFungal↑, *antiOx↑, *Inflam↓, AntiCan↑, *AntiDiabetic↑, *Obesity↓, TumCCA↑, *AntiArt↑, Imm↑, *P450↓, *GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, TumCP↓, TumCMig↓, Apoptosis↑,
6523- CRV,    Anticancer effects of Carvone in myeloma cells is mediated through the inhibition of p38 MAPK signalling pathway, apoptosis induction and inhibition of cell invasion
- NA, Melanoma, NA
AntiCan↑, TumCP↓, Apoptosis↑, TumCCA↑, TumCI↓, p‑p38↓,
6524- CRV,    d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells
- in-vitro, GC, AGS
ROS↑, MMP↝, JAK↓, STAT3↓, TumCD↑,
6525- CRV,    D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4)
- in-vitro, AML, NA
tumCV↓, ROS↑, antiOx↓, MMP↓, Apoptosis↑, Casp8↑, Casp9↑, Casp3↑, *neuroP↑, AntiCan↑, *AntiArt↑, TBARS↑, SOD↓, GSH↓, Catalase↓,
6526- CRV,    Multi-targeted effects of D-carvone against Non-Small Cell Lung Cancer (NSCLC): A network pharmacology-based study
- Review, NSCLC, NA
TumCP↓, Wound Healing↓, Apoptosis↓,
6528- CRV,    D-carvone inhibits growth, migration, cell cycle at G0/G1 phase and induces apoptosis in A431 cells by disrupting mitochondrial membrane potential
- in-vitro, Melanoma, A431
Apoptosis↑, ROS↑, MMP↓, TumCCA↑, TumCP↓,
6533- CRV,    Potential anticancer activity of carvone in N2a neuroblastoma cell line
- in-vitro, neuroblastoma, N9
*antiOx↑, tumCV↓,
6532- CRV,  doxoR,    R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity In Vivo and Potentiated Its Anticancer Toxicity In Vitro
- in-vivo, BC, MCF7 - in-vivo, Nor, H9c2
tumCV↓, ChemoSen↑, cardioP↑, *Catalase↑,
6531- CRV,    D-carvone attenuates LPS-induced acute lung injury via TLR4/NF-κB and Nrf2/HO-1 signaling pathways in rats
- in-vivo, Nor, NA
*TRAF1↓, *IL1β↓, *TNF-α↓, *ROS↓, *MDA↓, *GSH↑, *SOD↑, *Inflam↓, *NRF2↑, *Bcl-2↑, *IL8↓, *antiOx↑,
6530- CRV,    Monoterpenes as Anticancer Therapeutic Agents
- Review, Var, NA
selectivity↑, TumCP↓, Apoptosis↑, TumCCA↑, tumCV↓,
6529- CRV,    D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway
- in-vivo, Nor, NA
*ALAT↓, *AST↓, *MDA↓, *SOD↑, *GSH↑, *TAC↑, *eff↑, *TGF-β1↓, *SMAD3↓, *MMP9↑, *NRF2↑, *antiOx↑, *hepatoP↑, *Inflam↓, *NF-kB↓, *NO↓, *cAMP↑, *ROS↓,
7421- CS,    Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial
- Trial, Nor, NA
*hepatoP↑, *Dose↝, *toxicity↓, *BloodF↑, *ALAT↓, *AST↓, *Bil↓, *LDL↓, *HDL↓, *TG/TAG↓,
7417- CS,  CGA,    Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans
- Trial, Nor, NA
Dose↝, BioAv↝, Half-Life↝,
7418- CS,  CGA,  CA,  FA,    Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in human subjects: a pilot study
- Study, Nor, NA
Half-Life↝, Half-Life↝, Half-Life↝,
7419- CS,    Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial
- Trial, Nor, NA
*Dose↝, *other↓,
7420- CS,    Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial
- Trial, Obesity, NA
*LDL↓, *HDL↑, Dose↝,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
7416- CS,  Poly,    Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29
tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, Apoptosis↑, other↝, eff↑,
7415- CS,    Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells
- in-vitro, AML, THP1
AKR1B10↓, NF-kB↓, COX2/PTGS2↓, MMP2↓, ROS↓,
7414- CS,    Pro-Apoptotic Activity of Artichoke Leaf Extracts in Human HT-29 and RKO Colon Cancer Cells
- in-vitro, Colon, HT29 - in-vitro, CRC, RKO
*antiOx↑, *Inflam↓, tumCV↓, TumCCA↑, Apoptosis↑, eff↑,
7413- CS,  Poly,    Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines
- in-vitro, SCC, SCC25
AntiCan↑, tumCV↓, TumCG↓, Apoptosis↑, selectivity↑, BAX↑, Casp9↑, Bcl-2↓, TumCCA↑, other↝, hepatoP↑,
7412- CS,  Chemo,    Artichoke Polyphenols Sensitize Human Breast Cancer Cells to Chemotherapeutic Drugs via a ROS-Mediated Downregulation of Flap Endonuclease 1
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Apoptosis↑, ROS↑, TumCP↓, DNAdam↑, FEN1↓, ChemoSen↑, NRF2↑,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
7410- CS,    Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
- in-vitro, BC, MDA-MB-231
selectivity↑, other↝, Apoptosis↑, DR4↑, Casp9↑, Casp8↑, Bax:Bcl2↑, P21↑, MMP↓, TumCI↓, MMP2↓,
7423- CS,    Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats
- in-vivo, Nor, NA
*lipid-P↓, *GSTs↑, *GPx↑, *GSR↑, *SOD↑, *P53↑, *Bcl-2↑, *ROS↓,
7424- CS,  CGA,    Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells
- in-vitro, Nor, NA - in-vitro, Liver, HepG2
*ROS↓, *GSH↑, *MDA↓, tumCV↓, Apoptosis↑, Casp3↑,
7427- CS,  Poly,    Polyphenols from artichoke heads (Cynara cardunculus (L.) subsp. scolymus Hayek): in vitro bio-accessibility, intestinal uptake and bioavailability
- Study, Nor, NA
*BioAv↓, *BioAv↝,
7428- CS,    Exploring the Cardiovascular Potential of Artichoke—A Comprehensive Review
- Review, Nor, NA
*BloodF↓, *BP↓,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
7422- CS,    Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
- Review, Nor, NA
*LDL↓, *TG/TAG↓, *HDL∅,
1601- Cu,    The copper (II) complex of salicylate phenanthroline induces immunogenic cell death of colorectal cancer cells through inducing endoplasmic reticulum stress
- in-vitro, CRC, NA
i-CRT↓, ICD↑, i-ATP↓, i-HMGB1↓, ER Stress↑, ROS↑, DCells↑, CD8+↑, IL12↑, IFN-γ↑, TGF-β↓,
1642- Cu,  HCAs,    Copper-assisted anticancer activity of hydroxycinnamic acid terpyridine conjugates on triple-negative breast cancer
- in-vitro, BC, 4T1 - in-vitro, Nor, L929
tumCV↓, selectivity↑,
1639- Cu,  HCAs,    Green synthesis of copper oxide nanoparticles using sinapic acid: an underpinning step towards antiangiogenic therapy for breast cancer
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
angioG↓, tumCV↓, Dose↓, ROS↑,

Showing Research Papers: 2551 to 2600 of 8269
Prev Page 52 of 166 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8269

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AKR1B10↓, 1,   FEN1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↓, 1,   GSH↓, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 2,   ICD↑, 1,   NRF2↑, 1,   ROS↓, 2,   ROS↑, 7,   SOD↓, 1,   TBARS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

i-ATP↓, 1,   MMP↓, 3,   MMP↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDH↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Apoptosis↑, 16,   BAD↑, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 3,   Casp↑, 1,   Casp3↑, 6,   cl‑Casp3↑, 1,   Casp8↑, 2,   Casp9↑, 5,   DR4↑, 1,   p27/CDKN1B↑, 1,   p‑p38↓, 1,   survivin↓, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 3,   tumCV↓, 11,  

Protein Folding & ER Stress(tgid=8) ⓘ

i-CRT↓, 1,   ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   p16↑, 1,   P53↑, 1,   p53 Wildtype↓, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   P21↑, 3,   TumCCA↑, 8,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

FAK↓, 1,   ITGB1↓, 1,   MMP2↓, 2,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 8,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

cellSen↑, 1,   COX2/PTGS2↓, 1,   DCells↑, 1,   i-HMGB1↓, 1,   IFN-γ↑, 1,   IL12↑, 1,   Imm↑, 1,   JAK↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 3,   Dose↓, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 2,   Half-Life↝, 4,   P450↓, 1,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 6,   AntiTum↑, 1,   cardioP↑, 1,   chemoPv↑, 2,   hepatoP↑, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 84

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiArt↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 10,   Bil↓, 1,   Catalase↑, 1,   GPx↑, 5,   GSH↑, 5,   GSR↑, 2,   GSTs↑, 1,   HDL↓, 1,   HDL↑, 1,   HDL∅, 1,   lipid-P↓, 5,   MDA↓, 5,   MDA↑, 1,   NRF2↑, 2,   ROS↓, 12,   SOD↑, 7,   TAC↑, 1,   Thiols↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   cAMP↑, 1,   CREB↑, 1,   LDL↓, 4,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   Apoptosis↓, 1,   BAD↓, 1,   BAX↓, 2,   Bcl-2↑, 3,   Casp3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

Ach↑, 3,   other↓, 2,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 2,   GRP78/BiP↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑mTOR↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   MMP9↑, 1,   MUC1↑, 1,   SMAD3↓, 1,   TGF-β1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ICAM-1↓, 1,   IL1↓, 1,   IL1β↓, 2,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 9,   NF-kB↓, 2,   TNF-α↓, 3,   TRAF1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   BDNF↑, 2,   ChAT↑, 2,   MAOA↓, 1,   MAOA↝, 1,   monoA↑, 1,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   Dose↝, 3,   eff↑, 1,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   Bil↓, 1,   BloodF↓, 1,   BloodF↑, 1,   BP↓, 1,   IL6↓, 1,   TG/TAG↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↓, 1,   cognitive↑, 9,   cognitive∅, 1,   hepatoP↑, 3,   memory↑, 7,   Mood↑, 1,   neuroP↑, 7,   Obesity↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 93

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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